Januvia and skin disease,Why Do I Need tp take them? December 8, 2017

DPP-4 inhibitor (DPP-4i) is widely used to treat type 2 diabetes, but increased cases of bullous pemphigoid (BP) have been reported among patients taking the medicine. BP is the most common autoimmune blistering disorder, characterized by itchy reddening of the skin as well as tense blisters over the whole body.
 http://ift.tt/2y9mTpW

      Now the question is, why do I need this medicine? I am diabetic type 2. So, I need more then 200 units of insulin daily dose to limit gap between insulin available in secretion and insulin in demand.  In contract with type 2 diabetics type 1 need less then 100 units, and very often they are good with ten units or 25 units daily dose. I take from 300 units to 400 units daily.
     DPP-4: Ongliza, Januvia, Tridgenta, Nesina.
     This type of medicine demand that some chemicals stay in body longer, so this chemicals will force body to keep insulin secretion longer. To say it better, take a look at web. I really have no one idea how it works. When I took Ongliza mu sugar got up, and nothing got down.Also it was severe pain in lower belly. Then I read: say your doctor if you do have history on stones. WOW! Why MD did not ask me about it when medicine was delivered to my home?
     My reason is, if my pancreas does not secret insulin in amount of my body'e demand, then what will DPP-4 do im my body? How this medicine will cure diabetes type 2? No way for that. So, diabetic type 2 got additional problem. On one hand, the secretion of insulin would not approved, or if it effect the amount of insulin secretion then it would be deplete the Beta cells ability to do the job.
     On another hand, and really I am not able to get this point, how anything will lead insulin to stay longer in my blood? Just say me, how? The job insulin is doing in our body is to open door for glucose to enter into cell. This key can be used only once. Once it used there is no more key in our blood, insulin hormone. So, if insulin forced to stay in blood then it simple not capable to do the job. Really I did not get the point what medicine is doing and what for it was developed. So, I stopped to take this medicine. The belly pain stopped soon after.
    Skin disorders such as discolorations and blisters, probably deposit sugar under skin. Diabetics type 2 do have 'dirty feet'. My legs are 'dirty' with brown color on feet. It looks like I never wash them. It is not true. I take good care for my skin. Not the dirty color changed on gray dust. The toes getting white. The red durk burgundy color of legs started to get lighter. Under knees it is even white.  Why? My suggar is no longer over 599 mg/dl. It is getting much better. A1c dropped from 9.4% down to 7.2%. But many problem still present. Most important is that dose of insulin constantly getting up.
     I do have my theory about insulin, insulin secretion, and insulin in injections. This theory is mine, I never read about it anywhere.
     I think that insulin in injections fix the problem, really cure diabetes. But it is long process. It can take many years patience and work hard to keep sugar under control. Most of those who pretend they can reverse diabetes type 2 show that dose of insulin getting less then before diabetic started to participate in plan. The problem is only one, what would be soon after diabetes type 2 was reversed? The problem going deeper and next time it takes longer to improve numbers.
     I do not try to reverse diabetes type 2. This is not my goal. My goal is to keep numbers under tight control as closer to the normal numbers as I can.For this reason I increase dose of insulin rather then decrease it. I do have insulin right now, I do not need to use economy theory. So, I inject as many units as I capable to manage.

     According to the results, 70 percent of the 30 BP patients administered with DPP-4i fell into the noninflammatory type with less reddening of the skin (erythema). HLA analyses found 86 percent of the noninflammatory BP patients administered with DPP-4i had an HLA gene called "HLA-DQB1*03:01." The rate of having the HLA gene was much higher than was detected among the general population (18 percent) and non-BP type-2 diabetic patients administered with DPP-4i (31 percent). Meanwhile, 26 percent of BP patients who were not administered with the drug had the same HLA gene.

     I like all these %%%% and numbers and letters. If interesting, go to link I provided. I do have no one interest to this. My skin is clear, no any blasters. Discoloration of skin on my legs is result of DVT. I need Heparin. No one MD Rx it to me. Really they easy to Rx DPP-4 even it can lead to heart attacks and strokes, but in no one way to the recovery. I was in hospital with wounds on my legs. What MD said? He sent me home next day in the condition worse then I was admitted. It was severe allergy for medicine he Rx to me. I am happy to get home alive.
     It was in March. Now my legs are dry, no opened wounds. Still there is edema. I use to wrap them every day. (My man do the job).

The findings show HLA-DQB1*03:01 is not linked to ordinary BP nor type-2 diabetes, but is closely associated with the development of BP among DPP-4i takers. "However, as the probability of patients exposed to DPP-4i to develop BP remains unclear, further research investigating a much larger number of cases is needed," says Hideyuki Ujiie.

So, why do I need to weight till new researchers would show that there is nothing danger to take Ongliza? I already do know it is not medicine for me. So, I take insulin day after day from 300 units to 400 units, and very happy with result. At least I keep my legs and able to walk a little bit rather then be amputate.

via Ravenvoron