Semaglutide, SGLT-2 ,Body Weight, and Diabetes type 2. March 27, 2019

In the SUSTAIN 9 trial, type 2 diabetes patients with HbA1c levels of 7% to 10% despite being on an SGLT-2 inhibitor for at least 90 days were randomly assigned to semaglutide or placebo for 30 weeks. Most patients (71.5%) were also taking metformin, and 12.9% were on a sulfonylurea.


Semaglutide Plus SGLT-2 Inhibitor Reduces HbA1c, Body Weight
by By Reuters Staff
https://www.medscape.com/viewarticle/910618?nlid=129008_1521&src=WNL_mdplsfeat_190326_mscpedit_wir&uac=164666HZ&spon=17&impID=1919089&faf=1

What is "semaglutide"?
This is the medicine used to treat diabetes type 2 by forcing already impaired insulin secretion system to secret more insulin. If SGLP-2 such as Invocana taken orally daily, then  semaglutide is injectable and taken one times weekly. So, semaglutide is about the same, medicine which destroy natural insulin secretion. But naive diabetics do not know too much about medicine. They trust in MD, doctor. Big mistake. Doctor has different goal then diabetic patient. For diabetic most important is to survive and get as healthy as one can. For doctor the goal is to get as much from patient as MD can. So, what is good for MD is really too bad for diabetic patient.
     Trail:
diabetic patients with A1c from 7% to 10%,
medicine to control glucose level is:

•      SGLP-2,  very strong diuretic, to reduce weight it works for awhile, but then heart and kidney failure, death;
•     a sulfonylurea, medicine which effect insulin secreting beta cells to secret more insulin, even at the time when insulin is not in demand. With time beta cells wearied out, and SU no longer effective. The normal life duration on SU is less then 10 years after starting this medicine;
•    semaglutide, the same medicine as SU but taken in injections and only one time a week. It can work on another inhibitors then SU, still it is medicine which force to secret insulin and does not improve medical condition;  
•    metformin, medicine wich effect liver and muscles to demand more insulin, at the time when insulin secretion is limited.

       I did not look at the trial. No need for me. I am not diabetic educator, do not consider myself as one. I am just diabetic type 2. Will I take this medicine? Of cause not. I wish to live longer. And I do. I was diagnosed back in 2001. I took Metformin and SU, Glipizide. Less then 10 years and one after another MI, stroke, and how did I survive? Just pray in God. And use my own mind in stead of brain washing media and medical laundry machines. I switched to insulin in 2011. Now it is 2019. I am disable, but partially mobile and live in NYC in rented apartment on full support of my family, financial and physical. I use mobile wheelchair, thanks to my man working company.
      Why really diabetic will take this semaglutide? Because of right now many diabetics do know very well that oral medicine is not good for us, and we need insulin, injections. So, diabetics are fooled. Semaglutide taken in injections. Is this insulin? Not at all. Not even closer. This medicine increase insulin secretion by forcing insulin secreting system to secret more insulin, so, MD will fake diabetic type 2 that this is insulin, or it is the same as insulin.
       There is no such Rx to insulin. Every insulin has own name, so, it is very easy to fool everyone who is not very sure about medicine one take or need. In office MD Rx to me Atrovastatin. I said, I do not take this medicine, I take Lipitor. "It is the same," - doctor replied. "No. Atrovastatin is generic, and Lipitor is brand medicine. Generic of all kind does not work for me." I do know my medicine. I am not so easy to fool. But it took time, good reading, and a lot of money spent to books, text books, medical text books.
     Let us take a look at, would semaglutide lead to control blood sugar level? Show me how. We take one injection, about 1.0 mg of semaglutide in injection, and what next? This amount of medicine will work for the full week? Take a look at the beginning. Diabetics with A1c from 7% to 10%, and the treatment for them the same, 1mg of injected semaglutide for week? Good Lord!!!!!!! What will happened after week? Where medicine will go? But if this medicine is go somewhere after week then why this medicine is going to stay in system for week?
      It is clear for every one that all medicine come in dose, why? Because of if 1mg good for diabetics type 2 whose A1c=7% during full week, then for diabetic type 2 whose A1c=10% need more medicine, higher dose of medicine, or another medicine with different effect or concentration. To understand this simple logic no one need Medical Degree. But to fight MD medical degree is very effective. At least one will show, I am not full fool.

NEW YORK (Reuters Health) - Semaglutide is an effective add-on treatment for patients whose type 2 diabetes is not well controlled on sodium-glucose cotransporter-2 (SGLT-2) inhibitors, new research shows.

        SGLP-2 did not lead to glucose control, why? Before add-on another medicine take a look why this one did not work. If it is right medicine, then just increase dose of medicine to get better effect.  No one trail show that increased dose of SGLP-2 provide blood glucose control. Regardless how high dose of SGLP-2, the effect is the same. With time effect getting lower, and finally take opposite direction. All weight which was lost with SGLP-2 will return and no way to get it back.
      If SGLP-2 is not effective, then why another medicine must be add-on in stead of to take SGLP-2 off and replace it with a new medicine, more effective. Would Semaglutide do the job? No way for that. It is fixed amount of medicine injected once a week. The level of sugar in blood is different day from day, day from night, and many issue such as weather, rain, season, or flu or stress or .... you name it. Now, how Semaglutide suppose to control all that factors, with the same amount of active ingredients? Obviously, it is not possible.
     If  Semaglutideis good and effective then why take metformin and SU in addition to SGLP-2? Take a look at this medical list,
Semaglutide
metformin
SGLP-2
a sulfonylurea
all for just one goal, to control blood sugar number. No one of these named medicine control glucose level alone. No one of them can be increased in dose to increase the effect of medicine, and no one of these medicine act to improve other health problem but only symptom of diabetes, elevated level of sugar in blood, in urine, in bones, in .... . No one care. Only number on glucose meter is important. This number cannot be improved with wrong medicine. So, take one after another, taken all together, or taken separately, weekly or daily, they simple do not work, and diabetic type 2 getting from A1c=7% up to A1c=10% and above.

HbA1c was reduced by 1.42% and body weight by 3.81 kg, on average, with semaglutide compared with placebo.

HbA1c 10% - 1.42%- HbA1c=8.58%
Normal: HbA1c below 5.7%
How many different names of medicine must diabetic type 2 take to get control over glucose numbers? Of it is simple, just not possible with any oral medicine, but only with Insulin.
      It is interesting about weight loss. 8 pounds, it is all what diabetic will get with add-on medicine. But it is proudly pointed out, It Is weight Loss!
     
I do not trust in doctors. They are the same as every one else. For them patients are just business. They need us. and there is no way that they try to let us loose from the hook. This is why there are hundreds add-ons as tablets or injectables, but  there is no insulin, simple plane insulin, to let diabetic type 2 system rest and time for recovery, to full out insulin content in every diabetic type 2 cell, and let us live with light inconvenience of daily injections rather then blindness, amputations, CVD, to let us to die at home rather then in public facilities away  from public eyes.

via Ravenvoron