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Tuesday, 29 January 2019

Low Insulin Response. January 29, 2019

        Sugar is 83 mg/dl. Yesterday I injected 307 units of Lantus Solo Star. Sugar suppose to go up. To add more drama I ate a lot of carbs before bed. Sugar must be high. But it is rather normal. Why? Really why?
 We have for several years postulated that a diminished insulin response to glucose is the basic pathogenic factor in the development of the different stages of the  diabetic syndrome. The presence of low insulin response in healthy monozygonic twins of diabetic parents indicates that this insulin deficiency is inherited and precedes the appearance of decreased. (Page 33)
Impact of Insulin on Metabolic Pathways edited by Eleazar Shafrir
International symposium Commemoratingthe 50th anniversary of Insulin 24 to 29 October 1971, Jerusalem, IsraelAcademic Press. 1972
        There are many different aspects that effect insulin response. Probably this is the point when it is stated that insulin  used not properly in diabetic's type 2 body system. As it is all the time the first question is, are there are insulin to be used? But it in sot the point of discussion for today.
        Low Insulin Response, what does it mean? The quality of insulin can be different so the glucose utilization takes longer time then with more active and insulin action. Of it can be deficit in insulin secretion. So, insulin secreted by diabetic's pancreas, but it  is come to blood stream too slow, so it takes more time to utilize glucose load. And one more point is that insulin do the job in utilization of food, but do not utilize pure glucose load.
        No one of this question is important for me to study. It is important to understand the pathology in insulin secretion and glucose utilization. For me as diabetic the point is only one: to keep my life longer and happier as much as I can.
       In contrary, there are a lot of discussions on every forum and in every clinic I visit: my life style. No one really know what life style I do live. Every one do know perfectly accurate, I live in the way they present as I do according to my body shape. This is why I try to post it here. There is nothing about life style we have to change. We need Insulin to be added into our medical box, so we can live longer and healthier.
       The diagnose of diabetes based on the GTT. The level of sugar tested for three hours after glucose load. Why? It is pretended that after three hour level of sugar return back to normal. It is not the case with Low Insulin Respondents.  My sugar going up  five hours. Then just less then within an hour it drops. Then test stopped after three hours the level of sugar in my blood is not highest. It is highest after five hours.
       When test to diagnose diabetes performed the time and level of sugar is not taken into consideration. But there is interesting question, what is really going on after meal? How really insulin and food interact? What signal to secret insulin, or there is already insulin in blood which our system uses, but this level of insulin is very low? Probably the expression "Low Insulin respondents" in fact just meaningless? If there is no insulin available to be used that say me, what suppose to respond to glucose load?
      There is really very important question, why sugar rise after meal up to five hours? According to common presentation, as soon as glucose loaded the level of sugar in blood rises. Also it is very well known that sugar return down to normal just less then two hours after meal. Now the question is, for how long sugar raised in healthy man? How fast sugar dropped in healthy man? What are difference between healthy men and diabetic man?    


via Ravenvoron

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