Medicine for Diabetics type 2

Medicine for Diabetics type 2. These medicine never suggested to be used to treat diabetics type 1. Also right now more and more children as little as 6 years old diagnosed with diabetes type 2. Based on what this type of diabetes was diagnosed? Based on the level of sugar in blood, the same test as any adult diabetic type 2 or little one diabetic type 1. Even more then that. Child may be in hospital with all clear symptoms of diabetes, acute stage of diabetes ketoacidosis including. Still, diagnose for this child would be diabetes type 2, and mother of the child would be educated how to count calories and enforce diet to her 6 year old. After child would be discharged from hospital Life Style Modifications would be Rx. After awhile child would need to take all this trash medicine to control blood sugar as adult diabetics type 2.        The difference between adult diabetic type 2 and child diabetic type 2 in the stage of diabetes. For adult it is usually already chronicle medical condition with which we use to live since our childhood. For child it is the same as for type 1 diabetic child, it is acute diabetes. The same as diabetic type 1 child diabetic type 2 would survive with insulin. But child diagnosed as type 2 diabetic. This child usually Hispanic or Black and already do have overweight. With time this child if would be on insulin therapy, grow up and be healthy adult. Without insulin child has no future.

Rosiglitazone, Medical Reversal, and Back to Basics for Diabetes

VINAY PRASAD, MD, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland

Am Fam Physician. 2014 Sep 15;90(6):368-370.

http://ift.tt/2nQBIZA

Between 2007 and 2013, rosiglitazone (Avandia) was one of several highly publicized medical reversals of interventions thought to have done more harm than good. In a prominent meta-analysis from 2007, data first suggested that the widely used diabetes mellitus medication increased the rate of myocardial infarction (odds ratio = 1.43; 95% confidence interval, 1.03 to 1.98; P = .03). The conduct of the manufacturer in the wake of the evidence regarding rosiglitazone's putative harms became the subject of a Senate investigation, and the company was widely criticized for decisions made as it sought to protect the market share of a medication that earned $3 billion per year.

 There are many investigations done to find out if one or another medicine safe or not. After one medicine was stamped with Black Box, another  type of medicine with the same properties would enter on the market. When diabetic's child mother come to clinic with her child and complane that child has allergy on medicine  such as Metformin or any other oral medicine, they are all the same, doctor would take this medicine off, and Rx the same under different name manufactured by another company.They all reimburse doctor, so clinic has free room to play with medicine.

The problem is not that there are so many medicine and no one of them work. The problem in medical control, better to say that it is uncontrolled Medical Industry.When medicine does not work or very harmful, what is the next step? Black box stamped on the medical liable. The medicine still on the market. After awhile restrictions would be raised, and then dropped back and forth. Avandia still on market. Medication carry on its billions on market share. Diabetics type 2 die in suffering, diabetic's type 2 children including.

 Rosiglitazone has left a lasting legacy on the approval of diabetes medications. The drug's tumultuous history, in part, led to an FDA requirement that new diabetes drugs undergo testing to rule out excess cardiovascular events. This rule prompted large trials of two other diabetes medications-the dipeptidyl peptidase-4 (DPP-4) inhibitors saxagliptin (Onglyza) and alogliptin (Nesina)-which found that, although both medications lower the A1C level, neither improves cardiovascular outcomes, undermining A1C as a surrogate end point for this purpose. The history of diabetes studies over the past 10 years forces physicians to confront the reality that the best treatment for type 2 diabetes is not clear.

The reality is simple: There is no diabetes type 2. There are no types of diabetes regarding BMI or life style. There are stages of diabetes, regarding the condition of pancreas, how deeply ill pancreas, how it is effective to secret insulin in sufficient amount. The check up the condition of pancreas,  not the BMI and bathroom Scale Number.

 How should the findings of the past 10 years affect clinical care? For too long, the debate in diabetes has centered on the question: Is this medication harmful? It's time to revisit the more fundamental question: Is this treatment beneficial? Available data support use of the mainstays of therapy after lifestyle intervention (i.e., metformin [Glucophage], insulin, and sulfonylureas), and it is preferable for physicians to maximize the use of these agents, employing the newer A1C-lowering drugs as seldom as possible.

