I do understand that in 1964 the knowledge about diabetes were limited. On the same time Insulin already was discovered and in wide use. It was very well known that diabetes caused by limited insulin secretion. Insulin added in injections returned to the life, human or animals. Still, in 1964 the article The Metabolic Lesion in Diabetes Mellitus by R.Levine counted glucose. Insulin was left aside.
Author present that the extrahetic tissue utilize glucose, transforms it into H2O and CO2, and create needed energy. In diabetics system total utilization is decreased, and this resulted hyperglycemia. well, is so then there are two components play role in metabolic utilization, glucose and insulin. So, if glucose level is low then there is no need in insulin. If we do not eat then we do not need insulin to utilize glucose. Right? Wrong. We still need energy to function. We cannot live without energy. So, to get energy we need to take meal and transform meal into glucose, right?
If so then why diabetes is metabolic disorder? There is nothing about metabolism if there is no component to utilize, insulin. Insulin is limited or absent in out body system. Regardless if there are a lot of glucose, ready to be transformed into energy, or there is just normal, or even under normal amount of energy, still if there is no insulin then there is no energy. Heart will stop to push the blood.
To compare brain has another gland which secret insulin. This insulin used only for brain activity. Because of this insulin independent from pancreas our brain still functional even sugar in blood is high. In contrary, when this gland does not secret insulin brain disfunctionsl, even sugar in blood is normal.
Author of article presented that brain have normal rate in glucose intake. Not every time. There are other abnormalities involving insulin. Insulin added to those patient increases their activity and improve daily living. This insulin needed in very small amount and probably another way of administration.
Finally after all the discussion how glucose metabolized there is a few words about insulin.
"Insulin is only hormone which set up conditions favorable for storage and conservation, I.E. glycogen deposition and fat and protein synthesis". Page 5.
Interesting I will say. Is the job of insulin to set up storage of fat and conservation of glycogen? It is already 1964. It is not before insulin discovery but pretty after. There are many books published what is diabetes. Diabetes is limited insulin secretion. It is not metabolism of anything. It is absence of insulin. take off insulin secretion, and there is no life. Two weeks only, and diabetic will die. The same as it is with meal. If one has no meal and water then two weeks and even insulin secretion is normal and there is no diabetes human or animal will die.
"A dence fog of ignorance still covers the chemical events preceding hyperglycemia as well as those disturbances of cell metabolism which ultimately lead to angiopathy and nephropathy."
Really, look who is talking about ignorance.
Author present that the extrahetic tissue utilize glucose, transforms it into H2O and CO2, and create needed energy. In diabetics system total utilization is decreased, and this resulted hyperglycemia. well, is so then there are two components play role in metabolic utilization, glucose and insulin. So, if glucose level is low then there is no need in insulin. If we do not eat then we do not need insulin to utilize glucose. Right? Wrong. We still need energy to function. We cannot live without energy. So, to get energy we need to take meal and transform meal into glucose, right?
If so then why diabetes is metabolic disorder? There is nothing about metabolism if there is no component to utilize, insulin. Insulin is limited or absent in out body system. Regardless if there are a lot of glucose, ready to be transformed into energy, or there is just normal, or even under normal amount of energy, still if there is no insulin then there is no energy. Heart will stop to push the blood.
To compare brain has another gland which secret insulin. This insulin used only for brain activity. Because of this insulin independent from pancreas our brain still functional even sugar in blood is high. In contrary, when this gland does not secret insulin brain disfunctionsl, even sugar in blood is normal.
Author of article presented that brain have normal rate in glucose intake. Not every time. There are other abnormalities involving insulin. Insulin added to those patient increases their activity and improve daily living. This insulin needed in very small amount and probably another way of administration.
Finally after all the discussion how glucose metabolized there is a few words about insulin.
"Insulin is only hormone which set up conditions favorable for storage and conservation, I.E. glycogen deposition and fat and protein synthesis". Page 5.
Interesting I will say. Is the job of insulin to set up storage of fat and conservation of glycogen? It is already 1964. It is not before insulin discovery but pretty after. There are many books published what is diabetes. Diabetes is limited insulin secretion. It is not metabolism of anything. It is absence of insulin. take off insulin secretion, and there is no life. Two weeks only, and diabetic will die. The same as it is with meal. If one has no meal and water then two weeks and even insulin secretion is normal and there is no diabetes human or animal will die.
"A dence fog of ignorance still covers the chemical events preceding hyperglycemia as well as those disturbances of cell metabolism which ultimately lead to angiopathy and nephropathy."
Really, look who is talking about ignorance.
via Ravenvoron
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