Diabetes type 2 and complications of medical treatmnts. June 23, 2017

Previous research has focused on the management of T2D and osteoporosis as separate diseases. However, several studies have shown that fracture risk is increasing in people with T2D. T2D directly affects bone metabolism and strength. Certain diabetes medications affect bone metabolism, and an association exists between diabetic complications and the risk for falls and subsequent fractures.
 Specific diabetes medications to protect bone health recommended

Date: June 21, 2017

Source: Endocrine Society

 http://ift.tt/2swP42x

Now the question is, what medicine fight both, diabetes type 2 and osteoporosis? It is most important question, what medicine to use to fight one, another, or both? 

"Metformin, sulfonylureas, DPP-4 inhibitors and GLP1 receptor agonists -- medications for T2D -- should be the preferred treatment for T2D in patients who also have osteoporosis," said the study's first author, Stavroula A. Paschou, M.D., Ph.D., of the National and Kapodistrian University of Athens in Athens, Greece.

          Really?  Let us take a look how these medications effect diabetes type 2, and if these medications are really effective to improve diabetics type 2 pancreas condition?  That's right, diabetes is not the level of sugar in blood which can be abnormally high, or simple be normal. Diabetes is health condition of pancreas which secret insulin, and the ability of pancreas to secret insulin in sufficient amount for healthy living of diabetic. So, when we take a look at the medication which suggested by team of sturdier to fight both, diabetes type 2 and osteoporosis, we have to see, how medication effect pancreas, and how medication improve pancreas' health condition.
            Metformin. This medication effect liver and reduce ability of lives to discharge sugar at the time when we do not eat. Another action of metformin is to effect muscles to be more sensitive to insulin, to increase insulin consumption. This is for diabetics type 2, people whose medical condition effected by low ability of pancreas to secret sufficient amount of insulin to cover daily activity. 
Now I am lost, how Metformin suppose to improve pancreas health condition? How metformin suppose to effect bones health condition? Is there some answers from team of studies what they found?
             Sulfonylureas. This type of medication effect diabetic's pancreas, and force it to secret more insulin then body system needs in this particular moment. After medicine worked out, the secretion of insulin decreases, and with time the ability of ill diabetic's pancreas to secret insulin fail completely.  I still not able to get the point if this medicine helps with osteoporosis, but it definitely very negative for diabetics type 2. This medicine very difficult to control. With this medicine diabetic all the time on high- low swings, riding from fatally high blood sugar level down to the fatally low blood sugar level, and even does not understand, why his/her condition is so bad, no any improvement, no any diabetes type 2 control.

Paschou's team prefers these medications because they can help protect bone health. Studies show that Metformin has beneficial effects on bone formation and bone mineral density. Positive or neutral effects have been seen in bone metabolism with the use of DPP-4 inhibitors and GLP1 receptor agonists.

         They probably were able to find some benefits in the medication they highly propagandize, (I am sure they well paid for this propaganda) but I do not take any one of those. For me, it is Golden Rule, one step in one time. So, if I need to improve the work of my ill pancreas, then I need insulin in first place. Insulin prevent diabetes type 2 complications, and it let my ill pancreas to take time and to get better. If my pancreas is so il that to get better already left behind, then at least it will not get worse. SO, I take insulin, and looks like I prevent decrease in bones distractions. At least I can still walk on my two legs.

On the other hand, thiazolidinediones (TZDs) and canagliflozin should be avoided while other SGLT2 inhibitors are less well-validated options. Insulin should be used with caution and with careful measures to avoid hypoglycemia.

        WOW! At least Invokana is not effective to safe bones. It is nice to know.  No one diuretic is able to safe boned mineral content because of it is bones which lost minerals with heavy use of diuretics. Invokana is highly effective diuretic. It leads to increased urination, and as a result to the lost on mineral content in all body tissues.
According to insulin it is interesting. Cautions to use insulin because of hypoglycemia. What does it mean? It mean that with insulin level of sugar in blood going down, the effect all medicine try to get, and there is no such effect with all other medicine.
       Why SU does not lead to hypoglycemia? Because study avoided to mention it, to note that SU leads to highly unpredictable low blood sugar, very dangerous, absolutely uncontrollable, which can strike at any moment, and diabetic even have no one idea why his or her condition is so bad. As it is easy to see from this publications, diabetics type 2 who are taken SU have no one idea that SU lead to low blood sugar. They even do not know that this condition can be with SU. And most important they do not know how to deal with low blood sugar. There are no education for diabetics type 2 who take SU, no any protection from medical team we may have this condition.
      If someone think I am wrong, then read all above. Is there any mention that SU lead to low blood sugar? Not at all. It is insulin, which leads to low blood sugar, but there is no any mention that SU lead to low blood sugar. As I posted many times, read all, but with very very open mind. They can easy to lead us right to the end, and is this really spot we wish to go?

To determine the most effective treatment options, the researchers systematically reviewed past human studies and guidelines to develop recommendations for the most appropriate joint treatment approaches for diabetes and osteoporosis.

       What does it mean? There are studies of papers, not real patients. They study what they found easy to study, and according to the studies of text books and journal publications they provide us with recommendations what medicine is best for us. So, if we are looking to find best treatment option to  improve pancreas health and well being, then it is SU, Metformin, and all other medicine, Invokana including. If take a look at the mortality tables, diabetes type 2 number 7 cause of death in America, and it is getting up in mortality tables. What does it means? The studies are wrong, and they provide wrong recommendations.
         I take insulin, long acting Lantus Solo Star, 300 units every day.I do have low blood sugar. I can feel it and I can deal with it. Because of I do know I can have it at any time, I just get ready for this. There are Protein Bar in my handbag, I can eat it at any moment I need. I do have coffee every where in my house, and in my handbag. OJ and water all  time around me. So, insulin is not danger and it is convenient to be used at any place I am in. But when I read any articles, it is all the  time presented, avoid insulin, it is danger. Also there are not too much professional help how to dose insulin, how to use it. As I do see, SU and Invokana more convenient for medical care then insulin. Probably this is why diabetes is still so high in mortality. Simple, avoid treatment which work and replace it with treatment Medical care get most reimbursement. The trip to spot #7 would be speed up.

via Ravenvoron