Trajenta or Januvia and Diabetes type 2. January 10, 2017

DPP4 is an enzyme that inhibits the action of important intestinal hormones of the glucose metabolism. Various studies have shown that high blood glucose levels stimulate the body's production of the enzyme. In particular, people with non-alcoholic fatty liver disease have high DPP4 levels in the liver and in the blood. Until now, however, it was unclear whether increased DPP4 is a consequence or a trigger of fatty liver disease.

In other words, it is well known that diabetics type 2 do have fatty liver, still it is not clear, if fatty liver caused by diabetes or diabetes caused by fatty liver? So, there are studies. Still first question is, why study fatty liver, and still there are no studies of Pancreas? 

Some people with type 2 diabetes do not make enough incretin. This is where DPP-4 inhibitor medicines are helpful. Stopping (inhibiting) DPP-4 helps the incretin that is in the body to stay there longer. This triggers insulin to be released, which lowers blood sugar.

Now another question, when DPP-4 still in the body, does blood sugar is high? Very simple question. The point is, how DPP-4 help to release insulin which is not secreted?  Before pretend that insulin would be released it is better to check up if there are some insulin to be released? No studies like that. This point simple skipped, and studies go without any interruption, show all what sturdier wish to see.
      Right now there are another meters underway, meters which detect diabetes by checking level of sugar in human tears. So, how this connected with the definition of diabetes such as:

 Diabetes is the condition in which the body does not properly process food for use as energy. Most of the food we eat is turned into glucose, or sugar, for our bodies to use for energy. The pancreas, an organ that lies near the stomach, makes a hormone called insulin to help glucose get into the cells of our bodies. (CDC)

There are many different definitions what is 'Diabetes', still all of them based on the fact that diabetic, ether type of diabetes, has abnormally high level of sugar in blood. So, there many different medicine developed to deal with the medical problem. Still, regardless of any presentations it still the same, it is insulin which decrease level of sugar in blood, the cause of diabetes, according to definition. There is another trick: the cause of diabetes is not known. So, really, diabetes , what is it? Without answer to this very simple question, which still have no one answer, there is no one treatment can be reasonable or effective. Because of there is only one way which is right, there are limitless ways which are wrong. Just conduct study, and one never will be out of batter on the bread.

Nevertheless, some of the mice gain much more weight under the same high-fat diet and at the adult age of about 20 weeks develop a fatty liver. This suggests that the differences in weight development are due to epigenetic effects.

So, if I do understand it correctly, sturdier took healthy mice,
put healthy mice on very unhealthy lifestyle with high -fat diet and no work out, 
so mice developed fatty liver,
and sturdier come to conclusion, I do have fatty liver because of I do eat high-fat diet and low active life style.

"Therefore, in further studies, we should investigate how and at what point DPP4 inhibitors can be used in diabetes therapy to prevent the development of non-alcoholic fatty liver disease."

Still, I am sorry, I did not get the point, how prevention of fatty liver from being developed  will increase insulin secretion? At the end of the investigation we are at the same point of discussion, how increase insulin secretion? How delay in DPP-4 release will lead to increased insulin secretion? What really studies about? Money. I see nothing but money to investigate forever it is possible to investigate and Dress The King Naked.
      According to the article, it is Insulin which decrease level of sugar.  So, regardless if there is fatty liver or not, if insulin present in blood then there is no abnormally high level of sugar in blood, correct? If so, then why so much attention to the liver, and no any attention to the insulin secretion, pancreas health? If there is some insulin to be released? If there some beta cells are active, or they all almost death so  there is no insulin to be released? If so, then regardless for how long and how tight we hold incretin, there is nothing to be released, and so blood sugar cannot be lowered with any DPP-4 medicine:
Ongliza
Trajenta
Nesina
Januvia
or Janumet, combination of Januvia and Metformin.

iabetes is a problem with your body that causes

Diabetes is a problem with your body that causes blood glucose (sugar) levels to rise higher than normal. This is also called hyperglycemia. Type 2 diabetes is the most common form of diabetes. - See more at: http://ift.tt/2j190Gd

Diabetes is a problem with your body that causes blood glucose (sugar) levels to rise higher than normal. This is also called hyperglycemia. Type 2 diabetes is the most common form of diabetes. - See more at: http://ift.tt/2j190Gd

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http://ift.tt/2jek94iEpigenetic changes promote development of fatty liver in mouse and human

Date: January 9, 2017

Source: Deutsches Zentrum fuer Diabetesforschung DZD

Summary:

Mice with a strong tendency to obesity already exhibit epigenetic changes at six weeks of age, inducing the liver to amplify its production of the enzyme DPP4 and release it into the circulation. Over the long term, this favors the development of a fatty liver. Such changes in DNA methylation are also detectable in humans with fatty liver and suggest a similar causal chain.

via Ravenvoron