News from ADA 2018

The American Diabetes Association's Scientific Sessions for 2018 (called ADA2018 with hastag #2018ADA) just ended.  I was not there, but did monitor twitter and other social media to get a feel for what was going on.  As in previous years, it was about 90% type-2 and about 90% treatments (not cures), and of the remaining type-1/cure research, only a little was human trials of the type covered in this blog.

So anyway, here is a huge list of links (mostly links to tweets) which I found interesting for one reason or other.  I've tried to categorize them, and in a few cases, after the link, I've added a sentence or two about why I found them interesting.

Summary web sites:
https://ift.tt/2MAjSXf
https://ift.tt/2KxdAdp
https://ift.tt/2MCUSif
https://ift.tt/2KkJL0n
https://ift.tt/2MCUTTl

Cure Related
ATG/GCSF:
    https://twitter.com/BeyondType1/status/1011252403079745536
    https://twitter.com/Judithendo/status/1011240300742893568
Meta-Dopa, which I need to blog about:
    https://twitter.com/Judithendo/status/1011291591875743744
Encapsulation for beta cells (animals, I think):
    https://twitter.com/Cristob_Morales/status/1011230794831089667

Smart Insulin:
https://twitter.com/mbotana/status/1010599897987473410
https://ift.tt/2KiNE6a

ViaCyte:
https://twitter.com/ViaCyte/status/1010508277766082560
https://twitter.com/ViaCyte/status/1010493177273442304
https://ift.tt/2MAjW9r

Artificial Pancreas:
There were lots more, but these really called out to me.
https://twitter.com/danamlewis/status/1010527143938416641
https://ift.tt/2KwjFXO
https://ift.tt/2MBywgK

General Interest:
https://twitter.com/em_saidwhat/status/1010513691056451584
Pregnancy: https://twitter.com/RenzaS/status/1010494620512473088
Average A1c by age: https://twitter.com/RenzaS/status/1010476210088886272
Vit D: https://twitter.com/cristinatejerap/status/1010589989678305280
T2D delays T1D? https://twitter.com/cristinatejerap/status/1010604154186817537
Mice vs. Humans: https://twitter.com/Cell_Onion/status/1010543301580279808
Gut not important? https://twitter.com/DrKirstieBell/status/1010618697440989184
Patch Pump: https://ift.tt/2KwjGLm
Half Units Matter: https://twitter.com/Diabetes_Videos/status/1011391416889696256
Adjunct Therapy: https://ift.tt/2ImduQV?
Bariatric Surgery T1D: https://twitter.com/Ali_Aminian_MD/status/1011647953667272704
SGLT:
    https://twitter.com/MarkHarmel/status/1011646768776392705
    https://twitter.com/AmDiabetesAssn/status/1010860753589587968
    https://ift.tt/2Kw3Dx0

New Patch Pump: https://twitter.com/SanofiDCV/status/1011617549174353920

Type-2:
Lots of comorbid conditions: https://twitter.com/AstraZenecaUS/status/1010526644656799744

Transplants:
https://twitter.com/drpratikc/status/1011353557013073920
An attempt at a head-to-head comparison of islet transplants vs. Artificial Pancreas results.  Interesting!

The other form of bihormonal AP:
https://twitter.com/EndocrineToday/status/1011330691009658880
Most bihormonal AP research uses insulin and glucagon, but this one uses insulin and pramlintide.

Faustman:
News: https://ift.tt/2MxP09Q
Discussion: https://twitter.com/Drbeth_/status/1010431411671748608
Poster and Discussion: https://twitter.com/HangryPancreas/status/1011294476260831233
ADA and JDCA joint letter (later supported by the Berrie Center):
    https://twitter.com/keddy_moise/status/1011420460612030464
    https://twitter.com/DiabetesMine/status/1011400346441220096
    https://twitter.com/JDRF/status/1011399303665995776
    https://twitter.com/nbdiabetes/status/1011640607259930625
These two guys (and many others) report dropping A1c, but no one calls them a cure:
    https://twitter.com/snp_io/status/1010616966523088896
    https://twitter.com/Fallabel/status/1011280750967246848

Interesting to me:
Open Data Tools for Software Nerds: https://twitter.com/stales/status/1010599135576231936
I found the next tweet interesting because Cure was in title, but treatment in contents.  To me that shows a problem with "cure" research.  Much of it is not really aimed at a cure:
https://twitter.com/DanielJDrucker/status/1010870015183278080
TEDDY:
    https://twitter.com/cristinatejerap/status/1010586167102922752
    https://twitter.com/ERobertson02/status/1010614817244286976
    https://ift.tt/2Ky2YuV

Low Carb:
https://twitter.com/DikemanDave/status/1011393166849728512
https://twitter.com/JPMcCarter/status/1011328194115522560
https://ift.tt/2MAjYhz
https://twitter.com/JPMcCarter/status/1011697843260837888
https://ift.tt/2KAnlHO

Atkinson honored (nPOD and much more):
https://twitter.com/_HealthMyself/status/1011262077191716864
https://twitter.com/HIRN_CC/status/1011255219202633728

The "Most Obvious Research Conclusion Award"
https://twitter.com/DrKirstieBell/status/1010881942974291968

Joshua Levy 
https://ift.tt/29DuN3o 
publicjoshualevy at gmail dot com 
All the views expressed here are those of Joshua Levy, and nothing here is official JDRF, JDCA, or Bigfoot Biomedical news, views, policies or opinions. In my day job, I work in software for Bigfoot Biomedical. My daughter has type-1 diabetes and participates in clinical trials, which might be discussed here. My blog contains a more complete non-conflict of interest statement. Thanks to everyone who helps with the blog.


via Cure Research

Kismet: Attending #2018ADA As A Guest Reporter For Ascensia

Kismet has been occurring as of late and I'm embracing it!

For instance, I was able to attend The American Diabetes Association's 78th Scientific Sessions last week in balmy (code for UBER HUMID,) Orlando, Florida - and thanks to Ascensia Diabetes Care, who hired me to write a 3-part series re: my experiences as a person living with diabetes attending ADA. acting as their official on-site Guest Reporter for ADA 2018. 

ADA was awe inspiring; incredibly overwhelming, physically never ending, a total sensory overload, and IT WAS AMAZING! 

I learned so much, met incredible people,  reconnected with diabetes friends and colleagues. 

My first post is up and running and it's all about diabetes data; dtech, helping other people with diabetes in under-served communities and a very cool WHISK. Click  HERE and give a read!

