Sunday, 31 July 2016
Saturday, 30 July 2016
Friday, 29 July 2016
FDA OKs New Injectable Type 2 Diabetes Medication
Drug lowers blood sugar levels, and doesn't boost risk of heart problems, agency says
Source: HealthDay
via Diabetes
Thursday, 28 July 2016
Wednesday, 27 July 2016
Flu Shot Tied to Fewer Hospitalizations, Deaths in Type 2 Diabetes Patients
Risk of dying dropped almost one-quarter over 7 years in those who got the vaccine
Source: HealthDay
via Diabetes
Tuesday, 26 July 2016
Monday, 25 July 2016
Sunday, 24 July 2016
Saturday, 23 July 2016
Friday, 22 July 2016
Thursday, 21 July 2016
Wednesday, 20 July 2016
A Little Fear Can Be A Good Thing
I usually drop my daughter at her summer music program after helping make her lunch and gather her belongings for the day.
Last Friday I had to leave the house early and so she chose to walk the few blocks to the program rather than arriving half an hour before her first class and having to wait around. No big deal, I thought, and a great opportunity to be independent. When I left, she was eating breakfast, and her lunch was made. She had half an hour until she had to leave, plenty of time to get her stuff together and get out of the house.
She texted me before 9 to let me know she'd arrived at her destination and we continued on with our busy days.
Then at 11, my phone buzzed. Surreptitiously taking it out of my pocket for a glance, I saw this:
'I'm such an idiot I don't have the meter.'
Meanwhile the Dexcom sensor had breathed its last at 9 the night before and we'd decided a free day would be okay before replacing it.
The next text read: 'I felt low so I drank my one juice and now I'm eating and I'm gonna do like half my lunch and then I'm going to the store to buy a coke or something in case I'm low again.'
Fifteen minutes away and responsible for a group of 7 children until 12:15, and then expected to stay where I was until at least 1:30, I texted back,
'Sounds good.'
As it tuned out, she did absolutely the right thing with the lack of tools at hand. The low or low-ish she treated was likely real. When she bolused for lunch she factored in the amount of dancing she expected to do during the show rehearsal. As the afternoon wore on she thought often about how she was feeling. She realized, should she need it, that in addition to the soda she had purchased she had access to candy usually awarded as prizes for the daily trivia contest. When she got home her blood sugar was 79.
With some significant inconvenience to myself and others I could have left what I was doing to get a meter to her. Instead I let her wing it until her program was over for the day. Was it the safest plan? No. If I had it to do over again would I bail her out? I don't know. But when she got home, she said this:
'That was scary being without the meter. I don't think I'll forget it again.'
Sometimes a little fear can teach a very important lesson.
via Adventures in Diabetes Parenting
Tuesday, 19 July 2016
Monday, 18 July 2016
Sunday, 17 July 2016
Saturday, 16 July 2016
Polyclonal T-Regs Start A Phase-II Trial (T-Rex)
T-Rex is a phase-II study of polyclonal T Regulator ("T-Reg") cells. It is a follow on study to work done at UCSF and in Poland which I've blogged about in the past:
http://ift.tt/29EX2ea
A quick summary of this treatment is as follows: remove one specific type of T regulator cell (called "CD4(+)CD25(+)CD127(lo)") from a person with type-1 diabetes. Grow them out so you have about 500 times more, and then put them back in the same person. Since regulatory T cells naturally regulate the body's immune system, and the patient now has more of them, the hope is that they will prevent the autoimmune attack which causes type-1 diabetes.
The Study
This study will enroll 111 people divided into three groups (low dose, high dose, and placebo). Patients must be between 12 and 17 years old and be honeymooners (within 100 days of diagnosis). They will be followed for two years. The primary endpoint is C-peptide generation (the body making it's own insulin) after one year, while secondary endpoints are A1C, insulin usage, adverse effects, and C-peptide at two years.
The study started recruiting in February 2016 and is expected to finish in March 2020.
In previous studies, the treatment involves two trips to the clinic (the second being an overnight stay), about two weeks apart.
