Is One Basal Insulin Just Like Another? August 22, 2018

Long-acting insulin
Two types of this insulin currently on the market are detemir (Levemir) and glargine (Toujeo, Lantus, and Basaglar). This basal insulin begins working 90 minutes to 4 hours after injection and remains in your bloodstream for up to 24 hours. It may start weakening a few hours earlier for some people or last a few hours longer for others. There isn’t a peak time for this type of insulin. It works at a steady rate throughout the day.
https://www.healthline.com/health/type-2-diabetes/basal-insulin-types

        I used to take all types of Long-acting insulin but Basaglar. I take Lantus Solo Star right now for long many years. Highest dose I ever injected within 24 hr was 720 units of Lantus Solo Star. Very high dose I will say. Low sugar? Not at this time. But I do have low blood sugar almost every day now. Dose of insulin is dropping. I need between 300 and 400 units a day.  This is about low blood sugar. It is not type of insulin or dose of it but the right need for insulin in particular day. Easy to say, try to find this dose. I tried. I still do. 
        I started to take Levemir, 11 units. Then insurance preferred Lantus. And once I took Toujeo. All types of insulin in pan, so it is always Solo Star to be added to the name of insulin, Lantus Solo Star, Toujeo Solo Star, and so on. I took fast acting insulin too. Now I do not take it. So, there is not Med Pro blog, it is Diabetic type 2 blog.
        I do not see that Lantus Solo Start start to work 90 minutes to 4 hours after injection. If insulin injected and needed it start to do the job right away. Also when it said about 24 hr it is also not accurate info. At first what if dose of insulin too small? Would this dose stay in blood for 24 hr? Not at all. It is really low understanding in diabetes and how medicine works or not.
       BTW how author know that insulin stay in blood for 24 hr? There is no one test to check up the level of insulin in blood. If it was tested with C Peptide level then it is wrong test. C Peptide test does not show level of injected Insulin. So, it is better to ignore this wrong info.

       Another recently published study^[1] concluded that basal insulin analogs were no better than the old—and far less expensive—NPH insulin.
https://www.medscape.com/viewarticle/900600?nlid=124512_1521&src=WNL_mdplsfeat_180821_mscpedit_wir&uac=164666HZ&spon=17&impID=1718175&faf=1

With statement like that I will not trust in MD who publish this article. MPH is type of insulin where both, long acting and short acting insulin combined. I avoid to use combined medicine. How do I know if one works and another does not? If I do have side effect, then which medicine gave this effect? But it was time when I took Lantus Solo Star and Novolog, rapid acting insulin.  Side effect? Novolog "eat up" all what I ate right after meal, and soon I had to take another meal because of sugar dropping way to low, lower then 40mg/dl. On some point I lost when sugar is high and when it is low. Withing two - three  hours my sugar rised over 400 mg/dl, and then dropped down to 40 and then rised back up to 400 mg/dl. I stopped to take any short acting types of insulin, no combo insulins, and now take only Lantus Solo Star.

Bottom line: Many patients with diabetes will need insulin sooner or later. The higher cost of some newer insulins may not be matched by their clinical performance.

I like this conclusion. If so then why Insulin is not first line treatment in Diabetic type 2 therapy? When I started to take insulin back in 2011 less then 60 units was good for my day dose. Then one time after another  Insurance was terminated. Diabetes does not hold on till problem would be solver. It is blow up. This is why today I need so high dose of insulin.
      Also there is another point: Why level of sugar in blood is not vital? It is all about risk factors and prevention. But best way to prevent diabetes type 2 is diagnose it early and start treatment as soon as it was diagnosed, with most effective way to treat, Insulin?

via Ravenvoron