Diabetes type 2 trteatment and β-cell activity. June 7, 2018

HOMA-%B is a measure of β-cell activity, not of β-cell health or pathology. HOMA can be used in subjects on insulin secretagogues, but the results need to be interpreted with caution. For example, data from the UKPDS showed an initial increase in β-cell function (from 46 to 78%) at 1 year in subjects on a sulfonylurea, followed by a steady decline in function to 52% at 6 years (26). The apparent improvement in β-cell function in the first year simply reflects the secretagogue mechanism of action of sulfonylureas, and the following decline of ∼5% per year over 5 years is in line with that of the diet-only group (4% per year), showing that there has been no amelioration of the rate of β-cell failure with treatment. These data illustrate that the HOMA model of β-cell function reflects insulin secretion rather than β-cell “health.”
 http://care.diabetesjournals.org/content/27/6/1487

It is very important info to find in Med Pro publications. Take closer look at the info, and try to be open mind. 

β-cell function (from 46 to 78%) at 1 year in subjects on a sulfonylurea

SU  (sulfonylurea) is type of medicine which force diabetic's type 2 pancrease to secret more insulin. This insulin can be needed, or... not needed sat that moment. Medicine taken two times daily, in the morning, and in the eve. So, in the morning we take Glipizide 5 mg, and then 5 mg iin the eve.

Unfortunately, I was diagnosed with type 2 diabetes at the age of 30. I was on metformin 1000mg once a day which wasn't working. Numbers were still in the low 300's. Dr bumped me to 1000mg twice a day. Made me very sick to the point of calling into work for extreme diarrhea. Stopped taking it and contacted my Dr. He put me on 5mg twice a day. While it has helped my numbers, they vary constantly and aren't where they should be. Anyone have any advice for me? I am on a 1200 calorie, low-carb diet. Please help. I am too young to suffer like this.

This is one of the comments how Glipizide work.

 I was diagnosed with Type 2 diabetes 1.5 months ago. My A1C was 15.8, Urine Glucose over 500 (test max) and my first home blood glucose test was 577. My doctor had me start with one 500mg ER tablet a day for the first week, then two a day since then. I also was prescribed a 5mg tablet of glipizide a day. My Blood Glucose has been in the 85-150 range the past month. I have modified my diet some. I did experience some diarrhea, though am over it now.

      It is another comment by another diabetic type 2. I am diabetic type 2 who was diagnosed in 2001. The same as every one on SU I was Rx Metformin, and then, because of Metformin never decrease the level of sugar, doctor Rx Glipizide, SU, twice a day. So, I took Glipizide early in the morning and went to work, then to college. In the noon my sugar dropped low, and I was hardly functional. Then at eve it started come back to high level. In the eve I took another tablet. I could not sleep because of it was most active time when insulin rise and body get its energy. All this energy become hot sweat. Water run all over the body, in Winter, outside. I all the time was ill and had infections.
    Last time I took  Glipizide in 2010. Then in 2011 I started to take Insulin, first shot. Now, how function of B cells declined for the tiome I took SU? It was from 2001 to 2010. 9 years. For 6 years decline is 52%. + 3 another years, another 26%. It is 78% for the 9 years. The same as Med Pro used to publish. Diabetics type 2 die withing 10 years after being diagnosed with diabetes type 2 if they do not start to take Insulin. We cannot take Insulin. We need MD who will Rx Insulin, and there is not too many of them who fancy to give the Rx to Insulin. Diabetics type 2 die, 80,000 every year in America.
      The conclusion is interesting.

 the following decline of ∼5% per year over 5 years is in line with that of the diet-only group (4% per year), showing that there has been no amelioration of the rate of β-cell failure with treatment.

Fascinating!
      Usually diabetes type 2 defined as overeating, wrong unhealthy lifestyle. Diabetics type 2 eat too much, and thus why diabetes developing. Probably yes, probably no. In any case, no one person can became 400 pounds at one night. If so then why diabetes was not diagnosed  just at time when it started its wrongdoing? To diagnose diabetes all what our Med. Pro need just take level of sugar as Vitals. The same as tested BP, BT, and BS must be. No special education for nurse. No special testing device, just glucose strip. If sugar over 200 mg/dl, it is diabetes.  Why not? But with all loud shooting how bad diabetics are, how we are not responsible, no one pay attention for the fact 

  My A1C was 15.8, Urine Glucose over 500 (test max) and my first home blood glucose test was 577.

 Personally I was sent out of ER with sugar in urine 1000. Simple, no need in treatment. Next day in NYC Super Storm took over the NYC, no ER, medical help, or Insulin to inject. I survived. I am survival.

  My doctor had me start with one 500mg ER tablet a day for the first week, then two a day since then. I also was prescribed a 5mg tablet of glipizide a day.

Now the question is, would this diabetic type 2 survive next ten years, or it is one who will march into grave with MI, stroke, or high blood sugar level withing next one or two years?  As it was said above, withing 5 next years B-cell function will decline 52%. With sugar in blood  577mg/dl it is obvious  that B-cells does not function properly. Ans sugar in Urine 500, not really very healthy. Usually we do not have sugar in urine. It is only in case when sugar constantly very very high.

via Ravenvoron