Currently, this study is recruiting in two locations, but they hope to add more in the future:
Fargo, North Dakota, United States, 58122
Contact: Kathryn McEvoy 701-234-3722 kathryn.mcevoy@sanfordhealth.org
Contact: Vicki Oberg 701-234-6722 vicki.oberg@sanfordhealth.org
Sioux Falls, South Dakota, United States, 57104
Contact: Lynn M Bartholow, BA 800-305-5059 Lynn.bartholow@sanfordhealth.org
Contact: Alycia Brantz 605-328-1369 Alycia.Brantz@sanfordhealth.org
Discussion
This is a study where speed of recruitment is going to directly impact how long the study takes. This study gathers data for 2 years, so all data will be collected 2 years after the last patient is recruited. However, recruiting 111 teenagers from just two (relatively low population) sites, such as Fargo, North Dakota and Sioux Falls, South Dakota is going to take years. The sooner they can recruit from more places, and especially higher population cities, the sooner they can finish recruiting, and the sooner we can see if this works.
This study is sponsored by Caladrius Biosciences, Inc. in collaboration with Sanford Health (which is different than Stanford University). Caladrius Biosciences is a small pharma company specializing in bringing cellular therapies to market.
The term "cellular therapy" refers to treatments that use whole cells. Cellular therapy itself is a broad topic and can include stem cell therapies, cellular transplants, etc. In this case it refers to cellular "self transplants" where the patient receives cells that originated inside himself, but have been processed (in this case, grown out) outside his body.
The Company's web site: http://ift.tt/29DuuWq
More: http://ift.tt/29EWmFP
http://ift.tt/1RR4KTd
http://ift.tt/29EVLUr
Newspaper Article: http://ift.tt/29Dv867y
Clinical Trial Registery: http://ift.tt/1USxIpd
The same group of researchers are planning to start a another trial, which will combine Polyclonal Tregs and IL-2. I'll blog on that trial when it starts recruiting.
Joshua Levy
http://ift.tt/29DuN3o
publicjoshualevy at gmail dot com
All the views expressed here are those of Joshua Levy, and nothing here is official JDRF or JDCA news, views, policies or opinions. My daughter has type-1 diabetes and participates in clinical trials, which might be discussed here. My blog contains a more complete non-conflict of interest statement. Thanks to everyone who helps with the blog.
via Cure Research
Friday, 15 July 2016
Thursday, 14 July 2016
Wednesday, 13 July 2016
3 Foods That Will Make Your Type 2 Diabetes Even Worse
Did you know that some “safe” foods might be making your diabetes even worse?
You know to stay away from sweets, but some so-called “healthy” alternatives could be hijacking your blood sugar.
>>>What if you could REVERSE your Type 2 Diabetes and throw away your insulin shots? A new medical discovery makes it possible
Keep these blood sugar-boosters off the menu to maximize your energy level:
Many smoothies contain as much sugar as three cans of soda…
…especially fast-food and restaurant smoothies.
So how can you get the necessary vitamins and fiber while avoiding blood sugar spikes?
The solution: make smoothies yourself.
Just make sure to stay away from super-sugary fruits like bananas and peaches.
Try these instead:
“What could go wrong with a food that’s fat-free, cholesterol-free, and full of fiber and vitamins?”
The problem with starchy foods, like potatoes, is that they’re digested into the bloodstream lightning-quick and can trigger sharp insulin spikes.
Don’t scrap your spuds just yet, though. The key to a diabetes-friendly potato is in the preparation and portion size.
Preparation tips:
Combine this with all the frying and processing involved with cooking flour, and your bloodstream is about to become a war-zone.
In fact, regularly eating white rice significantly increases your risk for Type 2 Diabetes. The risk increases 11% for each additional daily serving.
Thankfully, there is another option: brown rice.
Whole grains have fiber, which slows the rush of glucose into the bloodstream. Two servings of brown rice per week can actually lower your risk of diabetes, and help keep your blood sugar in check.
What if you could REVERSE your Type 2 Diabetes and never stop enjoying your favorite foods, here’s what you need:
A recent medical breakthrough at Newcastle University has revealed 3 Proven Steps to Reverse Type-2 Diabetes. Click the link below to find out more.