As always, while Ascensia paid for my flight, hotel, and travel expenses, and provided me  

with an honorarium for my time and skills - ALL THOUGHTS are mine and mine alone. 

via Diabetesaliciousness

Diabet type 2, Weight, Med Pro, and Survival. June 27, 2018

Sugar is 77 mg/dl today.
It is good sugar, and I try to keep it in this way. The problem is, practically it is not possible. All the time Med Pro publish guidance how to deal with diabetes type 2, eat right and be active. They pretend, it is we are, diabetics type 2 done for ourselves. So, many of us, practically all with very small acceptation, trust in doctors and try to eat right, meaning stay hungry, cutting very important nutrition, and still not able to lose weight.
At first, what is weight?
It is not only fat as it is presented by Med Pro. They present, humans all what we eat. What about water? is water has weight? Try to check it out. Take basket of water and go to fitness club. If basket will heavy for you, it is because of water has weight.
Another way to see if water has weight is to take drink of water as much as one can and stand on the bathroom scale. Is weight getting higher then it was before water?
Of cause, it is primitive, and every one do know very well, water has weight. The question is, why Med Pro insist, if our kidney do not release water, we are collected pounds because of our extreme overeating, eating disorder? It is not. It is Edema, extreme water retention. Do not try to ask doctor what to do. The answer is only, take water pills, diuretics. It is fast and very effective way to temporary reduce weight. In long term? It is Heart failure. Kidney Failure. More water retention. Dangerously high swelling. Death.
What about bones weight?
We all do know very well, Asian population has lower weight then Westerns. If so then why we all have to have the same BMI? It is simple not possible. But in addition to our ethnicity differences we are diabetics type 2, people with very high blood sugar level, so high that to control it we have to take more then 200 units of Insulin.What does it mean? Sugar is not only in our blood. It is in every cell of our body, in teeth, in bones, in flesh, and so on. Now say me how Diabetic type 2 can have the same weight as healthy Asian girl, even if we  are the same high? Not possible. The BMI is creation to put people in constant combat with Nature. BMI is just math, no one man can fit into math formula. we all less of greater then standards created by Math.
In presentation of Med Pro Diabetics type 2 who has higher weight then general population, done it for themselves. Why it is so? Because of no one diabetic has the same weight as it is anyone non diabetic which is the same in any other measures. Add sugar to water and see if the weight of water still the same, or it got higher. We develop diabetes many years, one year after another, passing from one crisis and survive, to another. This is why our sugar level getting greater with years passed. If we were treated with Insulin in our early years we will not have those heavy bodies as we do have now. Prove?
Very simple. Stop to kill us with Oral Medicine, and start to treat diabetics type 2 with respect and proper medicine, Insulin in right regime. Why it is not in practice? Because of it is easy to put responsibility on sick people. We cannot protect ourselves.   When we are capable to do so we just do trust in doctors and follow doctors' orders. When it is too late, it is simple too late.
It is well known fact that most amputations done to diabetics patients. Why? Is this really necessary? Not at all. The same as it was 100 years ago diabetics lost legs and suffer extreme pain. 100 years of Insulin in practice reduced dramatically amputations in children because of they are treated with Insulin right after being diagnosed. In contrary adults must blame themselves for every bite we take. This is, how it is presented by Med Pro and Media, why our sugar is high. But in practice, if diabetic type 2 start to take Insulin in right dose and right regime, there is no weight gain, no amputations, and with time diabetic type 2 getting healthier.

via Ravenvoron

To Whome Oral Insulin Needed? June 26, 2018

Now, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed an oral delivery method that could dramatically transform the way in which diabetics keep their blood sugar levels in check.
Not only does oral delivery of insulin promise to improve the quality of life for up to 40 million people with type 1 diabetes worldwide, it could also mitigate many of the disease's life-threatening side effects that result from patients failing to give themselves required injections.
 https://www.sciencedaily.com/releases/2018/06/180625192838.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

      The new discoveries make our life easy. Do they? It is easy to say just taking one look at the promise,  oral Insulin Vs Insulin in injections. everyone will say, it is progress.I am not everyone. I am one, who suppose to swallow these oral medicine, and lost my beloved Insulin Lantus solo Star in injections. And I am really not so happy with that.
       Some doctors remember the time when Metformin replaced Insulin injections. It was progress, easy to take, easy to dose, easy to store, and very low price. This is look at the Metformin compare with Insulin. There is only one problem, Insulin works, decrease level of sugar in blood, and keep diabetics alive, complications-free. Metformin, in other side, doesn't work, and dramatically shorten human lives. With time Insulin was replaced by Metformin for 95% of American diabetics. Only children were diagnosed with diabetes type 1 and were used Insulin in injections. All adult diabetic population was diagnosed as diabetics type 2, and treated with Metformin.
       Now time is passed. To get Rx to Insulin practically not possible. Even children now treated with Metformin in stead of Insulin. Mortality diabetics type 2, those diabetics who take oral medicine to control blood sugar level, 80,000 Deaths every year. Diabetes type 2 is number 7 cause of Death, only high blood sugar level, or low blood sugar level which is practically the same, wrongly treated diabetes. Diabetes leads to many complications and many Deaths as underlying cause. 100 years after Insulin discovery our medical providers still not able to Rx insulin and have no one idea how to dose it.
       So, why it is so important to develop oral Insulin? BTW, why it is "Insulin" in first place? It would no longer be insulin, hormone which does not diagested but delivered right into blood stream? Give to that oral medicine another name? Why not? Because of benefits of Insulin in present time very well known. So, to fool diabetics and general population, there must be another shadow on sunny day. Still, let us take a look at the studies and yhe progress in developing this type of medicine to kill every one out of ten American.

Insulin therapy, by injection just under the skin or delivered by an insulin pump, generally keeps the glucose levels of most diabetics in check. "But many people fail to adhere to that regimen due to pain, phobia of needles, and the interference with normal activities," said senior author Samir Mitragotri, Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering at SEAS.     

        How easy to spread lie under high title of Med Pro. It is no problem to inject insulin. The problem is how many units to inject.  It is not "Insulin" injected under skin which keep glucose level under control, it is diabetes, medical condition, why glucose level is all the time out of control. Diabetics do not fail to inject insulin. We all the time do it. But there is the problem, too much insulin leads to low sugar, very danger condition which can lead to life threatening condition. When dose of insulin is lower then it is needed, glucose level is out of control, high, and getting higher.
      Ask any doctor, what dose of insulin you have to inject, and no one doctor can give you any answer. It is not because of they do not want to help or do the job. They cannot know it. Dose of insulin depend on many things, no one of them in direct contact with dose of injection. Even if dose of insulin injected according to the life-time level of sugar, it is really not effective. Sugar can run high, or low, in ether way. No math work for this situation. Just no one math can replace Bio activity.

        The key to the new approach is to carry insulin in an ionic liquid comprised of choline and geranic acid that is then put inside a capsule with an acid-resistant enteric coating. The formulation is biocompatible, easy to manufacture, and can be stored for up to two months at room temperature without degrading, which is longer than some injectable insulin products currently on the market.

