To Whome Oral Insulin Needed? June 26, 2018

Now, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed an oral delivery method that could dramatically transform the way in which diabetics keep their blood sugar levels in check.
Not only does oral delivery of insulin promise to improve the quality of life for up to 40 million people with type 1 diabetes worldwide, it could also mitigate many of the disease's life-threatening side effects that result from patients failing to give themselves required injections.
 https://www.sciencedaily.com/releases/2018/06/180625192838.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

      The new discoveries make our life easy. Do they? It is easy to say just taking one look at the promise,  oral Insulin Vs Insulin in injections. everyone will say, it is progress.I am not everyone. I am one, who suppose to swallow these oral medicine, and lost my beloved Insulin Lantus solo Star in injections. And I am really not so happy with that.
       Some doctors remember the time when Metformin replaced Insulin injections. It was progress, easy to take, easy to dose, easy to store, and very low price. This is look at the Metformin compare with Insulin. There is only one problem, Insulin works, decrease level of sugar in blood, and keep diabetics alive, complications-free. Metformin, in other side, doesn't work, and dramatically shorten human lives. With time Insulin was replaced by Metformin for 95% of American diabetics. Only children were diagnosed with diabetes type 1 and were used Insulin in injections. All adult diabetic population was diagnosed as diabetics type 2, and treated with Metformin.
       Now time is passed. To get Rx to Insulin practically not possible. Even children now treated with Metformin in stead of Insulin. Mortality diabetics type 2, those diabetics who take oral medicine to control blood sugar level, 80,000 Deaths every year. Diabetes type 2 is number 7 cause of Death, only high blood sugar level, or low blood sugar level which is practically the same, wrongly treated diabetes. Diabetes leads to many complications and many Deaths as underlying cause. 100 years after Insulin discovery our medical providers still not able to Rx insulin and have no one idea how to dose it.
       So, why it is so important to develop oral Insulin? BTW, why it is "Insulin" in first place? It would no longer be insulin, hormone which does not diagested but delivered right into blood stream? Give to that oral medicine another name? Why not? Because of benefits of Insulin in present time very well known. So, to fool diabetics and general population, there must be another shadow on sunny day. Still, let us take a look at the studies and yhe progress in developing this type of medicine to kill every one out of ten American.

Insulin therapy, by injection just under the skin or delivered by an insulin pump, generally keeps the glucose levels of most diabetics in check. "But many people fail to adhere to that regimen due to pain, phobia of needles, and the interference with normal activities," said senior author Samir Mitragotri, Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering at SEAS.     

        How easy to spread lie under high title of Med Pro. It is no problem to inject insulin. The problem is how many units to inject.  It is not "Insulin" injected under skin which keep glucose level under control, it is diabetes, medical condition, why glucose level is all the time out of control. Diabetics do not fail to inject insulin. We all the time do it. But there is the problem, too much insulin leads to low sugar, very danger condition which can lead to life threatening condition. When dose of insulin is lower then it is needed, glucose level is out of control, high, and getting higher.
      Ask any doctor, what dose of insulin you have to inject, and no one doctor can give you any answer. It is not because of they do not want to help or do the job. They cannot know it. Dose of insulin depend on many things, no one of them in direct contact with dose of injection. Even if dose of insulin injected according to the life-time level of sugar, it is really not effective. Sugar can run high, or low, in ether way. No math work for this situation. Just no one math can replace Bio activity.

        The key to the new approach is to carry insulin in an ionic liquid comprised of choline and geranic acid that is then put inside a capsule with an acid-resistant enteric coating. The formulation is biocompatible, easy to manufacture, and can be stored for up to two months at room temperature without degrading, which is longer than some injectable insulin products currently on the market.

Another lie.
        Insulin can be stored in ref. up to two years or even more. New types of insulin can be out of ref. for weeks, no damage. Also we can see  if insulin is OK or something wrong with it before taking injections. What about new oral medicine? Two month, and diabetic out or medicine. In present time mail delivery for medicine is common practice. It is all the time three month supply. With the capacity of new medicine to be in good condition diabetics cannot be free to take long vacation, or trip needed to work. Only two month for storage, it is not too much. We have to be bound to the ability to have this oral medicine.
         Capsules have another issue. It is obvious, and I do not want to discuss it. Just remember, we take this medicine day-after-day, full our lives, and capsules material will finally built up in our system. Is this really good idea? Probably it is OK for short time, but for full life?...... No, thanks.

"When a protein molecule such as insulin enters the intestine, there are many enzymes whose function is to degrade the proteins into smaller amino acids," explained first author Amrita Banerjee, who conducted the research while working as a postdoctoral fellow in Mitragotri's lab, and is now an assistant professor at North Dakota State University. "But the ionic liquid-borne insulin remains stable."

        I am sorry, but insulin is not protein molecule. It is hormone. For very tiny hormone the way to get into stomach, then to liver, and finally to bloodstream is way tooooooo long. A you sure, there are all insulin still present in the capsular? Remember, life of Insulin is short, and this is why it is too difficult to test how much insulin is in the system. In stead of Insulin it is C Peptides, Proteins, to count if pancreas still secret insulin. C Peptide level for healthy pancreas secreting insulin is from 1 to 5. This is irony. How many insulin hormones will enter into blood stream?
       This is all the time how easy to manipulate the studies or results, or any info published to the public. Just say, "this is how" under authority of pro, and any lie will be taken as true.

Banerjee also noted that ionic liquid-borne insulin can be prepared in a one-step process that could be readily scaled up for inexpensive industrial production, making the cost of manufacturing the oral formulation easily manageable.

Well, what can I say about it? Metformin is out of business. Its time coming to end. A new  cheap product must be developed to decrease American Population. This is why all the media and all the propaganda barking on obesity and presenting that diabetes is diabetic's choice. Why is it so? Because of human survive. Now diabetics live longer, much longer then it was in pre-insulin era. Even without treatment diabetics can survive. With help of Med Pro we will head to recycling facility our local hospitals. we provide a lot of organs for transplant. we are very important part of income for medical facilities, and donations for  politicians.

via Ravenvoron