>>>Click here to find out 3 Proven Steps to Reverse Type-2 Diabetes Discovered by Newcastle University
You know to stay away from sweets, but some so-called “healthy” alternatives could be hijacking your blood sugar.
>>>What if you could REVERSE your Type 2 Diabetes and throw away your insulin shots? A new medical discovery makes it possible
Keep these blood sugar-boosters off the menu to maximize your energy level:
- Fruit Smoothies
Many smoothies contain as much sugar as three cans of soda…
…especially fast-food and restaurant smoothies.
So how can you get the necessary vitamins and fiber while avoiding blood sugar spikes?
The solution: make smoothies yourself.
Just make sure to stay away from super-sugary fruits like bananas and peaches.
Try these instead:
- Apples
- Blueberries
- Strawberries
- Potatoes
“What could go wrong with a food that’s fat-free, cholesterol-free, and full of fiber and vitamins?”
The problem with starchy foods, like potatoes, is that they’re digested into the bloodstream lightning-quick and can trigger sharp insulin spikes.
Don’t scrap your spuds just yet, though. The key to a diabetes-friendly potato is in the preparation and portion size.
Preparation tips:
- Cook them with a healthy fat, like olive oil
- Add leafy greens or vegetables
- Chill the potato or add lemon juice to slow digestion
- White rice
Combine this with all the frying and processing involved with cooking flour, and your bloodstream is about to become a war-zone.
In fact, regularly eating white rice significantly increases your risk for Type 2 Diabetes. The risk increases 11% for each additional daily serving.
Thankfully, there is another option: brown rice.
Whole grains have fiber, which slows the rush of glucose into the bloodstream. Two servings of brown rice per week can actually lower your risk of diabetes, and help keep your blood sugar in check.
What if you could REVERSE your Type 2 Diabetes and never stop enjoying your favorite foods, here’s what you need:
A recent medical breakthrough at Newcastle University has revealed 3 Proven Steps to Reverse Type-2 Diabetes. Click the link below to find out more.
>>>Click here to find out 3 Proven Steps to Reverse Type-2 Diabetes Discovered by Newcastle University
3 Tricks for Managing Diabetes Your Doctor Won’t Tell You
When you leave your doctor’s office, do you ever wonder what he’s not telling you?
Every appointment, he tells you to eat less sugar and go on more walks, but aren’t there other ways to get your diabetes under control?
>>>Ever wish you could REVERSE your Type 2 Diabetes? Discover 3 Proven Steps with this discovery from a recent Newcastle University medical stud
Here’s 3 tricks to manage your diabetes that your doctor won’t tell you:
That’s because fat helps your body absorb insulin. That means the more fat you eat, the easier it’ll be to manage your blood sugar.
But here’s the kicker: It’s got to be the right type of fat.
You’re looking for Unsaturated Omega-3 Fat.
Here’s some great sources:
All the cardio your doctor tells you to do will increase your insulin absorption a little, but to really keep your body regulated you’ve got to get your entire body moving.
The best way to do that is any exercise that focuses on strength.
You want to avoid straining yourself, but make a habit of doing a few pushups every day, throw in some body squats, and soon you’ll be taking tighter control of your blood sugar.
Not to mention it’ll get rid of stress, and give you plenty of energy.
Not to mention, when you’re stressed out it’s easy to overeat, which obviously wreaks havoc on your blood sugar.
For easy relaxation, try out simple meditation or breathing exercises.
These tricks will help, but…
If You Want to REVERSE your Type 2 Diabetes and never worry about your blood sugar again, here’s what you need:
A recent medical breakthrough at Newcastle University has revealed 3 Proven Steps to Reverse Type-2 Diabetes. Click the link below to find out more.
>>>Click here to find out 3 Proven Steps to Reverse Type-2 Diabetes Discovered by Newcastle University
Every appointment, he tells you to eat less sugar and go on more walks, but aren’t there other ways to get your diabetes under control?
