Diabetes, Prediabetes, and why it is not curable? July 31m 2017

People with prediabetes have elevated blood sugar levels, but not so high that they have full-blown diabetes, which requires medication or insulin injections. With exercise and a healthy diet, prediabetics can halve their risk of developing type 2 diabetes, the CDC noted.
http://ift.tt/2vigh8v

       Why today diabetes type 2 is number 7 cause of death in America? If it is only the day how diabetics type 2 die, due to diabetes, high blood sugar level, or there are heart attacks and strokes, COPD and Asthma, kidney failure and heart failure also hit diabetics type 2? What if all deaths of diabetics type 2 would be counted, what rank it will be?  The first question is, when it is considered that diabetes type 2 in full blow? Really, full blow how it is diagnosed? And very interesting, why if diabetes is so highly developing why do not start to treat pre-diabetes when level of sugar is not high yet, but already going out of control? Is this not the point why do we have vaccination? To prevent developing of full- blow. Give to pre-diabetics 10 units of insulin, safe for every one, and they will never develop diabetes type 2.
      Now, if we say that there is full-blow of diabetes type 2 on one hand, and there is pre-diabetes on the other hand, then why it is never considered that diabetes has stages in development?
       Stage one when sugar is higher then normal, so 10 units of insulin to let pancreas to recovery. Probably after this treatment circle there will never be diabetes type 2, or any other types of diabetes.
      If 10 units still do not keep pancreas healthy, then add another dose of insulin, till pancreas recovered.
      Stage last, keep check up blood sugar level, do not let pancreas to get overwork.       

Those are among the findings of the latest study of the Joslin 50-Year Medalists, who have had type 1 diabetes for at least 50 years, published in the Journal of Clinical Endocrinology & Metabolism. The paper examines the health characteristics of 952 Medalists, divided into three groups by date of diagnosis, says lead author Liane Tinsley, M.P.H., the data analyst on the study.
 http://ift.tt/2wfmp0E

       Why diabetics type 1 survive for more then 50 years, and diabetics type 2 do not survive longer then 10 years after being diagnosed with diabetes if they do not start to take insulin?  And there is another question, why those who are medalists for 50 years still diabetics type 1?
        This is all about Joslin Diabetes Center. All the speculations, scam, but never true. There is no answer to the question why those people survived over 50 years with diabetes type 1? Because of they did not have fatally high blood sugar level. In childhood they were diagnosed with diabetes type 1, were treated with insulin, and .... now they live long and prosper. Why mother of doctor Joslin did not survive even she never broke her healthy life style, and even her son did not safe her? Let us remember that before pretend that healthy life style will prevent diabetes type 2 to be developed. It never happened, it never will be. This is why today diabetes type 2 is number 7 cause of Death in America.
       There is another very interesting fact. America has highest number people over 100 years old. Well, it is difficult to trust in any facts in present days. But at least it was published recently. So, if there are more old and elderly people then there will be more diabetics, right? Right. With age our hearts and all our organs became less healthy, regardless how well and right we eat.
       Remember, if diabetic type 2 start to take Insulin then diabetic type 2 will survive more then 10 years after being diagnosed with diabetes.  I do, I survive. I take 300 units of insulin daily, and I still alive and functional. With limited mobility, but not in bed, still on my two legs, and use glasses only to read. If I did not start to take insulin in 2011 then today there would not be blog, how to live with diabetes. Yes, there are many blogs, but try to find one who takes 300 units of insulin, passed MI and strokes, and survived all. Try to find how many of us still mentally functional. Is this my life style? Not at all. It is Insulin I started to take in March 2011. The price for insulin is way too high. I cannot afford to buy it, so every time when there is no health plan who pay for insulin I am down, sugar getting over the sky, and how I do survive no one mortal men can say.
       The same I can say about those medalists, diabetics type 1 who survived more then 50 years with diabetes.  As I just said, what stage of diabetes they are? And probably they perfectly control blood sugar level with right life style, no medicine, no insulin anymore. What can I say, give me insulin 50 years ago and I would be very healthy today. I could live over 100 years with my wrong life style, why not? I survived 59 years without insulin with high blood sugar numbers, passed coma, and stepped on the Last Point. But only since 2014 I do have insulin supply without constant terminations. Really, why do not I have Medal?
       There are many points can be discussed. But the real point is only one. Why today, almost 100 years after insulin discover, diabetes type 2 still number 7 cause of death? Why we have to die today when simple insulin, very nice and rewarding medicine, is not available for us? Do not say, it is diabetics type 2 who are Insulin - Resistant. Not at all. It is medical Care providers who resist to Rx Insulin. Say me why when I was in hospital in March 2017 first what my primary doctor done was termination of insulin injections. No one insulin injection. 300 units total daily dose was cut at once. According to medical providers we do not need insulin. If so, then say me, why type 1 diabetics need it? They need less then 50 units. Many of them take less then 25 units, and many take less then 12 units. 10 units of insulin is safe to inject to anyone, non-diabetics including. I need 300 units. And doctor insist, I do not need insulin, why?
      OK, I do not really need any Medal. But please, leave insulin for me as it is. I am happy where I am and who I am. If today I was not in this so down condition I would really drop dose of insulin down to the healthy 10 units a day. No low blood sugar, no high. Still, I am OK with 300 units if I do have it in my ref.     I am not insulin - resistant diabetic type 2. I am Insulin - Dependent Diabetic type 2 who was born diabetic but diagnosed with diabetes after 50.  Really, how it is possible to treat patient according to body shape, or age, or personal attitude? Why it is so difficult today to take test of Pancreas condition, if pancreas healthy or not to secret insulin? Not at all. All diagnostic based on level of sugar, with is never the say and can run from fatally low to fatally high and be healthy normal at the some point. How this can be taken as diagnostic mark? 
      It is not possible to cure disease if there is no diagnose if organ is healthy or not. There is no treatment progress can be seen. This is why we will die today, tomorrow, and another 100 years. Why not? We are profitable for medical providers, and they pay high to politicians to leave all as it is.

via Ravenvoron

Lake Eaton, Adirondack, NYS, from July 20 to July 30 2017

Lake Eaton.

Blood Sugar reading and Insulin dose.

