IMCY-0098 Starts a Phase-I Clinical Trial

I always enjoy blogging about a clinical trial for a new treatment, done by a new company, which hopes to cure type-1 diabetes. As I understand it, Imcyse, the company doing this research, has a method for creating peptides (small pieces of a protein) which will generate a type of immune cell that is able to destroy the immune cells of the body responsible for the disease. If this works, they can specifically target the cells that are causing autoimmune diseases. The company is going after Type-1 Diabetes (first), Multiple Sclerosis (second), and several other diseases after that. IMCY-0098 is the code name for their peptide targeting T1D.

IMCY-0098 Starts a Phase-I Clinical Trial

This study started in Aug 2017 and they hope to finish in Dec 2018.  They will enroll a total of 40 adult honeymooners (within 6 months of diagnosis) divided up into three groups. In addition to their regular insulin treatments, each group will get a total of 4 injections over 2 months (just below the skin, like an insulin injection).  One group will get low dose injections, one group medium dose injections, and the third group will get high dose injections; and each group will contain some controls who will get a placebo.  Patients will be followed for 6 months.  The researchers will track safety issues, effectiveness (C-peptide, A1c, etc.), and changes in the immune system.

They are currently recruiting in Belgium, Denmark, Cardiff and Oxford, and plan to start soon in France, Germany and additional location in the UK.  The list is long, and you can see the exact locations in their clinical trial record: http://ift.tt/2zUKK2c

Company Web Site: http://ift.tt/2AOkRRM
Trial Web Pages (in different languages):
http://ift.tt/2zUKLmM
http://ift.tt/2ALbRg6
Clinical Trial Registration: http://ift.tt/2zUKK2c
Most recent full paper / Results In NOD Mice:
http://ift.tt/2zUedJz
Some more web sites:
http://ift.tt/2ALye5k (Exalt study)
http://ift.tt/2zUeegB (Exalt study)

Discussion

The company's web site includes this page:
http://ift.tt/2AKvGEt
which discusses how they are developing their treatments.  Unfortunately, it is too technical for me to understand.  But for readers with a background in immunology, this page might be valuable.

Joshua Levy

http://ift.tt/2fs7dVR;
publicjoshualevy at gmail dot com
All the views expressed here are those of Joshua Levy, and nothing here is official JDRF or JDCA news, views, policies or opinions. My daughter has type-1 diabetes and participates in clinical trials, which might be discussed here. My blog contains a more complete non-conflict of interest statement. Thanks to everyone who helps with the blog.


via Cure Research

ADA Publications back to 1964, November 30, 2017

I do understand that in 1964 the knowledge about diabetes were limited. On the same time Insulin already was discovered and in wide use. It was very well known that diabetes caused by limited insulin secretion. Insulin added in injections returned to the life, human or animals. Still, in 1964 the article The Metabolic Lesion in Diabetes Mellitus  by R.Levine counted glucose. Insulin was left aside.
Author present that the extrahetic tissue utilize glucose, transforms it into H2O and CO2, and create needed energy. In diabetics system total utilization is decreased, and this resulted hyperglycemia.  well, is so then there are two components play role in metabolic utilization, glucose and insulin. So, if glucose level is low then there is no need in insulin. If we do not eat then we do not need insulin to utilize glucose. Right? Wrong. We still need energy to function. We cannot live without energy. So, to get energy we need to take meal and transform meal into glucose, right?
If so then why diabetes is metabolic disorder? There is nothing about metabolism if there is no component to utilize, insulin. Insulin is limited or absent in out body system. Regardless if there are a lot of glucose, ready to be transformed into energy, or there is just normal, or even under normal amount of energy, still if there is no insulin then there is no energy. Heart will stop to push the blood.
To compare brain has another gland which secret insulin. This insulin used only for brain activity. Because of this insulin independent from pancreas our brain still functional even sugar in blood is high. In contrary, when this gland does not secret insulin brain disfunctionsl, even sugar in blood is normal.
Author of article presented that brain have normal rate in glucose intake. Not every time. There are other abnormalities involving insulin. Insulin added to those patient increases their activity and improve daily living. This insulin needed in very small amount and probably another way of administration.
Finally after  all the discussion how glucose metabolized there is a few  words about insulin.
"Insulin is only hormone which set up conditions favorable for storage and conservation, I.E. glycogen deposition and fat and protein synthesis". Page 5.
Interesting I will say. Is the job of insulin to set up storage of fat and conservation of glycogen? It is already 1964. It is not before insulin discovery but pretty after. There are many books published what is diabetes. Diabetes is limited insulin secretion. It is not metabolism of anything. It is absence of insulin. take off insulin secretion, and there is no life. Two weeks only, and diabetic will die. The same as it is with meal. If one has no meal and water then two weeks and even insulin secretion is normal and there is no diabetes human or animal will die.
"A dence fog of ignorance still covers the chemical events preceding hyperglycemia as well as those disturbances of cell metabolism which ultimately lead to angiopathy and nephropathy."
Really, look who is talking about ignorance.

via Ravenvoron

One Last Story For November

Once upon a time there was a girl with diabetes who survived the whole month of November!

She ate some leftover Halloween candy but not too much.

She took an airplane trip to Florida where she celebrated her 16th birthday in the Wizarding World of Harry Potter. In Orlando she figured out how to bolus insulin to cover Butterbeer. She ate at restaurants and guessed the carbohydrate content of every meal, sometimes more successfully than others.

She had some long, busy days in November, including one when she ate dinner in the car on the way from a piano lesson to jazz band rehearsal. And another when she took two difficult and stressful tests.

She had a couple fun but out-of-the-ordinary evenings, like one which found her eating Nutella pancakes at a diner at 10 p.m. after working backstage for the school play. And another spent at the last Friday night football game of the marching band season, when she ate dinner on a school bus before spending 3 hours playing the clarinet in the freezing cold.

She thoroughly enjoyed Thanksgiving dinner, especially the stuffing, the cranberry bread, and the pumpkin pie. And the turkey sandwiches with cranberry sauce on white bread the next day. And Thanksgiving dinner round 2 (a.k.a. leftovers) on Saturday.

All through November, she checked her blood sugar, changed her pump sites, used her Dexcom, explained her diabetes needs to TSA agents and teachers, carried her supply bag wherever she went, counted her carbohydrates, corrected her highs and drank juice boxes for her lows. But those aren't the parts of November she'll remember.






via Adventures in Diabetes Parenting

childhood obesity 35 years after now. Where they go? November 30, 2017

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- The majority of children growing up in America today will be obese by age 35, a new computer analysis predicts. http://ift.tt/2ipOvFA

     So what? Really what wrong in this? Is that so bad that kids will be obese at age of 35 and live longer then 35? It is all the time predicted that obesity shorten live. How old would be those children when they die? As do I remember, the expectation are that girl who was born now will chance to live 120 years. Obese or underweight, lean or skinny, the life over 100 years for diabetic is not so bad. By 2052 obesity would not be the problem. People just will not see that 300 pounds is wrong. The same as back to 1850 the weight of 100 pounds was not seen as underweight. All population was in this shape.

35 years after mow it would be  2052. 100 years before that we were not obese. No one of us was obese. After 35 we started to collect pounds, why? Because of our life style? Not at all. Life style does not changes so fast. But at the time we were 35 we still alive. Many diabetics who was born before us, did not survive for this age.  My father and his sister gone by the age of 37 and 36. They did not have chance to collect pounds. I am alive. I am 65.  As it was predicted, I will survive next 35 years after being obese. Do not see what is bad in this perspective. My father and his sister gone,  as many others of his age and time. They gone not only because of diabetes.  They even were not diagnosed they are diabetics. Some of them gone because of many childhood disease. Other got stroke and heart attacks. Today they could live. Yesterday they died. There were no time for them to get obese. They simple were under 35. 