>>>Ever wish you could REVERSE your Type 2 Diabetes? Discover 3 Proven Steps with this discovery from a recent Newcastle University medical stud
Here’s 3 tricks to manage your diabetes that your doctor won’t tell you:
- Eat More Fat
That’s because fat helps your body absorb insulin. That means the more fat you eat, the easier it’ll be to manage your blood sugar.
But here’s the kicker: It’s got to be the right type of fat.
You’re looking for Unsaturated Omega-3 Fat.
Here’s some great sources:
- Fish
- Eggs (Any eggs labeled “enriched” have plenty of omega-3)
- Grass-fed beef (There’s lots of omega-3 in the grass)
- Do Some Pushups…
All the cardio your doctor tells you to do will increase your insulin absorption a little, but to really keep your body regulated you’ve got to get your entire body moving.
The best way to do that is any exercise that focuses on strength.
You want to avoid straining yourself, but make a habit of doing a few pushups every day, throw in some body squats, and soon you’ll be taking tighter control of your blood sugar.
Not to mention it’ll get rid of stress, and give you plenty of energy.
- Relax
Not to mention, when you’re stressed out it’s easy to overeat, which obviously wreaks havoc on your blood sugar.
For easy relaxation, try out simple meditation or breathing exercises.
These tricks will help, but…
If You Want to REVERSE your Type 2 Diabetes and never worry about your blood sugar again, here’s what you need:
A recent medical breakthrough at Newcastle University has revealed 3 Proven Steps to Reverse Type-2 Diabetes. Click the link below to find out more.
>>>Click here to find out 3 Proven Steps to Reverse Type-2 Diabetes Discovered by Newcastle University
Diabetes Type 2 What To Eat
Following a type 2 diabetes diet doesn’t mean you have to give up the things you love you can still enjoy a wide range of foods. The best diabetes diet is one that is well balanced and includes a variety of healthy carbohydrates, fats, and proteins. The trick to this balancing act is choosing the right combination of foods that will help keep blood sugar level in your target range and avoid big swings that can cause diabetes symptoms from the frequent urination and thirst of high blood sugar to the fatigue, dizziness, headaches, and mood changes of low blood sugar.
The Basics of the Type 2 Diabetes Diet
To follow a healthy diet, you must first understand how different foods affect your blood sugar. Carbohydrates, which are found in grains, bread, pasta, milk, sweets, fruit, and starchy vegetables, are broken down into glucose in the blood faster than other types of food, which raises blood sugar levels. Protein and fats do not directly impact blood sugar, but both should be consumed in moderation.
To hit your blood sugar level target, eat a variety of foods but monitor portions for foods with high carbohydrate content, says Alison Massey, RD, LDN, CDE, director of diabetes education at Mercy Medical Center in Baltimore, Md. “Carbohydrate foods have the most impact on blood sugar levels. This is why some people with diabetes count their carbohydrates at meals and snacks,” she says.
Best and Worst Type 2 Diabetes Choices by Food Group
As you fill your plate at each meal, here’s a helpful guideline to keep in mind: Fill half your plate with non-starchy vegetables. Round out the meal with other healthy choices — whole grains, nuts and seeds, lean protein, low-fat dairy, and small portions of fresh fruits and healthy fats. Sugar should be limited, says Massey.
Here’s what you need to know about choosing the best options from each group.
Protein
- Best options: The American Diabetes Association (ADA) recommends lean proteins low in saturated fat, like fish or turkey. Aim for two or three servings of seafood each week; some fish, like salmon, have the added benefit of containing heart healthy omega-3 fats. For a vegetarian protein source, experiment with the wide variety of beans. Massey adds that nuts, which are protein and healthy fats powerhouses, are also a great choice — just watch portion sizes as they're very high in calories.
- Worst options: Processed deli meats and hot dogs have high amounts of fat along with lots of sodium, which can increase the risk of high blood pressure. Heart attack and stroke are two common complications of diabetes, so keeping blood pressure in check is important.
- Best options: When choosing grains, make sure they’re whole. Whole grains such as wild rice, quinoa, and whole grain breads and cereals contain fiber, which is beneficial for digestive health. Whole grains also contain healthy vitamins, minerals, and phytochemicals.