July 20, 2017
82 mg/dl at 6;44 am
Headache. Very severe before sunrise.
Lantus Solo Star 100 units.
Excedrin 2+2
210 at 9;45 am
headache, very weak.
Lantus Solo Star 100 units.
Before 2 pm we left for Adirondack, Lake Eaton campground.
83 mg/dl at 7;20 pm
Lantus Solo Star 107 units.
      307 units total.

July 21, 2017
88 mg/dl at 10;57 am
Lantus Solo Star 107 units
261 mg/dl at 1;58 pm
Lantus Solo Star 100 units
      At night I woke up with severe sadness, fear, like I am going to die. There is nothing to be reasonable for this feeling. We come to good site, set up our camp, and all what seems to be good. But I was not good. Severe, very severe headache.
Excedrin  2,
Nitrostat 2.
My man sit with me till I got a little bit better, was able to go back to sleep.
Lungs are noisy, breathing is difficult. Sometimes I feel, I took my last portion of air.
My man still work to set up and collect woods for campfire. It looks like we have our privacy even in this so populated camping ground.
Lantus Solo Star 100 units at noon. I did not take reading.
116 mg/dl at 8;37 pm
Nitrostat 3 before bed.
      Total 307 units.

July 22, 2017
107 mg/dl at 7;22 am
Lantus Solo Star 107 units.
Headache. very severe. Noisy Lungs.
147 mg/dl at 12;36 pm
Lantus Solo Star 100 units.
95 mg/dl at 5;53 pm.
Lantus Solo Star 100 units.
Total 307 units.
We took our first trip on Lake Eaton

July 23, 2017
96 mg/dl at 8;19 am
Lantus Solo Star 107 units
It is cold outside the tent. We stay on the site, close to the campfire.
175 mg/dl at 3;46 pm
Lantus Solo Star 100 units.
Lantus Solo Star 100 units before supper.
I was sleepy all day. I took nap two times in this day.
At night was low blood sugar. I did not take reading. I was very very hungry. But still, I ate very slow, no hurry. It is odd as I do know for myself. This night was very very odd. For me it looks like I did have high blood sugar. Then it dropped and I got low blood sugar, withing very short time between. Then after meal it got up, but not too high. I cannot discribe it, but I am not first day have this odds.
      Total 307 units.

July 24, 2017
212 mg/dl at 10;21 am
Lantus Solo Star 107 units.
It is very cold today. Windy, rainy,  and cold. I sleep all day. 90 mg/dl at 3;19 pm
Lantus Solo Star 100 units
Sleepy. Excedrin 2+2 before sleep at night.
Nitrostat 2.
Difficult to breath. Noisy lungs.
I am hungry for air.
Cannot take any move, lost ability to breath.
      Total 207 units

July 25, 2017
69 mg/dl at 8;40 am
Lantus Solo Star 107 units
103 at 3pm
Lantus Solo Star 100 units
It is cold and windy, but no rain at day time, only at night.
We went to Blue Mountain Adirondack museum.
227 mg/dl at 6;58 pm
Lantus Solo Star 100 units
It it too high level of sugar for this time.
221 mg/dl at 8;40 pm
Lantus Solo Star 30 units.
    Total 337 units.

July 26, 2017
74 mg/dl at 9;39 am
Lantus Solo Star 107 units
Headache, severe. Excedrin 2+2
At night took Excedrin 2+2
152 mg/dl at 2;53 pm
Very cold. I am very sleepy.
156 mg/dl at 3;31 pm
Lantus Solo Star 100 units
97 mg/dl at 6;18 pm
Lantus Solo Star 100 units
Severe headache.
      Total 307 units

July 27, 2017
78 mg/dl at 7;03 am
All night it was rainy. Nightmare sleep
Lantus Solo Star 107 units
Headache. severe.
85 mg/dl
at 1;04 pm
Lantus Solo Star 100 units.
Blood on toilet paper.
163 mg/dl at 5;36 pm
Lantus Solo Star 100 units.
      Total 307 units.

July 28, 2017
97 mg/dl at 8;51 am
At night it was low blood sugar. Excedrin 2+2 and in the morning 2+2
Dizziness. Both legs swelled heavily.
Lantus Solo Star 107 units.
Forked Lake

       We went to Forked Lake. On back way to the beach it was low blood sugar. I did not take reading, did not have meter. So, I took cappuccino and protein bar. No effect. I still hungry.  It was too far for the beach, and there were nothing we could do. Finally protein bar did the job, and the rest of the trip was OK.
On the way home we stopped on eatery and I took soup.
124 mg/dl at 7;13 pm
At night severe headache, so severe that I even did not want to wake up and take Excedrin. I did not want to take any move.
     In the morning severe noise in the lungs right from the first moment I woke up. Headache a little bit easy, so I took Excedrin.
Looks like it was only 107 units at the day. Or I simple forget to put it in book. Not there is nothing to check up.

July 29, 2017
129 mg/dl at 9;19 am
Lantus Solo Star 100 units.
After meal we went for Raquette Lake.
Raquette Lake River outlet (Left)
from Raquette Lake (right)

 There is small parking lot to park a few cars. So, my man unloaded car and put on our Green Duck on water.

Do you see small island in the center? There was out turn point. We stopped on island.

Raquette Lake

Now I was wiser then day before. I did not take just meal. I took Lantus Solo Star 100 units, and only after that I took my meal, some bread and cappuccino.
On the way back I took one more bottle of cappuccino, and I was OK for the landing spot. Now there is our car, and I could have something to eat.

Of cause we did not take trip all over the lake. Lake is too big for our Green Duck to fly. What I do see so far, it is all the same around the lakes. They are big body of water, and green shores with property around, that we cannot cross.

Lantus Solo Star 70 units before eve meal.

 

      Total 277 units.

July 30, 2017

86 mg/dl at 7;23 am

Lantus Solo Star 80 units.

Lantus Solo Star 80 units before left for NYC. 

     Total 160 units. 

via Ravenvoron

The Trip I Never Thought Could Happen

My daughter is currently in a city 4 hours from here without a parent.

This is it: the moment I thought would never come.  No way. No how. She would NEVER grow up. At least not diabetes-wise.

I'm stunned that it's happening and even more stunned that I'm completely okay with it.

I was welcome to go on this trip- a service trip with the church's youth group. But this seemed, for several reasons, like the ideal opportunity for her to spread her wings.

