The origin of diabetes. January 29, 2019

"If, as we established, the first alternative is correct one, the majority of genetic diabetes  should originate from the population of low insulin responders." (page 33)

Impact of Insulin 
on 
Metabolic Pathways
edited by Eleazar Shafrir
International symposium Commemorating
the 50th anniversary of Insulin
24 to 29 October 1971, Jerusalem, Israel
Academic Press. 1972

        So, if parents, one or both are low insulin responders then children would be diabetics in some time of their lives. It is if diabetes is genetic. So, diabetes type 1 is genetic disorder, and if left untreated in parents then children probably would be born diabetics.  But if diabetics would be treated then children of those diabetics probably would be born not-diabetics or just low insulin responders. With time less and less diabetics would be born. Perfect diabetes development prevention.
      As it is already was established, insulin is good to treat any type of diabetes in any stage of it development. It is just logical to assume that treatment with insulin is cost effective medicine in long term. Even if it is costly to star with, it pays back with time and with every generation of less violent diabetes development.
      Because of Low Insulin Responders never diagnosed due to they do not have diabetes symptoms, this insulin deficiency just grow with time, and in any time it can burst up into full diabetes development. Diagnosed in adult it would be diabetes type 2, very often mild to begin with. When it is left untreated or treated wrongly with oral medicine such as Metformin and SU the insulin deficiency became more severe and less then within 10 years after being diagnosed with diabetes type 2 and treated with SU and Life style modifications diabetic gone.
       On the contrary if it is taken into consideration that diabetes may be as flu, the same pattern, then treatment with insulin will fix insulin deficiency in some point, and then diabetic would enter into Honeymoon phase for years to come. The perfect prove of this point is Hallie Berry.

 A similar trend toward a diabetic-like response - in this case in lipid metabolism- has been demonstrated in some low insulin responders during muscular exercise. ..... thus, these subjects could be considered to be normal with respect to GT but diabetic at the adipose tissue level. Furthermore, a group of pre-diabetics demonstrated stigmata of the diabetic state. (page 35) 

       What does it mean? It means that diabetes is more complex then simple ration glucose load/ insulin response. It is started with low insulin response, mild insulin secretory deficit, then it move to pre-diabetes, more insulin deficit, and then one after another all stages of diabetes development with wider and wider gap between insulin secretion and level of insulin in demand. But even when pre-diabetes was diagnosed there still no treatment for diabetic. No insulin. Just restrictions in diet and increas in work out.
       About work out, would it be so healthy for diabetic to practice more exercise? When diabetic was in state of low insulin responder he already demonstrated stigmata of diabetes state. When insulin deficit increased the condition of diabetic worsened. To add more drama, there are restriction in diet, so there is limit in nutrition. Some elements even absent in blood because of there is restriction in diet. Insulin secretion dropping.
      It is very widely known that diabetics type 2 develop diabetes due to diet high in carbs and fats. But as it is easy to see, diabetes developed long before it was diagnosed. In diabetes liver respond to meal in different way then in non diabetic normal person. With first line of treatment
 when Metformin taken at first to prevent diabetes then to treat diabetes, and Metformin effect lived to restrict glucose release between meals, and  impact on muscles to increase muscles demand in insulin, how does this type of treatment can effect diabetic type 2? Meant transformed into fat, and insulin deficit increased. 

via Ravenvoron

Friday

It was 6:45 p.m.

My daughter had gone straight from play practice to meet friends who were watching the end of a wrestling match in the high school gym. The plan was to go out for dinner afterwards.

I received a text:

'Dexi is dead and the meter won't turn on.'

We knew the Dexcom sensor was set to expire before the evening was out. But plan B was that she had her meter and would be fine using that instead.

But now she was not.

I grabbed two AAA batteries and let her know I would meet her at the front doors of the school.

'But what if it isn't the batteries?,' my daughter wisely replied.

So I also grabbed her spare pink one-touch mini meter.  Since two dead meters don't equal a useful one, I popped in a test strip to check it, and, inevitably, its battery was dead. It takes one obscure flat battery. By the time I found a spare one of those, the contents of our 'diabetes box' were strewn across my daughter's floor and she was texting, 'Are you here yet?'

I pulled up to the doors, and she came out. She sat in the car with me and replaced the batteries in the regular meter. "Low meter batteries," it read.

"But I just put them in there- you brought new batteries, right?" I had, straight out of a container full of new batteries in the basement, I reassured her. Fortunately, the pink mini meter was working just fine so she was equipped for dinner.

She enjoyed her evening out and got home early enough to put in a new Dexcom sensor before bed.

The next morning I replaced the batteries in the usual meter one more time, and it worked.

Weird stuff can happen on any given Friday.





via Adventures in Diabetes Parenting

Low Insulin Response. January 29, 2019

        Sugar is 83 mg/dl. Yesterday I injected 307 units of Lantus Solo Star. Sugar suppose to go up. To add more drama I ate a lot of carbs before bed. Sugar must be high. But it is rather normal. Why? Really why?

 We have for several years postulated that a diminished insulin response to glucose is the basic pathogenic factor in the development of the different stages of the  diabetic syndrome. The presence of low insulin response in healthy monozygonic twins of diabetic parents indicates that this insulin deficiency is inherited and precedes the appearance of decreased. (Page 33)
Impact of Insulin on Metabolic Pathways edited by Eleazar Shafrir
International symposium Commemoratingthe 50th anniversary of Insulin 24 to 29 October 1971, Jerusalem, IsraelAcademic Press. 1972

        There are many different aspects that effect insulin response. Probably this is the point when it is stated that insulin  used not properly in diabetic's type 2 body system. As it is all the time the first question is, are there are insulin to be used? But it in sot the point of discussion for today.
        Low Insulin Response, what does it mean? The quality of insulin can be different so the glucose utilization takes longer time then with more active and insulin action. Of it can be deficit in insulin secretion. So, insulin secreted by diabetic's pancreas, but it  is come to blood stream too slow, so it takes more time to utilize glucose load. And one more point is that insulin do the job in utilization of food, but do not utilize pure glucose load.
        No one of this question is important for me to study. It is important to understand the pathology in insulin secretion and glucose utilization. For me as diabetic the point is only one: to keep my life longer and happier as much as I can.
       In contrary, there are a lot of discussions on every forum and in every clinic I visit: my life style. No one really know what life style I do live. Every one do know perfectly accurate, I live in the way they present as I do according to my body shape. This is why I try to post it here. There is nothing about life style we have to change. We need Insulin to be added into our medical box, so we can live longer and healthier.
       The diagnose of diabetes based on the GTT. The level of sugar tested for three hours after glucose load. Why? It is pretended that after three hour level of sugar return back to normal. It is not the case with Low Insulin Respondents.  My sugar going up  five hours. Then just less then within an hour it drops. Then test stopped after three hours the level of sugar in my blood is not highest. It is highest after five hours.
       When test to diagnose diabetes performed the time and level of sugar is not taken into consideration. But there is interesting question, what is really going on after meal? How really insulin and food interact? What signal to secret insulin, or there is already insulin in blood which our system uses, but this level of insulin is very low? Probably the expression "Low Insulin respondents" in fact just meaningless? If there is no insulin available to be used that say me, what suppose to respond to glucose load?
      There is really very important question, why sugar rise after meal up to five hours? According to common presentation, as soon as glucose loaded the level of sugar in blood rises. Also it is very well known that sugar return down to normal just less then two hours after meal. Now the question is, for how long sugar raised in healthy man? How fast sugar dropped in healthy man? What are difference between healthy men and diabetic man?    

via Ravenvoron

The choice for treatement. January 27, 2019

Impact of Insulin 
on 
Metabolic Pathways
edited by Eleazar Shafrir
International symposium Commemorating
the 50th anniversary of Insulin
24 to 29 October 1971, Jerusalem, Israel
Academic Press. 1972

This is the book right now on my table. It is book I even did not imaging could exist. It is all about Insulin, Study of Insulin, and treatment with insulin.  In this book I found answers to many my questions.

• Most important answer is, injected insulin treat all types of diabetes in any stage of diabetes development. 
• The second important answer is that all oral medicine does not improve diabetic's health and in long term is danger for diabetic, destroy healthy right working organs and tissue.  Any oral medicine as it was in past the same it is in present. 
• Another answer is that diabetes is curable if cure start with right treatment and early diagnose. Children who were born to mothers who had low insulin response but never developed diabetes, might be born diabetics, or develop diabetes later. But they are not considered to be in risk to develop diabetes, so they would be diagnosed later when diabetes would be fully developed.

        This is what I use to say all the time, level of sugar in blood must be Vital. With this test diabetes can be diagnosed very early, and treated on-time.
       Treatment for diabetics is Insulin, first line, and add on dose of insulin as second line. More then that children may have insulin injections as it is vaccination at birth, and then all school years. This tactic will prevent diabetes development in adult and will give to children needed strength to grow and development.
       Early diagnostic of diabetes and early Insulin Therapy will prevent such complications as Alzheimer disease, and blindness, stroke and MI, kidney failure and liver disease.
      Once I was on forum, and all Old Woman recommended to buy and to read :"Think as Pancreas" book. I do not remember the author. I do not read contemporary books. Too bore. All what they are able to publish just what to eat and how to live. Really, just read one of them and all other just replica one of another.