- Worst options: Refined white flour doesn’t contain the same health benefits as whole grains. Processed foods made with white flour include breakfast cereals, white bread, and pastries, so avoid these options. Also try to steer clear of white rice and pasta.
- Best options: With only 6 to 8 grams of carbohydrates in a serving, plain nonfat Greek yogurt is a healthy and versatile dairy option. You can add berries and enjoy it for dessert or breakfast; you can use it in recipes as a replacement for sour cream, which is high in saturated fat.
- Worst options: Avoid all full-fat dairy products and especially packaged chocolate milk, says Massey, as it also has added sugar.
- Best options: Non-starchy vegetables such as leafy greens, broccoli, cauliflower, asparagus, and carrots are low in carbohydrates and high in fiber and other nutrients, Massey says. You can eat non-starchy vegetables in abundance — half of your plate should be filled with these veggies. If you’re craving mashed potatoes, give mashed cauliflower a try, she adds.
- Worst options: Stick to small portions of starchy vegetables such as corn, potatoes, and peas. These items are nutritious, but should be eaten in moderation. The ADA groups them with grains because of their high carb content.
- Best options: Fresh fruit can conquer your craving for sweets while providing antioxidants and fiber. Berries are a great option because recommended portion sizes are typically generous, which may leave you feeling more satisfied, Massey says.
- Worst options: Avoid added sugar by limiting fruits canned in syrup, and be aware that dried fruits have a very high sugar concentration. Also, fruit juices should be consumed in moderation as they’re high in sugar and don’t contain the same nutrients as whole fruit.
- Best options: Some types of fat actually help protect your heart. Choose the monounsaturated fats found in avocados, almonds, and pecans or the polyunsaturated fats found in walnuts and sunflower oil, which can help to lower bad cholesterol.
- Worst options: Saturated fats increase bad cholesterol, so limit butter, cheese, gravy, and fried foods. Keep calories from saturated fat to less than 10 percent of your total daily intake. Trans fats are even worse than saturated fats, so avoid them as much as possible. Look for the term “hydrogenated” on labels of processed foods such as packaged snacks, baked goods, and crackers. “I always tell my clients to double-check the ingredient list to make sure they don’t see any partially hydrogenated oil in their food products,” Massey says.
Tuesday, 12 July 2016
Diabetes Type 2 Treatment Guidelines
Treatment for diabetes aims to keep your blood glucose levels as normal as possible and control your symptoms to prevent health problems developing later in life.
If you've been diagnosed with type 2 diabetes, your GP will be able to explain your condition in detail and help you understand your treatment.
They'll also closely monitor your condition to identify any health problems that may occur. If there are any problems, you may be referred to a hospital-based diabetes care team.
This may seem daunting, but your diabetes care team will be able to give you support and advice about all aspects of your treatment.
After being diagnosed with type 2 diabetes, or if you're at risk of developing the condition, the first step is to look at your diet and lifestyle and make any necessary changes.
Three major areas that you'll need to look closely at are:
You should:
Losing 5-10% of your overall body weight over the course of a year is a realistic initial target.
You should aim to continue to lose weight until you've achieved and maintained a BMI within the healthy range, which is:
To help you achieve changes in your behaviour, you may be referred to a dietititian or a similar healthcare professional for a personal assessment and tailored advice about diet and physical activity.
For adults who are 19-64 years of age, the government recommends a minimum of:
In cases where the above activity levels are unrealistic, even small increases in physical activity will be beneficial to your health and act as a basis for future improvements.
Reduce the amount of time spent watching television or sitting in front of a computer. Going for a daily walk – for example, during your lunch break – is a good way of introducing regular physical activity into your schedule.
If you're overweight or obese, you may need to be more physically active to help you lose weight and maintain weight loss.
Your GP, diabetes care team or dietitian can give you more information and advice about losing weight and becoming more physically active.
If you've been diagnosed with type 2 diabetes, your GP will be able to explain your condition in detail and help you understand your treatment.
They'll also closely monitor your condition to identify any health problems that may occur. If there are any problems, you may be referred to a hospital-based diabetes care team.
