Finding In this randomized clinical trial of 632 patients with type 2 diabetes followed up for 31 weeks, oral semaglutide significantly reduced hemoglobin A1c level by up to 1.9% vs placebo (0.3%).
Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes. A Randomized Clinical Trial
http://ift.tt/2kY3x5DWell, there are two questions I would like to ask trial conductors:
why it was studied how semiglutide effected A1c level in Diabetics type 2? As long as it is known, diabetes type 2 is Insulin Resistant type of diabetes when insulin requirement is higher then 200 units daily. So, why there are studies how oral medicine effect diabetes type 2 if the requirements for treatment is Insulin, not oral medicine?
why it is all the time effect of medicine compared with placebo? Why this question needs to be studies? Placebo is the same effect as there is no treatment. So, when there is no treatment then diabetes gradually progresses, right? Why there are studied conducted 100 years after insulin discovery?
Design, Setting, and Patients Phase 2, randomized, parallel-group, dosage-finding, 26-week trial with 5-week follow-up at 100 sites (hospital clinics, general practices, and clinical research centers) in 14 countries conducted between December 2013 and December 2014. Of 1106 participants assessed, 632 with type 2 diabetes and insufficient glycemic control using diet and exercise alone or a stable dose of metformin were randomized. Randomization was stratified by metformin use.So, diabetics type 2, whose insulin requirement is higher then 200 units daily dose, where studied if they will control insulin resistance with diet, exercise, metformin and then it was found there is no sufficient blood sugar control, right? After these 'finding' another junk medicine, now in injection, was added, semiglutide. Was blood sugar under control now? Of caouse not.If it was controlled then they will say it. But they did not. They just said:
oral semaglutide significantly reduced hemoglobin A1c level by up to 1.9% vs placebo (0.3%).Very simple and brilliant. On one hand, it is positive result so junk medicine can be push to the market. On the other hand there are spot for new studies to say that Invokana is better then semaglutide, and that metformin is better then no medicine to address to diabetics type 2 needs. I have to be very careful to study which statement is true, when it is false, and really what medicine best work for me.
As I do know not every medicine is better then no medicine at all. I do know, without Metformin I do not have many problems I used to have when I took it. Invokana is fatally danger medicine for diabetics type 2. Absence of insulin in treatment regime will lead to development one conplication after another, and eventually to Death. Insulin will treat all complications, and it will lead to cure diabetes in next generations. No one MD do know it. What they do know very well, diabetes is very profitable to treat. It is diet and work out recommendations, heart surgery and amputations, home care and nurse visits, edema and COPD, you name it, we all do have it. And all these problems could be solved with insulin as first line treatment for Diabetics type 2, and blood sugar as vitals for all population.
Of the 632 randomized patients (mean age, 57.1 years [SD, 10.6]; men, 395 (62.7%); diabetes duration, 6.3 years [SD, 5.2]; body weight, 92.3 kg [SD, 16.8]; BMI, 31.7 [SD, 4.3]), 583 (92%) completed the trial. Mean change in HbA1c level from baseline to week 26 decreased with oral semaglutide (dosage-dependent range, −0.7% to −1.9%) and subcutaneous semaglutide (−1.9%) and placebo (−0.3%);There are results, effect of semaglutide as part of diabetes type 2 regime. What do we see? HbA1c reduction is highest 1.9%. So, if diabetic type 2 come to clinic with A1c = 9.4% then what is the treatment option for this diabetic type 2? No options. Just join the club, and jump into Death Pool.
via Ravenvoron
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