Comment to publication.
Once-a-day injections?
First, it is the matter of dose I have to inject. If I have to inject 300 units a day I will never try to inject full pen, 307 units at once.
Second, with high dose of insulin injection it is not wise to inject all dose at once. It can easy lead to low sugar at time of soon after injection, and then to high sugar when insulin already fall in dose in the blood.
Third, it is not natural to use high dose of insulin at once. In our body system the amount of insulin is tiny, never in big quantities. So, what is the point to inject high dose at once? No safe needle? Or something else?
I am all the time very confused when the effect of insulin based on how many injections a day or a week diabetic have to take. Why this is so important? Usually medical pro not capable to find out the dose of insulin they have to Ex to diabetic, but they replace all discussions, how many shots, niot units in every day shot, but the amount of shots diabetic must take. Ther shot is the same, regardless it is less then 10 units or over 100 units, it still only one shot, only one time needle enter into belly. The reaction of body very different. 10 units of insulin safe for everyone, even not diabetics. 100 units of insulin can be fatal, even for diabetic.
For me, as I said, it is meaningless. I do not bite it.As I said, it is all about nothing. A new medicine does not mean it is better medicine. I tried to take Toujeo, very well presented. I was not able to take it. My sugar went up, and I developed sort of allergy to this type of insulin. In past I thought any insulin is better then no insulin, probably I will keep this in my mined. But when I do have choice, I prefer insulin with effect I need.
Low blood sugar is not avoidable. I have to deal with it, and be ready to have low blood sugar at any time. This is just part of my life with diabetes. I may do not have low blood sugar, really it is not big problem for me. In this case my sugar would be high. Why do I need it? I do still fight the concequebses of fatally high blood sugar when insulin supply was terminated and I was left without insulin since may to September. My sugar run to over 599 mg/dl, the limit of my meter. After this number show: "High". Not I still pay the price. I still not able to recovery, and with severe swelling after crisis my vain broken, draining.
Well, when we say about treatment of diabetics, and about cost of insulin, let us take into consideration how much cost Metformin, SU, Invokana, and all Trash medicine our medial care industry highly aggressive to push into our big bellies. I just got my scooter, power wheelchair. The cost is $5,000. Free for me. Health plan paid it in full. This is the cost of Metformion I took more then 10 years + SU, Glipizide. Why do not add this price to the very cost effective Metformin which lead me to the non fatal MI and stroke? With insulin I still alive. With right care I still on my two legs. Today health plan pay $2000 for 4 times a year, $8,000 for insulin supply, only insulin supply. There are a lot of more medicine I take every day, Nitrostat including. If I did have insulin in 2001 when I was diagnosed with diabetes, today insulin for me would not cost $8,000 a year. Today I could work, not only able to walk and be happy with it.
In contrary with my best interests, our Medical Pro count, how much insulin injection cost to society compare with Lethal Medicine for elderly useless people.
Degludec insuline is called for a brilliant future from my point of view. Not only is it a secure and long lasting insulin but t could be prepared together with liraglutide in the same syringe. The once a day injection treatment is a possibility now for many diabetic patients.
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DEVOTE: Tresiba as Safe as Glargine With Less Severe Hypoglycemia
A new type of insulin, long lasting as MD said has brilliant future. Probably. I did not try it yet. I take long lasting Lantus Solo Star. What I try to see, how it suppose to work for me, and if the medicine meet my needs.
Once-a-day injections?
First, it is the matter of dose I have to inject. If I have to inject 300 units a day I will never try to inject full pen, 307 units at once.
Second, with high dose of insulin injection it is not wise to inject all dose at once. It can easy lead to low sugar at time of soon after injection, and then to high sugar when insulin already fall in dose in the blood.
Third, it is not natural to use high dose of insulin at once. In our body system the amount of insulin is tiny, never in big quantities. So, what is the point to inject high dose at once? No safe needle? Or something else?
I am all the time very confused when the effect of insulin based on how many injections a day or a week diabetic have to take. Why this is so important? Usually medical pro not capable to find out the dose of insulin they have to Ex to diabetic, but they replace all discussions, how many shots, niot units in every day shot, but the amount of shots diabetic must take. Ther shot is the same, regardless it is less then 10 units or over 100 units, it still only one shot, only one time needle enter into belly. The reaction of body very different. 10 units of insulin safe for everyone, even not diabetics. 100 units of insulin can be fatal, even for diabetic.
SAN DIEGO — For the treatment of type 2 diabetes, the ultra-long–acting, once-daily basal insulin degludec (Tresiba, Novo Nordisk) is as safe in cardiovascular terms as insulin glargine and is associated with much lower rates of severe hypoglycemia, new data confirm.Severe hypoglycemia. Another Toy taken into play. What does it mean, Severe hypoglycemia,which effect diabetic more or less? If insulin glargine safe then why Tresiba is 'safer'? Does not it looks like play with words? The severety of insulin, ether type of it,, depend on the dose of insulin, not on the type of insulin. Insulin can be more effective so diabetic needs less dose of it to get the same result, or less effective, so diabetic must adjust the dose of injection according to the level of sugar in blood, to avoid low blood sugar and at the same time keeping high blood sugar decreasing, or be under control. It this case the type of insulin can play important role. It is cost, it is effect, and diabetic may have some allergy on ingredients, so it is not acceptable to be used. But the expression, "much lower rates of severe hypoglycemia" is simple meaningless.