Making lifestyle changes
If you're diagnosed with type 2 diabetes, you'll need to look after your health very carefully for the rest of your life.This may seem daunting, but your diabetes care team will be able to give you support and advice about all aspects of your treatment.
After being diagnosed with type 2 diabetes, or if you're at risk of developing the condition, the first step is to look at your diet and lifestyle and make any necessary changes.
Three major areas that you'll need to look closely at are:
- eating healthily
- losing weight if you're overweight
- exercising regularly
Diet
Increasing the amount of fibre in your diet and reducing your sugar and fat intake, particularly saturated fat, can help prevent type 2 diabetes, as well as manage the condition if you already have it.You should:
- increase your consumption of high-fibre foods, such as wholegrain bread and cereals, beans and lentils, and fruit and vegetables
- choose foods that are low in fat – replace butter, ghee and coconut oil with low-fat spreads and vegetable oil
- choose skimmed and semi-skimmed milk, and low-fat yoghurts
- eat fish and lean meat rather than fatty or processed meat, such as sausages and burgers
- grill, bake, poach or steam food instead of frying or roasting it
- avoid high-fat foods, such as mayonnaise, chips, crisps, pasties, poppadoms and samosas
- eat fruit, unsalted nuts and low-fat yoghurts as snacks instead of cakes, biscuits, bombay mix or crisps
Weight
If you're overweight or obese – you have a body mass index (BMI) of 30 or over – you should lose weight by gradually reducing your calorie intake and becoming more physically active.Losing 5-10% of your overall body weight over the course of a year is a realistic initial target.
You should aim to continue to lose weight until you've achieved and maintained a BMI within the healthy range, which is:
- 18.5-24.9kg/m² for the general population
- 18.5-22.9kg/m² for people of south Asian or Chinese origin – south Asian includes people from Bangladesh, Bhutan, India, Indian-Caribbean, Maldives, Nepal, Pakistan and Sri Lanka
To help you achieve changes in your behaviour, you may be referred to a dietititian or a similar healthcare professional for a personal assessment and tailored advice about diet and physical activity.
Physical activity
Being physically active is very important in preventing or managing type 2 diabetes.For adults who are 19-64 years of age, the government recommends a minimum of:
- 150 minutes (2 hours and 30 minutes) of moderate-intensity aerobic activity – such as cycling or fast walking – a week, which can be taken in sessions of 10 minutes or more, and
- muscle-strengthening activities on two or more days a week that work all major muscle groups – the legs, hips, back, tummy (abdomen), chest, shoulders and arms
- 75 minutes of vigorous-intensity aerobic activity, such as running or a game of tennis every week, and
- muscle-strengthening activities on two or more days a week that work all major muscle groups – the legs, hips, back, abdomen, chest, shoulders and arms
In cases where the above activity levels are unrealistic, even small increases in physical activity will be beneficial to your health and act as a basis for future improvements.
Reduce the amount of time spent watching television or sitting in front of a computer. Going for a daily walk – for example, during your lunch break – is a good way of introducing regular physical activity into your schedule.
If you're overweight or obese, you may need to be more physically active to help you lose weight and maintain weight loss.
Your GP, diabetes care team or dietitian can give you more information and advice about losing weight and becoming more physically active.
Diabetes Type 2 Causes Signs And Symptoms
The common symptoms of diabetes
- Going to the toilet a lot, especially at night.
- Being really thirsty.
- Feeling more tired than usual.
- Losing weight without trying to.
- Genital itching or thrush.
- Cuts and wounds take longer to heal.
- Blurred vision.
Why does diabetes create these symptoms?
These symptoms occur because some or all of the glucose stays in the blood, and isn’t being used as fuel for energy. The body tries to reduce blood glucose levels by flushing the excess glucose out of the body in the urine.I have some diabetes symptoms. What now?
If you have any of symptoms of diabetes, you should contact your GP. It doesn’t necessarily mean you have diabetes, but it’s worth checking – early diagnosis, treatment and good control are vital for good health and reduce the chances of developing serious complications.Spotting Type 1 diabetes in children
To help you spot the four most common symptoms of Type 1 diabetes in children and young people, Diabetes UK has created the 4 Ts of Type 1 diabetes.
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