Why now?

-She's as ready as she'll ever be. She proves it every day. She especially proved it on the high school's spring music department trip which I, of my own free will, volunteered to chaperone so that I could be there 'just in case.' There was no 'just in case.' She did it all by herself while I shared a room with a (as it turned out, perfectly nice) stranger and worried endlessly about the whereabouts and safety of the rest of the kids.

-This trip is relatively close, just a four hour drive should I need to get there. And it's in the middle of a major city so there are hospitals, ambulances and pharmacies readily available should she need them.

-It's a small group: 6 kids and 2 adults. One of the kids is one of my daughter's closest friends. These kids genuinely like and care about each other. The chaperone to kid ratio is pretty great too.

-Speaking of chaperones, if I had to pick two people to send my kid away with for the first time, these two adults would be at the top of my list. Their willingness to take this on was, of course, one of the essential criteria. They're also responsible, concerned, and willing to learn everything necessary to support my daughter. And, probably most importantly, my daughter trusts them and likes them and will therefore include them in any issues she's having- diabetes-wise, and otherwise too.

-Lastly, and probably most importantly, my daughter was willing to go without me. That's been the bottom line for every big step towards diabetes independence we've made thus far. This decision was no different.

So far so good, considering the fact that diabetes does not travel well. One HIGH with double up arrows on the Dexcom required an emergency site change. An 82 at bedtime required some thinking about what to eat in order to make it until morning (a cherry Nutrigrain bar with no insulin- and yes, she made to morning). Otherwise she's guessing carbs as well as I could, remembering to carry her sack of dia-stuff, and keeping an eye on the Dexcom. I'm grateful to have the Dexcom share so I can check in when I'm worried, but I'm checking less than I thought I might.

Meanwhile she's having a huge adventure, both with the volunteer projects they're doing and with the sightseeing opportunities they're squeezing in whenever they can.

It's hard to wrap my head around how we got from a teeny, tiny person with diabetes who was totally dependent on me for every aspect of her care to this particular moment. It wasn't one giant step. It was a million teeny, tiny steps and suddenly, stunningly, here I sit over 200 miles away. And, inexplicably, I'm really pretty okay with it.




via Adventures in Diabetes Parenting

Early Menopause May Be Tied to Type 2 Diabetes

When periods stop before 40, risk is 4 times greater compared to late menopause, study suggests

Source: HealthDay


via Diabetes

Crispy bacon, creamy

Crispy bacon, creamy sauce, and juicy chicken will make you sing keto praises! Gluten free + Sugar free too! Only 1.7 net carbs per serving!

via Taylor

Day by Day. July 17, 2017

Blood sugar is 153 mg/dl.
We back from vacation to the Buck Pond, Adirondack. Now next week we are back to Adirondack to another campground. For this year we do have five weeks in Adirondack, two already passed.
       We left for Buck Pond on June 29, 2017. It was rain, and we have to set up our camp under rain. It is OK, we can do it under any weather.
      June 30, 2017.
       Fasting sugar 167 mg/dl. Probably it is because of I skipped one dose of insulin. I did not want to take shot before meal is ready, but then I was so tired, left to sleep right after Supper. So, next day I injected 100 units before any meal was ready. Sugar already was too high. Both my legs wrapped in attempt to get rid of water. I try to get compression sucks, but there is no my size. I do have three different types of bandages right now, try to use all of them at different time, just to be sure which one work and what is better for me.
        My lungs are noisy. My breathing can be heard down to the last site on the camp. Also it is so difficult to take air in that I worry what if I will stop to breath? At home I use Bi POP. On camp there is no electricity, so there is no way fro me to plug it in.
        I am very very dizzy. My man went to register booth. I was alone on site. I needed to take something from tent, so I walked to tent. But... I fall and I could not get up from the ground. There is no cane, no chair. I am very lucky. My men returned from registration booth and helped me to get up.
        It did not stop on this way. Soon I was on the ground another time, and I broke our tent. I lost control of myself, and simple collapsed. Happily my man was just out for hunting some woods.
       After I felt in tent, third time for one day, I finally got my lesson. Try to stay on seat or in bed. Period. So, if my man not around, I do not take any move, just stay where I am, in tent in bed, or on my chair before campfire. Only when he is around I can take some short move. Also I do not even try to get dressed or do anything around site. No. All job is just for my man He does cooking, washing, dishes, and all what must be done. Shame of me, but there is nothing what can I do now.
My legs, face, tongue  severely swelled. Blood on underwear.
sugar 110 mg/dl at 11;31 am.
Lantus Solo Star 107 units.
sugar 223 mg/dl at 7;47 pm.
Lantus Solo Star 60 units.

July 1, 2017.
77 mg/dl
So swing in the level of sugar. Lung gets less noisy.  Probably water finally will go away. we wrapped both legs. No pain so far.
Lantus Solo Star 60 units.
98 mg/dl at 12;06 pm
Lantus Sollo Star 87 units, the rest of the pen. At 2;02 pm I took another 100 units, and 80 units before bed. 327 units Total for July 1, 2017.

be continued

    

via Ravenvoron

Phase-III Results from an Oral Insulin Clinical Trial In Presymptomatics

A Quick Introduction to Oral Insulin to Prevent T1D

Obviously, all type-1 diabetics need to take insulin in order to process carbohydrates. This insulin must be injected, because if it were taken orally it would be digested into smaller pieces and would not work as insulin [d1]. Injecting insulin in this way does not cure or prevent type-1 diabetes, it just treats it.

However, one of the autoantibodies that is associated with type-1 diabetes targets insulin molecules[d2]. Therefore, there is a theory that giving insulin to people with T1D might prevent or delay the onset of type-1 diabetes by training the body not to produce this autoantibody. The process is vaguely similar to giving small amounts of peanut proteins to people with peanut allergies[d3]. Insulin pills may work for this purpose even though they would not work as a treatment for type-1.

The Phase-III Study (Structure and Results)

These researchers started with 10,000s of TrialNet participants, and enrolled 560 people who were "presymptomatic". They showed two autoimmune markers, but no symptoms of type-1 diabetes. All of these people tested positive for one particular autoantibody associated with T1D (micro insulin autoantibody) [d2], but they were further subdivided into four groups based on the other autoantibodies they tested positive for, and how much insulin they were producing.

