The origin of diabetes. January 29, 2019

"If, as we established, the first alternative is correct one, the majority of genetic diabetes  should originate from the population of low insulin responders." (page 33)

Impact of Insulin 
on 
Metabolic Pathways
edited by Eleazar Shafrir
International symposium Commemorating
the 50th anniversary of Insulin
24 to 29 October 1971, Jerusalem, Israel
Academic Press. 1972

        So, if parents, one or both are low insulin responders then children would be diabetics in some time of their lives. It is if diabetes is genetic. So, diabetes type 1 is genetic disorder, and if left untreated in parents then children probably would be born diabetics.  But if diabetics would be treated then children of those diabetics probably would be born not-diabetics or just low insulin responders. With time less and less diabetics would be born. Perfect diabetes development prevention.
      As it is already was established, insulin is good to treat any type of diabetes in any stage of it development. It is just logical to assume that treatment with insulin is cost effective medicine in long term. Even if it is costly to star with, it pays back with time and with every generation of less violent diabetes development.
      Because of Low Insulin Responders never diagnosed due to they do not have diabetes symptoms, this insulin deficiency just grow with time, and in any time it can burst up into full diabetes development. Diagnosed in adult it would be diabetes type 2, very often mild to begin with. When it is left untreated or treated wrongly with oral medicine such as Metformin and SU the insulin deficiency became more severe and less then within 10 years after being diagnosed with diabetes type 2 and treated with SU and Life style modifications diabetic gone.
       On the contrary if it is taken into consideration that diabetes may be as flu, the same pattern, then treatment with insulin will fix insulin deficiency in some point, and then diabetic would enter into Honeymoon phase for years to come. The perfect prove of this point is Hallie Berry.

 A similar trend toward a diabetic-like response - in this case in lipid metabolism- has been demonstrated in some low insulin responders during muscular exercise. ..... thus, these subjects could be considered to be normal with respect to GT but diabetic at the adipose tissue level. Furthermore, a group of pre-diabetics demonstrated stigmata of the diabetic state. (page 35) 

       What does it mean? It means that diabetes is more complex then simple ration glucose load/ insulin response. It is started with low insulin response, mild insulin secretory deficit, then it move to pre-diabetes, more insulin deficit, and then one after another all stages of diabetes development with wider and wider gap between insulin secretion and level of insulin in demand. But even when pre-diabetes was diagnosed there still no treatment for diabetic. No insulin. Just restrictions in diet and increas in work out.
       About work out, would it be so healthy for diabetic to practice more exercise? When diabetic was in state of low insulin responder he already demonstrated stigmata of diabetes state. When insulin deficit increased the condition of diabetic worsened. To add more drama, there are restriction in diet, so there is limit in nutrition. Some elements even absent in blood because of there is restriction in diet. Insulin secretion dropping.
      It is very widely known that diabetics type 2 develop diabetes due to diet high in carbs and fats. But as it is easy to see, diabetes developed long before it was diagnosed. In diabetes liver respond to meal in different way then in non diabetic normal person. With first line of treatment
 when Metformin taken at first to prevent diabetes then to treat diabetes, and Metformin effect lived to restrict glucose release between meals, and  impact on muscles to increase muscles demand in insulin, how does this type of treatment can effect diabetic type 2? Meant transformed into fat, and insulin deficit increased. 

via Ravenvoron