LADA, type 1, or type 2 Diabetes? October 19, 2018

Informally termed "type 1.5 diabetes," latent automimmune diabetes in adults LADA(LADA) is a relatively common disorder that shares features of type 1 diabetes (T1D) and type 2 diabetes (T2D). LADA is commonly misdiagnosed as T2D, as it presents in adulthood but doesn't initially require insulin treatment.
 First GWAS analysis of 'type 1.5 diabetes' reveals links between immune and metabolic disease
 Source: Children's Hospital of Philadelphia
https://www.sciencedaily.com/releases/2018/10/181017145320.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

There are two points I wish to consider.
At First, how common LADA to be diagnosed? Not even MD do know about this type of diabetes.  At least not every one who treat diabetics.
It is also not too many diabetics who diagnosed with LADA.
Finally, how often LADA discussed in public? On posts or in any Media?
If I take it all into consideration this does not sound for me to be 'common disorder'.
Second, why LADA does not require Insulin?  Because of regardless what diabetic said and wish to have as treatment option, no one MD will Rx Insulin for diabetic with LADA. LADA is not for children,. It is adults who diagnosed sometimes with LADA. Probably just because of some personal issue, such as diabetic's demand of Insulin as treatment option, or very good understanding of MD who do know very well what is diabetes about and wish to do the job without hurting own neck.

The new research, the first genome-wide association study (GWAS) of LADA, represents a large international effort, with dozens of co-authors from nine countries.

WOW! With these money how many diabetics could be cured with Insulin? Thousands. Not just treated but cured. And what after? No more studies needed. You must be kidding, yea? It is free money. And no any responsibility, no malpractice, nothing. Just pretend like professor R.Taylor, you see Beta Cells on MRI image.  COOL!

While the current study is larger than the 2017 analysis, and had genome-wide reach, both studies found the strongest genetic signals in LADA were associated with T1D, the autoimmune form of diabetes that usually presents in childhood and requires treatment with insulin. The current analysis also found genetic signals linked to T2D, the metabolic type of diabetes, more typically appearing first in adults, and by far the most common type of diabetes.

Why type 2 diabetes is metabolic type of diabetes? It is diagnosed the same way as Diabetes type 1. It can be perfectly treated with Insulin in injections. It can be cured in the same way as type 1. As one once said, if it is sound like duck, smell like duck, lucks like duck, then it must be duck! 

 Overall, the team found that the strongest genetic signals in LADA were mainly shared with established variants known to be linked to T1D. However, the researchers discovered a novel locus with genome-wide significance near the gene PFKFB3. This gene codes for a protein that regulates both insulin signaling and glycolisis, the chemical reaction that yields energy from glucose. "This finding points to how variants at PFKFB3 may help to drive LADA," said Cousminer, who added that because the gene's product not only impacts metabolism (a key feature of T2D), but also regulates inflammation in autoimmune disease (a key feature of T1D), "this protein therefore appears to sit at the intersection of both major types of diabetes."

 Personally, I will stop on this point. I am not interesting in Con-men who try to sale A New Dress For King. My point is very simple and very clear: if Insulin in injections can treat all types of diabetes, and no one test ever done to diagnose type of Diabetes I do have, then I am better to take General type of treatment which easy to apply and which can be applied for every type of diabetes.
     So, I take Insulin in injections, every day, day after day.
What did I learn since I injected my first dose of 11 units? It works. Without Insulin I would not be posting now. I would not be alive.
Today with 380 pounds I walk on my two legs. Not fast, not far, not long, but I am able to take short walk.
I do not wear glasses. I use glasses for reading, but only for reading. My vision is pretty good and still serve me well.
I am not amputee. Two years ago clot stopped in my legs, and wounds were developed. I still fight this condition today. Every time I wear wrap to prevent old wounds to pop up. But regardless, I do walk on two legs, and I am really happy I still do.
There are much more what is going on. Something worse, something better. I was born diabetic to diabetic father. I was diagnosed with type 2 diabetes short then 20 years ago. Is this right diagnose? Probably it is LADA? Maybe it is type 1? I do not know. And I do not care what is in my file. What I do care is what is in my Medical Box. There are Insulin, Lantus Solo Star. As long as Insulin is in my Medical Box, in my Ref. I can breath, I can live.
       I really do not care that someone look at me and see 400 pounds in wheelchair. They do know very well, this is why I am disable, I do not behave! In contrary, I do have very good care for myself. I used to be ill full my life. Now with almost 400 pounds body I am healthier then ever.

via Ravenvoron