Another lie.
        Insulin can be stored in ref. up to two years or even more. New types of insulin can be out of ref. for weeks, no damage. Also we can see  if insulin is OK or something wrong with it before taking injections. What about new oral medicine? Two month, and diabetic out or medicine. In present time mail delivery for medicine is common practice. It is all the time three month supply. With the capacity of new medicine to be in good condition diabetics cannot be free to take long vacation, or trip needed to work. Only two month for storage, it is not too much. We have to be bound to the ability to have this oral medicine.
         Capsules have another issue. It is obvious, and I do not want to discuss it. Just remember, we take this medicine day-after-day, full our lives, and capsules material will finally built up in our system. Is this really good idea? Probably it is OK for short time, but for full life?...... No, thanks.

"When a protein molecule such as insulin enters the intestine, there are many enzymes whose function is to degrade the proteins into smaller amino acids," explained first author Amrita Banerjee, who conducted the research while working as a postdoctoral fellow in Mitragotri's lab, and is now an assistant professor at North Dakota State University. "But the ionic liquid-borne insulin remains stable."

        I am sorry, but insulin is not protein molecule. It is hormone. For very tiny hormone the way to get into stomach, then to liver, and finally to bloodstream is way tooooooo long. A you sure, there are all insulin still present in the capsular? Remember, life of Insulin is short, and this is why it is too difficult to test how much insulin is in the system. In stead of Insulin it is C Peptides, Proteins, to count if pancreas still secret insulin. C Peptide level for healthy pancreas secreting insulin is from 1 to 5. This is irony. How many insulin hormones will enter into blood stream?
       This is all the time how easy to manipulate the studies or results, or any info published to the public. Just say, "this is how" under authority of pro, and any lie will be taken as true.

Banerjee also noted that ionic liquid-borne insulin can be prepared in a one-step process that could be readily scaled up for inexpensive industrial production, making the cost of manufacturing the oral formulation easily manageable.

Well, what can I say about it? Metformin is out of business. Its time coming to end. A new  cheap product must be developed to decrease American Population. This is why all the media and all the propaganda barking on obesity and presenting that diabetes is diabetic's choice. Why is it so? Because of human survive. Now diabetics live longer, much longer then it was in pre-insulin era. Even without treatment diabetics can survive. With help of Med Pro we will head to recycling facility our local hospitals. we provide a lot of organs for transplant. we are very important part of income for medical facilities, and donations for  politicians.

via Ravenvoron

FDA Clears First Point-of-Care Test to Diagnose Diabetes. Why it is so Important? June 22, 2018

The US Food and Drug Administration (FDA) has approved the Afinion HbA1c Dx assay (Abbott), the first rapid point-of-care test to diagnose diabetes and assess a patient's risk of developing the disease, the company announced.
 https://www.medscape.com/viewarticle/898415?nlid=123380_3901&src=wnl_newsalrt_180621_MSCPEDIT&uac=164666HZ&impID=1664131&faf=1

      OK, if it is rapid test for diagnose of diabetes, then really when it must be so urgent? In case that diabetes is already advanced, and test needed to see what treatment must be applied in ICU. In this case simple and best way to diagnose diabetes just take blood sugar reading, and see, how this reading high above 200 mg/dl.  First rapid test for diagnose of diabetes is not the A1c but simple blood sugar reading above 200 mg/dl, random. Not only any clinic, dental including, but patient who has own glucose meter can diagnose diabetes. This is why I all the time ask, why blood sugar readings still not Vital? With one out of ten Americans who are diabetics, why test for sugar in blood still not Vital?

 "With our new expanded test indication, patients at risk for diabetes can receive their assessment within minutes, allowing them to work with clinicians to customize a care plan during a single visit. This is especially impactful for patients who can't easily access or make multiple appointments at labs and doctor's offices," said Balthrop.      

      It is interesting that FDA pay attention to those who are at risk for diabetes. What if one is already diabetic? That's right, patient diagnosed with diabetes, and then what? Nothing good. Life style modifications, low carb diet for those who has A1c=12,2%. The question is, why FDA is not interested, how diabetics are treated? Is treatment for diabetes effective? Not at all. There are three types of diabetes. All three have the same testing tools to diagnose diabetes, A1c or other random test for level of sugar higher then 200 mg/dl.Then for no one reason or testing results, diabetics divided on three groups.
Children, if they are not obese, diabetics type 1. They treated with insulin. They do have pretty good outcomes and good future. For this type of diabetics diabetes is regressive. After being discharged from ICU they have lower dose of insulin then they had in hospital. Also they do have insulin supply, so they have opportunity to control blood sugar.
If child obese then regardless of the level of sugar in blood child will be diagnosed as type 2 diabetic, have nutrition education, and discharge from hospital with diet plan, Metformin and Glipizide to control blood sugar level. This child never will be able to achieve blood sugar control. If parents will not find doctor who understand diabetes without prejudice, child will die.
Adult diabetics also divided on two types: those who fit, and those who obese. As anyone can see, LADA is type of diabetes which practically almost never diagnosed. Type 2 diabetes diagnosed in 90% of American Diabetes population. Treatment for LADA is insulin, and not too many doctors understand how to dose insulin. So, doctors do not diagnose LADA. They diagnose type 2 diabetes. Every one with high blood sugar numbers will be diagnosed as type 2 diabetic, why? Because of doctors have no one idea how to dose insulin, and they do know very vell, insulin leads to low sugar.         
           It is not the case that insulin dosed incorrectly. It is simple not possible for doctor to dose insulin for patient. Dose of insulin is different every day, and it is not directly depend on what diabetic eat. To reduce pressure MD simple Rx Metformin hich never reduce blood sugar level so MD is safe. Diabetic has low cost medicine. If this treatment effective? Not at all. One year after another the number of victims to diabetes is the same, 80,000 Americans. These Deaths are 100% preventable with Insulin Therapy. There is no MD who get really good training in diabetes treatment. FDA and ADA, CDC and WHO, and a lot of other organizations very busy to collect donations how to stop diabetes which provide great add-on to their incomes. Say me, do they really care how to stop diabetes? Better to ask if they ready to stop to collect donations. Then answer will be clear. 
       To show, they do the job, they run and publish studies, what can help to stop diabetes. It is a new system to check BG, or new test to diagnose diabetes or ..... the list is go on and on, hands -by- hands with diabetes. Without so many diabetics what all those organizations are going to do? To whome they are going to show their gallant dancing?