"For me, this is a robust demonstration of the cardiovascular safety of degludec — and a dramatic and unimpeachable demonstration of the relatively lower rate of severe hypoglycemia" with degludec compared with glargine, senior investigator of DEVOTE, John B Buse, MD, PhD, of University of North Carolina School of Medicine, Chapel Hill, told Medscape Medical News.
For me, as I said, it is meaningless. I do not bite it.As I said, it is all about nothing. A new medicine does not mean it is better medicine. I tried to take Toujeo, very well presented. I was not able to take it. My sugar went up, and I developed sort of allergy to this type of insulin. In past I thought any insulin is better then no insulin, probably I will keep this in my mined. But when I do have choice, I prefer insulin with effect I need.
Low blood sugar is not avoidable. I have to deal with it, and be ready to have low blood sugar at any time. This is just part of my life with diabetes. I may do not have low blood sugar, really it is not big problem for me. In this case my sugar would be high. Why do I need it? I do still fight the concequebses of fatally high blood sugar when insulin supply was terminated and I was left without insulin since may to September. My sugar run to over 599 mg/dl, the limit of my meter. After this number show: "High". Not I still pay the price. I still not able to recovery, and with severe swelling after crisis my vain broken, draining.
"There's always been this theory, demonstrated over and over again, that severe hypoglycemia is a big risk for subsequent cardiovascular events," Dr Buse explained to Medscape Medical News. "Whether it's related to the fact that the people who have severe hypoglycemia are also people who have cardiovascular events — because they are frail and have lots of comorbidities — or whether there is a causal relationship is still uncertain."Well, a little be confusion. Really, how CVD is related with severe hypoglycemia? Severe low blood sugar level leads to coma. Does coma can be fatal due to heart will stop to pump the blood? When patient die due to natural cause the temperature of body drops, the BP drops, and blood sugar drops, that's true. Still, it is not the case with diabetes. We do not discuss fatal end of the life. It is diabetic who take medicine to treat medical condition, diabetes, pancreas disorder. The side effect of medicine can be low blood sugar, when diabetic treated with insulin or SU, the same result. The heart is also effected by pancreas disorder, the same as liver, lungs, and kidney, and eyes, and many many other effect which lead untreated diabetic to disability and early Death. I really not able to get the point of Dr.Buse 's explanation. Does he understand what does he is talking about?
"As cardiologists, we tend to be focused on the [atherosclerotic] plaque, I think too much focused, and I think in the diabetes world they tend to be too much focused on the hypoglycemia, and I think it's going to be much more complicated than just one or the other." (Steven P Marso, MD, of the Research Medical Center, Kansas City, Missouri.)Plaque can resulted by medicine diabetic takes, Metformin and absence of medicine diabetic need, Lipitor. Statins such as Atrovastatin, Simvastatin, Provastatine, do not do the job, and diabetoc's blood vessels still plagued. In contrary, other party concentrated on low blood sugar, and do not remember that diabetes is not low blood sugar but pancreas disorder, resuled to high blood sugar. The concentration on low blood sugar is so severe that the fact, diabetes is not treatable and medicine they Rx destroy diabetics healthy and still well working organs but does not lead cure, or improvement and life saving.
So, let us see, what are the answers.Is Insulin the Right Treatment for Type 2 Diabetes?
It is almost impossible to assess how the cost of different insulins compare with each other, both within one country and from country to country.Say me, why Dr discuss cost of insulin in stead of it effect and if it is right medicine for diabetics or not? really why? Say me, how much cost treatment of alcoholism or addiction? How much cost treatment of cancer? Stroke? any other disabilities? But it is always top of any discussions, how much cost of diabetics treatment.
Well, when we say about treatment of diabetics, and about cost of insulin, let us take into consideration how much cost Metformin, SU, Invokana, and all Trash medicine our medial care industry highly aggressive to push into our big bellies. I just got my scooter, power wheelchair. The cost is $5,000. Free for me. Health plan paid it in full. This is the cost of Metformion I took more then 10 years + SU, Glipizide. Why do not add this price to the very cost effective Metformin which lead me to the non fatal MI and stroke? With insulin I still alive. With right care I still on my two legs. Today health plan pay $2000 for 4 times a year, $8,000 for insulin supply, only insulin supply. There are a lot of more medicine I take every day, Nitrostat including. If I did have insulin in 2001 when I was diagnosed with diabetes, today insulin for me would not cost $8,000 a year. Today I could work, not only able to walk and be happy with it.
In contrary with my best interests, our Medical Pro count, how much insulin injection cost to society compare with Lethal Medicine for elderly useless people.
via Ravenvoron
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