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Tuesday, 11 October 2016

Pediatric Type 2 Diabetes Mellitus. October 11, 2016

The article was published back in past and last time was updated in May 2014. Still, when I read it, I do have the same questions as it always was. There are some answers for my questions, but does it really can be accepted as medical guidance? Really, why some kids diagnosed as type 2 and other as type 1 diabetics? I am sure, all mothers ask the same question as I do: diabetes type 2 how it was diagnosed and really what is it and how type 2 different from type 1?

The marks for diagnose diabetes type 2:
  • Glucose level in blood stream.
  • Elevated fasting C-peptide level,
  • Elevated fasting insulin level,
  • Absence of autoimmune markers (glutamic acid decarboxylase [GAD] and islet cell antibodies).
     I almost ready to bite it, still, why never insulin level tested in my blood, ether fasting nether random, ever? Is this really possible in present time to check up level of insulin our body system needs during all day long? Insulin is tiny hormone which released by very tiny amount all day long. So, if in one moment insulin level is high (after meal) then another moment it is low (high activities and limit in nutrition). Then really, how amount of insulin needed for daily activities was tested? It never was done. Ether diabetics type 1 Nether diabetics type 2 ever were tested for level of insulin. This mark simple do not exist. Then what really is guidance about how to diagnose diabetes if there is  tests for diagnose available in present time?
       In present time level of sugar tested and it is presented that level of sugar must be in range, different as day activities go on. Fasting level of sugar is lowest, and level of sugar after meal is highest. It is also presented that level of sugar must drop back to normal two hours after meal. This is why testing based on this understanding. As I posted all the time, I do run my studies. I took one hour reading the level of sugar in my blood, and this level of sugar run up and up about 5 hrs after meal till it reached highest level, and then start to drop.
       What about level of insulin? How level of insulin run in our blood? when it is highest, when it is lowest? What amount of insulin we use during regular daily activities?  There are no one publications with this info. There is no one mention that level of insulin never tested in anyone diabetic blood. Then say me, what is this about, 'elevated fasting insulin'? Does this test is different then test for  C-peptide level?
      Now, there is another mark, C-peptide level, fasting. The mark for C-peptide is 'a few' or 'many'. Is this could be considered as any mark? My C-peptide level, random, not fasting 3 . Is this 'a few'? or it is 'many'? Also never forget, it is fasting level of C-peptides. There is no activities yet, no meal. To run any test for diabetes it must be taken into consideration that diabetics cannot process meal in regular base. So, why it is fasting state taken as diagnostic mark to diagnose medicinal condition which is abnormal in the way after meal taken? Why there are no tests how diabetic handle meal processing? What would be level of C-peptides in non-diabetic blood after meal, one hr after meal? two hr after meal, and so on? There  are must be table rather then just mark, 'a few' or 'many'. There are no tables like that. Diagnose of diabetes type 2 barbarian, based on personal judgement. If so, then why it is presented as scientific method of diagnose? It is BARBARISM, Shamanism.
      Finally, it is another mark:
"Autoimmune markers (glutamic acid decarboxylase [GAD] and islet cell antibodies) are usually negative in type 2 diabetes but are frequently present in type 1 diabetes."
To say about this marks it is important to understand that diabetes is not one day fasting onset of medical condition. So, when these marks would be present? At the time when diabetes type 2 diagnosed with level of sugar 120 mg/dl? or at time when level of sugar in  diabetics type 2 blood is over 600 mg/dl, the limit of home glucose meter? According to the level of sugar and duration of this condition, autoimmune marks show up. This is why they mostly present in type 1 diabetics because of they do have high level of sugar at the time of diagnose. They are not usually present in type 2 diabetic blood because of ... well, probably because of diagnose diabetes type 2 is judgemental and after diabetes type 2 was confirmed the statement that there is no antibodies already done, so there is no need to run the test. Stupid, but it works in this way.
 In January 2013, the American Academy of Pediatrics (AAP) issued clinical practice guidelines on the management of type 2 diabetes in children and adolescents. The guidelines recommend insulin treatment in all patients who present with ketosis or extremely high blood glucose levels because it may not be clear initially whether these patients have type 2 or type 1 diabetes. Once a diagnosis of type 2 diabetes is confirmed, lifestyle modification and metformin treatment should be initiated.
Now there is another question, how diagnose of diabetes type 2 was confirmed? This is important to understand. If diagnose for type of diabetes not clear then the treatment for ether type of diabetes insulin only. After that  for any unclear reason diagnose of type 2 diabetes was confirmed, and child stated treatment with life style modifications and Metformin. 
     I am not medical pro. I am mother. My mind does not work in direction of medical studies or provider income. My mind work in one direction, how to help my child to stay as healthy as child can be. So, regardless what diagnose doctor stamped I will take insulin, insulin only, and I will put my child on insulin rather then any Junk Medicine provider happy to push my child. 
      It is easy to see, diabetic of any type of diabetes will benefit with insulin therapy. Life style modification Rx only for type 2 diabetic. Say me, why type  1 diabetics should not practice healthy life style? Why for type 1 diabetic it is not treatment regime? The answer is only one, it does not work. So, to treat diabetic type 1 insulin therapy applied. Why it is not treatment regime for diabetic type 2? Why should I take treatment regime which does not work, and lost my life timelessly? Or as mother I do value my diabetic type 2 child less then mother of diabetic type 1 child? Not at all. 
The goal of therapy is to achieve and maintain euglycemia, as well as near-normal hemoglobin A1c (HbA1c) levels (≤7%). Patients who are not ill at diagnosis can be treated initially with lifestyle changes (eg, diet, exercise, weight control). However, because few patients can maintain euglycemia with lifestyle changes alone, most children and adolescents require medication.
No comments. Life style modifications can treat patient who does not have diabetes. Diabetic with highly elevated level of sugar must be treated with insulin. Then what is the reason to treat elevated level of sugar with diet? Why do not start with lower level of insulin therapy and CURE diabetes type 2 as soon as it was diagnosed? Look like very reasonable.
If goals in step 1 not achieved after 3 months (fasting glucose level >126 mg/dL or HbA1c level >7%), add 0.4-0.6 U/kg of 24-hour insulin at bedtime (Glargine or Levemir). If combination therapy is adequate, continue therapy. If combination therapy is inadequate after 3 months, intensify insulin therapy until the fasting plasma glucose level is less than 126 mg/dL and the HbA1c level is less than 7%. 
Why do not start insulin therapy as soon as diabetes any type diagnosed? Simple brain work with open mind looks logical that Insulin Therapy is reasonable solution. So, why take risk and lead to progress of diabetes if it is possible to start insulin therapy and at least stop the progress toward complications? Metformin, which did not work in first place, why it still in treatment regime as part of combination therapy? Only to keep profit manufacturing company. But Metformin destroy liver and muscles. Just try it, if level of sugar under control without Metformin then why diabetic any age need Metformin?
     So, if treatment the same, medical condition the same, the diagnostic the same, then why diagnose is different? The answer is only one, do not trust in diagnose. It is judgemental. It is not reasonable. But all the time fight for the treatment you need to protect your child. Insulin, and insulin only, no any Junk Medicine such as Metformin or Invokana. Just say 'no!' to any Junk. This is what we can do.

Pediatric Type 2 Diabetes Mellitus

  • Author: Alba E Morales Pozzo, MD; Chief Editor: Stephen Kemp, MD, PhD  more...
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