 We already have point-of-care fingerstick A1c's.  More puffed-up "breaking news" by Medscape. (MD. Family Medicine. Response to the publication)

via Ravenvoron

May Diabetic type 1 die if one skipped insulin shot? June 21, 2018

Today sugar is 122 mg/dl.
       Why it is so interesting to point out what today sugar is? well, it is all the time presented but id Type 1 diabetic skipped one shot of insulin, diabetic type 1 can even die. True? False. Yesterday I skipped night time shot, and it is 160 units. Today sugar is 122 mg/dl, not so high I would like to say. Of cause, I am diabetic type 2, not type 1. Diabetics type 2 are insulin resistant, which means we need more then 200 units on insulin in injections.Diabetics type 1 need less then 100, and mostly of them with time take less then 25 units, even less then 10 units. So, is this really true that type 1 diabetic will die if one skipped one shot of insulin? Not the chance.
       On June 18, 2018 I did not inject insulin at all. Before that every day I injected 370 units, day after day. On June 18, 2018 fasting sugar was 61. On June 19, 2018 fasting sugar was 107. Pretty good I would say, and weird. 370 units skipped, and sugar still normal. Maybe I am no longer diabetic type 2? Maybe I already cured? Diabetes type 2 reversed? Not at all. It is easy to see that after 61 fasting sugar jumped to 107, and if left without insulin I would return back to fatal end.
      It is very odd what is going right now. My skin getting back to create new wounds. Right now it is on hands. But more and more spots getting effected. At first it is itching. Then it is rush. After bubbles with sort of liquid under it. Finally skin is broken, and liquid run down effecting more and more surface. I try to dress my wounds. Not so effective.
      Another big problem is Edema. I am collecting water, getting more and more of it. The tongue does not fit inside of mouth. Face is round and swelled. I hardly able to walk. My legs are swelled, do not hold the body. I cannot stand, walk, even get off bed is big problem for me now.
     Every night I do have severe headache. My Bi-Pop broken. I have to buy a new one, and I cannot do it. It is two years, and it is gone. My C Pop worked without problem till I got a new Bi Pop. It was more then 5 years. Probably that C Pop could work even now. Company demand money. They all do it. 100$ just to replace power cord. Then it would be another problem. And another.... , No Thanks.
    

via Ravenvoron

Diabetes may be an early manifestation of pancreatic cancer. June 20, 2018

It is all the time "May be", and it is never for sure "It does".

Pancreatic cancer is one of the most fatal cancers, with a five-year survival rate of only 8 percent. This is because the vast majority of pancreatic cancer patients (some 80 percent of them) are diagnosed at a late stage. Identification of high-risk people and ability to detect pancreatic cancer earlier would likely improve patient outcomes.
 https://www.sciencedaily.com/releases/2018/06/180619122923.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

      If early diagnostic so important in best outcome, then why today diagnose of most fatal cancer is so late? Just take a look at, how diagnose made. it is identification of people of High Risk. So, is this people who are in high risk group who die because of pancreatic cancer?  How this group identified that these people are in highest risk to develop this fatal medical condition?
    Well, let me take a look at the most common for me, diabetes type 2. Who are in high risk to develop diabetes type 2? Obese people. What about those who are fit or underweight? They usually never tested for diabetes. And they are already have abnormal A1c. If all people who come to clinic would be tested for level of sugar in blood then it will be very big surprise how many people out of risk would have abnormally high A1c. At the same time they do have normal Fasting sugar and after meal level of sugar.
      In our studies it is taken for granted that obesity leads to development type 2 diabetes. It is easy to state the fake statement as it is true. But this "True" collapse under first wave or real study. Take blood sugar level as vital, and see, how many people do have abnormally elevated level of sugar in blood. This level come long before middle area widened, and obesity diagnosed in diabetes type 2 victim.
           Now it is theory that

Diabetes has been consistently associated with pancreatic cancer in previous studies, with a twofold higher risk of developing pancreatic cancer among diabetes patients. Diabetes has been proposed to be both a risk factor for and a consequence of pancreatic cancer. The prevalence of diabetes among pancreatic cancer patients is unusually high relative to other cancers.

       Is this really diabetes type 2 which identified with pancreatic cancer? Or probably it is wrong treatment and wrong diagnose of diabetes which leads to pancreatic cancer? Of cause, there are no studies how  Invocana or Metformin lead to pancreatic cancer. Really, who is going to pay for these studies? At the same time it is well known fact that diabetes type 2 is progressive. Why? People never stop eating. So simple. We really do have choice, to die because of Starvation, or due to high blood sugar, or because of Keto Diet which lead to ketoacidosis. The choice is up to us, diabetics type 2. What is out of our choice is Life.
       It is well known that Diabetes type 1 is regressive. People who were diagnosed with diabetes type 1 live full life, long and pretty comfortable. They take less then 50 units of insulin, and live over 60 years with diagnosed diabetes. No pancreatic cancer. MAny of those type 1 diabetics take less then 10 units of insulin.
       In contrary, type 2 diabetics live less then 10 years after being diagnosed with diabetes type 2. Those who live longer then ten years already take Insulin, the same as type 1 diabetics but in higher dose. Dr. E.Joslin identified Insulin Resistance as condition when dose of insulin is higher the 200 units daily. Highest dose of Insulin I injected was 720 units.

 The majority of the diabetes patients with pancreatic cancer are diagnosed with diabetes less than three years before the cancer diagnosis. Among pancreatic cancer patients undergoing pancreaticoduodenectomies (the surgical operation often used to try to remove pancreatic tumors), over half of patients with recent-onset diabetes have no diabetes postoperatively. Researchers have observed no effect in those who have had diabetes for more than three years.

          There is another point in favor to take blood sugar level as Vitals. Level of sugar is the same as it is temperature of the body. We do not know about disease, but virus or bacteria already do nasty job in our body. The temperature of the body rises. The same with level of sugar. Just start to take level of sugar as Vital, and cancer will be diagnosed early and timely.  Any type of it.
         It is fact, not fiction. 80,000 diabetics die every year in America due to elevated level of sugar, diabetes. It is 100% preventable Deaths. Today no one have to suffer because of diabetes. And there are no types of diabetes, type 2 , type 2, LADA, MODY, or any other. Any type of diabetes 100% treatable with Insulin. If it is not curable then it is treatable, and many follw up Deaths may be preventable. Just stop to dance around middle area and take a look at the Vitals, Level of sugar in blood with every visit to any clinic. 

via Ravenvoron

A Long Night

It's 10 p.m. The teenager has been home for an hour from band practice. She has showered and is thinking about going to bed. She checks her blood sugar in order to calibrate the Dexcom.

"WHAT?!?!"

The parents watch warily from the couch while the teenager gets another test strip and rechecks her bg.

"WHAT IS GOING ON??? HOW IS THAT POSSIBLE??? HOW DID THAT HAPPEN???"

The teenager is distraught.

"Mom...can you help me do a site change so it goes faster? APPARENTLY I'M 485."

The mother rises wearily from the sofa, her plans for quiet time with her book followed by a good night's sleep dashed. She fetches a large glass of water for the daughter, in hopes of keeping ketones at bay.

"Yup. Drink this first. What happened do you think?"