Each subgroup was split in half. One of these halves got oral insulin twice a day, and the other half got a placebo. They were followed for a year or longer to see how many people in each group developed type-1 diabetes as measured by "classic" symptoms.

If you look at the entire study, oral insulin did not have a statistically significant effect. However, if you looked at one subgroup specifically [d4], that subgroup did show a statistically significant effect. For that one subgroup, about 18% of the treated group came down with T1D, while 34% of the untreated group did. The researchers viewed this as delaying the onset of type-1 diabetes by 2.5 years (on average) for this subgroup.

Presentation Slides:
http://ift.tt/2uk5Cw8

News Coverage:
http://ift.tt/2t0StnU
http://ift.tt/2srlGvV

Clinical Trial Record:
http://ift.tt/2u92YGO

Discussion Of This Study

The results of this study are clearly "bad news on one hand, good news on the other". If you look at the study as applied to all presymptomatics, it was not successful. On the other hand, if you look at it for one specific subgroup, then it was successful. So the obvious thing to do is to try to replicate the results on the specific subgroup where it was previously successful. If so, this could turn into a delaying or preventative treatment for the 10% of patients who fall into this group. Since this subgroup had a specific combination of autoantibodies, it is straightforward to test ahead of time, and give oral insulin to people with this same combination, but not other combinations (where it did not work).

This trial was the size of a phase-III trial. However, the success was only seen in a subgroup, and that subgroup was the size of a phase-II trial. So I would not think of this as a successful phase-III trial, but rather as a successful phase-II trial (meaning that at least two phase-III trials should be expected before it becomes commonly available) [d5].

It is also important to remember that as group size gets smaller, the chance for accidental correlation gets bigger. With these sorts of subset analysis, it is always possible that the effect seen is cause by luck rather than effect. In this particular case, the results were statistically significant even for the smaller group, which is a good sign, but only larger studies will be conclusive.
The History of Oral Insulin

Oral Insulin has a long, complex history of clinical trials, and the results are very mixed (like this study). Just before I started my blog (so 10+ years ago), the results of an oral insulin for prevention trial were announced, and the trial was unsuccessful. However, the researchers analysed the data in more depth after the study concluded, and realized that it had worked for one subgroup (sound familiar?) That was the micro insulin autoantibody subgroup, and that's why everyone in this study had that antibody.

But the idea that oral insulin might prevent/delay type-1 is a popular one, and there are at least three clinical trials running right now. All three of these studies are similar, except for size: the first is 44 people, the second is 220, and the third is 92.

Oral Insulin Starts a Phase-II Trial In Germany (pre-POINT Early)
Recruiting:
Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Lehrstuhl für Diabetes und Gestationsdiabetes der Technischen Universität München, München, Germany, 80804
Started in Aug 2015 and expected to finish in Aug 2017
News: Vaccination against type 1 diabetes may soon be available to young children:
Clinical Trial: http://ift.tt/2t0TKv9

Phase-II Oral Insulin Trial In Germany (Fr1da)
Recruiting:
Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Lehrstuhl für Diabetes und Gestationsdiabetes, der Technischen Universität München, München, Deutschland (DEU), Germany, 80804
Anette-G. Ziegler, Prof. Dr., MD +49 (0)800 464 ext 8835 diabetes.frueherkennung@helmholtz-muenchen.de
Started in Dec 2015 and expected to finish in June 2021
Clinical Trial: http://ift.tt/2ukg5bd


Phase-II Oral Insulin Trial In The US (TN20)
Not recruiting.
Started in Jan 2016 and expected to finish in Dec 2017.
Clinical Trial: http://ift.tt/2t0XOvE

Extra Discussion

[d1] To complicate things, several researchers are working on creating a form of insulin which could be eaten, but which would avoid digestion, so that it could be used to treat type-1 diabetes. This is also called "oral insulin" research. In this blog posting, I'm talking about oral insulin as a cure or preventative for T1D, not as a treatment.

[d2] Autoantibodies are the malfunctioning antibodies which cause the immune system to attack beta cells. There are five autoantibodies associated with type-1 diabetes, and there may be more that we haven't discovered yet. The five we know about are:
* micro insulin autoantibodies (mIAA or just IAA)
* islet-cell antibodies (ICA)
* glutamic acid decarboxylase (GAD) antibodies
* islet antigen-2 (IA-2) antibodies
* zinc-transporter 8 (ZnT8) autoantibodies
The last one was not used in this study, possibly because it tends to show up later in the disease process.

[d3] It is important to realize that type-1 diabetes is NOT a conventional allergy to insulin. It is similar to allergies in that it is the body's immune system overreacting to something that it should not react to, but other than that, is quite different. Allergies involve the immune system overproducing histamines. These histamines attempt to get physical irritants, like pollen, out of your body. You can counter this histamine reaction by taking antihistamines. Type-1 diabetes involves the immune system overproducing malfunctioning killer T-cells (or perhaps under producing regulatory T-cells). These malfunctioning killer T-cells mistakenly kill beta cells, thinking they are foreign cells (ie. living creatures like viruses, that have invaded the body). So the mechanism is different (histamines vs. T-cells), and the mistaken target is different (physical things, like pollen or wheat vs. living organisms, like viruses).

[d4] The subgroup that showed the effect was the micro insulin autoantibody (which everyone in this study had), and either the ICA autoantibody or both the GAD and IA-2 antibodies, and also low insulin secretion at the start of the study.

[d5] As far as I can tell, oral insulin is not approved for the treatment of any disease in the US, and is not available either by prescription or "over the counter". Therefore, it will need to go through full US FDA approval, which requires two phase-III trials. I don't know if the FDA would consider this a phase-III trial for approval purposes.

Joshua Levy
http://ift.tt/29DuN3o
publicjoshualevy at gmail dot com
All the views expressed here are those of Joshua Levy, and nothing here is official JDRF or JDCA news, views, policies or opinions. My daughter has type-1 diabetes and participates in clinical trials, which might be discussed here. My blog contains a more complete non-conflict of interest statement. Thanks to everyone who helps with the blog.

via Cure Research

New Drug Classes for Diabetes Mean New Options, Really? July 14, 2017

Hello. I am Cyrus Desouza. I am an endocrinologist from Nebraska. Today we are going to discuss three new classes of drugs, their clinical usefulness, and certain subsets of patients in whom they should be avoided.