      Another point what authors do not see is, how tall these kids? Do they go to the streets? Do they see kids and teens today? I do not think so. I live in NYC. There are a lot of Chinese people. Traditionally Chinese are short. Today Chinese kids are tall. They are not obese, well fed, and very athletic. They are tall. Some teens I see in Met Opera or NY Phill are so tall that they have difficulty to take a seat because there is no space for their long legs. I do straggle to put myself in seat because of I am round. They do need wider space from front seat. They need higher seat to be comfortable. So, is that really true that their children would be obese? I do not think so. They simple would be healthy and perfect in shape. But they would be different then we are now.

      Those of us who today between 60 and 80 years old where not obese as kids. Many of us were simple too hungry. This is why we are shorter then we could be if we did not have childhood as we did have.  

"For example, we found that three out of four 2-year-olds with obesity will still have obesity at age 35," he said. "For 2-year-olds with severe obesity, that number is four out five."

It is really very interesting, why these kids would be obese at age of 35? How today it is predicted that those 2 years old would be fat or skinny, smart or nut, and so so on? Doesn't it looks like hysteria around nothing?  Let kids to grow healthy and without stamping and shaming with body shape. It is illegal by the way.  There is nothing illegal when it is MD. They can stamp us we ill because of lifestyle. They refuse to Rx medicine they do know we need. They are aggressive to recommend treatments we do not need and it is danger for us. Say me, why diabetics have so many amputations? Because of it is good business. So, why treat diabetic with insulin? No diabetics, no obesity, where MD business will come from?

 According to the U.S. Centers for Disease Control and Prevention, roughly 20 percent of American children 6 to 19 years old are obese. That reflects a tripling of the number since the 1970s.

 It is interesting what CDC studying. Why they do not study how effective medicine for diabetics type 2? How many diabetics type 2 die because of MD Rx Life style modifications? We die because high blood sugar and thrombosis, stroke and heart attacks, COPD and Asthma, Cancer and so so so on. We die. If we do have insulin as our treatment we can survive. In this case MD would not have so high number of patients in their clinics. No patients no business. Is this good? Is this bad? Simple, take better look who is bad guy and who is not so bad as bad guys show us. With Life Style Modifications as first line of treatment MD never would be out of business. Why do they need to go to Medical school? To have good time to grow up. There is no any diploma needed to Rx Healthy Life style. No one do know what is it? So, regardless of Rx MD all the time right, never can be wrong.

via Ravenvoron

what eat in the morning? November 30, 2017

Regularly eating breakfast affects our body fat cells by decreasing the activity of genes involved in fat metabolism and increasing how much sugar they take up, according to new research. This may lower diabetes and cardiovascular risk.
http://ift.tt/2AtUeRL

      I am ESL. English is my second language.  So, simple say me, do I need to take meat at morning, or I have yo skip it? If so then when I have to take it? If I take it after 12 pm would in morning or it is already dinner even if it is first meal at day? Usually I do not sleep night because of severe pain in watered legs and I use to wrap them very tight. So, when it is morning meal, when it is 6 am or it is first meal at day?
      Usually it is very impress me with every  research  findings. How they are found what they pretend it is true? Say me, how they found that cells increase/decrease activity after breakfast and increase how mush sugar cells take up? I just wish to see, how they found it? What if after eating breakfast beta cells activity is higher and so insulin secretion is higher  and so the level of sugar lower? This is the same study, just speculations, just another turn head into tail and vase versa.

The team in Bath and Nottingham also found that fat in obese people responds less to insulin, which regulates blood sugar, than lean people do. Importantly, this decrease is proportional to the person's total amount of body fat.

     Great finding! What if the abnormality in cells, in pancreas, leads to abnormalities in beta cells, such as developing fibrosis, so beta cells cannot function properly. As a result insulin secretion is limited, and eventually decreases down to "0"  which leads to Death of diabetic? Or it is hydration of cells and Beta sells cannot secret insulin, simple drown under high water secretion? Did researcgers looked at this direction? Or they simple do know nothing about diabetes but very well educated in making money?
       Fat in diabetics type 2 is not lead to diabetes type 2. It is result of limited secretion in insulin. If there is no insulin diabetic is hungry, but meal we eat cannot be used as energy, or make cells feel full. Cells still hungry. There are fat develops. We cannot mover, be active, but more and more fat deposited around middle aria. When diabetic type 2 try to avoid eating, diabetic can skip into coma, die. No any studies in this direction. Say me, why diabetics die? Why people who are overweight can be non diabetics, and live. Diabetics type 2 die. Why it is so? What leads diabetics type 2 to Death?
      There can be a lot of speculations, but the reason only one. Take reading sugar in blood. Take these readings in diabetic type 2. What are they? Sorry guys,  it is not 129 mg/dl. As I posted before lady with 700 mg/dl was in clinic, and .... yes, she was injected with insulin and sent home. She did not make it. Good she returned back to clinic. She was with her aid. If there were no aid MD could be out of service. Why person with 700 mg/dl was not sent to hospital but sent home? It is far away from that scam D1T post how they are suffering. They were diagnosed with type 1 at age of 6 with sugar 400 mg/dl. I was not diagnosed as type 1 with sugar 599 mg/dl. Why it was 599 mg/dl? Because of it is limit for home glucose meter. How high really sugar was there is no clue. I was discharged from hospital with sugar 400 mg/dl in blood, and 1000 mg/dl in urine. No insulin. No any treatment for me.
     I am type 2 diabetic, not type 1. To control blood sugar I need more then 200 units of insulin daily dose. I usually take 300 units. At time when I am sick I take up to 500 units. So, there is no ER service for me. Our MD simple discharge us and usually too busy to come to check up how treatment they Rx work or not. Usually it does not work.

Before and after the six weeks, the researchers measured metabolism (how did they do measured it?) , body composition (OK, it is possible to diagnose. Just measurement as we use for quilting), appetite responses (WOW! What they do mean ?) and markers of metabolic (?????) and cardiovascular health (sorry guys all D2T have poor working heart and high tombing blood). They also measured participants' fat for the activity of 44 different genes and key proteins, and studied the ability of the fat cells to take up glucose in response to insulin. I am lost. How they do it?)

      WOW!" the researchers measured metabolism" how? Really, how they did so? How much output in toilet was dropped? Sorry! I am diabetic type 2 with poor carbs metabolism. How anyone MD diagnosed this poor metabolism? Usually it is only sugar in blood, and never any output. So, why it is said all the time I do have poor metabolism? Really I do not.
   I posted many times, I do run my studies. It is nothing too complicated. Just sugar readings, insulin dose, and something else. Yesterday my man and I cooked. Usually it is long day when we do so. I got very tied. He finished job. I left to take my routine. Suddenly I was not simple hungry, but I started to eat candy, one after another, and I could not stop. One after another, and so so on. I do not eat to much sweet. Not because of diabetes but because of I cannot eat sweet candy. Even apples must be not sweet. Even berries too sweet for me. Now I eat sweet, very sweet candy, and canot stop. Then I went to bed.
      86 mg/dl fasting sugar today.
     It is even more significant that dose of insulin Yesterday was less then 300 units.
     Today I do not eat candy. All back to normal.

Javier Gonzalez, lead author of the study said, 'by better understanding how fat responds to what and when we eat, we can more precisely target those mechanisms. We may be able to uncover new ways to prevent the negative consequences of having a large amount of body fat, even if we cannot get rid of it.'