Impact of Insulin 
on 
Metabolic Pathways
edited by Eleazar Shafrir
International symposium Commemorating
the 50th anniversary of Insulin
24 to 29 October 1971, Jerusalem, Israel
Academic Press. 1972

 It is different in all aspects. There is Gold and Pearls on every page. There are answers on all our questions. If one has question then just open the book and answer is in it.

via Ravenvoron

Why insulin is not number one medical choice? January 27, 2019

         All the time I just wondered, why when any studies were conducted all medicine was taken into consideration, but never insulin. Really why? The matter of fact before 1980 Insulin was all the time in studies. The studies were conducted in a few groups: placebo, SU, Metformin, standard insulin, and varied insulin. All groups were placed on diet. Then result were compared, which medicine worked better. In all studies varied insulin showed best results.
       At that time before 1960 it is already was known that Metformin (another generation of this type of medicine) and SU effected negatively diabetic's health in long term administration. So, in 1980 the classification of diabetes was done: diabetes type 1, insulin dependent type of diabetes, and type 2, insulin independent type of diabetes. Diabetes treatment was divided on two different types: Insulin for insulin dependent diabetics, and all types of oral medicine for the rest of diabetic population, 95% of diabetics type 2. Diabetes as cause of death and all cause mortality moved slow to the top of mortality table.
       In present time millions of diabetics world wide treated with oral medicine. All medical pro do know very well this medicine is fatal for diabetic. The mortality tables confirm this fact. It is diabetics type 2 who are on the tip of Death List.
      The question is still stand, why? Why today Insulin is not Number One doctor's choice in treatment of diabetes?
       Another question is why level of sugar in blood is not vital? How many patients come to clinic with elevated body temperature? At least not every one. But this is vital and every will be tested. How many addicts come to clinic? At least not every one. But in every clinic every one will be tested for STD even very old patients. Diabetes, elevated level of sugar in blood, every one out of then patients do have it, why it is not vital?
      There are every year walks in NYC "Stop Diabetes!" There are a lot of programs to educate public what to eat and how to live. $$$$$ every years spend on diabetes prevention. The problem is only one, diabetics do not have right treatment. When diabetes diagnosed diabetic do have most dangerous medicine which within less then 10 years after diagnose will bring diabetic to the top of Death List.
      There is no need to find cure for diabetes. It is already found almost 100 years ago. But diabetes is wonderful disease. It brings millions to medical industry. Then part of money donated to the politics. Really, diabetes is very good disease. It is selective. If diabetic belong to elite part of society then treatment with insulin will heal and support healthy life style. If diabetic is low income family member, Simple part of society, then treatment with oral medicine will bring millions into medical pocket just less then during ten years. At the same time it is reduce unwanted  human population. Adult and elderly, sick and Veterans, just Rx Metformin, SU, and Invokana and diabetic done with life. No crime committed even there is body in morgue. 

via Ravenvoron

insulin or Oral agents to treat diabetes. January 26, 2019

" The oral hyperglycemics are effective only in some types of diabetes and in some times, while insulin is effective in all types of diabetes at all time." Page 324)

 Impact of Insulin on Metabolic Pathways

edited by Eleazar Shafrir
International symposium Commemorating
the 50th anniversary of Insulin
24 to 29 October 1971, Jerusalem, Israel
Academic Press. 1972

Study conducted UGDP in US to find out how oral agent may prevent CVD and mortality. 5 groups about 200 participants in each were given insulin, Tolbuonide, and placebo. All participants were placed on diet. Insulin was Standard, the fixed dose, or variable, the dose to keep level of sugar closer to normal level.

"After the second year, significant differences in the course of glycemia become apparent and persisted from then on throughout the study." (Page 325)

       At the end of third year of study the effect of medicine was even greater. The group treated with Tolbuonide had as twice higher mortality due to CVD compare with group of insulin treated diabetics. Important fact is that diet treated diabetic had mild abnormality in glucose level. SU treated group was in advance progressive state of diabetes. Insulin treated diabetics were those with highest level of sugar in blood. The fact that in insulin treated group mortality due to CVD was as twice as low then in SU treated group is very important finding.
      Study were criticized and result were not widely accepted by clinicians. But later Joslin Clinic repeated the same studies, and results were similar.
       In present time studies like that practically out of practice. Mortality of diabetics rises in all cause of death, and now diabetes type 2 which treated with oral medicine such as SU or Metformin  first line and there are many other agents as add-on, second, third, and so is number 7 cause of death in all mortality tables. Unnecessary timeless Deaths which can be easily prevented with insulin therapy,
       Probably it is right that mild types of diabetes can be treated temporary with SU, Metformin and diet. In contrary all types of diabetes, pre-diabetes including can be treated with insulin, and cured. If so then what is the reason to take SU and metformin which will increase insulin deficit less then within two years of treatment, and less then 10 years after therapy started diabetic probably will die due to any cause of death such as stroke or CVD, Asthma or COPD, Pulmonary embolism or kidney failure.

via Ravenvoron

Insulin Secretion and body function in regard with season and weather. January 26, 2019

       In all medical education brain washing publications presented that there is direct dependency in proportion between glucose  or carb intake and insulin release. The trick is that level of insulin not really measured. The level of sugar was taken, then the amount of glucose was in-taken. And then what level of sugar was after glucose load, or after insulin injection. Usually all formulas developed as speculations that this is what going on and right way to assume.
      Now, let us see what happened in dog which pancreas was removed. The dose of insulin injected was stable. Still, it is complicated to assume that the dose of insulin in experimental dog was the same for the rest of dog's life. And also it suppose to be studied for how long dog lived and on what dose of insulin.
       In contrary with experimental dogs human do not have pancreas removed. Pancreas still inside human body and no one really know how much and for how long insulin secretion still in effect. In some patients dose of insulin decrease with time. Usually it it those patients who started insulin therapy as children. When those diabetics grow up the dose of insulin decreased if diabetic-child was treated right.
       Diabetics type 2 who stay on oral medicine for the about 10 years actually experience dose of insulin increasing with time. Why?
       When it is taken into consideration that insulin is stored in every cell of human body then it is obvious that insulin depletion started with low active organs such as legs. Paradox, but legs are really less needed for human body. There is no problem to live without leg. It is inconvenient, and it is not the case that anyone like to be amputated, but amputation of legs does not effect vital organs such as heart or lungs or kidney or liver.
      So, circulation would be lost in extremities to preserve vital organ to be functional. Flesh, skin, muscles would be effected by insulin depletion before vital organ would develop abnormalities in functions. This take time.  When experimental dog get back its insulin in injection, dog still in good shape, no any prime organs were effected  as it was before operation. The dose of insulin still stable only to support daily function of body.
       There is difference with human diabetic. Diabetic lost part of insulin in many if not in every cell of the body before diagnose of diabetes was established and treatment with insulin therapy started. The first step is to support daily body function. Dose of insulin is not high. If higher then needed dose of insulin was injected diabetic has low blood sugar.
      Step by step other function started to improve their work. To do the job they also lost insulin and they needed to fill out the deficit. Dose of insulin increased.
      After all function would be improved and deficit in insulin would be fixed, the improvement in health can be seen. Step by step dose of insulin would be decreased.
     Of cause it is my theory, and there is no studies done. I do have only one patient to observe, myself. As I can say, dose of insulin I need to inject to keep level of sugar in blood under control in constant increase. It is under high effect by weather or storm outside the planet in space. It is effect of the season, and flu season effect the health and reflected on the level of sugar. In Summer there is lowest dose of insulin needed. In Winter dose of injections going up and up. 

via Ravenvoron

Low Carb Diet and glucose intolerance. January 26, 2019

Impact of Insulin 
on 
Metabolic Pathways
edited by Eleazar Shafrir
International symposium Commemorating
the 50th anniversary of Insulin
24 to 29 October 1971, Jerusalem, Israel
Academic Press. 1972

"After a low carb diet, glucose tolerance was significantly impaired and insulin secretion clearly delayed." (Page 562)

       Interesting. Low carb diet which all the time presented as cure for diabetes type 2, in fact decrease insulin secretion and increase level of sugar in blood.  Of cause, it is 1972, long way away from 2019. The fact is fact, low carb diet is not cure for diabetes type 2, never will never was.
      There is another fact, when one try to find information it is best way to look at printed books. In our time when all info is digital only books, printed books will say the true. The true is complicated issue. When I take a book published by Joslin Diabetes Center it is not the fact that there are true which published. It really does not matter. Published book cannot be re-written. I am keeping that book on my shelf, and no one will re-write it. Difference with re-print or digital print.
      I collect books published before 1980, and I prefer first print, first publication. Very often books are from libraries. Many of them in poor condition. I do not care too much. If book is readable, and price is right then it is my way to have it, to order it. The price for the same book may wary from under $10 to over $300. I order only if it is very ware and less then $100. But I check up if anything a new come to market. Often one book which was over $300 not I may buy for less then $20. I will take the chance.
       Then it is tame to read. And dig deeper to find the Pearl.

