Dibetes type 2, fat, mice, and natural sugar benefits. August 28, 2018

Mice fed a diet high in trans fats and cholesterol for 12 weeks show fatty deposits in the liver (red staining). A new study from Washington University School of Medicine in St. Louis shows that the natural sugar trehalose blocks glucose from getting into the liver and turns on a gene, Aloxe3, that improves insulin sensitivity and other measures of metabolic syndrome, including reducing such fatty liver deposits.

Credit: Brian DeBosch

 https://www.sciencedaily.com/releases/2018/08/180823092016.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

         So, they took healthy mice, fed it with high trans fats, and this is how fatty deposits were developed. Then they look at diabetics type 2 and see, there are fatty deposits in our bodies. The conclusion is? We eat fat trance diet. So simple. If mice developed fat then I eat fatty food. I am not. My liver does not allow me to eat any fat, oil, or batter since I was child. Fat will kill my liver. But before that there is pain, hardly bearable pain, and I do not like any pain. So, I avoid fat in any means, oil, batter, fatty food. But anyway I am 400 lbs. So, according to all medical publications I am diabetic type 2 because of I eat fatty food. Many studies prove this claim.
         Now studies show that natural sugar is very beneficial. It is actually improve health of diabetics.

While potential medicinal use of trehalose still requires considerable research, the investigators found that giving mice trehalose via drinking water resulted in beneficial effects on the animals' liver metabolism -- similar to benefits that resulted from fasting. In fasting mice, the liver also turns on the same gene that improves the body's ability to use insulin.

Great studies, I will say.  Just remember, mice were fed with wrong diet. I am not. Mice was healthy before studies were  started, and diabetics type 2 already ill people. I will add-on that if mice will jhave right food and bigger cage then mice will be healthy as it was before. So, really what studies studied? Nothing. They just studied if wrong food beneficial or not. They just need more prove that diabetics type 2 ill because of wrong food choice. And they do not see that mice have benefits from drinking water, diabetics type 2 still progress to deeper insulin limited sickness. Are you remember, one of symptom of diabetes is drinking a lot of water.
       I suggest to add to study Diuretic medicine and give it to mice. Then take a look at how mice would develop CVD and diabetes and so so on. Diuretics are in everyone diabetic medical box. Diuretics kill heart. There is no studies how danger or beneficial diuretics are. It is just must have medicine. In every hospital we do have this medicine. It helps to reduce weight. Some people take this medicine for many many years. They do have strong and healthy heart. Other who do not have such luxury die soon because of kidney failure.

"In mice, this gene is turned on as part of what seems to be the normal fasting response. Our data suggest that fasting -- or giving trehalose with a normal diet -- triggers the liver to change the way it processes nutrients, in a beneficial way. And if glucose can be blocked from the liver with a drug, it may be possible to reap the benefits of fasting without strictly limiting food."

This is why it is good to take studies on animals. It is easy to do whatever studier wish. It is not the same with humans. If we are healthy, we do not participate in medical studies. When we are ill, we do not response to wrong medicine. Say me, what Brian DeBosch, MD, PhD, an assistant professor of pediatrics is going to do if there is no insulin  in secretion? Or it is so limited that no one diabetic type 1 may have. How in this case normal diet will be processed? So, regardless of all the studies which done, they are fake. It is in no one way that healthy mice and diabetic type 2 can be compared. So, regardless of studies outcome no one diabetic type 2 can benefit from these studies. There is no way that insulin sensitivity can be improved if there is no insulin in secretion. And if there is insulin added in injection then any normal diet will be easily processed, and no weight gain will be.

The researchers found that activating Aloxe3 in the mice given trehalose improves insulin sensitivity in a way that is similar to how thiazolidinediones work. Studying healthy mice given only water over a 48-hour period, they found that fasting, likewise, activates Aloxe3 in the liver. This activation could boost insulin sensitivity in the same way.

What does it mean? In body where insulin secretion is limited with treatment like this insulin sensitivity increases, so human will be more insulin-hungry. This is how Actos and Avandia work. These med increase insulin sensitivity. These med do not add insulin. The insulin still absent and any diet cannot be processed without insulin.

via Ravenvoron