Diabetes. Easy to diagnose, just one glucose strip and if reading above the normal range, one is diabetic. Still these are so many questions, and so little understanding, what id diabetes, and how this disease developed?
The discovery of insulin by Dr. Banting was based on the fact that in experimental animals removal of pancreas leaded to diabetes. Still, diabetes was in those whose pancreas was apparently normal. And another point that with one out of eight part of pancreas still animal did not show diabetes. Also the same time time patients did not have diabetes when their pancreas was destroyed by some disease such as necrosis or malignant. Those findings made diabetes then more complicated then more info and pathology studies were done. With Langerhans Island damaged regardless is pancreas was damaged or not, diabetes was developed. If Langerhans Island was not intact then even with pancreas removed, diabetes did not developed. It looks like pancreas is not vital in diabetes development, and without pancreas but with healthy Langerhans Island there is no diabetes. It did not prove in this way, and pancreas still vital.
On first look it is not so important what is first and what is second, Pancreas or Langerhans Islands. But regarding of this understanding another theories raised. What is diabetes, and how it is developing? The book I read right now is one of the out of print books. If today all MD publish books how to treat diabetes type 2, and what really diabetes is, Shields Warren took studies of Pathology. Not so often today we do have books like that. Really, I did not meat any one. I tried to find books in Pathology of Diabetes, but there is not too much to read. Just no value. The book of Shields Warren real Treasure. Published in 1930 it give more info then all Joslin Books all together.
I will post from these book when I read it as much as I can.
The discovery of insulin by Dr. Banting was based on the fact that in experimental animals removal of pancreas leaded to diabetes. Still, diabetes was in those whose pancreas was apparently normal. And another point that with one out of eight part of pancreas still animal did not show diabetes. Also the same time time patients did not have diabetes when their pancreas was destroyed by some disease such as necrosis or malignant. Those findings made diabetes then more complicated then more info and pathology studies were done. With Langerhans Island damaged regardless is pancreas was damaged or not, diabetes was developed. If Langerhans Island was not intact then even with pancreas removed, diabetes did not developed. It looks like pancreas is not vital in diabetes development, and without pancreas but with healthy Langerhans Island there is no diabetes. It did not prove in this way, and pancreas still vital.
On first look it is not so important what is first and what is second, Pancreas or Langerhans Islands. But regarding of this understanding another theories raised. What is diabetes, and how it is developing? The book I read right now is one of the out of print books. If today all MD publish books how to treat diabetes type 2, and what really diabetes is, Shields Warren took studies of Pathology. Not so often today we do have books like that. Really, I did not meat any one. I tried to find books in Pathology of Diabetes, but there is not too much to read. Just no value. The book of Shields Warren real Treasure. Published in 1930 it give more info then all Joslin Books all together.
I will post from these book when I read it as much as I can.
The Pathology of Diabetes Mellitus. With a Foreword By Elliott P. Joslin. Illustrated with 83 Engravings and 2 Colored Plates
by Warren, Shields
Hardcover
- Publisher: Lea & Febiger; First Edition edition (1930)
- ASIN: B0032OM5Z4
via Ravenvoron
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