Diabetes type 2 Treatement and its Effect. January 14, 2019

To treat diabetes type 2 developed many oral medicine. They all belong to different families and have different mechanism of action. What they all do have in common, they all work out to destroy healthy well working organs, and lead to deeper diabetes type 2 state. Why is this so?

• At first as it is all the time claimed, they do not lead to low blood sugar, so they do not reduce level of sugar, the prime work they pretended they do. 
• Second, they all effect healthy tissue and healthy well working organs so the side effect is that diabetic who takes any one of these medicines develop more complications then if diabetes was left untreated. 
• Third, they all have side effects such as stroke and CVD, high blood pressure and DVT. High level of sugar in blood lead to effect blood  clothing. Clots in blood lead to CVD, stroke, and so on. Complication due to these medications are amputations, lost vision, Asthma, and tumors.
• Lastly the problem with diabetes is not high blood sugar but not sufficient insulin secretion. If so the any medicine must work to increase insulin available to be used, and storage capacity of Beta Cells.

Alpha-glucosidase inhibitors are oral anti-diabetic drugs  that work by preventing the digestion of carbohydrates (such as starch and table sugar).
 Precose, Glyset, Voglibose
Common side effect is malnutrition. Would these medicine work?No. Diabetes is not digestion but availability of insulin to be used. Nether one of these drugs work to increase the level of insulin in blood available to be used.

Bromocriptine oral tablet is available as a generic drug and as brand-name drugs. Brand names: Parlodel and Cycloset.
Bromocriptine works in different ways, depending on the condition it’s being used to treat. 
It’s not known exactly how this drug works to treat type 2 diabetes. It may affect rhythms in your body and prevent insulin resistance.
If someone so smart to take that risk then be my guest. I am not going in this boat.  I do not believe in miracle. I do not believe in drugs that can treat different condition with the same name of medicine. Insulin Resistance and Parkinson’s disease? Not for me.

DPP-4 inhibitors help the body continue to make insulin. They work by reducing blood sugar without causing hypoglycemia (low blood sugar).
These drugs can also help the pancreas make more insulin. These drugs include:

 alogliptin (Nesina)
alogliptin-metformin (Kazano)
alogliptin-pioglitazone (Oseni)
linagliptin (Tradjenta)
linagliptin-empagliflozin (Glyxambi)
linagliptin-metformin (Jentadueto)
saxagliptin (Onglyza)
saxagliptin-metformin (Kombiglyze XR)
sitagliptin (Januvia)
sitagliptin-metformin (Janumet and Janumet XR)
sitagliptin and simvastatin (Juvisync)
 From all this family I took Onglyza. A few month later there are pain in abdomen.  Soon I got mail from CVS that Ongliza may cause stoned development. "Say to your doctor if you do have history of stones," - was suggest in mail letter. Are you kidding? How do I know what to say to doctor? Why doctor did not ask me this question before Rx this medicine for me? It is all the time humor: tell your doctor if you do have ..... . Why doctor never ask questions if I do have or not what I have to say to doctor? Really, who is educator to  whom? 

Glucagon-like peptides (incretin mimetics)

These drugs are similar to the natural hormone called incretin.
They increase B-cell growth and how much insulin your body uses. They decrease your appetite and how much glucagon your body uses. They also slow stomach emptying.
These are all important actions for people with diabetes.
These drugs include:
albiglutide (Tanzeum)
dulaglutide (Trulicity)
exenatide (Byetta)
exenatide extended-release (Bydureon)
liraglutide (Victoza)
semaglutide (Ozempic)
Really I did not get the idea, what those drugs are about? Because of diabetes is not sufficient insulin secretion then why do I need to increase use of insulin? Another point is about B-cells grow. Are this safe? As I do know so far there is no one number in B-cells amount in every one of our bodies. If this medicine provide B-cells grow to what is the point of final number? When that medicine must be stopped? How it would be detected that there are no diabetes because of beta cells in the right amount? What if there is another defect in all that chin glucose-insulin-metabolism-appetite? Anyway as it is presented this medicine work, supposedly, in different directions: decreases appetite, increases beta cells growth, decrease in glucagon use, and emptying stomach. So different and complicated mechanism of action in one tablet? I do not like combination therapy. Prefer do not use it.

Sodium glucose transporter (SGLT) 2 inhibitors

These drugs work by preventing the kidneys from holding on to glucose. Instead, your body gets rid of the glucose through your urine. 

dapagliflozin (Farxiga)
dapagliflozin-metformin (Xigduo XR)
canagliflozin (Invokana)
canagliflozin-metformin (Invokamet)
empagliflozin (Jardiance)
empagliflozin-linagliptin (Glyxambi)
empagliflozin-metformin (Synjardy)
ertugliflozin (Steglatro)

Diabetics type 2 have  kidney complications. Now there is medicine which increases urination, in diabetic who already do have it is very frequent. Now it is presented that Invokana will decrease level of sugar in blood by diuretic effect. We all do know very well that siphon effect does not cure diabetes type 1. Any diabetic with very high level of sugar in blood has high urination and high thirst. But in spite of urination, diabetic does not get rid of sugar in blood. Diabetic die. It was in past. It is in present time. All this medicine lead only to kidney failure, heart failure, severe asthma and pulmonary embolism, and wound development, amputations. 

      This is not complete list of medication to treat diabetes type 2. So many of them, no one effective. Why so many? Because if one medicine does not work, and there are allergy or severe side effects, MD all the time may Rx another name from the same family of medicine. Would it work. Not at all. Does MD know about it? Yes, he does. Does patient know about it? Not really. Diabetic trust in doctor and believe that doctor know the best. 

     As Dr. E. Joslin said long time ago, diabetic who know most live longest. Best way to educate yourself then relay on education of some person who will teach what to eat and how to hold spoon in hand to reduce appetite.

via Ravenvoron