     Stop to blame me I am diabetic type 2. Give me insulin I need and stop to Rx stupid Healthy Life Style. I cannot live healthy. I am ill. I am diabetic type 2. I am insulin resistant type of diabetic which means I need more then 200 units of insulin daily dose. In addition to this medicine I need much more. My blood in clotting. Clots stop in lungs and heart, in brain and in legs. Edema. Very severe edema. This edema cannot be treated with diuretic pills. Our researchers never studied what to do with edema. They are easy to see that body shape is fat. They are not able to see edema. It is so obvious. It is on our faces and legs. Our foot are puffy. It is not fat. It is water deposit. Our lungs are 'singing' like I am operatic soprano. It is water between cells. We hardly able to walk on our watered wounded legs, short of breath right after first move. What MD said about us? Too fatty. Wrong life style.
     Many, very many people post that in 1980th there were not so many obese people as today. Right. We all were in graves right before we started to collect pounds. Today we alive. Fatty. Obese. Alive. Ten years ago I did not see so many old disable people in Lincoln Center, in Metropolitan Opera or NY Phill. Today there are scooters one next to another. House is not ready to store our scooters. There is no place for them. There is not in every house where acceptable restrooms. In soon future there would be line in acceptable restrooms. More and more of us come to concerts on scooters. We live longer. Obese or  lean, it does not matter. I am alive, and this is all what count.

via Ravenvoron

Day by Day. November 29, 2017

Sugar is 91 mg/dl.
Perfect fasting sugar.
     Yesterday it was only 267 units of Lantus Solo Star. Only 267, less then 300 units. Sugar getting down very fast. I had low sugar episode Yesterday. Sugar was only 66 mg/dl, and it was felt low, pretty low I would say. I took 80 units at eve. I planned to take 120, but with low episode really I am not so brave. In the morning today it turned very right choice. Sugar just great.
      In the eve Yesterday I put off wrap on my legs. It started to painful, and I wanted to have good night sleep. In the morning today my legs looks great. Swelling getting down. It is not disappeared, but pretty down. Both legs are dry, no opened wounds. The color of skin still dark red. But there is light spots below knees. Most important legs looks normal in shape. No waves, legs are smooth and even. I do not remember when I did see my legs like that. I worried, my legs took abnormal shape and never ever would looks normal again. So nice to be wrong.
     In the morning my man wrapped both legs again. At day time there is no pain. Pain come at night when I fall asleep.
      Also I got delivery Yesterday. It is cream for wound care. Silver and sulfa. Good cream I would say. The infection and inflammation calm down very good under this cream.
     Second dress is guise bandage.
     Third dress is to worm and to soft the dressing. I use worming quilters use for quilts. I make 4" bandage and put it on legs as bandage to wrap leg to provide warmness and comfort. It workss very very good.
      Forth dress is compressing bandage. I use pins to secure it does not drop down with move. I tried all what usually nurses use. It left a lot of irritation on my skin. Now I use pins only. It is face, secure, and pretty convenient. Also it is not expensive.
      Lastly I put compressing sleeve. This sleeve secure all dressing in place and so makes wrap secure warm and comfortable.
      Lastly I sleep a lot. Yesterday I fall asleep about 6 pm. I woke up today shortly before 5 am. Now at 7;30 I am sleepy as I did not sleep all night. I slept very well. As I said, wrap was taken off, no pain.

via Ravenvoron

Diabetes type 1 scam and reality. November 28, 2017

Interview with professional Soccer Star. He is Diabetic type 1 since age on nine.

I know that when I was growing up with the disease, I looked to athletes playing professionally and they were huge inspirations to me. I hope to be that for the younger generation as well as getting out and being able to talk with them and let them know that anything is achievable even with T1D.

True? Scam. Diabetics limited in their dreams.
         A lot of professionals out of their goal. When I was kid I dreamed to be a pilot, to fly in sky!  I knew, my health has such problem that I will not be able to pass health requirements. So, I abandoned my dream. Simple, it is not possible to reach when one is diabetic.
        Still, other jobs are available even they are not  not for diabetics. Simple, do not show up, you are diabetic, hide it, and hide it good. I passed every year my health tests when I worked as dispatcher high voltage stations, 220,000 volts. I cheated nurses and doctors, and almost never go to clinic, especially when I feel ill. This let me work 20 years on the position which would be out of choice as soon as diagnose of diabetes or high blood pressure made.
      This is what I will say that Soccer Star actually great dishonest man. He is fake. He cannot be inspiration for children. There is nothing true.

It can be very tough but what I have been trying to tinker with is giving myself some insulin before I play so there is a little insulin in my system when I’m playing.

This part I did not understand.What really Star is talking about? Why this is problem for me to get the point? Well, when I go out for Lincoln Center or shopping I do know I will have more activity then usual, and it would be less possibility to deal with low sugar. So, I prefer to keep numbers higher then usual, and do try to avoid low numbers.

If there isn’t any than I notice my blood sugar spikes even though i’m running around like you said.

        Does Star know what he is talking  about? I do not think so. It is pure scam. To take some insulin means nothing. There must be number what one inject, in units. Star looks like have no one idea what he is talking about. Next I will say, how it is possible that he notice his sugar spikes? Just say me, how it suppose to work? That dose of insulin was too small and he needed more insulin right in the meddle of the play?
        It looks for me that Star pretend, insulin like candy. One more is too little, one less is too much. But if Star really has issue with diabetes then it would understand things differently. There is no way to play with insulin injections during the game. Every one diabetic understand it.

 For dinner, I try to focus on eating less carbs and having more proteins and fats. I feel that this helps my blood sugar stay stable. So I usually have some type of meat (chicken, fish steak) with vegetables or a salad.

 Scam! Scam! cam!
Really, how salad can provide energy to play professionally? If I do eat salad it is Ok. I am stay home disable person. But he is not disable, he is professional player. And he eats salads for dinner to keep numbers under control? Really? He spend more energy then any non athletes do. So, this energy come from where?

I use a Dexcom G5. I would highly recommend it to other type 1s. It makes it so much easier and really helps you catch your blood sugar before it gets too high or too low.

Scam. Pure scam.How one can play with this system on the body? And I do not see the system attached to the star right on the picture. Most important, how this system helps to catch numbers? Just say me, how really it is working? The Star run to goal line and then he feels he need to inject some insulin. He stops. He inject some insulin. And then he score under joyful cheering of the crowd!

 My main message to kids is that anything is possible even with this disease. I made the decision not to let it hold me back from doing what I dreamed of doing and my message to them is that with hard work and really trying to control your blood sugar, the same thing is possible for them, whatever their dream may be.

I do have another message for kids. Do not listen the scam, do not take scam as inspiration. Use your own brain. If it happened one is ill then it is not the end of the everything. Find another way to live your life. If one love soccer but too ill to be pro take carrier in journalism, or medicine, or any other field. Life should not be hard work. Life is greatest gift we do have. It is really scam that everything is possible. It is not. But it does not mean that happiness impossible. We will find our way to live, and to be happy in our lives. Just do not follow inspiration. Be inspiration to yourself. Do not follow scam.

via Ravenvoron

Gringotts

One last story from our Universal Studios vacation:

We arrived at Gringotts, the goblin-operated bank frequented by the characters in Harry Potter. We stored our belongings in the lockers provided. No bags were permitted on the ride. Before a similar ride that morning we'd stuffed our pockets with airheads candy before stashing the rest of the supplies in the locker. This time we forgot.

Ten minutes into what was reported to be a 35 minute line to board the ride, the Dexcom alarmed.

"70 with a down arrow," my daughter reported. I had one airhead left in my pocked from the morning, which I handed over.

Three minutes later, the Dexcom alarmed again.

"It's double down now and says I'm 55."

"Do you feel low?"

"Yeah- I can't wait here."

There was a staff member nearby.

"My daughter is having a medical issue," my husband explained." What's the best way to exit?"