"I DON'T KNOW!!!"

The teenager is grumpy, irrational and teary. Probably because of the blood sugar of 485. She gathers herself for a moment.

"I don't know... I was fine at dinner - 130 something. I don't remember Dexi alarming at band but it must have. It alarmed again a little while ago. But not that high. It's been iffy all day- it's like 10 days old - but I didn't know it was that far off and now I'm really high and I don't know WHY!"

The mother and teenager go off to the teenager's room to change the site. The chain of events leading up to the current situation is reviewed.

"I bolused dinner - I'm sure..." opens the pump's memory and double-checks "yup- and it wasn't a lot of carbs and you used the measuring cup. And then I just went UP! And I didn't eat anything at band- I just drank my water and I never had anything when I got home and now I'm SO HIGH FOR NO REASON."

When the site is removed the cannula is gunky, clearly clogged up. The mother thinks out loud.

"I don't think, in 13 years of pumping, you've had a pump site conk out that quickly. Usually they take a gradual turn for the worse, but this one seems to have suddenly and completely stopped working. That's the only logical explanation to go from 130 to almost 500 in 4 hours."

The teenager curls up on her bed, nursing her second pint of water. She is clearly miserable. She complains of a headache.

"... not just in one spot but like...my whole head...it just hurts...it's awful."

The mother initiates calming conversation … a friend's new puppy, a funny story someone posted on Facebook. Eventually, it's been 30 minutes since a correction dose of insulin was given. The teenager rechecks and is now just barely over 400. She gets up to brush her teeth and finish preparing for bed. The Dexcom alarms... FALLING! … and hope increases that the correction dose will work.

The teenager goes to bed. The mother gets to read her book, but for much longer than she'd intended, staying up until 12:30 a.m., when the blood sugar has dropped to 230-something.

The mother is awakened at 2 a.m. by the Dexcom alarm (which is now, incidentally, spot-on again) and gives the teenager some juice for a bg of 76.

The father gets up at 3:45 to give more juice for a bg of 68.

The family gets up in the morning. The teenager has a bg of 77. They are all tired. They are all grateful for the discovery of insulin. But moreso now for the discovery of caffeine. .







via Adventures in Diabetes Parenting

GNbAC1 Starts A Phase-II? Trial

GNbAC1 is a monoclonal antibody which has completed phase-II testing for treating Multiple Sclerosis, which (like type-1) is an autoimmune disease.  GNbAC1 was developed by GeNeuro SA, a Swiss company, but is being tested in Australia.   They have partnered with Servier, a large French pharma company to do the phase-III trials required to bring it to the Multiple Sclerosis market.

A monoclonal antibody is an artificially created antibody which targets one very specific type of cell in the body.  Different monoclonal antibodies target different types of cells.  So if a disease is caused by a problem in one type of cell, then using a monoclonal antibody to target that type of cell is a promising treatment.  Because several monoclonal antibodies have been successful in treating other autoimmune diseases, they are an active area of research for curing type-1 diabetes.

Previously, GNbAC1 has been tested in four clinical trials as part of the Multiple Sclerosis development program, so its safety is well established (for an investigational drug).  However, since this is the first trial aimed at type-1 diabetes, I'm calling it a "Phase-II?" trial.  (The question mark meaning "no previous testing on people with type-1".)

This Study

This study has enrolled 60 people who were diagnosed with type-1 diabetes within the last 4 year.  The first part will be double blind, with 2/3s getting the treatment and 1/3 not.  After that will be a second, optional part which is not blinded (everyone will get the treatment).  Unfortunately, the primary end point for this trial is safety related.  But their press release does say that they will track various effectiveness outcomes as well (for example: C-peptide and insulin consumption).  The drug will be given as an IV drip once a month (six doses in each part of the study).  People in the study will be followed for about a year.

This study completed enrollment in January 2018, and GeNeuro plans to publish the results from the first part of the trial in September 2018, and the second part of the trial in the first half of 2019.  That is pretty quick!

Press Release: http://www.geneuro.com/data/news/GeNeuro-TD1-Study-Enrollment-Complete.pdf
Clinical Trial Registry: https://clinicaltrials.gov/ct2/show/NCT03179423
Company: http://www.geneuro.com/
General Background News Article: http://www.biotuesdays.com/features/2017/11/16/geneuro-pioneering-hervs-against-neurodegenerative-and-autoimmune-diseasess

MS research:
● http://www.msdiscovery.org/research-resources/drug-pipeline/10103-gnbac1
● https://www.ncbi.nlm.nih.gov/pubmed/25392325

Background and Rational

This clinical trial has a very different rational, as compared to previous attempts to cure type-1 with monoclonal antibodies.  In the past, these antibodies have been used to target one of the defective cell types within the immune system.  The idea is to find an immune cell which is involved in the attack on the beta cells, and kill off those immune cells.  That idea has led to some progress, some suggestive results, but nothing like a cure.

These researchers have a different idea.  They note that part of the human genome contains HERVs, which are the remains of retroviral DNA which merged into our DNA millions of years ago.  The researchers believe that while this DNA does nothing most of the time, infection can sometimes cause one of these HERVs (called "pHERV-W") to activate and generate a protein (called "pHERV-W env") used by the retrovirus the DNA came from originally.  Even after the infection, the HERV DNA stays activated.  The pHERV-W env, in turn, causes autoimmune diseases.  If true, this would explain how viral infections can "trigger" type-1 diabetes.

These researchers believe that by using a monoclonal antibody to target pHERV-W, they can stop this process.   So while previous attempts to use monoclonal antibodies targeted malfunctioning immune cells, this attempt is targeting HERV DNA which (according to this theory) is the root cause of the autoimmunity.

Background reading: https://en.wikipedia.org/wiki/Endogenous_retrovirus


Joshua Levy 
https://ift.tt/29DuN3o 
publicjoshualevy at gmail dot com
All the views expressed here are those of Joshua Levy, and nothing here is official JDRF or JDCA news, views, policies or opinions. My daughter has type-1 diabetes and participates in clinical trials, which might be discussed here. My blog contains a more complete non-conflict of interest statement. Thanks to everyone who helps with the blog.


via Cure Research

Diabetes And Periods - In This Case - My Period.

Yeah, I’m getting personal - I do that on this blog - so if you don’t want to hear about me talking about all that is the glory of having my period and diabetes - OH WELL. 

I’m on the last 24ish hours of my period and I am fucking tired.

Diabetes and periods - at least for me, means elevated blood sugars for a few days prior to Aunt Flow actually getting her “flow on,” and blood sugars that are perfect, low, or elevated - or a wicked and sometimes manic trifecta of all three, during said period. 

And lets not forget no appetite; boobs being tender (yes, as in it can actually hurt to shower, unless the shower-head is set to the "Gentle Rain setting", stomach issues, salt cravings, bloating, emotions running high, ( as in #POGDogs will make you cry like a baby,) and bitch cramps to boot. 