"Among individual subjects, delayed insulin secretion was a frequent though not universal finding; however even in those subjects in whom the rise in insulin levels  remained normally prompt, glucose tolerance become impaired." (page 562)

        There are many different answers available for this phenomenon.  The fact is still that carb restriction is not cure for diabetes type 2. It is not only does net lead to cure or reverse diabetes type 2 but the fact is it is effect diabetic's health in very deep negative way. There are no studies how low carb diet effected those who practice it in long term.  Also there is fact, history of insulin development, that practice in low carb, highly carb restricted diet lead to death due to malnutrition, the damage to the health which is not reversible.
        These are facts. It is not fictional Diabetics type 2 Education Brain Washing. It is well known that diabetics type 2 developed diabetes because of overeating and continuing eating. No one can prove that 95% of diabetic population overeat and wrongly behave. There is no prove for that, only speculation. When we come to places such as Lincoln Center we can see many obese patrons who hold their seats for full life long. Some patrons come to The Met or NY Phill as long as 60 years. They were in their 20th when they took first subscription and now they are old. Some got obesity, other got stroke and hardly able to walk, use walkers and wheelchairs. What is important, there is no one patron who eat without stopping.
       It is very wide spread the idea that obese people hold some food in every pocket, and cannot restrict themselves to eat it in any spot we are. The matter of fact, there are no people like that on streets or in Lincoln Center. Personally I never saw anyone. What I can see in Metropolitan Opera, how old and obese people walk up to highest level of Family Circle, slow, but still walking. These patrons would not eat during all the duration of the opera. To eat in house is prohibited. To walk down and then up is too complicated for these people. So, we all stay on our seats for the final sound of music. Usually duration of the opera about 5 hours.
       It is in every medical clinic in every Diabetes Education Center that diabetics type 2 must practice low carb diet. Also for this reason it is very widely recommended weight loss surgery. When it is done, it is too late to fix anything. Just accept the consequences. The time to think is long before. This is why it is really true that educated diabetic live longest.
     Digital print replace all fashioned books. Like in movies in digital prints any modifications easily would be made. Old books go to trash, they never will be back as they were printed at first time. As I see right now if a few years early when I just started my old books collection the price for them was very low. Many cost just $4,  the cost of shipping $3,99 and the rest is pay for book, just $0.01. I do not see that price anymore. More and more books I ordered a few years ago not cost $$$. Why not? Only in those books it is possible to find Gold and Pearls of valid information.

via Ravenvoron

Three Months Of New Studies

One way that I find new studies which are aimed at curing type-1 diabetes, is by searching the FDA's Clinical Trial Registry. (Luckily for me, this site even works during a partial government shutdown.) In this posting, I'm going to summarize all of the type-1 studies I found which were first registered from Oct-1 to Dec-31, 2018 and which either were recruiting patients, or had been.  (I'm specifically excluding studies which were registered, but which had not yet started recruiting.)

Out of the 41 studies which started during this time, only three (7%) were focused on curing T1D.  However, I'm summarizing all of them here, to give everyone a feel for all the types of type-1 diabetes research underway, and because some people might be interested in some of the non-cure research.

I divided these studies into 6 broad categories:

1. Treatment (16 Studies)
This section included psychological techniques to improve BG numbers, technology such as apps, training to recover low BG awareness, non-insulin drugs to treat or prevent lows, etc.

2. Technology (10 Studies)
These studies were mostly aimed at closed loops, but also other forms of technology, such as meters.  The most interesting (which I will not be covering) is a triple hormone artificial pancreas: researchers at McGill University are testing an artificial pancreas which doses Insulin, Pramlintide, and Glucagon.  They hope it will remove the need for carb counting.
https://clinicaltrials.gov/ct2/show/NCT03800875

3. Diet (4 Studies)
Two low carb studies, one on something about buckwheat, and I can't remember the fourth.

4. New Insulin (8 Studies)
I'm not particularly interested in new types of insulin, and most of these were standard "we hope it is a little better, and a little more expensive, than you get now" type insulin.  However, two of these studies were looking at a weekly use insulin.  Called "Insulin 287", it is a background insulin, similar to Lantus, Levemir, or Tresiba, but designed to be taken once a week.

5. Basic Science (1 Study)
Basic science studies are usually done on animals or in petri dishes, however there is one being started on people.  It is studying TMEM219 also called "TMEM219 death factor" and "Transmembrane Protein 219".  This protein is clearly involved in the death of beta cells, and is sensitive to insulin-related proteins.  There is hope that it is part of the process that kills beta cells to start type-1 diabetes, and therefore if we learn more about it, we can prevent type-1.
https://clinicaltrials.gov/ct2/show/NCT03794739

6. Cure Focused Research (3 Studies)
Finally, there were three studies which were focused on a cure.  I plan to blog on each one of these separately in the coming weeks, as they are all interesting and worth an individual blog:
MER3101 (an adjuvanated Insulin B Chain vaccine)
https://clinicaltrials.gov/ct2/show/NCT03624062
AG019 and Teplizumab (a mash-up of Proinsulin, IL-10, a monoclonal antibody, and bioengineering)
https://clinicaltrials.gov/ct2/show/NCT03751007
GABA (a dietary supplement)
https://clinicaltrials.gov/ct2/show/NCT03721991


Joshua Levy
http://bit.ly/29DuN3o 
publicjoshualevy at gmail dot com
All the views expressed here are those of Joshua Levy, and nothing here is official JDRF, JDCA, or Bigfoot Biomedical news, views, policies or opinions. In my day job, I work in software for Bigfoot Biomedical. My daughter has type-1 diabetes and participates in clinical trials, which might be discussed here. My blog contains a more complete non-conflict of interest statement. Thanks to everyone who helps with the blog.


via Cure Research

What diet is best? Plant based or meat based? January 25, 2019

5,000 units of insulin were injected within 24 hr. Where these insulin gone? We all the time think about insulin in blood. 5,000 units of insulin could not be in blood. If so then where insulin which was injected gone?
      As it was published before, insulin is in every cell of our bodies. Long before C.Best and others exerted insulin from different part of bodies it was said by Dr. Gallen. His statement even it was long way to discovery insulin he stated that : Digestion in the stomach is not only one of the change food undergoes. In living organism undergoes continues change. Stomach  is first, than liver, than all other organs, and finally change we shall call assimilation.
      No digestion or food change can be done without insulin. This is why insulin must be present in every cell of living organism.
     The history of insulin discovery is long. Many names which contributed to the discovery of insulin now forgotten. Other names are robbed of its credits by dishonest doctors who took credits for job they never did. This twist in history and dishonesty lead to millions of innocent Death. Today when there are so many types of insulin which is great and powerful medicine to safe millions of lives, insulin is out of medical box of 95% of diabetic population. Profit. Gold Idol hold everything in its gold hands, our lives including.
      The question still stand, where insulin gone in such high dose such as 5,000 units?
      Usually it is different schemes how insulin works in human body. It is presented that insulin started to be secreted by pancreas in response to meal intake. It does not looks like that. Regardless how many carbs and anything diabetic took 5,000 units cannot be needed to convert that food. Also it is best to remember, diabetic was near coma state, very little food needed. In this state diabetic lost weight, do not take food but water in big quantities.
      In contrary with medical education to public if we take into consideration that insulin must be present in every cell then limited secretion of by ill pancreas wrapped in diabetes fibrosis  will effect every cell of human body. One organ after another ill start to function abnormally due to inability of changes within cell, reproduction, creating a new cells, discharge wast, and all what must be done.
      As it is well known from many publications, articles and medical books, diabetics do not die within two weeks after diabetes development. The time is long, about one or two years of pain, suffering,  lost mobility regardless of body size, lost vision, carbuncles, other infections, and so so on and on.
       Insulin saved life of diabetic. Regardless of so high dose of insulin diabetic did not die due to low sugar. The matter of fact, woman recovered. Even she was not diabetes - free, she lived healthy normal life with injections of insulin a few times daily. She got two children, and 30 years after so fantastic recovery she still alive and well being.
      In contrary with this lucky one diabetics stamped as type 2 population die less then 10 years after being diagnosed with diabetes. In every clinic they treated with Barking Therapy demanding to loose weight, and eat right. What is right to eat? It is presented in modern medicine that plant based diet is the best. In contrary with these presentations Dr. Rollo, 19th Century Naval Surgeon treated his diabetic patient with meat diet. His patient gained weight, and get urine sugar-free. Dr. Rollo published in his book that food from plants is converted into sugar by means of abnormal gastric secretion.
      Dr. Rollo did not apply on the popular publications. His practice was based on careful observation of his patients. If patient get better then it does not matter what medical society present. His patient gain weight, but live and functional, able to do his job. In contrary with those diabetics who were treated with plant based diet and died from malnutrition and starvation.

via Ravenvoron

Level of cholesteron in diabetes treatement. January 24, 2019.