•       Metformin, the medicine which do the job to increase sensitivity of muscles on insulin, and suppress liver to secret glucagon. So, diabetic liver, which already effected by poor insulin secretion, hardly effected by medicine. Then diabetic's liver became fatty, and it is of cause all from life style wrong. 
•       SU, medicine which force poorly able to work pancreas to secret more insulin at the time when insulin is not needed at all, bed time for instance. No one doctor take into consideration this fact that SU at bed time lead to active insulin secretion. The already limited beta cells die as a result of SU therapy. Without SU there is no one way that level of sugar would drop with life style modifications or Metformin. This is the fact. Try it. Check up, how Metformin decrease level of sugar. Just stop to take Metformin and see, would your sugar go up? Would it go down? If I missed shot of insulin I can see it on my next readings. This means Insulin decrease my blood sugar level, control it with right type of insulin and right regime insulin therapy.
•        Authors of the publications pretend that it is preferable by physicians what medicine to use to treat diabetes or to diagnose type of diabetes. I cannot effect the diagnose. If my doctor said I am type 2 part of American Population, so be so. What no one doctor can do is to force me to take medicine which is harmful for me. So, I do not take SU. Really why do I need this trash? I prefer to keep my beta cells as long as I can and as many of them as it is possible. Nether I am going to take Metformin. What is good in this Trash? Liver decline? Muscles pain? I do not see any good in any of the properties of Metformin. So, there is no room for Metformin in my medical box.
•       Insulin. Lantus Solo Star. 80 units four times daily. 320 units total daily dose. I love Lantus Solo Star. It is easy to use: just put on needle. 5 mm, very short. I can take shot in any public place. No one even would see it. Needle is shot and tiny. Easy  disposable. I use container after Syrup. 
•       Excedrin. Migraine. two tablets two times daily. Probably it would be better if I do have coumadin. I do not have one. So, at the time when headache is too severe I increase the dose of Excedrin, and take it as much as 20 tablets a day. Bot right choice I do know. Still, I do not use any narcotics or any painkillers.
•       Lipitor 80 mg once daily.  I take Lipitor, and I do not take any generic to reduce high level of cholesterol. Before I started to take Metformin and SU back to 2001 my cholesterol level was very good. Then it ride up and up. TG got over 900. Finally I trashed all trash medicine and now my cholesterol is normal. Probably I need to decrease dose of Lipitor, I have to work on it after Summer. 
•      Nexium. 40 mg once daily. This is medicine to help liver to do the job. There are generic available for this medicine, as well as generic for cholesterol. Generic is not the same. I prefer to take brand. Anyway, generic did not decrease my cholesterol level and I did not feel good with generic for liver.
•       Isosorbide. 30 mg. once daily. It is the same as Nitrostat but slow release. With this medicine I am no longer need to take 2 pills two times daily of Nitrostat. I take it only as rescue medicine.
•       Plavix. 75mg/ once daily.
•       Carvedilol 25 mg., Metoprolol 25 mg., Lisinopril 40 mg, once daily, Losartran 100 mg daily. Looks very odd. Every time when I am in clinic I do have problem with doctors. They prefer to change medicine I take. I refuse. With this regime BP no longer run over 160. It is pretty under control. Some day in clinic it is even normal. 
•        Gabapentin 300 mg two times daily. I do have neuropathy. This medicine pretty helpful. I can walk, and I can function. Some day it is hard to get out of bed, so I take two more caps. But it is not so often, usually two is OK.
•         Citalopram. 10 mg. once daily. It is anti depressant. I need it. It is not high dose. I take it last ten years, and I am OK with it.

Beyond the choice of metformin, insulin, and sulfonylureas, an abundance of drugs that lower A1C levels are available, representing diverse classes. These include meglitinides, thiazolidinediones,

 Probably all these drugs reduce level of A1c. Still, no one of them heal my poorly working pancreas. No one of them restore death beta cells. So, regardless how effective this medicine to decrease level of sugar in my blood, I still take Insulin, insulin only, to let my pancreas to have rest, and preserve remaining beta cells. This is the problem with diabetes treatment. Medical Care treat symptoms, such as level of sugar or BMI, but the cause of diabetes, Pancreas disease, left untreated.

via Ravenvoron