"Just walk up this ramp and you'll get out."

"Is there any way we can skip some of the line when we come back- it'll be about 10 minutes we think."

"Yes- absolutely- just tell the person at the entrance that Maya said you can come in through the express pass entrance. It shouldn't be a problem."

"Awesome- thank you so much."

So we went out and emptied our locker. We sat on the ground near a statue of a goblin holding a stack of gold while my daughter checked with her glucometer (55) and drank a juice.

We waited there a few minutes, people-watching.

"You feeling a little better?"

"Yeah- I'm definitely coming up."

A recheck showed 68. She ate another airhead for good measure, and we stuffed our pockets full of them before getting another locker.

The staff member at the entrance allowed our reentry through the express line, and with an elapsed time of under 15 minutes, we were soon standing next to the people who had been ahead of us in line before we exited.

The ride was great.


via Adventures in Diabetes Parenting

High Carbs, Low Sugaar, and dose of insulin. November 26, 2017

Sugar is 86 mg/dl, Fasting.
     Yesterday we went to Metropolitan Opera, so it was something different then usually I use as my routine. I took 120 units in the morning and we left  for the Lincoln Center. Then we come back about 6 pm, and I injected another 120 units.Last shot 120 units was before night. So total was 360 units for 24 hours. It is 40 units down as lastly I take.
      Another point about my blood sugar, I take a lot of sweeties. Usually I do not eat so much sweet staff. But recently I just burst up and it is too much for my diet. My study is, how high carb diet with many sweeties every day, one day after another would effect my blood sugar. The result is very surprising. Not only sugar went down, but the dose of insulin decreased to keep sugar in normal range and do not let it go low. Really surprising result.
       I posted that  I lastly I took up to 500 units of insulin. There were two types of insulin, Lantus Solo Star and Toujeo Solo Star. For my big surprise sugar went up and up. One after another day after day I added units of insulin, usually Toujeo. Also I started to feel very ill. Edema went out of control. My legs started to swell as balloons. It is not only the problem they increased dramatically in size. There is pain inside, in the area around bones. The spots were so painful that I hardly was able to keep wear wraps on my legs. I started to suspect that I need more and more units of insulin to compensate Toujeo.  Not good way to go. So I dropped Toujeo all at once, and not I do take only Lantus Solo Star.
      The color of my legs is much better. There is no wetness or any leaks on my legs. Legs are dry. But still there are wounds, dry wounds, but red spots with pain deep inside. I think that I need some different treatment then I use. Today I ordered compression sleeve. Actually I order all supply on Amazon. MD give me Rx, but there is my duty to find where to find this supply. So, Amazon is only place I can order it. So, I have to pay by my credit card. They do not use Rx and do not work with medical clinics. even my health plan would pay for this supply I have to pay out of my man's pocket all supply I need to safe my legs.
      Usually it is very important if one lose weight. Also in all Diabetic's forum it is all the time posted that we have to test blood sugar level. So, there are two stamps in our medical discussions:
See your doctor;
Test your sugar;
Lose weight;
Life style modifications.
It is so boring! But usually it is all what every one educated diabetics type 2. Lose weight!!!!!!!!! Say me, why it is so important? Just a few days ago I got book, re-printed copy of 1917 diabetes tretment and diagnose. In the begingin I thout there is nothing interesting for me. I was wrong. It is really interesting to see :
how treatment was right or wrong 100 years ago;
what recommendations and treatmnt options were given to diabetics;
how they survived and for how long?
 When I will start to read this book I will post something from it. One point already attracted me. Author gave many tables. One of them weight of his patients. Usually it was 52 Kg (about 104 Lbs) and very often less then that. People still have diabetes and died in coma. With so low weight diabetic did not survive. The treatment at that time was Starvation diet to extend diabetic's life. The choice, to die due to diabetes, or to die due to starvation, or both.
     My recent studies shoe, there is no effect how many carbs I do eat. Level of sugar and dose of insulin effected by something else, but not the amount of carbs or calories.

via Ravenvoron

Diabetes: Immune system can regulate insulin, so what? November 25, 2017

Inflammation processes are responsible for the failure of insulin production in diabetes patients. The patients' own immune systems can contribute to treatment of this disease: researchers have found a feedback mechanism that could help maintain insulin production in overweight sufferers.
 http://ift.tt/2zBrR4m;utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

How it is easy. Just read it. The publication is small, easy to read, and open all the absurd we will find in every one of presentations and studies like that.

 In their study, the Basel-based researchers focused specifically on recently discovered ILC2 immune cells in the pancreas, where, under diabetic conditions, the protein IL33 is activated, among others.

What is "Diabetic Condition"? No one clue. So under this junk studies it can be studied all what one wish and presented any result studier wish to publish. Shame!

 This protein stimulates the ILC2 cells, which trigger the release of insulin in overweight individuals using retinoic acid and could therefore be used to inhibit the failure of insulin production.

Another scam. ILC2 stimulated in overweight people, right? What about underweight people, does ILC2 stimulated in them? Those overweight are adults or children? What is the cause of diabetes they do have? As long as I do remember there are many different causes of diabetes. In one case it is fibrosis, in another case it is hyaline changes. And it can be both at the same time in the same individual. Do not mention other pathology of diabetes. So, in what case Ilc2 stimulated to release insulin, and when this stimulation is failed?
BTW, if it was study of individuals under diabetic condition, then probably it is not head but it is tail, the result of diabetes condition rather then normal non diabetic insulin release, right?

It is already known that obesity and diabetes lead to an excessive, pathological activation of the immune system in which the messenger substance IL1-beta plays a central role. This results in the death of insulin-producing cells.

True? false. If this was true then there would not be overweight people without diabetes. Operatic Sopranos really overweight. They could not sing if they diabetics. Diabetic's lungs are severely effected by medical condition we do have. This is why we do have asthma and COPD.
    What if true is on the other end of the story? What if immune system activated because of diabetes,  fibrosis, other beta cells destruction? We all do know that diabetics type 2 can live about ten years after being diagnosed with diabetes type 2. No more. If diabetic type 2 does not start to take insulin early then less then ten years and diabetic will gone: stroke or heart attack, high sugar or low sugar, appendices or flu, Asthma or pneumonia. 

However, if IL1-beta is blocked, diabetes and its complications -- in particular cardiovascular diseases -- can be inhibited. Diabetic inflammatory reactions are already finding use in clinical applications.

This is why I try to avoid hospital as much as I can. We are just Guinea Human Rats for them, MD and Labs.  I hate to be Rat. I try to find MD who will see me as person with all my pain and surviving energy.
    Really what this studies about? What they found? What did they were looking at? That's right, $$$$$$, and they found it. Simple. Brilliant. Shameless.

via Ravenvoron

High Carb Diet, Low Sugar Results Post two. November 24, 2017

So, I still looking how sugar will go all day long today. Right now it is 95 mg/dl at 11;39 am. I feel 'low'. I went to kitchen and took second meal for today. I did not take so many sweets as I did Yesterday, but still I take it, and I love it! Usually my man try do not buy it because it is too much for me to refuse to eat what I like. Still it is Holiday season, and he try to please me and give me something nice and lovely. I am good all year long. With my so painful legs IO still functional, and it is really very good.
 So, second time for today I feel low sugar. Yes, 95 is far away to be considered as low sugar. Still, when I feel "low' sugar drops so fast that if I try to ignore first call the second call I probably would not be able to care for myself. So, I try to react on first call.
      Usually we educated that with low sugar we have to adjust dose of insulin, to drop it, to take less units as usual. It is wrong way for me. I tried. Some days my low was so low that I was in great fear to take any dose of insulin, any injection. But after injection and short sleep I feel good. With every time low sugar does not drop so low, and I can feel it long before sugar drops to uncomfortable or danger low level. Today in real count there is no low sugar. But I feel it is low and I take actions.
      On my table there is thermos with sweet hot tea. Also there is protein bar and some dry bread. So, if I do feel low I just take this tea, and  I am good to get to the kitchen.This way is comfortable and very convenient.
     OK. I do not drop dose of insulin with every time I do have low sugar. Still if sugar getting low one time after another, one day after another, and this is not as low as 40 mg/dl. I do not have so low sugar anymore. It is is past. The same way I do not have 400 mg/dl and higher anymore. Usually it is under 200 mg/dl. As a result of this control low blood sugar is higher then 50 mg/dl. Today fasting was 65 mg/dl. Not so bad.
As I just said, sugar level drops, but I still take sweet candy and other sweeties.

