semaglutide is a new drug to suppress appetite. October 24, 2017

A drug that targets the appetite control system in the brain could bring about significant weight loss in people with clinical obesity, according to new research.

Drug can dramatically reduce weight of people with obesity

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Probably it is OK to suppress appetite and reduce weight. The point is not in the drug if these drug do the job or not, but in the most important issue, does it really appetite to blame high pounds? If so then does not matter how appetite suppressed the body will get bigger and bigger with every next attempt to lose weight. It is simple wrong way to go, soo this way never will bring to the right destination.

On average, people lost 5kg (11lbs) over a 12 week period after receiving weekly doses of semaglutide, a compound currently being developed as a treatment for Diabetes.

So, it is appears that diabetes is caused by abnormal appetite and this is why  semaglutide was developed. The problem is, no one test for diabetes type 2 diagnose what caused diabetes type 2. The cause of diabetes can be very very different. One of it is hydropic change. With insulin treatment this very danger and speedy developing type of diabetes would be slow down and with time it probable reverse changing back to normal. This is lesion of pancreas watered cell. If this is the case of diabetes development then no appetite involved, but insulin therapy can suppress the diabetes development and even reverse it if case is mild.

Notably, the 40-week study evaluated the efficacy and safety of two dosages of semaglutide, in addition to initial standard-of-care therapy metformin against dulaglutide plus metformin. While 0.5 mg semaglutide was compared with 0.75 dulaglutide, 1.0 mg semaglutide was compared with 1.5 mg dulaglutide, when added to metformin.        

      I am a little bit lost in this explanations.
so, 40 weeks of study.
two doses of 0.5 mg; 0.75 mg; 1.0 mg; or 1,5 mg. of semiglutide.
metformin as standard care.
 So, what I will have? I really do not know how to be sure that it is fat go away rather then water. Most of the weight loss came from a reduction in body fat. There is no test to separate fat from water.

We saw results in 12 weeks which may take as long as six months with other anti-obesity medication.

Good. What about sugar? Does sugar go up? or down? Still, there are no numbers how drug effect blood sugar level.
Also, it is easy to lose weight withing 12 weeks. Then it is slow down, and with time weight come back. This is how it works with diuretics. A new drug suppresses appetite. It work in brain. For how long it can be used? If it is used too long atrophy can be developed and appetite would be suppressed so highly that actually it is eating disorder, clinical case.

"The drug reduced hunger but also cravings for food and the sensation of wanting to eat -- and these had previously been thought to stem from different parts of the brain."

Does someone ready to get ticket to the train? I am not. The train is heading in wrong direction, and I am not going to that point as long as I would. Personally I prefer to keep my brain impact. 

In the study, the drug was given to 28 people with a body mass index (BMI) range of 30 to 45 kg/m2 -- meaning they were very overweight with a lot of body fat.

As long as I do remember the new drug was developed to treat diabetes type 2. So, now, if someone without diabetes type 2 would take it, what about sugar level: Would they have low blood sugar? It is the case if insulin taken by non diabetic. One would develop  low blood sugar. So, treatment obese person without diabetes with medicine which developed to treat diabetes will lead to low blood sugar if medicine works, and will have no effect on person if  a new medicine does not effect blood sugar level. If so then how it can be pretended to treat diabetes type 2?
      Very complicated I would say.

via Ravenvoron