Another SGLT2 That You Can Feel Safe Prescribing. I do not see if it is safe for me to take. August 29, 2018

A new study concludes that canagliflozin (Invokana) is not associated with an increased risk for below-knee amputations. A previous large trial^[1] had raised this concern, although predominantly in patients with risk factors, including previous amputations, peripheral vascular disease, severe neuropathy, or high A1c.
 https://www.medscape.com/viewarticle/899712?nlid=124081_1521&src=WNL_mdplsfeat_180731_mscpedit_wir&uac=164666HZ&spon=17&impID=1699896&faf=1

     So, because of so negative reaction of Diabetics type on treatement and soo negative outcomes, there are another studies were conducted, and of cause they show that .... really what they show?

But this new observational study, based on data from more than 700,000 patients, found no increase in risk with use of this agent compared with other sodium-glucose co-transporter-2 (SGLT2) inhibitors or glucose-lowering medications. As expected, canagliflozin was associated with a lower rate of hospitalization due to heart failure compared with other medications for diabetes.

         As usual, if patient does not get better with medicine MD used to Rx then it is best way to change this medicine to another medicine from the same family. This will take time till patient get right understanding that newly Rx medicine has the same effect, and even worse.  When this happened, it is time to Rx another medicine from the same family of medication. The better way is to Rx two or three different medications at the same time and then manipulate naive patient. Perfect MD strategy.
      As someone mentioned in comment, Invokana or canagliflozin are the same. The difference is only time when Invokana was on market, and so complications developed so badly. New medicine is no more safe then old Invokana, but did not collect so many negative outcome.
      How Invokana work? It is great and very strong diuretic. Diuretics effect heart and kidney. It is also effect blood circulation. The result is, amputations, DVT, CVD, and high blood sugar. Really, why take Invokana, very expensive brand medicine? Take generic diuretic before and see, if your numbers will go down or up. Also pay closer attention to the heart rate.With any diuretic heart rate increased. If heart is good and patient still young then there are less obvious declines. If one is diabetic type 2 with high A1c then heart is already effected. A new medicine will add complications.
       It is easy to Rx diuretic when it is edema and it is obvious that to fight edema best way is to get rid of water. But with very close observation this way does not work, so simple, it does not work in this way.Diuretics bring additional complications, but never benefits to Diabetic type 2.
        DVT going deeper and deeper. With time at first skin goes away. Then flesh started to rib off, opening naked bones. Infection follow up. Amputation is only the option.

If one try to go to hospital then ...  there is not too much pelp. as diabetics type 2 we are very hard effected by diabetes type 2. usually MD in hospital prefer to send us home to find our way back to life. With time if right actions were not taken, amputation become not avoidable.
       Best way I found after I was sent home from hospital in the same condition I was admitted, is to wrap my legs. A little bit more then month all wounds were cleaned, and even legs still dark in color, they were dry. No wounds. Now two years later I still wear that wraps every day. It is a lot of money, because of to get Rx to supplu MD must diagnose DVT and that I need this supply. MD resist to diagnose medical condition, to Rx medical supply. I have to pay it on Amazon. Now my legs getting light and return to normal color.
    As I said before, I never take diuretics, nether types of it, Invokana including.

via Ravenvoron