via Ravenvoron

High Carb Diet, Low Sugar Results. November 24, 2017

Sugar today is 56 mg/dl. Fasting.
It is a little low today. Still it is not so low to any worry about it. I went to kitchen and took my meal. I forgot to take shot before meal. I already took all meal I usually do, and still not really full. Now I recalled, I did not take my shot before meal. Big mistake.
       What really is so significant in today's level of sugar that it is Friday after Thanksgiving Day. Yesterday I ate all what normally I have not to eat. It is not only the meal I took, but quantity, and what one meal followed to another. Full mess up. Too much salt. Fish was too salty, very salty, and I took two big rings, fatty and round with fat running out of it right to my fingers. LOL, I love that fish. Later it cost me additional Nexium capsule, 40 mg. One 40 mg I took before dinner. LOL!
    Next after salty fish was sweet candies, and another sweets. My Goodness, I love it! It is very bad to take sweets after salt fish. But to take salty fish after sweets even worse, so I did right choice.LOL!
I was so full I could not move and right after dinner I took my bed and fall asleep instantly.  Night before I almost did not sleep because of wrap on legs, and severe not bearable pain. Yesterday my man re-wrapped legs and there is not elastic bandage on them so no pain, and I could sleep sweet as my sweet dinner.
     After such eve what I suppose to expect? Sugar over the sky! It is low. I took Yesterday the same dose of insulin as day before without so crazy meal, 400 units. No one unit more then usual. So, why sugar is low rather then be high? Mystery.
     Right now at 10 am sugar is 135 mg/dl. I already injected 227 units of Lantus Solo Star. I took my meal at 5;30 am and then left to bed because of I was too sleepy. Now I am up. Sugar is normal. I took another 100 units. No meal so far.
I am wander, is this really the case that sweet candy will rise sugar if sugar is low? It never happened with me. But there are two different way to be. In one way sugar really go up, but it does not let me to feel good. I need nutrition, and this nutrition does not come to cell with sweet carbs. Carbs still in blood, even it is high. Another way, it does not work at all and sugar really do not go up. In case of low sugar I never took readings and sweet candy to bring sugar up.
      What I do remember that sweet tea did not work for me and sugar dropped very low even I sipped tea all the way. We went to hike and I did not have any meal but tea only. Sweet nice tea in bottle. We even did not have nuts I usually carry everywhere. Hike was lovely but at one point I started to worry I cannot take way down to the camp spot. We turned and went down. The tea was all the time in my hand. I seeped it all the way. With every step I became weaker and weaker. At the time we descended from the mountain it still way to go to the spot, and I was not able to walk. My man rushed to the camp, took some meal and returned to me. Now I could move. On camp I took meal and went to bed.
         So, for me it never worked. I take nuts and coffee, protein bar and cheese, pretty fatty I will say, but really good in case of low sugar, and easy to carry. In hot Summer it is difficult with protein bar. It is melting. Cheese is good. But I never carry on any candy or cooky. It is useless.

via Ravenvoron

How to Spot an Eating Disorder by By Mary Elizabeth Dallas.

It's estimated that 30 million Americans will have an eating disorder -- such as anorexia, bulimia or binge-eating -- at some point in their life.
How to Spot an Eating Disorder by Mary Elizabeth Dallas.
http://ift.tt/2BavaMZ

So, from 321 million of all American's population 30 millions have or would have eating disorder. In this point it is necessary to find out and diagnose disorder as early as it is possible, and start treatment.  So, what is 'eating disorder'? and how to diagnose it?

Binge-eating: Binge-eaters consume large amounts of food very quickly, stopping only when they are uncomfortably full. When bingeing, they tend to feel out of control. Binge-eating is hard to identify because it may happen only occasionally. This behavior can continue for a long period of time before anyone notices.

Binge-eating is easy to identify. Just put victim on bathroom scale and there is diagnose, Binge- eater if weight is higher then standards on BMI  determined back to 1850. Simple. Reliable.
      What about water? what about those victims who suffer of obesity due to edema? Demand they stop to drink water? It does not work. And BTW regardless how much diabetics drink water when they are under siphon effect, they lose weight, never gain it.
      What about bones? Did someone compared weight of bonce people in 1850 and weight of bonce population 2017? No one. But bones weight is highly effected by diet. Easy to see at Chinese girls and Northern girls.
      So, Bathroom scale do not give answer if one has Binge-eating disorder or not.
     We see one is eating fast and out of control. Eating disorder? No. It is diabetes type 2, not diagnosed not treated. In America more then 8 millions do live with undiagnosed untreated diabetes type 2. Why these people eat too much? In system they do not have insulin to convert food into energy. When they eat they are never full. They are all the time hungry and trusty. They must be diagnosed with diabetes but many prefer do not take this diagnose because it will be very difficult to find the job, to find medical coverage, and many more limits. so, people hide there condition as long as they can.
        Another visual Binge-eaters are diagnosed diabetics type 2. They do have medicine which drop sugar too low. In this case eating is only way to prevent coma. Also it is important to understand when they start to eat they are more hungry then before first bite. Then more they eat then more hungry they are. No meaning of meal, no taste of meal, just not controllable hunger. It is diabetes type 2. These people have to take insulin and with insulin they will not have this condition such as Binge-eating. Even when sugar is low small dose of insulin will prevent Binge eating, and even make diabetic full without any meal.
      This tip never in diabetics' education. all treatment and education is only one, lifestyle modifications. No one do know what modify and for what it must be modified, but every one talking about it, and proud, they modified their lives. Really? How?

Bulimia: People with bulimia are always dieting and hiding food. They may eat to the point of discomfort but only when no one is watching. After overeating, people with bulimia force themselves to throw up, usually by putting their fingers down their throat. Marks on the back of their hands may indicate bulimia. Routinely using laxatives or going to the bathroom right after eating are also signs of bulimia.

What is overeating? It is condition when stomach cannot take more food in. Where this eating disorder come from?
      It is strong public believe that overweight people always overweight. It is not. The condition when diabetic has small stomack  but demand in food is high the bulimia disorder takes a root. It is the same with those people who undergo weight loss surgery. They do have small stomach but after three years us ally they start to pick up pounds, and they need another weight loss surgery.

Anorexia: Weight loss is one of the most obvious signs of anorexia. But even when they're drastically underweight, anorexics may still think they're too heavy. Some people with anorexia try to hide their thinness beneath layers of baggy clothes. They may eat just one small meal, always say they aren't hungry or avoid starchy foods or carbohydrates. They may also avoid social situations, and exercise excessively. Anorexia can lead to dizziness, concentration problems, pale or dry skin, trouble sleeping, weak muscles and thin hair. Girls and women with anorexia may also stop menstruating.

