Hello. I am Cyrus Desouza. I am an endocrinologist from Nebraska. Today we are going to discuss three new classes of drugs, their clinical usefulness, and certain subsets of patients in whom they should be avoided.

Well, at first, hat a new drugs are?

What is the most important information I should know about Saxenda^®?
Serious side effects may happen in people who take Saxenda^®, including:
Possible thyroid tumors, including cancer. Tell your health care professional if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer.

Show me one diabetic type 2 who does not have this types of problems.When we start to take this type of medicine it will take time to develop thyroid tumor. So, at the time when diabetic takes first pill there is still no swelling. With time when edema get out of any safety no one would see it is Edema, but see our Bathroom Scale reading, obesity. After it would be obesity blamed, our non-healthy lifestyle, why we do have thyroid tumor. Perfect Crime I will say.

Dr. Jack Merendino, MD , Endocrinology Diabetes & Metabolism, answered on behalf of The Best Life

Glucagon-like peptide-1 (GLP-1) gets its name from the fact that it is chemically similar to glucagon, but, like insulin, it lowers blood sugar. GLP-1 is made by cells in the intestine after eating, and it travels via the bloodstream to the pancreas, where it increases the amount of insulin that's made and also reduces the amount of glucagon. Several medications available to treat diabetes increase the effects of GLP-1: Januvia and Onglyza, both oral medications, and Byetta and Victoza, given by injection.

Still, it is not clear for me, why should I take GLP-1? Simple, Rx insulin, not 'like' but real insulin, and there is no so fanny side effects. With insulin is only side effect, low blood sugar. Ongliza does not lead to low blood sugar, why? It does not low blood sugar so sugar never will hit low mark.

DPP-4 inhibitors.
For me it is still complicated to get the point why should I use it. It is Incretin, hormone used to signal to the body to release insulin. Looks like if someone said to me I have to buy health insurance I have to do so. Just say me, how. I cannot work, have "0" income, so how I suppose to pay for health care? The same I can say about DPP-4. Incretin signal to the pancreas to secret and release insulin. Pancreas is too ill to respond. Say me, insulin will come from where?

SGLT-2, Invokana, very strong diuretic. For every one diabetic kidneys in the constant risk to be damaged. To avoid this complication diabetic type 2 suggested to take Invokana, strong diuretic. Sorry, I still not able to get the point, what is new and where are new options in treatment of diabetics?
There is another question, does Invokana lead to low blood sugar? It can cause hypotension in many patients, but what about low blood sugar? Would it lead to hypoglycemia, and if it is not then why? Remember, how our body fight high blood sugar? by increasing urination and increasing water intake. If water intake suppressed, we do have severe dehydration. Now in addition to the natural problems which due to diabetes, I will have this problems doubled with treatment. Does someone see benefits? I still do not.

It is not the question why Dr. Cyrus Desouza created this scam. The question is, why Medscape published it? Why many medical providers thanks author for this scam and present it as valid info? Really, what all those discussions about? Who would benefit from what drug? Sorry, is this the important question? There is no such question when insulin discussed. With insulin as the prime treatment regime it is dose of medicine which is most important to discuss. Medical Providers still not able to use insulin as treatment for 90% of diabetics population. This is the point of discussion. Practically it is out of Medscape Editorials point of interest. Why? Because of they already good. If there is no diabetics type 2, the hell do know what it is, then what they suppose to publish? How to treat cancer? Or CVD? They have no one idea how to do so. To fill out the gap they publish Scam, and happy to collect salaries and donations.

Really, it is time to have another editor for this Worm Chair.