Understanding Insulin Resistance. August 30, 2018

 Understanding Insulin Resistance.
By Erika Gebel, PhD
 http://www.diabetesforecast.org/2011/jun/understanding-insulin-resistance.html

 The bodies of many people with diabetes are fighting a quiet war against the essential hormone insulin. This conflict is called insulin resistance, and while it's a hallmark of prediabetes and type 2 diabetes, it can also affect those with type 1. Just why a person fails to respond properly to insulin is something of a mystery. But there are ways to make the body more receptive to insulin, which can help prevent or ameliorate diabetes.

      This is author present Insulin Resistance.  As it is easy to see, type 2 diabetics do have Insulin resistance, type 1 diabetics does have Insulin resistance, and some diabetics type 1 do have Insulin resistance. So, it is important to recognize when it is resistance to insulin and what really is it? And when it is Insulin Dependency? It is unclear so far why this happened. But still, it is clear that there aare two different types of diabetes, Resistance to insulin and Insulin Dependency when insulin in  shots needed to person who effected by this condition, to survive.

In people who have neither diabetes nor insulin resistance, eating a typical meal will cause blood glucose levels to rise, triggering the pancreas to produce insulin. The hormone travels through the body and induces fat and muscle cells to absorb excess glucose from the blood for use as energy. As the cells take up glucose, blood glucose levels fall and flatten out to a normal range. Insulin also signals the liver—the body's glucose repository—to hold on to its glucose stores for later use.
However, people with insulin resistance, also known as impaired insulin sensitivity, have built up a tolerance to insulin, making the hormone less effective. As a result, more insulin is needed to persuade fat and muscle cells to take up glucose and the liver to continue to store it.

     Let us take closer look at this statement.

In people who have neither diabetes nor insulin resistance, eating a typical meal will cause blood glucose levels to rise, triggering the pancreas to produce insulin.

Are you sure, pancreas start to produce insulin in response to eating?  What if this is not really the case? What if insulin is already in blood, or in some places in cell ready to deploy in response to glucose rising in time of eating? If so then it is more obvious why level of sugaar in blood dropping fast. Also it is easy to understand why in case of diabetes type 2 level of sugar does not return back to normal level. There is no secreted insulin to be stored and ready to use. In this case insulin must be at first secreted, and only after being secreted and sent to blood stream it can be used. Time Factor. In case of diabetes type 2 the time for level of sugar in blood to drop is longer. In some cases it is more then 5 hours.

However, people with insulin resistance, also known as impaired insulin sensitivity, have built up a tolerance to insulin, making the hormone less effective. As a result, more insulin is needed to persuade fat and muscle cells to take up glucose and the liver to continue to store it.

How this claim was ever proved? How it was ever tested that insulin is not effective, and how effect of insulin was determined? Simple, with level of sugar in blood. Because of there is all the time only one test, and there are so many medical conditions then to determine which one and when it is up to MD, or Medical Care Pro. They are doctors, and we are not. we will take all for granted what they said. I am not one of them. I ask questions.

In response to the body's insulin resistance, the pancreas deploys greater amounts of the hormone to keep cells energized and blood glucose levels under control. (This is why people with type 2 diabetes tend to have elevated levels of circulating insulin.)

Really? What is the normal level of insulin that our body used during 24 hours? hen insulin use higher, at night or at day time? There are so many gustions can be asked, but the answer is only one:

 Doctors don't usually test for insulin resistance as a part of standard care. In clinical research, however, scientists may look specifically at measures of insulin resistance, often in an effort to study potential treatments for insulin resistance or type 2 diabetes.

Bingo!!!!!!!!!!!!!!!!!!!!!!
No tests for level of insulin!!!!!!!!!!!!!!!!!!!!!! In labs researchers study how diabetes type 2 developed in mice which was fed with fatty diet and deeply depressed in its cage. After study mice behavior researcher notify public that diabetes type 2 caused by fatty diet. If diabetic type 2 will starve her/him-selves for Death, they will not have diabetes type 2. No. Sugar still in bones and thiis is how many years after diabetic died the cause of death can be identified.

Insulin resistance comes in degrees, with important health implications for people with diabetes. The more insulin resistant a person with type 2 is, the harder it will be to manage the disease because more medication is needed to get enough insulin in the body to achieve target blood glucose levels.

This is also interesting point, the degrees of insulin resistance, so it is stages of diabetes. Then more insulin needed to bring level of sugar back to normal then higher stage of Insulin Resistance. Also it is very easy to see that to insulin delivered into blood stream can lead to drop blood sugar level. As we can see, there is no one medicine so far to treat any type s of diabetes in any stages of it with any degree of it. It is Insulin in injections, or insulin which was secreted by diabetic's own ill pancreas and limited beta cells.

The ability of the pancreas to increase insulin production means that insulin resistance alone won't have any symptoms at first. Over time, though, insulin resistance tends to get worse, and the pancreatic beta cells that make insulin can wear out. Eventually, the pancreas no longer produces enough insulin to overcome the cells' resistance. The result is higher blood glucose levels (prediabetes) and, ultimately, type 2 diabetes.

Now just think about it how beneficial SU, medicine to increas insulin secretion for diabetics type 2, can be for victims? Withing less then 10 years after diabetes type 2 treatment started, diabetic die.  It is not all time due to diabetes as it is stated in Death certificate. It is CVD or stroke, cancer or Asthma, and many other All Cause Death mortality causes. But diabetic type 2 die less then within 10 years after treatment with SU and Metformin started. In contrary, diabetics type 1 live longer then 60 years after being diagnosed with Diabetes type 1. Simple math. Do I really will live if I trust in MD?

via Ravenvoron