Impact of Insulin 
on 
Metabolic Pathways
edited by Eleazar Shafrir
International symposium Commemorating
the 50th anniversary of Insulin
24 to 29 October 1971, Jerusalem, Israel
Academic Press. 1972

Since insulin plays a critical role in both the production of tryglycide-rich lipoproteins and their removal from plasma, it is not surprising that alterations in insulin secretion or action lead to a multiplicity of forms of hypertriglycemia in man. (page 129)

        It is well known that diabetics type 2 do have high level or TG and cholesterol. Usually it is diabetic type 2 to blame for wrong diet and wrong behavior.  Remember, diabetes type 2 is Insulin Resistant type of diabetes which treated will all medicine but not with insulin injections. In contrary diabetics type 1 Insulin Dependent type of diabetes treated with Insulin injections.

The enzyme deficiency is reversible with hormone repletion; insulin administration promptly restores PHLA , improves triglyceride and reduces plasma triglyceride level. ( page 129)

       This phenomenon can be easily observed  in diabetics triated with different medicine, and classified differently. Type 1 diabetics do not have high TG and cholesterol level. Diabetics type 2 all do have high TG and high cholesterol level. when all diabetes type 2 anti-diabetic medicine stopped at once and replaced with Insulin injections promptly after level of TG going down and return back to normal. There is no changes in diet or starvation needed, just different type of medicine and right classification in diagnosed diabetes.

Thus the majour mechanism for hypertrigleceridemia associated with severe insulin deficiency appears to be impaired LPL related triglyceride removal.

        This is not the end of the story. The rest of article for difference between normal insulin deficient diabetics and obesity based high level of TG and cholesterol. In the rest of the article authors actively try to re-write all what they stated in first part and put all writing  up-side -down. There are importance of weight loss and all the blame why diabetics do have high TG and high cholesterol put on diabetics poor soul.
       Still, before taking sides and starting so differential treatment let us take first line in treatment and see if this line work for both types of diabetes and diabetics, low income or high level of human society. Let try insulin injections to all diabetic with high plasma TG and cholesterol. If level of TG will drop then Insulin is right medicine for diabetic, regardless of diagnosed stamp.
      In 2011 I stopped all anti-diabetic types of medicine and took insulin, insulin only to reduce my very high glucose numbers. My TG were above 900. I took Lipitor, 80 mg daily and another medicine I do not remember name to reduce cholesterol and TG. Nothing worked. TG level went above the sky. After a few month in treatment with insulin injections TG level started to drop, so cholesterol. Now my blood is looking good, no high TG or cholesterol.
      I am diabetic type 2 by diagnose. I was treated with all types of medicine at that time. Of cause the most important part as always was to lose weight. I did, I lost 60 pounds and .... I there were stroke. No one promised stroke for me. If they did I would not loose weight. After I recovery all pounds returned with great plus. Edema, very severe edema. I still fight it. Every night my man wrap my legs to reduce edema on legs and keep my legs attached to my body. Very funny. As DR. E. Joslin said, diabetes is good disease. There are a lot of money for medical industry. All what doctors need just  educate  medical staff n right way, one part of lecture is how to treat prominent members of our society with insulin and another part that for Simple there is no need in insulin. Simple must modify life, and reduce weight down to skeletal.

via Ravenvoron

Impact of Insulin to safe diabetic's lives. January 24, 2019

Impact of Insulin 
on 
Metabolic Pathways
edited by Eleazar Shafrir
International symposium Commemorating
the 50th anniversary of Insulin
24 to 29 October 1971, Jerusalem, Israel
Academic Press. 1972

Insulin resistance is defined as injections of at least 200 units per day with failure to lower significantly an elevated blood sugar in the absence of ketosis or acute infection. (Page 542)

Interesting definition I would like to say. If diabetic is Insulin Dependent than diabetic need less than 100 units of insulin. If diabetic is not insulin dependent than dose of insulin would be over 200 units daily. If some one able to get the medical logic or it is medical humor I still do not see what, than I hope one understand the point and difference between two definitions. I still do not get it.

In 1946, the author reported a young woman patient whose diabetes was so hypo-responsive to the action of insulin that she reached a peak requirement of 5,000 units per 24 hr to avert entry into ketone acidosis. Her case was constituted the focal point of a survey in 1948, which presented the natural history and clinical appraisal of 54 cases of insulin resistance. ( Page 542)

       The case of Insulin Resistance. No mention of the level of insulin. was insulin present in blood? No answer. But because of dose of injected insulin was over 200 patient was diagnosed "Insulin Resistant". I wander, if Insulin resistance is the condition of diabetes with need over 200 units of insulin in daily injections than why Insulin resistant Diabetics Type 2 do not have Insulin in Rx? Interesting, is not it?
      Diabetes type 2 presented that it is type of diabetes when insulin secretion is too high, but insulin used in wrong way. I am happy to accept it. There is only one problem. Why insulin in injections, so high in dose as 5,000 units a day, does not lead to complications, and diabetic finally recover and after 30 years of Insulin Therapy got it sugar-free. In contrary, when diabetic type 2 treated with life style modifications and Metformin as first line of therapy, life expectancy of diabetic type 2 less then 10 years after treatment started. Sugar constantly go up and up till finally life stop to exist.
      Every one do know how much medicine diabetic type 2 take, and how long do they live. What no one really know is that insulin resistance is the condition of the same insulin dependency but in very higher dose.

Current statue of patient: age , 47 ( was diagnosed at age 17) good general health and leads normal life:
premeal insulin dosage in units, 10 regular,12 regular,15 regular, - 26 ultralente with blood glucose, fasting - 2 hr postbreakfast-2hr post lunch = 85-115 - 100 mf/dl;weight 205 lbs, BP, chest film, ECG is normal; eyes, vision 20/20 , no retinopathy or glaucoma; kidney - blood urea nitrogen 16 mg/dl 24 hr urine , albumin 1.8 g; culture and ......... (page 543)

        Of cause, diabetics type 2, Insulin Resistant type of diabetes do not have so high insulin to inject. We are too good as we are. as Dr.E.Joslin said, diabetes is good disease.  Very profitable for all medical industry and political power. Take a look how much every diabetic type 2 cost to society. All that money go where? Right. Follow money before to blame victim. In case above diabetic is no longer 'Insulin resistant'. She is regular diabetic type 1 with dose of insulin to inject less then 100 units daily. Did she reversed her diabetes type 2? Sure she did. To decrease insulin injections from 5,000 units down to less then 100 units, she is hero.
     Not so many diabetics type 2 so lucky. At first diabetic must lost weight and then ....  .Well then there is no need in insulin injections. If there is no blood then there is no sugar in it. Simple logic, not possible to bit. Life perfectly modified.

via Ravenvoron

Day by Day. January 23, 2019

sugar is 224 mg/dl.
      Last night after NY Phill concert I was so tired that after meal I did not have energy to take a shot. I simple left to bed and fall; asleep instantly. So, Yesterday it was only 300 units of insulin, and today fasting sugar is high. In the morning at 7;25 am I took reading and injected 160 units of Lantus Solo Star. No meal after injection. Right now it is 12;53 pm, and I still do not have meal. 160 units of insulin, no meal, and there is no low sugar  still.
      It is important to understand how all the system works, and it is difficult with widely spread fake medicine and education. This is why now I read all old books I can get, published before 1980. It is interesting to read those books which where published before Insulin Discovery. Still that books are out of interest in mean to get diabetes-free or prevent deadly diabetes complications. Books published after insulin discovery but before 1980 are most important and most powerful to deal with diabetes type 2 today.
       When I started to collect that books and develop my diabetes library at first I tried to buy newest books, with hope that they provide best understanding based on the latest technologies and knowledge. I was wrong. All that books published after 1980 just fake medical advice what to do and how to prevent diabetes type 2, how to treat it, and to accuse diabetics in wrong behavior. Best at all what I read so far was Dr. E. Joslin expression: "Diabetes is good disease." Of cause it is good disease if it is not you who are diabetic but someone whom you treat how to eat. I am diabetic, I do not feel that I am so happy to be diabetic type 2. But there is nothing what can I d, so I try my best just keep going with hope that one day I would be recovery at least will not vanished without trace.
      Today it is surprise for me, why I still do not have low sugar and do not need to start to eat even after 160 units of insulin and fasting. It was not in the way like that in past. After injection I all the time must to eat, no way around. Otherwise there would be low sugar. Sugar is dropping, but slow, not too fast.
       It is important to see and understand. When I just started to take insulin, and my sugar was above 599 mg/dl, limit of home  glucose meter, after injection sugar dropped fast, down from 400 to 40, just one hour. I had to take meal, otherwise low sugar is not bearable and very danger. After meal sugar raised up to over 400 mg/dl, and I had to take another shot to drop blood sugar level. Round after round. Now I do not need to rush to eat, and sugar practically does not go over 400 mg/dl. It is even stay under 300 mg/dl so far. Sometimes it is above 200 mg/dl but usually it is within normal healthy range. So speeding up and down.
     A few days ago my kidney got infected. It is Winter, it is cold outside. We went to Metropolitan Opera. It was cold. Next day I got sick. Today it looks like I am getting better. Will see in time.