Well, at first, hat a new drugs are?

What is the most important information I should know about Saxenda^®?
Serious side effects may happen in people who take Saxenda^®, including:
Possible thyroid tumors, including cancer. Tell your health care professional if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer.

Show me one diabetic type 2 who does not have this types of problems.When we start to take this type of medicine it will take time to develop thyroid tumor. So, at the time when diabetic takes first pill there is still no swelling. With time when edema get out of any safety no one would see it is Edema, but see our Bathroom Scale reading, obesity. After it would be obesity blamed, our non-healthy lifestyle, why we do have thyroid tumor. Perfect Crime I will say.

Dr. Jack Merendino, MD , Endocrinology Diabetes & Metabolism, answered on behalf of The Best Life

Glucagon-like peptide-1 (GLP-1) gets its name from the fact that it is chemically similar to glucagon, but, like insulin, it lowers blood sugar. GLP-1 is made by cells in the intestine after eating, and it travels via the bloodstream to the pancreas, where it increases the amount of insulin that's made and also reduces the amount of glucagon. Several medications available to treat diabetes increase the effects of GLP-1:  Januvia and Onglyza, both oral medications, and Byetta and Victoza, given by injection.

Still, it is not clear for me, why should I take GLP-1? Simple, Rx insulin, not 'like' but real insulin, and there is no so fanny side effects. With insulin is only side effect, low blood sugar. Ongliza does not lead to low blood sugar, why? It does not low blood sugar so sugar never will hit low mark.

DPP-4 inhibitors. 
For me it is still complicated to get the point why should I use it. It is Incretin, hormone used to signal to the body to release insulin. Looks like if someone said to me I have to buy health insurance I have to do so. Just say me, how. I cannot work, have "0" income, so how I suppose to pay for health care? The same I can say about DPP-4. Incretin signal to the pancreas to secret and release insulin. Pancreas is too ill to respond. Say me, insulin will come from where?

SGLT-2, Invokana, very strong diuretic. For every one diabetic kidneys in the constant risk to be damaged. To avoid this complication diabetic type 2 suggested to take Invokana, strong diuretic. Sorry, I still not able to get the point, what is new and where are new options in treatment of diabetics?
     There is another question, does Invokana lead to low blood sugar? It can cause hypotension in many patients, but what about low blood sugar? Would it lead to hypoglycemia, and if it is not then why? Remember, how our body fight high blood sugar? by increasing urination and increasing water intake. If water intake suppressed, we do have severe dehydration. Now in addition to the natural problems which due to diabetes, I will have this problems doubled with treatment. Does someone see benefits? I still do not.

      It is not the question why Dr. Cyrus Desouza created this scam. The question is, why Medscape published it? Why many medical providers thanks author for this scam and present it as valid info?  Really, what all those discussions about? Who would benefit from what drug? Sorry, is this the important question? There is no such question when insulin discussed. With insulin as the prime treatment regime it is dose of medicine which is most important to discuss. Medical Providers still not able to use insulin as treatment for 90% of diabetics population. This is the point of discussion. Practically it is out of Medscape Editorials point of interest. Why? Because of they already good. If there is no diabetics type 2, the hell do know what it is, then what they suppose to publish? How to treat cancer? Or CVD? They have no one idea how to do so. To fill out the gap they publish Scam, and happy to collect salaries and donations. 

Really, it is time to have another editor for this Worm Chair.

New Drug Classes for Diabetes Mean New Options

Cyrus V. Desouza, MBBS

Disclosures

June 30, 2017

http://ift.tt/2sYuztf

via Ravenvoron

US Healthcare Fraud/Opioid Scams or how to treat pain? July 13, 203

More than 400 people, upwards of 120 individuals involved in prescribing and distributing narcotics, have been charged in connection with healthcare fraud and opioid scams totaling $1.3 billion in false billing.
 http://ift.tt/2sW0wlR

       How many lives taken by medical pro only by Rx medicine patients do not need, but get addicted to it and then carry on addiction and money to the health care pro? How many other lives taken by medical pro by wrong diagnose which leads to wrong treatment and early deaths?  In my file my primary placed diagnose, " diabetes type 2 with hyperglycemia". Is this possible to get any idea what this diagnose mean? At least I still not get it. Doctor prefer do avoid diagnose such as stroke, or MI, even COPD is not listed in my diagnose anymore. But diagnose 'Diabetes type 2 with hyperglycemia' really first time listed in my file. I saw it after visit. Otherwise I would try to ask doctor what does it mean. But really, does not matter how do I try, there would not be answer to any my questions.
     I am allergic to alcohol and painkillers such as opioids. I simple cannot take it. My headache will not take me any drug which is wrong for me. This is why they still not able to get me on the hook. But they tried many times. One day doctor said to me, there is nothing he can help me, why? He tried all what was good for him, including Botox, but I still have that headache. He tried to insist, I should stop take Excedrin, but it is only one medicine which helps me to deal with severe headaches. I can take it as high as 20 at one day, but also I can stop to take it when there is no headache. It works. It is nice for me. But opioids ... , no, thanks.
     The same with insulin. Many times insulin supply was dropped. Doctors refuse to accept, I need insulin to survive. Really, it does not matter, it is I who need it, but they do not have benefits from Rx it. Also it is far away from being 'cost effective treatment' another loud toy in arms of babied- medical providers. What does it mean? No one of them would be able to answer, but they all play with this toy with very smart grim on faces.
      Today I read article how Metformin danger for diabetics. I was almost ready to jump in to wagon, but then I read a little bit more, and it was clear scam, just scam, nothing more. Only one good news, Metformin started to be pushed into scam as it is negative medicine. Of cause, there was Brooklyn Bridge to buy, healthy life style, organic food. LOL! Where organic food will come from? Do you remember mad cows problems with meat on our tables? Now in America there are deer with the same danger and there is no way to get rid of them. Are you sure that mushrooms and berries in forest are healthy and organic? This twice.
     Why fraud in medical care so easy to be spread? Is this possible to get control over the medical care? Who is really can control medical care?
      Well, it is not so difficult as it looks like. Today more and more patients record medical visits, and provider even have no one idea, they are recorded. In most states it is legal, just take a look which stay you are in and if this stay one party recording records. In NYC I can do it legally. Almost all of us do have cell phones. So, recording is easy then every. Provider do know that he can be recorded secretly he will think twice before star Barking Therapy. Also I can ask scribe where is doctor, and what title this girl has to ask any questions. The same about Shadow Doctors who come to clinic room, and we have no one idea why this doctor ask me questions. It is all the time in office I asked to show picture ID. Why there is no rules that doctor show the patient his picture ID with title on it. Is this really person who Rx opioids doctor I come to visit? Good question, Very often they are not.
      Now there is another way to get some control. If I ordered some goods on-line there are questions, how good product is, how service was good or not, and so so on. Why there is no one call after my visit to clinic? Do I got answers to my questions? Was visit beneficial for me? Or it was  benefits for doctor and pain killers for me? I am sure, if this survey would be done then many doctor would lost their clients. Why not? If I see my primary once a year, and all other time there is no visits for me or visits with scribe, then what benefits do I have? Why health plan must pay for the treatment doctor avoid to provide?
      Probably with outside control there would be more graduates who would have clients and would not take own lives? Right now situation is very bad. We enter to clinic, and all what we do have the answer what medicine we take. Sorry, if I take this medicine, do I really need to be told what medicine I take? It is only show that med pro do some job, and fill out time to let patient to go out. Disgusting.