And because strokes, t1 diabetes, and heart issues run in my ginormous family tree (as does tenacity, talent, good looks, and humor,) - I am not a candidate for the pill.

PSA - THIS IS IMPORTANT: If you have diabetes and are considering birth control methods:

1. Be honest about your diabetes diagnoses and your family history with your Gynecologist, Planned Parenthood professional, or GP - because the pill can be dangerous depending on your family history of strokes, heart attacks, and diabetes

2. Make sure all your doctors are on the same page 

3. Pill, IUD, or Diaphragm, you still need to use condoms to prevent the spread of sexually transmitted diseases. 

 AND NOW BACK TO OUR REGULARLY SCHEDULED PROGRAM~

Also: I was anemic as kid, and my iron has been on the low side of normal for years - so there’s that. Luckily I have a friend (NO, not that friend, but I could see how you'd go there,) who could totally relate and recommended that I try Blood Builder supplements since last summer and for me, it's helped even out my iron levels (which are now on the normal side of normal,)  and my energy…most of the time.

We know that hormones and diabetes are never a smooth ride - don’t even get me started on cortisone!

But as women with diabetes know, hormones and periods, being premenstrual or para-menopausal, or post-menopausal the hormonal douche-baggery (yes, I absolutely meant to use that phrase,) can be brutal.

For me, some menstrual periods are worse than others - sometimes killer cramps, sometimes not so much, plus everything else I've already mentioned.- 

This time around, it was on the worse side - at least for the first few days. 

So even though my blood sugars were pretty damn good over the weekend - I spent a lot of time on the couch, wrapped in a blanket and drinking hot tea, while snuggling with my friend’s cat  (OK, not snuggling because she’s not a snuggler, but she did let me pet her while she leaned against my leg,) and watching season 4 of Shetland (because Netflix is dropping the ball, BIG TIME,) and #POGdogs on Britbox. 

Sidebar: It rained all weekend so I wasn’t compelled to be outdoors. 

Also: It pays to house/pet sit for friends with Amazon Prime! Which I’ve stubbornly avoided getting, but am now strongly considering - and it’s all The Marvelous Mrs. Maisel’s fault!

God, so much great writing, acting, set design, costumes and coat porn! 

So diabetes; hormones and periods, being premenstrual/para-menopausal, or post-menopausal, and you feel like sharing - great. 

If you don’t - I get it and no pressure.

And if you are a guy - I hope you’ve learned something - Also: MENSES. 

You know I was going to sneak that word in there !

via Diabetesaliciousness

Genocide of new generation Diabetics discovered. It is SU for Infants. June 7, 2018.

"All infants diagnosed with diabetes before 6-7 months of age should be given a rapid gene test to change treatment as soon as possible from insulin to sulfonylurea tablets. They can expect a long and very good effect of the treatment of blood sugar control, and the treatment is safe," says Professor Pål Rasmus Njølstad at the University of Bergen.
https://www.sciencedaily.com/releases/2018/06/180607101013.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

Just a few days ago I published data, an official data, how within next 6 years  on SU beta cells decrease its activity, die. What about infant baby? Would this infant baby survive for sweet 16? Not at all. As it is very well known, diabetics type 2 live about 10 years after being diagnosed with diabetes type 2. Now infant baby diagnosed with diabetes type 2, based on what? Really, diagnose diabetes type 2 for infant baby based on what test? And why Insulin for baby replaced with SU?
     It is very simple. Med Pro do not need these babies.
     Without SU many babies would survive and with time probably even recovery partly. On SU no one baby will survive. SU will kill insulin secreting B cells, so with time there is no way that SU will work. Simple, SU stimulate those B cells that still alive and acting. If cell death, then there is on one stimuli will be effective. Without insulin no one human can live.
    The question is, do Med. Pro know all what I just said, or it is I who is so smart that I know more then any Med Pro? Not at all. Every Med Pro know this. No exceptions. Baby's mother will not understand what is going on with her baby. But MD know. I am sure, next step is to add Metformin to baby diabetes treatment. Mather will not know what is going on, so baby will forced to take this poison. Baby will never say, it is poison, so profit will be provided.
How can we name this Diabetes Treatment in scientific name? Genocide.

I do have only one question to all those who put its name under this "discovery'. Would they treat own baby with SU? Or they will still treat own babies with diabetes with Insulin? Interesting question. There is no good answer. In ether way, MD stupid or Exterminator.  Ether way is not good to carry on.

via Ravenvoron

Diabetes type 2 trteatment and β-cell activity. June 7, 2018

HOMA-%B is a measure of β-cell activity, not of β-cell health or pathology. HOMA can be used in subjects on insulin secretagogues, but the results need to be interpreted with caution. For example, data from the UKPDS showed an initial increase in β-cell function (from 46 to 78%) at 1 year in subjects on a sulfonylurea, followed by a steady decline in function to 52% at 6 years (26). The apparent improvement in β-cell function in the first year simply reflects the secretagogue mechanism of action of sulfonylureas, and the following decline of ∼5% per year over 5 years is in line with that of the diet-only group (4% per year), showing that there has been no amelioration of the rate of β-cell failure with treatment. These data illustrate that the HOMA model of β-cell function reflects insulin secretion rather than β-cell “health.”
 http://care.diabetesjournals.org/content/27/6/1487

It is very important info to find in Med Pro publications. Take closer look at the info, and try to be open mind. 

β-cell function (from 46 to 78%) at 1 year in subjects on a sulfonylurea

SU  (sulfonylurea) is type of medicine which force diabetic's type 2 pancrease to secret more insulin. This insulin can be needed, or... not needed sat that moment. Medicine taken two times daily, in the morning, and in the eve. So, in the morning we take Glipizide 5 mg, and then 5 mg iin the eve.

Unfortunately, I was diagnosed with type 2 diabetes at the age of 30. I was on metformin 1000mg once a day which wasn't working. Numbers were still in the low 300's. Dr bumped me to 1000mg twice a day. Made me very sick to the point of calling into work for extreme diarrhea. Stopped taking it and contacted my Dr. He put me on 5mg twice a day. While it has helped my numbers, they vary constantly and aren't where they should be. Anyone have any advice for me? I am on a 1200 calorie, low-carb diet. Please help. I am too young to suffer like this.

This is one of the comments how Glipizide work.

 I was diagnosed with Type 2 diabetes 1.5 months ago. My A1C was 15.8, Urine Glucose over 500 (test max) and my first home blood glucose test was 577. My doctor had me start with one 500mg ER tablet a day for the first week, then two a day since then. I also was prescribed a 5mg tablet of glipizide a day. My Blood Glucose has been in the 85-150 range the past month. I have modified my diet some. I did experience some diarrhea, though am over it now.