via Ravenvoron

Elliot P. Joslin in Diabetes treatment. January 22, 2019

        Dr. E. Joslin was one of the first doctors who started to treat diabetics with insulin. He published many books how to treat diabetes for medical pro and for the mutual use of doctor and patient. He was popular in his time. He still popular today.
        What is interesting in Dr. Joslin books how he understood diabetes. He did published all different aspects of complications in diabetes. He gave many descriptions of his diabetics' cases. Many of those cases were fatal. What he said, diabetes is good disease.  This is how Dr. Joslin presented his understanding of diabetes, and there are most important point of understanding on which treatment of modern diabetics bases. For Dr. Joslin the cause of diabetes in adult is overeating and continuous eating. Based on what evidence this statement was developed? It is based on the appearance of sick people who severely effected by diabetes. Diabetics with duration of years usually overweight and obese.
       It is also important to understand, how doctor E./Joslin know why diabetic overweight? It is easy to see, diabetics have severe hunger. What about those diabetics who are type 1, children? Do they are hungry? Yes, they do. Are they obese? yes, in modern time they are. Children in our time do not die because of diabetes. There are no wards in hospitals where comatose children occupy every bed, about 100 in every ward. There are no more wards in our modern hospital with comatose children. In wards in past children were underweight. Practically all of them died in hospital, no return at home.
      Today those children who are diabetics overweight or obese, for humiliation on human society. probably community rather prefer to see these kids in skinny coffins than in oversized clothing walking on the streets. Family love to see children alive.
     As I said, there is no one prove that diabetes, ether type of it, caused by overeating. Still, what about Dr. E. Joslin? How effective his treatment ever was? Read his book and see what is most important step in diabetes treatment of any type? Diet. This is what he all the time pointed out: diabetic tolerated X g. of carbs with Y units of insulin. How Dr. Joslin found dose of insulin to inject? Simple. 10 units is safe to inject for anyone, non diabetics including. For every diabetic, for any diabetic, child or adult, this dose of insulin is not sufficient.
      There is another question: how Dr. Joslin counted what amount of carbs diabetic must take to sustain body function? Really, it is all the time a lot of paper work what to eat and how to count cabs, fats, calories. There is never any info how to find out what amount of food must one take to sustain life. It is well known that malnutrition is danger for human health. In nutrition there is not only amount of carbs or fats or calories but the quality of food. 
       In his book Dr. Joslin provide all info how to count how many carbs in every bite of food. There is one problem with this math: in diabetics body there is poor metabolism of carbs. How Dr. Joslin know if carbs where used to support body function or simple go away as wast? Usually it is worse then simple to away, it is stay in liver and in belly, creating extra weight, but no use to convert this carbs into energy. So, really, how info about carbs can be used and how it is proven to be right? No one prove for that.
      It is all the time told that fat prevent glucose to enter into cell or it is prevent insulin to exit pancreas and to be used in proper way. I happy to accept this point if ... I do take insulin in injections, and the injected insulin used by my body system even fat is still present. So, injected insulin enter cell and do the job. If insulin secreted by my pancreas cannot be used then why do not let me to use injected insulin to support my body function?
     Dr. E. Joslin created public opinion that diabetics are to whom to blame. we can be diabetes free just only with simple food restrictions. Most diabetics trust in doctors and try to lose weight in any means. The result is catastrophic. Than more we lose than more we gain, getting fatter and fatter with every attempt to use any diet. Our Medical Industry develop one medicine after another, pretending that they try to find the cure for diabetes. Cure was found 100 years ago by Dr. Banting. all what our Medical Industry need right now just use it.
      No way for that. Dr. E. Joslin predicted many years ago that diabetics can be doctors for themselves. What to do with all that army of diabetic educators who know nothing about everything and able to do only one job, provide Barking Therapy. What Dr. A. Peters suppose to do? Go to nursing school? No. She understand  her riches come from where. So,there is no insulin for her diabetic patients. She rather educated patients and our families how to use Trash Medicine, add one after another from big company who pay her for promotion.

via Ravenvoron

Malnutrition as cause of Death. January 21, 2019.

The Treatment 
of
Diabetes Mellitus 
by
Elliot P.Joslin, MD (Havard), M.A. (Yale)
Lea & Fiboger
Philadelhia
1928

Case No.1085, a frail woman of thirty-four years with a history  of diabetes of seven month' duration, become sugar-free with great difficulty despite fasting and low diet. After four months the sugar in the blood decreased from over 0.5 to 0.1 per cent coincidentally with a fall in weight from 88 to 61 pounds, of which the las 10 pounds were lost between November 3 and 10, 1915. At this time her weight represented a total lost of 95 pounds and was 56 per cent below standard. No subsequent blood sugar determination was made, but  inasmuch as a few days later, without changes in treatment or in general condition, she died at her home without pain or coma, ther is little doubt that hypoglycemia was present. (Page 215)

       It is difficult to say was it low sugar or sugar was just right. There is no  reading was taken in level of sugar at that time. Also it is difficult to see that low sugar lead to silent death without coma and pain. But it is not important. Important part is, woman died even she was sugar-free.  What would happen if she start to take food more then she took before her final meal? She would eat and gain weight back, all what she lost. Then she no longer would be sugar - free. And so on and on. She did not start to eat. She died. 
     In this book there are a few other cases when people died even they become sugar free. The cause of Death is  malnutrition. The same cause of death as many patients of Dr. Allen in NY City. Dr. Allen treated diabetics with very low calorie diet, low cards. His nickname was Dr. Death. 
     Today after more then 90 years of after Insulin discovery by Dr. Banting and his assistant  C. Best the treatment for 95% of diabetic population is Weight Loss. Most effective in this treatment is Weight Loss Surgery. 
      More then 20 years in practice, what do we know about effect of this surgery? Not too much. Yes, sugar going down right after surgery. Is this good? Does it bad? Nether. The level of insulin still the same, regardless of level of sugar, not sufficient. If diabetic will not start to eat and provide good quality nutrition for the body, diabetic will die. If diabetic will overstep the point that his/her stomach is too small to support his/her body system then malnutrition would be developed and diabetic would die. The WLS never were successful to treat diabetes. But all this is out of report and out of public attention.
      To reduce level of sugar in blood is simple with shots or insulin. Very simple, just take a shot and sugar will go down right away. If Level of sugar in blood still not under control than increase dose of insulin. So simple. So simple. Every one will learn this practice just after short time. When it is not full diabetes with very high insulin deficit then to return to healthy life style is easy. It is difficult to do when diabetes is out of any control after years of wrong treatment with Metformin and SU, Invokana and Janimet, and all that Trash Medicine which treat the level of sugar and never able to take sugar under control.  If so then why take this medicine? No any reason. 
     How calorie and carbs restriction can increase the level of insulin secretion? At first, to secret insulin pancreas must be functional. Without energy pancreas as any other organ in body system cannot function. The result is, in stead to increase of insulin secretion pancreas of diabetic on restricted diet would shrink, cells would die of Starvation. 
      Prove? Insulin is stored in every cell of our bodies. This is how cell can function, to grow to do the job, to reproduce. Every cell needs nutrition to function. There is no nutrition when diet restricted so dramatically that fasting state became a normal way of living. 
      Depending on stage of diabetes, on the level of decreased insulin secretion, diabetic live longer or shorter. 
     In some point to prove the effect of Weight Loss Surgery and its benefits for diabetics the studies of three years were conducted.The studies were cut short. The results were so dramatically negative that it was better to keep it away from public attention. Still, with simple understanding the Nature of Diabetes and the Nature of body function it is very reasonable to live with the size of stomach which one has right now. Stomach is very flexible, and there is reason for that. 
      Is that really true that our medical and political power so worry about public health and well being? If so then why level of sugar in blood is not vital? With this simple test the myth that diabetes type 2 caused by overeating will be broken. There are  so many diabetics who fit perfectly, but has elevated level of sugar in blood. Let them take insulin right away, and they never will be fatty, and will never have level of sugar above mortal line. 

via Ravenvoron

Where is Insulin in body? January 20, 2019

The Treatment 
of
Diabetes Mellitus 
by
Elliot P.Joslin, MD (Havard), M.A. (Yale)
Lea & Fiboger
Philadelhia
1928

How mach insulin is in healthy human body? Where this insulin present and can be found?

Insulin is found in tissues other than the pancreas but the pancreas appears to be the one and only original sours. Best and Scott (1922, 1923) prepared insulin from the sub-maxillary, thymus, and thyroid gland, and from liver, spleen, and muscle tissue and in fact insulin was present in every tissue they investigated. it is not reported as having been found in the hypoplysis. The total muscular system of a dog contain at least twenty times as much insulin as his pancreas, his blood  as five times as much, the liver fully as much as the pancreas. (Page 37)

Insulin found in urine, and pregnant woman exerted greater amount of insulin than by normal man. Insulin was not found in diabetic's urine and it disappeared withing a few days from the urine of dog after extirpation of the pancreas.
      Very interesting to know. In present time we all do know that diabetes type 1 is medical condition when insulin secretion is absent. This is definition of diabetes type 1. Also it is very widely spread that diabetic type 1 even may die if insulin shot was missed.