via Ravenvoron

How to prevent Diabetes type 2? Ignore it. July 12, 2017

The US Preventive Services Task Force recommends that primary care professionals individualize the decision to offer or refer adults without obesity who do not have high blood pressure, abnormal cholesterol or blood sugar levels or diabetes to behavioral counseling to promote a healthful diet and physical activity. Existing evidence indicates a positive but small benefit of behavioral counseling for the prevention of cardiovascular disease in this population.
 http://ift.tt/2t3JKoY

I really do love it! look at,  The US Preventive Services Task Force recommends best way to treat Americans, just consult them to practice healthy life style. It is best way, of cause, to 'prevent' then 'to treat', right? What about treatment? Do we have to have medical attention if we are diabetics type 2, obese because of food does not converted into energy due to limit of insulin secretion?  What about high blood pressure? High cholesterol, resulted by Metformin and other Junk Medicine diabetics type 2 taken from the first visit to the doctor's office? Really, it is best way to ignore that we are ill people and we need medicine to survive, every day we need to take medicine. How medical primary pro meet our needs?
      In March 2017 I was in ED and then in hospital. Not for long. Just one night  in hospital bed, why? did I got better after one night? Of cause not. But my blood sugar went out of any control, and if I will stay out of insulin injection more I would die in hospital not from wounds but from heart would stop to pump the blood, of clot would black the way to breath. My primary understood it, and he discharged me right to the next day. Really I even did not see him, there was another doctor who told he works behind my primary. Now what? It was March 2017. Usually we have to have follow up app with doctor withing one or two weeks. Not so fast. My primary canceled one my app after another, and only June 20 he show up in office to see me.
     Really why it is so? There is the point. I do have very high blood sugar. To compensate it I need 300 units of insulin every day. In hospital I was not given even one unit. No insulin in ED, or in hospital. Really, I have to behave, and I did not.
      In hospital there were no one visit of wound care doctor or nurse, why? I was admitted to hospital with wounds, so why there were no one attention to the primary cause of my condition?
     Well, it is easy to prevent diabetes type 2 with right life style, but to prevent amputation we need wound care specialists. With this care probably there would not be so many amputations for diabetics type 2. Why it is type 2 diabetics do not control blood sugar level, and type 1 diabetics, so smart, just practice healthy life style and they take good care for diabetes type 1. even more then that, many diabetics so mart, they control diabetes with healthy life style, no medicine. Only one discrepancy in this statement, why they are diabetics? Probably they are no longer diabetics, so they do not need medicine or medical care. we need it. We cannot live without medicine.

Existing evidence indicates a positive but small benefit of behavioral counseling for the prevention of cardiovascular disease (CVD) in this population.

      Not really true. Of cause I do not take participation in any studies. I do run my studies, only for benefits of one patient, myself. So, I used to have membership in Bally Fitness Club since 2002. When first time I started to work out my heart rate was over the sky. One day it was above 200. All room started to spin around. For some reason tread mill stopped. I took some rest, and push machine back to work. Machine stopped, and I pushed it up, and up. Finally, one day, after I think full year work out my heart rate got NORMAL. I could not believe in my own eyes, but next day it was N and next time it was N.
      I gave up my membership when I started to fall and was not able to go to work out anymore. Now I can get to club, but still I cannot dress or put on my shoe. I cannot go to work out anymore. It is interesting, would canceling help me to stay healthy? Oh I forgot, I am OBESE! This canceling is not for me. Stroke or heart attacks cannot be prevented for me. So sad!

Behavioral counseling interventions led to improvements in systolic and diastolic blood pressure levels, low-density lipoprotein cholesterol (LDL-C) levels, body mass index (BMI), and waist circumference that persisted over 6 to 12 months. The USPSTF found inadequate direct evidence that behavioral counseling interventions lead to a reduction in death or CVD rates.

   I still not able to get the point. If there is no high blood pressure or cholesterol, high blood sugar or obesity, then what are improvements? BTW, the canceling does not prevent CVD, right? Or, no, there are  "inadequate direct evidence", and really what they are? Sure, money,

Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.

      So simple, follow money, and all the problem would be prevented. Why they still not able to prevent Global Warming? They should. They take so mush money to this prevention, but looks like then more they take then less they prevent, so money must follow up and up and up.
      The same with diabetes type 2. Prevent diabetes type 2, or treat it in healthy way, and there would not be obesity, no need in canceling, and we will take more trips  Adirondack then to Medical Clinic. We would need more National Parks then Obesity Prevention, and Behavior Therapy. What JAMA suppose to publish? Where money would come from? If there is no drama then there is no money. So, it is better to "prevent" then to treat our wounded legs and ill pancreas.
      Perfect solution for the complicated problem.

via Ravenvoron

There is growing evi

There is growing evidence a low-carb diet may be useful for diabetes. This article looks at the best evidence available, and whether you should consider it. Learn more here: www.dietvsdisease...

