Switching therapy from metformin to a sulfonylurea (SU). August 20, 2018

Switching therapy from metformin to a sulfonylurea increases the risk for adverse outcomes in patients with type 2 diabetes, according to a new study of 77,000 patients in the UK Clinical Practice Research Datalink.
 https://www.medscape.com/viewarticle/900498?nlid=124433_381&src=WNL_mdplsnews_180817_mscpedit_wir&uac=164666HZ&spon=17&impID=1715134&faf=1

 Well, the first question is, why to switching from one medicine to another?

•        it does not work because of it is wrong medicine to treat this condition;
•        it does not work because of diabetes developed into next stage of its;
•        there are a new medicine which is more effective developed;
•        there is a new medicine which is the same in effect but lower in price;
•        there are better medicine for this condition with less side effects and better outcome; and so on. 

So, why to switch from Metformin to SU?
         To see if medicine works for you or it does not I use mine own study. Just stop to take this medicine for short time and see, if numbers on glucose meter go up or stay the same. If numbers go up, re-start stopped medicine, you need it. If numbers stay the same then more chance it is wrong medicine and the new medicine is better to try. If numbers go down, this medicine does harm for you, stop to take it and never take it in future.
       I did it. For 10 years I trusted in MD without using my own brain. I do not have med degree, do not know medicine. This is why now I am in so deep crises. Of cause, all MD and those who use own agenda to increase own value in expense of sick people, will say that I am in crisis because of I do not do one or other things, that diabetes type 2 can be re-versed with weight loss or starvation diet, intense work outs and Metformin and SU, one or another, or both, I do know very well, it is wrong. It will never happen. So, now I trust in Insulin, Insulin only, and actually getting better.  At least I still alive and able to use my own bathroom.
       I took Metformin and SU, Glipiszide, for 10 years. I know these medicine way too well.
      Metformin is medicine which cost $4 month supply. These medicine Rx for every one to prevent diabetes type 2, to treat pre-diabetes, and to treat diabetes type 2. I took this medicine 10 years. Now the question is, is this really good medicine to treat diabetes type 2? It did not prevent diabetes type 2 development. It did not re-verse pre-diabetes. For 10 years A1c jumped over 9.4%. So, how this medicine can be good for me? Thanks. I stopped metformin in 2011 and never took another tablets.
     
    Sulfonylurea (SU).
    This medicine developed to force diabetic's type 2  already ill pancreas to secret more insulin. The same as if one has flu then let patient sent to cols street to increase defense against inflamation, to use natural way to treat highly dangerous medical condition if it is left untreated. On the same times it can be easy treated with some cold medicine.  SU kill hardly working B Cells, without any improvement for medical problem. At the same time if treatment started with Insulin, then pancreas has better chance to recovery. At first it is no danger pressure on ill and weak organ, and second, Insulin secreted B - Cells still have time to recovery and multiply. Insulin is expensive. But when Insulin Therapy started as soon as diabetes was detected the price would not be expencive, and time for treatment will be shorter. From 10 to 20 units of Insulin Lantus Solo Star safe to take even for non diabetics. Every diabetic will have benefits of this treatment.

Patients taking sulfonylureas as second-line therapy—replacing rather than adding on to metformin—had increased risks for myocardial infarction, all-cause mortality, and severe hypoglycemia compared with those on metformin monotherapy. This was true even when metformin-only patients had suboptimal glycemic control.

This is all already said. SU is danger therapy, and has no improvement in medical condition. The problem is, Metformin was first line, and it did not work. Numbers on glucose meter still high. Now second line adds, SU, and it leads to all-cause mortality. What our MD suggest? Take two medicine which does not work, and pretend that all-cause mortality will not hit you. Nice try. This is why Diabetes type 2 is number 7 cause of death in USA.  I suggest to add as second line Green tea. Add honey as third add-on nine. And add milk as five add-on line. They all will work the same, but only Metformin and SU have side effects. So, choice is yours.

Current guidelines downplay the use of sulfonylureas, although they remain the most common second-line agents for type 2 diabetes despite their consistent association with higher cardiovascular risk and the availability of newer classes of medications.

The question still stand, why add-on SU? Just stop it! Return to 100 years ago when Insulin still not discovered yet. Take Metformin. Then take a look at Mortality Tables, on what spot Diabetes type 2 would be moving?
BTW, if diabetic do not take Metformin, do not use starvation diet or try to lose weight in heart way, or do not take extensive work outs diabetic type 2 has better chance to survive.  No one of these MD recommendations lead to Diabetes type 2 cure. Every one of them lead to deeper diabetes type 2 development. 

via Ravenvoron