      Why this eating disorder? This is Social disorder. The media so aggressively push on weight loss that it is only what remained on TV to see. No one movie, TV show, Medical Clinic, any gym discussion or forum left without discussion of weight problems. Lifestyle is only one important subject to discuss. Loos like there is no life only weight loss. People look at each other and see only amount of pounds around middle are. If one occupy wide space then people see that person ugly, stupid, and ready to give lesson in way of abuse and humiliating.
      Some people can eat twice as others and be half of others in size. No one will see they do have eating disorder. No one clinic discuss their medical condition and why they still skinny. really it is not healthy. But in our society they are OK. Those who are healthy but not fit into standards of 1850 they considered to have behavior disorder, misconduct. So, those people are not really do have eating disorder. They do have behavior disorder.
      So, what is eating disorder? If this is disorder then there must be diagnose and treatment options. If treatment is lifestyle modification then it is something different then medical therapy. We remember how wrongdoers were treated in former Soviet Union or by Nazy. We cannot live as we wish, eat what we want, watch movies, or anything else. We have to practice diet, go to gym club to shed some weight, wright journals input - output.
    Really what disorder do have author of this dirty brain washing propaganda?
    Mary Elizabeth Dallas would you please identify your disorder? Greed? Dishonest? Aggression?

via Ravenvoron

#WaybackWednesday: Diabetes And The Energizer Bunny

A #WayBackWednesday pic that will hopefully make you chuckle!

I shot this pic from a rooftop terrace on the upper WestSide, Thanksgiving Day, 2011.

1. It reminded me of people with diabetes, because we keep going.. and going...and even when we don't feel like it.

2. Also, I immediately checked the status of my pump batteries...just in case! 

Sidebar: I originally posted this picture on the blog in December, 2011.

Just like people with diabetes, the Energizer Bunny keeps going...
and going...and going.

via Diabetesaliciousness

Why Sugar Get Low and what to do with it. November 22, 2017

Sugar is 137 mg/dl.
       It is a little bit too high for fasting. I need it around 100 mg/dl. Yesterday I injected only 300 units of Lantus Solo Star. I was ill all day long. I did not  take last shot. Simple, did not have energy to take it. I went to bed early and fall asleep instantly. My hope was that 300 units would be enough for day, and I was wrong. I need more then 300 units.Today even it is only 10;30 and I woke up at 8 am I already took two shots 80 units of each. I try do not put all eggs in one basket at once.
      I all the time hoped that dose of insulin will go down. It did not happen. Dose of insulin go up and up. I have to consider 400 units, and probably even 500 units. I am lazy now. I do not take reading every hour. I am not so brave to start a new regime without study. Probably a little bit later I will take these studies and make needed adjustments.
       In one case of autopsy I read that girl died in coma due to diabetes. Even small dose of insulin dropped her into low sugar. What I do thing that her sugar was so high that she needed special regime of insulin therapy. It is not the case she did not need insulin.  It is all the time supposed that if sugar is low then insulin is high, It is not. The small dose of insulin was good fer this girl. Then she must take not Glucose or sweet tea, but chicken brow, something work to eat. At the same time the another small dose of insulin, and so so on. Small dose of insulin, good nutrition, not sweetness or candy or anything sweet, just nutrition. Soup is good. It is all the time best way to keep sugar under control, especially when sugar drops sharp and unexpectedly.
      I cannot give good scientific explanation why this regime rather then what used in hospitals in modern time. It is my experience, and this experience is real, it worked. I was in condition closer to the final breath. And I was able to manage it. This is all the time biggest mistake our MD educate us. It is all the time said, when sugar getting low we have to decrease the dose of insulin, and this regime never works. Why? I do not know. But it does not work. I tried to find out when I have to start to decrease dose of insulin, and I sill not able to get it. Right now dose of insulin getting up and up. Yesterday 300 units give me fasting sugar 137 mg/dl, high number.
      Another good reason to think if really I need to decrease dose of injected insulin is that probably insulin not only convert food into energy as we all educated, but also make a hole patch work. As We all do know insulin is released by Beta cells. When the amount of these cells decreased the sugar in blood goes out of range. Then more Beta cells destroyed then less insulin is available to be used. This is why diabetics type 1 take insulin, to replace limit of insulin secretion with the insulin injections. Diabeties type 2 is not acute but chronicle type of diabetes. The distruction of Beta cells takes place long time. At the time when diabetic finally get insulin there are very few active Beta cells remained. Of cause it is only mine own speculations.
      Now with insulin injections more and more beta cells returned to the function. Still, more is needed. There is why dose of insulin increased. It is process of active recovery. In stage of recovery we still ill, not healthy. We also need more rest and more attention to the health. Probably we even can be more ill then before process recovery started. What happened after surgery? One is ill, cannot even take care of him/her self. But still, it is temporary, and it is way to recovery,
     It is usually every one do know, Hope Die Last.
     I do have headache today. It is rainy day in NYC. Probably I do have BP.

via Ravenvoron

Diabetes, Labs, And Taking A Beat Before Clicking On The Link.

Back in early August, when I was dealing with a nasty viral infection that made me break out all over and feel like crap; required a slew of lab work and forced me to finally signed up for LabCorp’s patient portal. 

Bottom line it made communicating with my GP's office easier, especially since the staff was in rotating vacation mode, which resulted in unreturned phone calls re: my labs. 

I’ll admit that it was cool to see years worth of my lab work online, at my fingertips, and organized in one place by date and doctor.

At the time I thought it was great. But last week? Not so much.

######

Cut to last Wednesday afternoon. 

3pm, me deep in thought and working on a project that was due on Friday.

I took a break, opened my email tab and immediately focused on the Subject Line  of an email from labcorp, letting me know that my labs were available online.

All I needed to do was click on the portal link and sign in. 

 INSTEAD, I IGNORED IT. 

I knew if I clicked on the link,I would be either happy... or I wouldn’t - because of my a1c .

Clicking on that link would take me down the rabbit hole of numbers that I didn’t have the time or mindset to go down.  

And at that moment, I knew I was reaching the brink re: my diabetes numbers breaking point. I took a beat, told myself my Endo appointment was the next morning and I would go over the results then.

It wasn’t easy to ignore the email.... at first. 

Seriously, (like for the first 20 minutes,) I kept toggling back and forth between screens. 

But slowly, I forgot about it, except for when I didn't - but I never clicked on the link.  

Cut to Thursday morning at my Endo’s office. 

I sat in the exam room with a slightly elevated blood sugar and a normal blood pressure of 120 over a number I can’t recall. 

Dr. J walked in, said hello, shook my hand and stated: The good news - your A1C didn’t go up.......It’s exactly what it was last time you were here.

And at that moment I was so glad I'd stayed above ground and hadn’t clicked on the link and ventured down the diabetes rabbit hole of numbers and what-ifs. 

I would have lost focus and been upset for the rest of the day. 

Today, I wasn't thrilled, but I  ready to talk it out and make some changes. 

Sidebar: I know a 7.4 A1C isn't terrible - it's not.
But honest to God I really thought that I'd made strides since the beginning of August. 

I'd started on the Omnipod, (and really like it,) I'm taking less insulin per day, (by at least 10+ units,) and I thought my A1C would have reflected that. 

I was expecting it to be 7.0 or lower and not stuck in an the same a1c moment - and I told him that.

I was frustrated with myself and with diabetes - and I knew Dr. J was too - even though he remained calm and kept his game face on. 

We talked it out. Dr. J asked me what changes I’d made that led me to believe my a1c would be lower.

I told him about cutting back on my daily insulin intake and how I’d been trying to eat healthier. 

He asked if I’d been sick or dealing with anything that might have contributed to my A1C.

I explained about the viral infection that had me down for the count for parts of July and August... but it was November 18th. 

I was grasping at straws and we both knew it. 

He asked me if I thought I was getting enough exercise.  

I was honest. I told him that needed to do better in that department. 