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Clean-Eating Strawbe

Clean-Eating Strawberry Oatmeal Cookies -- these skinny cookies don't taste healthy at all! You'll never need another oatmeal cookie recipe again!

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Ginger Soy Bok Choy

Ginger Soy Bok Choy – the easiest and healthiest bok choy recipe ever. Calls for only 4 ingredients and 10 minutes to make. It’s so delicious | rasamalaysia.com

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Crispy bacon, creamy

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How to Make Sugar Fr

How to Make Sugar Free Kettle Corn

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Drop the simple carbs and add the complex carbs to keep your blood sugar under control

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Turmeric Gingerade - A refreshing sugar free lemonade that sooths, heals and helps detox the body.... made with fresh apple juice, lemon juice, turmeric root and ginger. | www.feastingathom...

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How Consuming Less T

How Consuming Less Than Half Teaspoon Cinnamon Per Day Reduces Blood Sugar Levels In People With Type 2 Diabetes

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This easy Sugar Free

This easy Sugar Free Candied Pecans recipe makes a wonderful homemade gift. You can also use the sugar free candied pecans in salads, in baking, on yogurt, and in granola and trail mix. It's made with natural, no calorie sweeteners for a guilt free candied pecan snack!

via Taylor

Sugar free brownie r

Sugar free brownie recipe for diabetic with coconut flour. 1.4 net carb per square. Made with coconut flour, stevia (swerve) , gluten free

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21 Diabetic Recipes:

21 Diabetic Recipes: Low-Carb Desserts. If you thought desserts were out of your meals forever, think again! From cheesecake to cookies and ice cream to cakes, here are delicious diabetic dessert recipes that have 15 grams of carbohydrate or less per serving.#Repin By:Pinterest++ for iPad#

via Taylor

Clean-Eating Chocola

Clean-Eating Chocolate Chip Peanut Butter Oatmeal Cookies -- these skinny cookies don't taste healthy at all! You'll never need another oatmeal cookie recipe again!

via Diabetic-recipes

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Sugar-Free & Gluten-free Lemon Meringue Pie (pie crust, cornstarch, gluten-free all-purpose flour, lemon, butter, egg, cream of tartar, granulated Splenda)

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Low Carb, Sugar Free Almond Joy Cookies

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German Chocolate Coo

German Chocolate Cookies (Low Carb, Sugar Free, THM-S)

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5-minute Very Berry

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To die for sugar fre

To die for sugar free cheesecake recipe

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Sugar-Free, Dairy Fr

Sugar-Free, Dairy Free, Low Carb Copycat Ferrero Rocher- sugarfreemom.com

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4 Ingredient Sugar-F

4 Ingredient Sugar-Free Mocha Mousse

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Homemade Marshmallow

Homemade Marshmallows are super fun to make and have no artificial flavors or colors. Now can make them Sugar-free too! via Adrienne {Whole New Mom}

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kick sugar cravings

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Homemade Marshmallow

Homemade Marshmallows? Yes, please! Fun to make and Sugar-free and Vegan to boot!

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We've found some fun

We've found some fun and tasty recipes like truffles, pie, cheesecake, donuts, ice cream and cookies for you to browse through and pick your new favorite dessert for your next celebration. Check out our 20 best low-carb sugar-free dessert recipes now and be prepared to satisfy your sweet tooth again!

via Taylor

Believe it or Not, U

Believe it or Not, Use Frozen Lemons and Say Goodbye to Diabetes, Tumors, Obesity!

via Taylor

Presymptomatics and Two Clinical Trials for Victoza / Liraglutide

First, a new word: "Presymptomatic". This refers to people who have tested positive for two autoantibodies, but who have no other symptoms of type-1 diabetes. Their blood glucose levels are normal (not elevated), etc.

Presymptomatics are not yet diagnosed with type-1 diabetes in the classic way, but current theory is that all of these people will eventually be diagnosed. It is just a matter of time. So in the same way I might say "Drug X starts a phase-I trial in honeymooners" or "Treatment Y starts a prevention trial" or "Drug Z starts a trial in people with established type-1 diabetes", I will also start to report "Drug W starts a phase-I trial in presymptomatics".

You can think of presymptomatics as pre-honeymooners.  They are like honeymooners, but even earlier in the disease process.

I also want to stress that although the JDRF, the ADA, and the Endocrine Society agree that two autoantibodies is the earliest diagnostic for type-1 diabetes, this is not universal agreement, and what agreement there is, is only about 2 years old.  Here are some web sites which describe this view of the stages of type-1 diabetes:

• http://ift.tt/2tLn5xg
• http://ift.tt/2srOe4u

This also changes when "diagnosis" occurs.  In the past, diagnosis occurred when symptoms were seen, and confirmed with a blood glucose measurement.  However, now diagnosis occurs when two autoantibodies are measured, and this is often years before symptoms are seen, or blood glucose levels are noticeably abnormal.

So, moving forward, I will use the term "classic diagnosis" or to refer to people who were diagnosed because they showed symptoms, as was done in the past, so it's obvious what kind of diagnosis I'm talking about.

Discussion

I expect there will be more studies like the two described below, that specifically target presymptomatics. After all, any treatment that researchers thought might work for honeymooners (but did not), should now be retested on presymptomatics. This is especially true of treatments which change the immune system.

In the past, it's generally been understood that to cure type-1 diabetes, you needed to change the immune system (so it stopped generating autoantibodies and stopped attacking beta cells), but you also needed to regrow beta cells.  However, presymptomatics have enough beta cells so that they can regulate their own blood glucose levels.   To cure them (ie. to prevent symptoms from ever showing up), "all" you need to do is change the immune system.  No need to regrow any beta cells.

That sounds important, and it is, especially when you think about treatments that have already been shown to stop the destruction of beta cells.  In the last 5-10 years, several treatments have been shown to "preserve beta cells" meaning that once given, beta cells stop being killed off by the immune system.  Since these studies were typically done in honeymooners, this did not cure anybody, it just extended the honeymoon.

But if those same treatments showed the same results in presymptomatics, then it could be said that they prevented type-1 diabetes.  I very much hope that every treatment which has previously been found to preserve beta cells, will now be tested on presymptomatics. Some of the treatments which have preserved beta cells in honeymoon diabetics (at least to some degree) are: T-Rex (polyclonal Tregs), Abatacept (Orencia), Etanercept (ENBREL), and Teplizumab. 