      It is another comment by another diabetic type 2. I am diabetic type 2 who was diagnosed in 2001. The same as every one on SU I was Rx Metformin, and then, because of Metformin never decrease the level of sugar, doctor Rx Glipizide, SU, twice a day. So, I took Glipizide early in the morning and went to work, then to college. In the noon my sugar dropped low, and I was hardly functional. Then at eve it started come back to high level. In the eve I took another tablet. I could not sleep because of it was most active time when insulin rise and body get its energy. All this energy become hot sweat. Water run all over the body, in Winter, outside. I all the time was ill and had infections.
    Last time I took  Glipizide in 2010. Then in 2011 I started to take Insulin, first shot. Now, how function of B cells declined for the tiome I took SU? It was from 2001 to 2010. 9 years. For 6 years decline is 52%. + 3 another years, another 26%. It is 78% for the 9 years. The same as Med Pro used to publish. Diabetics type 2 die withing 10 years after being diagnosed with diabetes type 2 if they do not start to take Insulin. We cannot take Insulin. We need MD who will Rx Insulin, and there is not too many of them who fancy to give the Rx to Insulin. Diabetics type 2 die, 80,000 every year in America.
      The conclusion is interesting.

 the following decline of ∼5% per year over 5 years is in line with that of the diet-only group (4% per year), showing that there has been no amelioration of the rate of β-cell failure with treatment.

Fascinating!
      Usually diabetes type 2 defined as overeating, wrong unhealthy lifestyle. Diabetics type 2 eat too much, and thus why diabetes developing. Probably yes, probably no. In any case, no one person can became 400 pounds at one night. If so then why diabetes was not diagnosed  just at time when it started its wrongdoing? To diagnose diabetes all what our Med. Pro need just take level of sugar as Vitals. The same as tested BP, BT, and BS must be. No special education for nurse. No special testing device, just glucose strip. If sugar over 200 mg/dl, it is diabetes.  Why not? But with all loud shooting how bad diabetics are, how we are not responsible, no one pay attention for the fact 

  My A1C was 15.8, Urine Glucose over 500 (test max) and my first home blood glucose test was 577.

 Personally I was sent out of ER with sugar in urine 1000. Simple, no need in treatment. Next day in NYC Super Storm took over the NYC, no ER, medical help, or Insulin to inject. I survived. I am survival.

  My doctor had me start with one 500mg ER tablet a day for the first week, then two a day since then. I also was prescribed a 5mg tablet of glipizide a day.

Now the question is, would this diabetic type 2 survive next ten years, or it is one who will march into grave with MI, stroke, or high blood sugar level withing next one or two years?  As it was said above, withing 5 next years B-cell function will decline 52%. With sugar in blood  577mg/dl it is obvious  that B-cells does not function properly. Ans sugar in Urine 500, not really very healthy. Usually we do not have sugar in urine. It is only in case when sugar constantly very very high.

via Ravenvoron

Almost Wordless Wednesday: Advocate Everywhere

"ADVOCATE EVERYWHERE," are the words printed on the front of one of my
favorite T-shirts, obtained years ago (maybe 2013 or 2014,) from the Diabetes MasterLab, which at that time, piggybacked CWDFFL, in Florida. 
And they are words that continue to inspire me in my life... and my life with diabetes. 

I wear this shirt because I love the message and the spirit behind it. 
I love how this message sparks
conversations whenever and wherever I wear it. 
Lastly, I love how it encourages us to use our voices individually and collectively, because all our voices matter and no act of advocacy is too small. #AdvocateEverywhere ~

via Diabetesaliciousness

I Almost Asked

My daughter's Dexcom G4 sometimes chooses to stop 'sharing' these days, making its receiver the only source of information. When this happens, as it did this week, I try to take a quick peek at the receiver once in a while, just in case we need to talk about tweaks in the basals, carb ratios, correction factors and such.

I looked at the receiver this morning - it was on the table after breakfast - and yesterday morning showed a spike, reaching the top of the graph, and hanging there for an hour or so before coming back down to a reasonable range by noonish.

My initial instinct was to ask something along the lines of, 'What the heck happened yesterday???"

Then I realized three things:

1. I already knew what happened  yesterday. Her grade had a delayed opening because of standardized testing at the high school. She had been out to breakfast with friends and she ate eggs and toast and potatoes- which was a better choice than pancakes - but she clearly either under-guessed on the potatoes or forgot to bolus until too late.

2. The evidence showed that she'd picked up on her mistake, corrected her blood sugar, and gotten herself back in range by lunch. She had solved the problem by herself.

3. Nit-picking is counterproductive. She'd just get defensive if I brought it up, no matter how much I tried to turn the conversation towards 'all's well that ends well.'

So I didn't ask. 



via Adventures in Diabetes Parenting

insulin resistance studies. June 5, 2018

"Our preliminary findings show that a single night of light exposure during sleep acutely impacts measures of insulin resistance," said lead author Ivy Cheung Mason, PhD, who was a postdoctoral fellow at Northwestern University Feinberg School of Medicine when this study was conducted. "Light exposure overnight during sleep has been shown to disrupt sleep, but these data indicate that it may also have the potential to influence metabolism."
 https://www.sciencedaily.com/releases/2018/06/180604172736.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

This is studies and in studies there is no measure the most important part of study, Insulin Resistance. There is even no definition, what is it, Insulin Resistance. Take a look at the study, and what they pretend that Insulin Resistance is? 

Oral glucose tolerance tests were performed on both mornings following sleep in the dark or 100 lux of light.

Sorry, OGTT is not test to measure Insulin resistance. It is actually measure nothing, truth to say.  Test measure level of sugar at first fasting, and then with glucose loading. Test run two hours. during which level of sugar in blood measured. It is pretend to be test to diagnose diabetes. At the same time when sugar is higher then 200 mg/dl OGTT is not necessary, so it never run in type 2 diabetic. Type 2 diabetics are those types of diabetics who has Insulin resistance, according to Med. Pro.

  Homeostatic model assessment of insulin resistance change values were significantly higher (p<0.05) in the morning following sleep in the light (DL group) compared to sleep in the dark (DD group). This effect was primarily due to increased insulin levels for DL compared to DD group.    

At first, to say "higher" is to say nothing. Show difference if it is. Because of small difference will be all the time at any time, and this difference does not support theory. 
Now what about   "Homeostatic model assessment of insulin resistance"? What is it? There is not so many people who know what is it. It is better to open this measurement in discussion. Yes, there is nothing to open. This Insulin Resistance never measured. It is Math formula how to count Insulin Resistance.
 http://care.diabetesjournals.org/content/27/6/1487




On first look all those tables seems complicated and very difficult to understand. At the same time any table and any picture can be presented by two measurements. According to article, there was only one measurement, OGTT, level of sugar in blood.  So, regardless how complicated table and pictures are, they are all fake. No one picture or table show Insulin Resistance. In studies only glucose was tested. In tables Tests for Insulin used together with level of sugar. But level of insulin never measured. So, what authors talking about?