And then he asked if I’d downloaded the Glooko app on my phone so I could download  my Omnipod PDM’s info, share it with my Sorceress of a CDE, Cheryl - so she could work her magic and help me. 

“Cheryl’s really knows what she’s doing,” he said. 

And she really does - and we'd discussed me getting my info to her via Glooko when she was training me on the Omnipod. 

I told her I would - and I talked about doing it. 

But I didn't.

Clearly I needed too.

Calmness prevailed and Dr. J pointed out the many good parts of my labs - and I love that he always points out the good. ALWAYS. 

We both knew what I needed to do. 

And then I blurted out how I’d ignored yesterday’s email and he looked a little surprised  - and then he asked me how come. 

Me: I knew that if I clicked on the link and it didn't take me to the number I wanted to see - I wouldn’t be able to concentrate or get things done. I’m always dealing with numbers - I knew I was seeing you this morning. I needed a break, so I took one. 

Dr.J: OK, fair enough. Get the Glooko app and set up an appointment with Cheryl for December. I'll be right back, I’m going to see if we have any insulin samples for you.

When he came back with insulin in hand, I had downloaded the Glooko app. 

And now, I'm forging ahead. 

via Diabetesaliciousness

Day-by-Day. November 20, 2017

Sugar 75 mg/dl. Perfect sugar.
      For today I injected 374 units Lantus Solo Star. Now I take only Lantus Solo Star, no Toujeo anymore. Dose of insulin dropped. Right now I cannot take 500 units of insulin. It would be too high dose to inject. I injected 374 units, but I think tomorrow I will need less then this dose. Sugar is already on the road to low numbers, and I do not like to have low sugar. It is stress, and after stress system try to return to the balance, so sugar usually high. Swings from low to high and back to low.  It usually takes time to return to the medium.
       My legs are wounded. Both of them. It is difficult for me to keep them from getting watered. When I wrap them, there are wounds from wrapping. If I do not wrap, there is wounds because of edema. Pain located deeper inside, somewhere around bones. Pain of wounds which no one can see. They are invisible.
      We went to The Met on Saturday. I parked my scooter near restroom, and when I done the house was just opened. People went in. Two old ladies stand next to my scooter, and I could not pass them to take my seat.
"Excuse me,"- I asked a few times. Lady, my goodness, why do I call this bitch 'lady'? pretended she cannot hear me. I cannot stand. Also I just walked pretty long way from bathroom to the spot. My heart jumped over the head. I am 377 pounds. It is visible to every one why heart does not work correctly.
     As I just said, no one see my wounds, or tightly wrapped legs, so hard to stand or walk, but every one see 377 pounds, and hate me that I still alive. So ignorant people. It is good to do not have brain. At least one can pretend to be smart.
      Finally people went in, and I was able to ride to the another door to park my scooter and enter to the house. I have to go to the Family Circle, it is steps up. With my tightly wrapped legs it was very difficult. Also two legs work differently and every time I have to find leg which would be able to hold my body weight till I move another one to the right position. I am still happy, I can fit into seat. It is tight, but still I can sit in it. So, I took Nitrostat, Symbicort, and full hand of Ricolla. It is how and dry inside of house, so, we all start to cough.
      Today it is Monday. Tonight I got another problem. It is my Bi Pop. All night I had nightmare. By morning my man woke me up. Container was almost empty, just for one night. Usually it is half of it for one night. When I took a look at the machine, it was said that mask was good. If so then water go where?
     My sleeping machine is Bi Pop. It works in two ways, in and out. When I put it last night it was not in-and-out. The pressure was way too high, and no in - and - out. My Bi Pop operated by some office on distance. So, someone easy to change regime of my machine. It is not first time I feel that regime of my sleep machine changed. Every time it is nightmares. Last time I could not breath at all, like suffocated. Now it was not the case, but still too high pressure did not let me to sleep.
      I woke up with severe headache and I needed to take a few Nitrostats.
      It is nice I do have C Pop. This is not so sophisticated machine but easy to operate and reliable.

via Ravenvoron

Possible Cures for Type-1 in the News (November)

Merck Cancels "Smart Insulin" (MK-2640) After Unsuccessful Phase-I Trial

This is the news everyone hoped we would not get.  After completing a phase-I trial of "Smart Insulin" (also known as MK-2640), Merck has decided not to move forward with it.  They have not published the results, but have published this: "MK-2640 was discontinued due to lack of efficacy".

News report:  http://ift.tt/2m8QJdn

Discussion

This was the first (and so far only) glucose responsive insulin to be tested in humans.  However, there are several "smart insulins" being tested in animals, not to mention "smart artificial cells" and "smart membrane" based technologies, all aimed at automatically regulating the amount of insulin in the blood stream.  I expect some of these to enter human trials in the next few years.  So "smart insulin" may yet be a trail blazer, even if it itself was unsuccessful.

If results from this study are ever published, I'll blog on them here.  However, there is nothing forcing Merck to publish these results if they don't want to.

Phase-II T-Rex Trial Update

Caladrius Biosciences recently announced that they had enrolled the 70th patient (out of 111) in their clinical trial of CLBS03 for T1D.  So it has taken them roughly 18 months to recruit 2/3 of the patients they need.  If they can keep up that pace, they will finish recruiting in the third quarter of 2018, and finish collecting data in the third quarter of 2019, and publish in 2020.

Previous Blogging: http://ift.tt/29EX2ea

A quick summary of this treatment is as follows: remove one specific type of T regulator cell (called "CD4(+)CD25(+)CD127(lo)") from a person with type-1 diabetes.  Grow them out so you have about 500 times more, and then put them back in the same person.  Since regulatory T cells naturally regulate the body's immune system, and the patient now has more of them, the hope is that they will prevent the autoimmune attack which causes type-1 diabetes.

They are recruiting patients in about 15 locations all over the US, so read the clinical trial registry to get a complete list and some contact information.

News Report: http://ift.tt/2j9RL3V
Clinical Trial Registry: http://ift.tt/1USxIpd

SIMPONI (Golimumab) Starts A Phase-I Trial In Pre-Symptomatics

Golimumab (sold as Simponi) is an immune system modulator, which has been approved in the United States and many other countries for treatment of several autoimmune diseases, so testing it on type-1 diabetes makes a lot of sense.  This is the second trial underway for this drug.  (The other one is called T1GER, and is for honeymooners.)  Simponi has already been approved to treat rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and ankylosing spondylitis.

This study is recruiting people who have two autoimmune antibodies (but no other symptoms of type-1 diabetes). They are recruiting 30 kids (aged 6-21), and will follow them for 17 months. Each kid will get 26 weekly injections.  Half the patients will get Simponi and the other half will get a placebo.  They hope to finish this study in mid 2021.

This study is current recruiting in Linkoping University Hospital, Linkoping, Sweden, SE 58185.
Study contact: 844-434-4210 JNJ.CT@sylogent.com
They hope to start recruiting at other locations in Sweden and Finland soon.

The unusual thing about this trial is that they will not measure any effectiveness data at all.  The only data gathered will be safety and side effect data.  No C-peptide data, no A1c, or insulin usage.  That's very unusual for a type-1 diabetes study.  In my experience, even the phase-I studies gather some effectiveness data.

