treatment of Diabetes Mellitus. Metformin. January 12, 2019

Diabetes
Edited by Werner K. Waldhausl. 1979
Published by Expedia Medica, Amsterdam-Oxford-Princeton. 1980
Procceding of the 10th Congress
of the International Diabetes Federation.
Vienna, Austria, September 9-14, 1979.

Treatment State of the Art.

Regarding the obese, non insulin dependent diabetic available data demonstrate that frequently a loss of 3 - 5 kg will already cause a market improvement of fasting blood glucose. But we should be aware that short term fasts as frequently recommended by Nauyn in 1906, or zero calorie diet require strict medical supervision, since they lead to ketoacidosis, increase in plasma uric acid concentration and hypocalemia. (page 12)

       As do I remember so far, no one diabetic survived under Dr. Nauyn care. His follow Dr. Allen who treated Elizabeth Hughes, was nicknamed Dr. Starvation and Dr. Death. Patients did not survive under his care in the sanatoriums he treated them. When he was asked if Elizabeth would be cured with so strict diet, he answered: "No. But we can buy the time when treatment for diabetes would be available." She survived till insulin was discovered and first shots of insulin already were taken.

Elizabeth Hughes Gossett (August 19, 1907 – April 21, 1981), the daughter of U.S. politician Charles Evans Hughes, was the first American, and one of the first people in the world, treated with insulin for type 1 diabetes. She received over 42,000 insulin shots before she died in 1981

     Today she presented that she was diabetic type 1.Why? Because of she was treated with insulin shots, so she was insulin dependent diabetic. At the same time because of insulin was not available for every one and was very expensive, diabetics did not have this effective treatment. So, they all were non insulin dependent diabetics type 2 insulin resistant because of sugar in blood was way too high to survive.
      Today is 21st Century. Is there some differences in diabetes care? Not at all. The same as 2000 years ago diabetics type 2, millions of human being treated with life style modification, weight loss. It is presented that it is well demonstrated and documented. Show me this data when diabetics type 2 survive with weight loss. No one, because of weight loss is not effective ether for type 1 nether for type 2 diabetics, the same as for every one type of diabetes.
     Yes, weight loos 3-5 kg, about 10 Lbs will show difference in fasting sugar. For how long? Day? Two days?  Also it is possible to decrease fasting level of sugar when dinner is not taken. And best result to lose weight is stop to eat completely. My ugly humor does not want to let me free. Was diabetes type 2 cured? or reversed? Not at all. Why? Because of diabetes is not the level of sugar in blood, fasting, after meal,  or A1c. It is state of pancreas and Beta Cells ability to secret insulin. Did someone ever read how fasting effect health of pancreas? Never. It never was published. If so then what all this talks really about? How fasting can be effective in diabetes treatment? At least I have to see any reasonable explanation what will happen in my pancreas in sate of fasting.

As to Biguanides  the situation is even more complex since the mode of action is rather unknown. Besides impaired glucose absorption from gut, accelerated glucose intake by muscles and reduction of hepatic gluconeogenesis have been suggested to explain the hypoglycaemic action of biguanides in man.In this contest it has also to be mentioned that neither sulfonylureas nor biguanidesare able to normalize the post-prandial insulinogenic index.(page 13)

 This is what most important to finally find. Metformin today is number 1 Doctor's choice to treat diabetes type 2. There are many posts on google and all forums how Metformin help people to keep blood glucose in normal range. I suggested many times, before jump into wagon try to see where this wagon is heading.  At first,  stop to take metformin for a few days and see how your own level of sugar in blood going. If it is getting up and up, then re-start metformin. This is right medicine for you. If blood sugar stay not changing or even going down then do not take metformin. It does not work for you. Very simple and most effective way to see if medicine is right for you or not.
      In 2011 I tool last tablets of metformin. Before I took it every day since I was diagnosed with type 2 diabetes in 2001, 2000 mg daily dose. I never returned to metformin since I stopped to take it once. I do have poison effect. 40% American diabetics do have poison effect due to metformin. But usually doctors insist we have to take it. Metformin is medicine to treat our high blood sugar level. It is not.
    Now about type 1 diabetics. They also take metformin. With mode of action such as reduction of hepatic gluconeogenesis and insulin therapy how they manage low blood sugar? Metformin is really not medicine for type 1 diabetics. 

Clinically, the main side effect of biguanide administration are nausea, diarrhea, and development of lactic acidosis. 

Why not? If metformin does not reduce post-prandal increase in level of blood sugar then what this medicine is good for? Sugar in blood still high and rising because of medicine not only not effective  to treat diabetes but also worsen medical condition and increases level of sugar in blood due to side effects. Lactic acidosis is result of poorly controlled diabetes. In case of metformin if it is number one medicine to control blood sugar then diabetes stay not treated, rather treated in wrong way, which is worse then stay be not treated.

via Ravenvoron