This research was supported by the National Institutes of Health grants 5T32HL7909, P01AG11412, and 8UL1TR000150-05.

This is what I use to say every time. Do not donate money to researches.  They study nothing, and never would be able to find any cure for any medical problems. About diabetes and cure for diabetes, say me, why they need to find cure? They do not need it. If there is no diabetics type 2, what all those
Phyllis C. Zee, MD, PhD, professor and principal investigator; Daniela Grimaldi, MD, PhD, assistant professor; Kathryn J. Reid, PhD, professor; and Roneil Malkani, MD, assistant professor. All work at Feinberg School of Medicine, in the Department of Neurology, and
lead author Ivy Cheung Mason, PhD, who was a postdoctoral fellow at Northwestern University Feinberg School of Medicine when this study was conducted
going to do? Go to construction? Or probably be home health aide?  To low income in any case.

via Ravenvoron

ADA Issues Recommendations to Improve Insulin Access, What is good for us, DT2?

I started my post with comments. They are usually very interesting. How people react on the issue?

Persons with Type 1 diabetes, most of whom are diagnosed in childhood, should receive free or very low cost insulin. There is no life without this hormone replacement. (RN)

 In diabetes type 1, the same as in diabetes type 2 there is no hormone Insulin Replacement. In any case when secretion of insulin is limited and does not cover human or animal body needs, Insulin must be added from outside, in shots. The Med. Pro, nurse, who very proud to share own pro opinion, there is no pro understanding. Insulin in injections never replace secreted insulin. It is Add-on medicine.

Not enough preventative measures put into placement in order to stop the spread of this disease , simple example making it free , people will abuse it , preventive screenings is the best answer to help curve the onset and keep cost down , just the plane fact of educating people and checking fasting blood sugars at the very least help explain the lifestyle changes and maybe decrease morbidity rates what good is a dead patient long term ....... dead short term will not solve anything ......(Licensed Practical Nurse (LPN/LVN)

23.1 million of Americans are diabetics. population are diabetics. 95% are diabetics type 2.  12.2% or 12 millions of Americans 65+ diabetics type 2 because of it is not "usually" but it is always diabetes type 1 diagnosed only in children. Adult diabetics diagnosed with type 2, even sugar in higher them meter llimits, 599 mg/dl, closer to Death.

Diabetes remains the 7th leading cause of death in the United States in 2015, with 79,535 death certificates listing it as the underlying cause of death, and a total of 252,806 death certificates listing diabetes as an underlying or contributing cause of death. (ADA)

It is easy to say that all those millions of diabetics just do not behave.
       Let us take a look at the types of diabetes, what are difference between two types, type 1 and type 2?
1.Diagnose.
Diagnose is the same for ether type of diabetes with one exception: only brave endo will diagnose type  Usually diagnose is "Diabetes type 2" because of in case of type 1 MD must Rx Insulin, and too little of them so brave to Rx effective but complicated medicine. This is why today Type 2 diabetes is 95% of all diabetic's population. MD Rx Metformin and then Add-on such as Invovana, Actos, or Avandia. Diabetic will die because of heart attack, and diabetes will be 'underlying condition". Take a look at diagnostic of diabetes, and there is no one tool to diagnose type of diabetes. Usually mo one test run to diagnose diabetes type 2 but the level of sugar in blood.
2. B Cells or C Peptide level.
Show me what symptoms diabetics type 1 do have and diabetics type 2 do not have? Type 1 diabetic's immune system attack own B Cells, and destroy them. What about diabetics type 2? This test never run in type 2 diabetics. The amount of B Cells in blood of diabetics type 2 is the same as it is in diabetics type 1, low. Just run this test and the result will confirm the reality of difference between types of diabetes. There are no differences.
3. Antibodies.
Usually it is said that diabetics type 2 do not have antibodies, and type 1 diabetics do have them. When? That's right. At the time of diagnose type 1 diabetics tested for antibodies, and type 2 never did. Now after diagnose and treatment, run this test another time. Is this really true that type 1 diabetics have antibodies in blood? Not at all.

    Finally, take last look at the difference between type 1 and type 2 diabetics? What is so obvious? We are very very ill, have a lot of complications, amputations, take a lot of medicine, and most important, we never get better. With time type 2 diabetics need more and more medicine, home care, disability,. And final point, diabetics type 2 die withing ten years after being diagnosed with diabetes type 2.
     What about diabetics type 1? With time they decrease dose of insulin, even it was not dramatically high at the first place. And they live full life. 50+, 60+. 70+. 90+..... . No one diabetic type 2 can stay alive for so long.
    
It is easy to blame victim but why do not try another way around? Just stop to stamp diabetics on types, and let every one of us have medicine we need. Why not?

I AM TELLING THE TRUTH FROM LONG EXPIRIENCE FOR 35 YEARS
35 % OF PEOPLE ON INSULIN FOR TYPE 2 DIABETES DON'T NEED INSULIN !!!!!
MD.  Endocrinology, Metabolism

 Now let us take a look at the 65% of diabetics type 2 who take Insulin? As MD said, they need Insulin, yes? 35% do not need Insulin, but 65% need it, and it is diabetics type 2. So, how MD see, when type 2 diabetic need Insulin and when not? And also, is this really true that all type 1 diabetics need Insulin? Many of them take less then 10 units. Some of them take about 5 units. Try any one not diabetic any type to inject 5 or 10 units. trust me, it is safe.
      As doctor I. Joslin identified Insulin Resistance it is medical condition when dose of insulin to support life is higher then 200 units, diabetics type 2, who are Insulin Resistant, cannot live without Insulin. Also 200 units daily usually is not affordable. It is $1000+ every month. About the price of rent. In addition to cost of Insulin we usually need Asthma treatment, and it is brand, never generic, so it is costly. $200 every month at least.

IT IS MORE IMPORTANT NOT TO PRESCRIBE INSULIN FOR TYPE 2 DIABETES , WHERE OTHER PRODUCTS ARE MOST OF THE TIME MORE INDICATED  - LIKE GPL1 ANALOGS, SGLT2 BLOCKERS  AND PIOGLITAZONE

 So simple. When diabetic type 2 come to clinic or ER, simple sent its away to die at home. This is usual practice in clinic or in hospital. They send us away. They do not Rx Insulin, and we cannot live without Insulin. The end of story.

 ADA Issues Recommendations to Improve Insulin Access by Miriam E. Tucker

 https://www.medscape.com/viewarticle/897325?src=wnl_mdplsnews_180601_mscpedit_wir&uac=164666HZ&impID=1647092&faf=1

via Ravenvoron