Clinical Trial Record: http://ift.tt/2j7d86a
Previous Clinical Trial Record: http://ift.tt/2zVJ6Ko

Joshua Levy
http://ift.tt/29DuN3o
publicjoshualevy at gmail dot com
All the views expressed here are those of Joshua Levy, and nothing here is official JDRF or JDCA news, views, policies or opinions. My daughter has type-1 diabetes and participates in clinical trials, which might be discussed here. My blog contains a more complete non-conflict of interest statement. Thanks to everyone who helps with the blog.


via Cure Research

The Pathology of Diabetes Mellitus 2. November 17,2017

       It is book published back to 1952. Interesting book. At that time there were no transplant and our bodies were no used as soon as we departed from this world. Actually I am very worry that if I go to hospital then no one would weight till I die. It is time, and time is essential. So, then faster organ removed from the body then less postmortem changes happened, so it is better to be used as transplant. There are many evidence when people come back after pretty long after-death experience. Before we die there is not simple line which we cross withing fraction of seconds. There are actually two lines. One line we cross, and looks like our bodies are death. But still our Soil inside. It did not left the body. Only after we answer to the question what hold us in this side we actually step over the second line, no turn. Today we do not have this time to return back to life when we are in hospital. Just no time for it.
      I really do not know if transplant are good or bad. It is often presented that lives were saved. Really, whose life? There is one pancreas for two bodies, one heart for two bodies, and so on. Whose life was saved? Whose life was taken? But it is not really question I am looking to find the answer.  My point is, what is diabetes and how it looks like when autopsy performed.
      There are millions of studies that diabetes type 2 is resulted by obesity, highly fat diet. When in my book there is one of the pathology, Fatty infiltration. So, this pathology confirm, probably , that diabetes type 2 caused by fat in pancreas or Langerhans  Island cells. If so then in all autopsy of type 2 diabetics it would be the same, infiltrated fat. It does not the case.
     As it is stated many times that diabetes type 2 developed later in life. The obesity is the mark to diagnose. Diabetes type 1 is immune system disorder, and type 2 diabetes is obesity disorder. But in contrary with this believe there are marks of the same, as in children such in adult such as Hyaline Degeneration. Hyaline is the substance which replace cells and when this process highly marked the diabetes occurred. Substance  which replace cells is massive, and in many times in large in size. This substance is not only in pancreas cells but in many other organs of diabetic's body such as spleen or blood vessels. The process start slow and with time it can be re-generated, so cells restore ability to secret insulin, With time more and more cells died, so process regeneration is slow, and finally there is no re-generation is possible.
      Some treatments and early diagnose can not only slow the process of degeneration of cells, but increas the process of regeneration if diagnose done early and tratmnt started early. This is why it is so oimportant that blood sugar level is vital. The treatmnt is with insulin rather then with life style modifications, the hell know what is it, or SU which speed the process of degeneration of cells.
     When we go to the forest and see the mashroom which is nice looking and healthy,we do take this mashroom in our basket. What if mashroom looks dark in color? with net of fibrisis, and with greay spots on it? This mashroom is ill, no longer eatable. No one of us will take it.
      Inside of our body many processes go in the same way. Does any one familiar that woman with history poly-cystic ovary syndrome are at risk to develop diabetes type 2 later in life, regardless if they eat right or wrong? Usually those of us cannot became pregnant. Only after surgery when those cysts were removed we get our babies. Why? Because of fibrosis is already started. The cells in our body ding. It is not visible from outside. No one diagnose made. We are ding. In past many woman died giving birth, and many died when they became pregnant. Now it is treatable and less woman lost life when get pregnant.
     Still, even we do not lost our lives during pregnancy and delivery, we do hive higher blood sugar numbers. It is suggested, this numbers would go away after delivery. In some woman it is true. Many of us still have high numbers but because of now there is no attention to the woman there is no treatment. Later we finally diagnosed with diabetes type 2, and all junk medicine to our disposal. No insulin. Insulin is for Noble type 1 who do have the same problem, but better life.    

via Ravenvoron

A Security Story

As we arrived at the airport security gate on our way to Florida, my daughter disconnected her pump. "This needs to be visually inspected. It can't go through any of the scanners," she informed the TSA agent.

"That's what you'd like to do?" was the reply.

"Yes, please."

We walked through the body scanner and met the agent on the other side. We stood near him as he swabbed the pump to check for explosives and then returned it to my daughter.

Meanwhile I watched our toiletries and my carry-on bag slide into the 'to be inspected' holding area instead of continuing along the conveyor belt to be retrieved.

The first thing I was asked about was the Frio insulin cooling case.

 

 

"It's a gel cooler for insulin," I explained. "It has a vial of insulin and an insulin pen in it." The TSA agent handed it back, satisfied with the answer.

He still had my large backpack. "Anything in here you can think of that would have caused this to be pulled aside?"

"Um- it's got lots of diabetes supplies...syringes, insulin pump infusion sets, glucometers...I'm not sure what might have caused the concern."

So the TSA agent, who was very nice, rummaged through the bag, pulling out every make-up case and Ziploc bag, methodically opening and examining them one at a time. When those were all on the metal table and the only things left in the bag were books and a few other obviously safe items, he sent the backpack through the x-ray machine again.

"Okay- you're good to go," he said upon his return.

I observed the collection of items spread around the metal table, all of which needed to be fit back into the backpack in a way that would enable us to access the important ones during our flight, and stifled a laugh.

"Easy for me to say," the TSA agent said with a friendly smile as we started to repack.

It's November...Diabetes Awareness Month! My plan for this month involves stories. Simple, everyday, real-life stories about living with diabetes. I plan to tell them here as narratives, like this one, just snippets of a day with diabetes, and I plan to tell them, or stories like them, more often in the 'real world' this month when friends ask, 'How's it going,' or relatives ask what I've been up to.  


via Adventures in Diabetes Parenting

The Pathology of Diabetes Mellitus. November 16,2017

        Finally I got the some point where at first there was definition that our MD use today very widely and aggressively. It is definition that diabetes type 2 is type of diabetes when body system does not use insulin properly. It is book published back to 1952. Very good book I would say. The book when authors study the pathology of diabetes mellitus, looking at the autopsy. The book is very good and I am happy I do have it in my medical library. Authors study many cases of Autopsy and what happened with diabetic, what diagnose of death, and for how long diabetic lived with diabetes. It is obvious today that diabetic live with diabetes longer, much longer then one was diagnosed with diabetes. Also in 1952 there were no glucose meters we use today, so diagnose of diabetes was usually controlled with  level of sugar in urine rather then in blood. This tools is less accurate and the level of sugar in blood show up diabetes faster then it is available with urine tests.
         I wish to say that today autopsy can be more accurate and even one was not diagnosed with diabetes in life diabetes can be diagnosed after death.
        One of most interesting points in this study was that Langerhans  Island show no visible changes in diabetic patient or rather to say corps. Why is this so? And also it was known that this diabetic was treated with insulin.
        There are many studies how people can get in rick of developing diabetes. There are no studies how diabetics effected by treatment we do have. In this book authors show that 33% of diabetics in study did not show changes in Langerhans  Island after death. 33%. Those diabetics were treated with insulin which means they were diabetics type 1. But there are only 5% of diabetics type 1 who today qualified for insulin therapy. 95% of us are diabetics type 2, insulin resistaant diabetics who considered to be insulin resistant or insulin independent. In any case we are nor qualified for insulin therapy. We have to take Invokana, Metformin, and lose weight by modifying life style. This therapy never worked. Diabetes type 2 is number 7 cause of death in US.
       What happen when diabetic type 2 start to take insulin? Diabetic getting better if the treatment regime is right. Some diabetics die with very small dose of insulin. I really have no one idea which dose of insulin is 'small' and when dose of insulin is 'big'. I take 500 units and no problem with that. Why dose increased so dramatically? It is edema. This edema leads to gangrene and amputation. There is no one treatment to safe my legs and arms. There is no one MD who will do anything about it. There is help I can have. Who is going to help? No one. So, I try my best to do something to keep my legs in place they are right now. I cannot take invokana or any diuretic. I do wrap every day, and buy a lot of supply for this reason. Also I use old t-shirts to make bandages.       

via Ravenvoron