In type 1 diabetes, the body does not produce insulin.(ADA)

The fact is really very different.

Best, Smith, and Scott conclude that insulin may be a consistent in every cell which metabolizes carbohydrate and that the island of Langerhans may be specially developed structures which supply active material when the demand is too great to be met by the insulin-producing power of the individual cell. It remains to be seen =whether any diabetic is so severe as to have lost entirely the power of producing insulin. (Page 38)

       It is important to understand what is True and when the info is Scam. What I still not able to understand why they do what they do?  Do they know all what I just started to read and see? If they do not then why? At least they must do the job. They do not. They simple do like to educate people what to eat then see how to do the job they trained to do and they paid for.
      No one cell can function if there is no insulin. The process is going on and on, reproduction, metabolism, growth, all need insulin. So, even when there  is no pancreas there for some short period insulin present in body and human or animal  still alive.

via Ravenvoron

Treatment of Diabetes Type 2 with Insulin. January 18, 2019

The Treatment 
of
Diabetes Mellitus 
by
Elliot P. Joslin, MD (Harvard), M.A. (Yale)
Lea & Fiboger
Philadelphia
1928
The dosage of insulin which keeps these (the depancreatized) dogs alive has not been increased or could not be diminished.Insulin therefore does not lose its power in the course of time. But on the other hand no organ of the body can assume the function of the pancreas and reduce it. But this is not quite whole story. Regularity in administration has allowed a gradual reduction in dosage and conversely the dosage had to be notably increased when a deficiency of insulin developed in the body either as a result of insufficient doses or because of voluntary suspension of treatment. (page 22)

Now let us talk about second part of this statement.

Regularity in administration has allowed a gradual reduction in dosage and conversely the dosage had to be notably increased when a deficiency of insulin developed in the body either as a result of insufficient doses or because of voluntary suspension of treatment. (page 22)

       As it is said, if there is deficit in insulin dose or secretion then dose of insulin needed to survive is higher then when it is healthy dog was  the depancreatized. For dog it will take time to develop deficit in insulin to lead to the final breath. In contrast, diabetics already do have this deficit in insulin secretion, and so the dose of insulin is getting higher and higher with every passed day.
     What happens when insulin added in injections to diabetic type 2? Would diabetic survive? Would diabetic get into deep coma because of low blood sugar? Would be diabetic type 2 cured if insulin available for treatment? Dr. Joslin present that insulin uses was voluntary suspended. Why? Why anyone will stop to take medicine which make one better?
        In his book Dr. Joslin described many episodes when people died because of coma. He presented that in present time ther is no need to die because of diabetes. All those deaths are not necessary the result of diabetes but rather it is result of poor diet and low activity. It is easy to say back in 1929. Diabetics did not live so long as it is right now. Many diabetics died in early childhood, even in infancy, right after birth. The only reason they were not in list because of no one diagnosed them with diabetes.
      In present time there are many elderly diabetics who hardly able to walk, to move. Many diabetics cannot even turn on own bed. But treatment for every one diabetic type 2 is only one, diet, active life style, and some trash medicine which effect healthy tissue and healthy well working organs. How reliable this treatment can be? Simple take a look at the diagnose guidance by WHO or ADA. What they suggest? Fasting sugar over 100 mg/dl. How 'over' is 'over'? 120 mg/dl is 'over', and 370 mg/dl is 'over', and 599 mg/dl is 'over'. Easy to see the difference in medical condition of diabetic. But if there is difference in medical treatment? Not at all. Because of regardless on level of sugar in blood First Line Treatment is always the same : Life Style Modification, Diet and Work Put. If my reader has no idea wht diabetes type 2 is then just trust in me, with 599 mg/dl children skipped into coma, and adult develop stroke or MI.
      Still, if insulin is effective treatment for diabetes then why do not start treatment with insulin rather then with any Trash such as Metformin or Invokana? If insulin does not work then probably it is OK to Add-on Invocana or Metformin, or both. Bust why start with less effective medicine and lost time when diabetes can be easily taken under control before coma, and any other complications would be developed?

via Ravenvoron

Thursday

My daughter and I had dinner around 5:45. It was a regular meal. In fact it was leftovers, so it was the exact same thing she'd eaten earlier in the week. She bolused for the carbs with no correction since her blood sugar was in range.

She left at 6:25 for jazz band. I left at 7:10 for choir rehearsal. My husband, who we usually leave home alone on Thursday nights, was out late for a work event. By the time I pulled into my destination, I had a Dexcom alert on my phone. My daughter was low-ish. She was in the 60's. Which had happened the night before after dinner too, and she'd gotten kind of stuck there. There are a couple of days every month when sticky lows tend to occur, and I began to wonder if that was what was happening.

I texted her suggesting that, given the stickiness of last night's low, adding a temp basal reducing or suspending insulin delivery might be a good idea.

By the time I got upstairs to my rehearsal I had another alert and she was now in the 50's. She had not texted back. I resorted to texting, "Please tell me you are okay."

She replied that she was, that she would suspend insulin delivery on her pump, and that she'd had juice.

For the next 25 minutes I sang and texted and watched the Dexcom app and wished my husband was home, two blocks from my daughter, to run her up some juice. The alarms went from low to urgent low. I realized I'd stopped singing entirely.

By 7:55 my daughter had consumed everything in her bag and a sugar packet she scavenged from the band director's desk. She was in the 40's.

I left rehearsal, clutching my phone, mysteriously muttering, "I need to go," and zipping out the door.

By the time I got in my car, 2.5 miles away from the high school, the Dexcom app read 'LOW.' That's below 40.

When I texted my daughter I was leaving, she replied, 'Why? No. I'm fine. Go back. Don't Worry.'

That didn't work.

I did not drive the speed limit. I texted and drove. I Dexcomed and drove. All I could hope was that my daughter would continue to text me and that all of the steps she'd taken so far would tide her over until I could help.

I ran in and out of my house to grab a juice bottle. I double-checked I still had glucagon in my purse from our Christmas trip.

She was back 'up' to 44.

I texted her I was on the way to the school with the juice.

'Well I can't leave.'

I left it outside the band room door, hoping nobody would think it was anything other than a sealed bottle of apple juice, and asked her to let me know when she'd gotten it. I assumed she would come to her senses and sneak out and retrieve it quickly and surreptitiously. If she didn't I'd have to go back in and make a scene.

She'd retrieved and consumed it long before I'd driven the two blocks back home.

Then, slowly, she started to come back up.

She was 90 by 9, when jazz band was over and she drove home.

This wasn't a case of being unprepared. Maybe she was un-overprepared. But when leaving the house for two and a half hours, it's extraordinary to expect to be in a situation where you consume 45 grams of carb and suspend insulin delivery while your blood sugar continues to drop like a rock. At least after an accurately bolused dinner, and no unusual level of activity.

I'm grateful for whatever combination of grace, steps taken by us, and dumb luck saved us from a bigger disaster. From 7:30-9 last night was the most scared I've been of diabetes in years. We work so hard to keep things predictable and on an even keel but this was a sobering reminder that danger lurks around the corner at any moment.

Extra juice bottles will be squirreled away around my daughter's home-away-from-home in the band room and stage area of the high school. She'll stuff a few more airheads in her diabetes bag.

We're not inclined to let this particular diabetes emergency happen again. Unfortunately I'm certain there are plenty of other possibilities we'll continue to discover along the way.





via Adventures in Diabetes Parenting

Hedan dog and other depancreatized dogs. January 18, 2019

The Treatment 
of
Diabetes Mellitus 
by
Elliot P.Joslin, MD (Havard), M.A. (Yale)
Lea & Fiboger
Philadelhia
1928
The dosage of insulin which keeps these (the depancreatized) dogs alive has not been increased or could not be diminished.Insulin therefore does not lose its power in the course of time. but on the other hand no organ of the body can assume the function of the pancreas and reduce it. But this is not quite whole story. Regularity in administration has allowed a gradual reduction in dosage and conversely the dosage had to be notably increased when a deficiency of insulin developed in the body either as a result of insufficient doses or because of voluntary suspension of treatment. (page 22)