Victoza / Liraglutide Starts A Phase-I Trial In Presymptomatics

About this trial: it's testing the theory that Liraglutide (sold as Victoza) might help people use less insulin or delay their use of insulin, when given to people before they are classically diagnosed with type-1 diabetes.  This is an early phase-I trial.  Only 10 people will be enrolled, and there is no control group.   This trial recruits people who have started to have trouble generating insulin in response to food that they've eaten.  They will be followed for one year.  The trial started in March 2016 and they hope to finish by July 2018.

They are recruiting only by invitation at several nordic hospitals:

• University of Oulu and Oulu University Hospital, Dept of Children and Adolescents Oulu, Finland, 90029
• University of Tampere and Tampere University Hospital Tampere, Finland, 33520
• University of Turku and Turku University Hospital Turku, Finland, 20520
• Lund University and Skåne University Hospital Malmö, Sweden, 205 02

Clinical Trial Record: http://ift.tt/2tL0tNH

Discussion

The Clinical Trial Record lists this as a phase-II trial, but with only 10 people included and no control group, I consider it a phase-I trial.

I don't see how this trial could ever prove any level of effectiveness.  We don't know how many people eligible to enroll in this study would "naturally" have type-1 diabetes symptoms within the one year study time.   And, this trial has no control group.  So there is no way to compare the results from this study to "normal" results to see if it worked or not.

It could show safety, but the drug being tested has been approved for use in overweight people and also people with type-2 diabetes for years, and is used "off label" by some people with type-1 diabetes, so safety is not really an issue.

Victoza / Liraglutide Starts A Phase-I Trial In Presymptomatics

This trial is similar to the one above, except that it is much larger, and recruiting a slightly different population.  This second trial recruits people who have two autoantibodies and one of several different glucose abnormalities, so it's a larger group of people, and also more in tune with the "two autoantibodies means type-1 diabetes" definition of Presymptomatic.  

This is an phase-II- trial which will enroll 82 people with half in a control group and half getting the treatment.  People will be followed for one year.  The trial started in 2016, and is expected to finish in mid 2019.  They are recruiting by invitation only at the same hospitals listed in the previous trial.

Clinical Trial Record: http://ift.tt/2sse9t1

Discussion

(As you read this remember that I'm not a statistician, and have never take a college level class in statistics.)
I'm a little worried about the statistical power of this study.  They are going to have 41 people in their treatment group, and will follow them for one year.  The data I've seen suggests that about 10% of the people with two more more autoantibodies will show classic type-1 diabetes systems each year.  So that means that we should expect about 4 from this group to show symptoms by the end of the study. If this treatment were perfect in preventing type-1 diabetes, then 0 in the treated group would show symptoms.   But the difference between 0 and 4 is not that large.   And the treatment is unlikely to be perfect the first time it is tested.  Let's say that 2 people in the treated group get symptoms, but 4 people in the untreated group get them.  Is that a 50% reduction in diagnosis (which would be huge) or is that just a little good luck involving two patients?  It's hard to tell, and that is what I'm worried about.

On the other hand, this is a phase-II study, so will not be the last word, in any case, and Victoza is already approved, so is not a particularly risky drug.  Also, if the results for the first year are good, then it would be relatively easy to extend this trial for another year (or longer) which would increase its statistical power.

Joshua Levy 
http://ift.tt/29DuN3o
publicjoshualevy at gmail dot com
All the views expressed here are those of Joshua Levy, and nothing here is official JDRF or JDCA news, views, policies or opinions. My daughter has type-1 diabetes and participates in clinical trials, which might be discussed here. My blog contains a more complete non-conflict of interest statement. Thanks to everyone who helps with the blog.

via Cure Research

Look at That!

"The lady with the Omnipod is still at the pool with her kids most days," my daughter reported the other night.

"And there was another woman there. She had a pump clipped to her bikini top but the tubing was connected to her hip.  It would make sense if the site was in her arm maybe. It looked uncomfortable to me.  Or like you could accidentally yank it out with your own arm somehow- but whatever I guess...it's up to her."

It's summer again, which is prime pump-sighting season, especially at the pool and the beach.

Last years' beach vacation tally was 2 dexcoms and an Omnipod.  Our town pool tally was 2 omnipods and a tubed pump a little too far way to identify the brand of.  Walking around various cities and towns added 3 more pumps that I can remember. 

We've never spoken to any of these people about their devices.

But we always speak to each other about them. "That guy has something on his stomach...over there by the purple striped umbrella...is it a Dexcom or an Omnipod?" Or "That lady's making me nervous standing knee deep in the water- over there near the jetty- I think that's a Medtronic pump, right- those aren't waterproof are they? The tide's coming in fast." We discuss where the devices are worn, attempts to disguise them or not, and how far down the beach the people with diabetes walk without bringing a meter or a container of glucose tabs with them.

It's fascinating to watch other people with diabetes in the wild. It's also comforting since every sighting-spurred conversation boils down to this: "Hey- look- there's another person with diabetes just living life," and especially at the beach or the pool, "and having fun."




via Adventures in Diabetes Parenting

Yes you can have dia

Yes you can have diabetes and eat desserts ! Indulge with those guilt free sugar free dessert for diabetics. Low carb, sugar free, and absolutely delicious !

via Taylor

Batteries Need Charging - Headed out to #CWDFFL2017

So it's been a while since I've posted and I apologize. 
It's been a little crazy on this end and honestly, I've been burned out as of late - like crazy burned out - my preverbal well is dry and my batteries need recharging - and I can cop to it. 
Which is why I'm incredibly grateful to be flying out this morning to attend The 2017 Children With Diabetes, Friends for Life Conference in Orlando, Florida. 
I can't wait to get my green bracelet on, (literally and figuratively,) and spend 5 days with friends who are indeed family. 
Working and attending amazing sessions, running the #IwishPeopleKnewThatDiabetes booth, and spending time with people who "get it!"
Also, did I mention that all the cwdffl meals have carb counts listed?

follow the #cwdffl2017 hashtag and I promise to post from the Orlando! 
If you're attending - I can't wait to give you a hug! 



via Diabetesaliciousness

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This Low-Carb Fudge

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