Potential target for developing obesity and diabetes treatment identified. August 28, 2018

Seventeen authors were listed on the article, "HDAC11 suppresses the thermogenic program of adipose tissue via BRD2." Nine of the authors are members of the CU School of Medicine. The research was supported with funding from the National Institutes of Health, the American Heart Association, and the Canadian Institutes of Health Research.
 https://www.sciencedaily.com/releases/2018/08/180809112422.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

So, so many authors, and what they found?

Mice lacking HDAC11 were protected from obesity, insulin resistance and other effects of high-fat feeding.

        Almost perfect solution. just take off HDAC11 and the problem is solved. Which one?That's right, what is the problem 17 authors pretend to solve? Obesity? Diabetes type 2? Insulin resistance? Insulin dependency? Usually it is said by all MD that diabetics type 2 do have too much insulin in blood. No one test for insulin ever taken. Yes, it can be tested with C Peptide level, but remember, C Peptide level show only one moment of insulin secretion, the moment when blood was taken. Was it is right level of insulin in blood? What will happen when diabetic type 2 takes food? Would be level of insulin sufficient to digest this food and convert it in right way? As long as I study diabetes this studies never being run. At least they were not published  in the most popular e-journals.
        When mice taken as a subject of study, and then compared with humans, then one must remember, mice never live 76 years. Human do. So, when mice studied, what age of mice was, and to compare with humans, what age it was to take into consideration?
       Mice as I do see did not have diabetes type 2 even with so wrong fatty feed. Mice just developed obesity. It is obvious, no space to run, no food to chaise, and only food available just fat. It is cage, and in cage everyu one will develop depression, regardless it is mice of human. Did those 17 authors took this fact into consideration? Not at all. All what they need just prove, fatty food leads to develop obesity. Obesity leads to develop many medical condition. Because of people do have diabetes type 2 this mean they are fat-eaters. They done it for themselves. Cause found. Just put human on starvation and there is no diabetes type 2. Really?
       Take these studies. Study people who lived in places effected by war or Natural Disaster, and starved. How numbers on glucose meter changed after calamities passed by? How many new cases of diabetes were diagnosed in effected areas?

"Through our investigation we found that inhibiting HDAC11 increases energy expenditure, which highlights its potential as a target in obesity and metabolic disease therapeutic strategies," said McKinsey. (a postdoctoral fellow in the laboratory of Timothy A. McKinsey, PhD, associate professor of medicine in the Division of Cardiology, who is the corresponding author of the article.)

So, if I did get it right, to cure diabetes type 2 it suggested to decrease energy expenditure, right?  For me it is difficult to get. Why healthy part of my body which is working and working good, must be effected by suspicious treatment? I am already too tired because of diabetes type 2. If I will take this type of treatment, how I suppose to live? Well, probably I will not have obesity. But I will not have energy to push air or pump blood. Would I take this treatment? Not at all. Now I am able to move my 380 pounds, and it is not healthy but OK so far. If my body would be 200 pounds, and no energy to move then what is good in that?

"We now need to test the role of HDAC11 in large animal models of metabolic disease and in human cell systems as we attempt to translate these exciting findings to the clinic."

This is what I all the time use to say. Have your log book ready. Every time when MD give you any treatment, wright it in log book. Try to take a look at what medicine you take, and how this medicine effect you, or your loved one. It is important to have this log book for all family members. If it is only one log book, and all in it for every one, it is important to have, and keep it safe. Life is long. One day it can safe your life.

via Ravenvoron