       Pancreas is so valuable that the capacity of survival is greatest. It was known that as much as 9 out of ten part of pancreas can be removed, and animal will still alive.  In early Insulin Ara there were many studies done to try the way how to treat and cure diabetes. It is different then now. That's why to find out more about diabetes it is best way to return to older publications such as E, Joslin and Conferences books. Best info I found so far in books which were published before 1980, when WHO developed universal classification of types of diabetes.
      I take all reading and all doses of insulin I injected in my log books, and I keep these books, so I can see how dose of insulin and level of sugar come together, when dose of insulin going up or down, and under what reason I suspect it is happened.
     Still, I do not understand, why my dose of insulin going up and up? Why it does not stay the same day after day? There are not so many differences in my life. Day after day about the same. There is no activity which would demand more insulin then usual. I am stay home, low active person. Regardless of my activity are high or low the dose of insulin suppose to be the same.
       The same about my doeiet. Regardless it is high in carbs and fat or low, it is the same day after day, so it should not effect readings and dose of insulin.
      The real fact is different. 
Today sugar is 65 mg/dl. Dose of insulin was 467 units Yesterday
Yesterday sugar was 66 mg/dl. Dose of insulin day before was 374 units.
Day before sugar was 61 mg/dl. Dose of insulin was 347 units.
Day before sugar was 87 mg/dl. Dose of insulin 414 units.
      Now there are questions:
Why dose of insulin higher to keep sugar level in range?
Is this would be the same if I will take the same dose of insulin day after day, then how level of sugar would be different?
      I do not play with my life or well being. I simple keep going day after day. It is not my goal to study and answer to the questions which are very reasonable to ask.  My goal is to keep sugar level as closer to the normal range as it is possible. So, reading are first priority, and dose of insulin is only to keep reading in tight control.
       Still I do have questions and I try to find the answers. What are difference between dog with pancreas removed and human diabetic?
     Dog was healthy at the time when dogs pancreas was removed.
     Diabetic was already ill when diabetes was diagnosed and treatment started.
All organs of dog functioned and there were no developed complication or any health issue. In diabetic all organs of the body and body functions were effected by diabetes long before it was diagnosed that there is problem with pancreas. Many diabetics died long  before they got treatment. Most of diabetics never have the treatment they need.  Diabetic's lungs, liver, mobility, blood quality all in lower ranger compare with healthy human. It did not started yet in depancreatized dog.
     Dog lives in lab under constant supervision of staff.
     Diabetic live at home.  There is not too much attention how diabetic feel, ill, sick, or well.
It is signature of our time. Go to Google and see what you have to say to doctor when MD Rx medicine to you. No one mention that it is actually doctor who must ask patient if one has history of stones development before Rx Ongliza. Every one do know very well that it is not the case we do have copy of results our visits to any clinic or lab. Not at all. But every doctor ask me what diagnoses I do have, when and how I was diagnosed with what. What treatment did I have for mu condition.
      Well, there are clots in my blood. What MD said to me? That I do have clots in my blood. What MD Rx to me? Antidepressant. Every one is smiling. Why not? Every one do know I am idiot, do not understand what clot in blood mean. The matter of fact I do understand. What they do not understand that MD does not want to Rx any effective medicine, or sent victim of malpractice into hospital. Not at all. I have to walk back home, alone, at night, more then 10 bloods away from home on dark NY Streets. It is taken for granted that patients are idiots, and Med Pro are smart and know-how-and -why.

Undernutrition prolonged the life of such animals, whereas over-nutrition with any kind of food shortened it. (Allen dogs.)

This findings now very widely used to treat 95% of diabetic population.  What is difference between Allen's dogs who were treated with diet before insulin was discovered by Dr. F. Banting? Dogs did not go to work. They did not provide family with living, did not pay rent. Diabetics type 2 today must go to work and take care for children and families.
 Low nutrition kept dogs alive. Diabetic must keep himself/herself not only alive but functional on diet 400 calories how it is suggested by ADA. And ADA even pretend that diabetic type 2 would be cured. Dr. Allen famous patient was able to still alive for three years, did not go to school and was under constant supervision and care her nurse. Still, she did not recovery. Only insulin discovery saved her live.

via Ravenvoron

Scene of the Crime

On Christmas eve I had the unexpected opportunity to revisit the emergency room where my daughter was diagnosed with T1D.

I was the patient this time, having passed out on the kitchen floor of my in-laws' home first thing in the morning. It turns out that I probably should have been taking better care of the bronchitis that had been brewing over the preceding week instead of powering through Christmas prep, travel and time with family. The good news was that the experience was more surreal than serious and I'm making what promises to be a full recovery from both the bronchitis and the ribs I injured on the way down.

We lived two towns away from my in-laws when my daughter was diagnosed, so the drive to the hospital at dawn was familiar. Winding roads taken at a speed slightly over the limit, the beginning of daylight, anxiety and uncertainty. At the ER entrance there seemed to be an upgraded reception area, but the interior was about the same.

I was settled onto a gurney in an ER sized cubicle room and asked a hundred questions. A team of professionals got busy taking my vitals, taking some blood, and hooking me up to machines to continuously monitor my oxygen, blood pressure and heart. And all I could think about was 16 years and 3 days before, when I stood where my husband was standing. Out of the way, but in clear view, watching my daughter being hooked up to all of those things. And the interminable wait while they tried to get blood and insert and IV into her tiny dehydrated veins. I made out much better in that department.

Near the end of my 4 hour visit I was taken for a walk around the unit while hooked up to equipment to monitor my blood pressure and oxygen - making sure nothing dropped precipitously while I was upright and moving.

We passed the cubicle my daughter had been in. We saw the conference room where the doctor had taken us to discuss her condition. We walked over the place where I had stood with the helicopter EMT when she demanded insulin be started before transporting my daughter.

When I was released, I exited through the ER doors and we drove past the helipad from which my daughter and I had taken off, headed to the big children's' hospital in the city. We drove back to my in-laws' where my daughter had been hanging out with her grandfathers, playing cards, starting a crock-pot dinner and making and bolusing for her lunch.




via Adventures in Diabetes Parenting

Olivia Ann Kunik - I Will Love & Miss You Forever

My magnificent niece Olivia Kunik left the world on Tuesday, January 8th 2019 and my family is heartbroken.
Olivia was magic - incandescent, bright, funny, talented beyond belief and filled with love  - she was a ray of sunshine.

We lost her to suicide on Tuesday.

My fantastical niece struggled her whole life with depression and mental illness - and she was always transparent and incredibly candid about her struggles - and by doing so she helped so many of her friends and aquantances seek help with their own depression and MI issues.
Depression and mental illnesses are diseases  - very real ones that have the potential to take the ones we love from us.
Livy loved everyone - sadly, she didn't love herself enough and had difficulty seeing or believing in the magic she possessed.

I'm sharing because I don't want anyone else to suffer from a suicide tragedy.
 Our family is talking about our loss to save lives and to keep Livy's memory alive.

If you or someone you love is struggling, you are not alone and your life is worth living.
Please call 1-800-273-8255
Or text 741741 & someone will respond and reach out.

 Please take a moment  to click on the link below and read about the magic that was our Livvy.
https://www.dignitymemorial.com/obituaries/boulder-co/olivia-kunik-8120159

Liv was also a diabetesaliciousness Rock Star back in 2008 - she stole DOC hearts on that day.
Click on the link and read.
https://diabetesaliciousness.blogspot.com/2008/08/kids-say-darndest-thingsand-damn-if.html?m=0

In Liv’s memory, do something silly and fun for our girl.
Here are some recommendations directly from our Liv: “Perform a random act of kindness, share your favorite meme, make a prank phone call, sing your favorite song, spin until you are dizzy, make music with pots and pans, stomp on grapes in the bathtub, give names to your body parts (Liv’s pinky toe was Lois), cut your hair and regret it later, see how many licks it takes to get to the center of a tootsie pop, get a pet rock, decorate it, name it Glenn, and take it for a walk.”

 #LivForLiv #LivingForLiv

via Diabetesaliciousness

Non-Insulin Dependent Diabetes is predominately Inherited. January 16, 2019

Diabetes
Edited by Werner K. Waldhausl. 1979
Published by Expedia Medica, Amsterdam-Oxford-Princeton. 1980
Procceding of the 10th Congress
of the International Diabetes Federation.
Vienna, Austria, September 9-14, 1979.

Non-Insulin Dependent Diabetes is predominately  Inherited.
    Almost all the NIDD pairs of identical twins are concordant. In only 8 out of 55 pairs are they discordant and all but one of these the effected twin has been discovered to have diabetes only within the last 5 years.We have not seen discordance of more than 7 years duration. This is in spite of the fact that most of those twins were over the age of 40 when diagnosed and nearly all were living apart at the time. The conclusion must be that NIDD is largely, if not entirely, due to genetic causes.

