insulin or Oral agents to treat diabetes. January 26, 2019

" The oral hyperglycemics are effective only in some types of diabetes and in some times, while insulin is effective in all types of diabetes at all time." Page 324)

 Impact of Insulin on Metabolic Pathways

edited by Eleazar Shafrir
International symposium Commemorating
the 50th anniversary of Insulin
24 to 29 October 1971, Jerusalem, Israel
Academic Press. 1972

Study conducted UGDP in US to find out how oral agent may prevent CVD and mortality. 5 groups about 200 participants in each were given insulin, Tolbuonide, and placebo. All participants were placed on diet. Insulin was Standard, the fixed dose, or variable, the dose to keep level of sugar closer to normal level.

"After the second year, significant differences in the course of glycemia become apparent and persisted from then on throughout the study." (Page 325)

       At the end of third year of study the effect of medicine was even greater. The group treated with Tolbuonide had as twice higher mortality due to CVD compare with group of insulin treated diabetics. Important fact is that diet treated diabetic had mild abnormality in glucose level. SU treated group was in advance progressive state of diabetes. Insulin treated diabetics were those with highest level of sugar in blood. The fact that in insulin treated group mortality due to CVD was as twice as low then in SU treated group is very important finding.
      Study were criticized and result were not widely accepted by clinicians. But later Joslin Clinic repeated the same studies, and results were similar.
       In present time studies like that practically out of practice. Mortality of diabetics rises in all cause of death, and now diabetes type 2 which treated with oral medicine such as SU or Metformin  first line and there are many other agents as add-on, second, third, and so is number 7 cause of death in all mortality tables. Unnecessary timeless Deaths which can be easily prevented with insulin therapy,
       Probably it is right that mild types of diabetes can be treated temporary with SU, Metformin and diet. In contrary all types of diabetes, pre-diabetes including can be treated with insulin, and cured. If so then what is the reason to take SU and metformin which will increase insulin deficit less then within two years of treatment, and less then 10 years after therapy started diabetic probably will die due to any cause of death such as stroke or CVD, Asthma or COPD, Pulmonary embolism or kidney failure.

via Ravenvoron