       Now, is that really possible to prevent diabetes type 2 with diet and right life style? Diabetes is in our genes. We were born diabetics, so early or late diabetes will take over.
     Now, there are 95% of diabetics type 2 from all diabetic population. Diabetics type 1 got diabetes because of some infections, or trauma, or any other reasons. Diabetics type 2 born diabetics with not sufficient insulin secretion. In time when there are no other issue diabetics type 2 live undetected. When there are trauma, emotional or physical stress, infections, and so on, the insulin secretion must increase, and diabetics type 2 pancreas cannot keep up with increased demand in insulin.
        In West Point Military Academy a few cadets graduated when they were diagnosed with diabetes. At first, no one cadet will be admitted to West Point Academy with diabetes. If diabetes was diagnosed in first two or even three years of training, cadet will be discharged from Academy. But if there is last year of training, cadet will graduate. There are just a few of them. Training in West Point Academy is hard to accomplish even for very healthy cadet. In different study in another university or in any other places these cadets probably never would develop diabetes, or have it diagnosed at the end of the lives. In West Point Academy medical supervision is on the top of priority.
    This is what most important in diabetes treatment and in decrease of mortality due to diabetes: early diagnostic.   In the contrary for reason still not clear for me, diagnose of diabetes type 2 preferable to delay. Why? Why do it is better to delay diagnose of diabetes type 2? It is very logical to diagnose diabetes early and start treatment with most effective medicine. But it is not the case. Treatment based on many years to delay insulin therapy. In addition to this there are many medicine to developed to kill diabetic's type 2 insulin secreting Beta Cells. Some diabetics type 2 finally will get insulin, very limited dose of it such as 25 units a day. Most diabetics type 2 die without any effective treatment.

via Ravenvoron

Central Obesity Linked to Lower Brain Volumes. January 15. 2019

"We know obesity contributes to cardiovascular disease and diabetes, but it is also becoming increasingly likely that it is associated with brain health as well. Our results suggest that if we can control obesity better at a population level then this could be one way of reducing the future dementia epidemic," Hamer said.
 Central Obesity Linked to Lower Brain Volumes by Sue Hughes
 https://www.medscape.com/viewarticle/907545?nlid=127210_1521&src=WNL_mdplsfeat_190115_mscpedit_wir&uac=164666HZ&spon=17&impID=1860632&faf=1

As it is well known diabetics type 2 do have wide middle are. No one prove that it is overeating that caused diabetes type 2. Still there are many prove that there is no difference between Insulin Resistance and Insulin Dependency. As it is well known in medical community, there is no mark how to diagnose types of diabetes. 

 Comparison of type 1 and type 2 diabetes. Similarities and Dissimilarities in Etiology, Pathogenes, and Complications. 
Edited by Mladen Vranic, Charles H. Hollenberg, and George Stiener.
Plenum Press. New York and London. 1985.

The simplest way to produce resistance to insulin-stimulatd glucose intake is to destroy Beta Cells function in an experimental  animal. Since it is quite clear that insulin treatment restores insulin actions to normal, it is tempting to speculate that insulin deficiency, per se, is the cause of insulin resistance in diabetes. (Page 133.)

        So, if in animal pancreas was removed then animal develops Insulin Resistance, right? It is simplest way to study Insulin Resistance. Otherwise there is no way to see what is it and how to diagnose it. If there are higher need in insulin dose then diabetic is Insulin Resistant. If there is no need in Insulin injections, then diabetic is Insulin Dependent. Really it is easy to get lost in all that definitions and classifications.
     Now it is presented that diabetics type 2 do have low brain volumes. How it was studied? How Mr/Mis Hamer found it, no reason to assume without reasonable doubt. Still, wjo caras? Public will believe in all what was said by Med Pro, and it is easy to understand, diabetics type 2 sort of idiots, and this is why they cannot stop to eat.
      Simplest way to hide Medical Ignorance and charlatanism. Does not matter what was told, "I said you so." - apply to any medical care pro, and they are all the time right. At least it is they are who judge patient and why patient has or has not health or illness. 

Hamer noted that previous studies have suggested that obesity is a risk factor for later dementia. "We wanted to try and understand the mechanism for this," he said. "Gray matter atrophy is also a risk factor for dementia — we wanted to investigate whether there is a link between obesity and gray matter volume. This study includes a considerably larger population than previous work that has looked at this issue, and our results suggest there does appear to be such a link."

        As I posted already, the mortality of due to diabetes is in wrong classification what diabetes is. The wrong classification leads to wrong understanding the nature of health complications and the treatment which will or will not work to cure patient. Now, the question is, was obesity which led to diabetes? it is is diabetes which led to obesity? If it is obesity which lead to diabetes then it is important to reduce obesity in every one patient with active diabetes. But at the same time, is this really true that effectiveness or diabetes treatment will be due to obesity rate?
         Not at all. If one got cold because of one did not put on worm jacket when it was cold outside then it is not effective to treat patient with cold to put on worm jacket. No. The treatment is antibiotics. What are differences between cold and diabetes? Nothing. If as a result of obesity one got diabetes it is not obesity must be treated, but diabetes. It is too late to modify live style. It is time to inject insulin to reduce high numbers of sugar in blood stream. Dose of insulin must be in the way to keep sugar under tight control. Then it is possible to start to work to reduce obesity. If there is need in it.
      Our medical industry work in opposite direction. Any problem with health treated in 'one - size-fit - all' , obesity Barking Therapy. Would it effect victims of Dementia? Why not? The same as diabetic type 2 they will get wider and wider, so the theory it is wide middle area to blame will have prove. Simple and Brilliant.
      Dementia  and Diabetes in direct dependency. Why not? If there are limit in insulin secretion then there is limit in brain function. If other organs of the body can use fat as energy then brain can use glucose only. When insulin is not available there is no energy for brain to function. Brain shot down. Coma. In state of coma there are small amount of insulin used to fit heart and lungs and metabolism. But brain activity shot down. Of cause it is possible to see brain activity as it is in state of sleep. This is because we really do not know the process of ding. It is very complicated process, not the sate of just a minute. 

via Ravenvoron

Ustekinumab Starts A Phase II Clinical Trial Called USTEKID

Ustekinumab was approved in the US in 2009 for treating psoriasis, which is an autoimmune disease (where the immune system self attacks skin cells rather than pancreas cells, as with type-1).  It has also been tested on multiple sclerosis, Crohn's disease, and sarcoidosis (also all autoimmune diseases).  Ustekinumab is thought to work by blocking inflammation, and specifically blocking two immune molecules called IL-12 and IL-23.

The USTEKID Trial

This trial will enroll 72 adolescent (aged 12-18) honeymooners (within 100 days of diagnosis).  2/3s of them will get the drug (an infusion of Ustekinumab) once every two months for almost a year, and the other 1/3 will get a placebo, as a control group.  The study will use C-peptide in response to a meal as a primary end point (measured one year after start of treatment).  There are also a bunch of secondary end points.

The first patient started the trial in Dec-2018 and they hope to finish by Oct-2022.

Web site: http://bit.ly/2ALye5k
European Clinical Trial Registration: http://bit.ly/2AMxyei
EudraCT number: 2018-000015-24

Sites

Primary contact: Dr Kym Thorne
Floor 2, ILS2, Swansea University Medical School
Swansea, SA2 8PP, United Kingdom
+44 (0)1792 606372     k.thorne@swansea.ac.uk

Participating Locations:
(Note that not all sites are recruiting all ages, and not all have opened as yet.)

• Royal Aberdeen Children’s Hospital, Westburn Road, Aberdeen, AB25 2ZG
• Countess of Chester Hospital, Liverpool Road, Chester, CH2 1UL
• Tayside Children's Hospital, Ninewells Hospital, Dundee, DD1 9SY
• Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW
• Royal London Hospital (Barts), Whitechapel Road Whitechapel, London, E1 1BB
• University College Hospital London, 250 Euston Road, London, NW1 2PG
• University Hospital of Wales, Heath Park, Cardiff, CF14 4XW
• Noah’s Ark Children’s Hospital of Wales, Heath Park, Cardiff, CF14 4XW
• Evelina Children’s Hospital, St Thomas' Hospital, Westminster Bridge Road, London , SE1 7EH
• St James’ Hospital, Beckett Street, Leeds, LS9 7TF

This study is supported by National Institute for Health Research (NIHR) (UK), and is part of the ADDRESS-2 network, which is funded by JDRF.

Other Ustekinumab Studies
You can read my previous blogging on Ustekinumab here:
https://cureresearch4type1diabetes.blogspot.com/search/label/Ustekinumab

Both of these studies have the same warning signal.  Both completed over a year ago, but have not yet published their results.   My experience is that studies which are successful publish quickly, usually within a year of completion, so the fact that these researchers have not yet published is a bad sign.

Ustekinumab and INGAP
A small combination study of Ustekinumab and INGAP started in November 2015 and ended in March 2017, but the results have not yet been published.
https://clinicaltrials.gov/ct2/show/NCT02204397

Phase-I Clinical Trial For Ustekinumab
A 20 person phase-I trial for Ustekinumab started recruiting in March 2015 and finished recruiting in May 2016 and therefore should have completed after May 2017, but the results have not yet been published.
https://clinicaltrials.gov/ct2/show/NCT02117765


Joshua Levy 
http://bit.ly/29DuN3o 
publicjoshualevy at gmail dot com 
All the views expressed here are those of Joshua Levy, and nothing here is official JDRF, JDCA, or Bigfoot Biomedical news, views, policies or opinions. In my day job, I work in software for Bigfoot Biomedical. My daughter has type-1 diabetes and participates in clinical trials, which might be discussed here. My blog contains a more complete non-conflict of interest statement. Thanks to everyone who helps with the blog.


via Cure Research