It's Not the Fat That Makes Us Unhealthy. August 31, 2018

And it wasn't all bad science. The massive effort at culture change—stop eating this, that, or the other fat—was excessive, considering the meager amount of supporting data. The unintended effects were so extreme and went so unrecognized because of this huge effort based on what had become dogma: that eating fat is bad (9 calories per gram vs 4 calories for protein and carbs). The laws of thermodynamics—calories in, calories out—had been everything in weight control.
 It's Not the Fat That Makes Us Unhealthy. 
 by George D. Lundberg, MD
 https://www.medscape.com/viewarticle/900495?nlid=124787_381&src=WNL_mdplsnews_180831_mscpedit_wir&uac=164666HZ&spon=17&impID=1727339&faf=1

 Author of an article can think, it was good science. I think it was stigma.There is nothing as science.

It has been 11 years since independent investigative science journalist Gary Taubes published his best-seller, Good Calories, Bad Calories, after 15 years of serious study, enabled by that amazing new tool, the Internet. Turns out, it's not fat that makes us unhealthy. In 640 total pages with 459 notes, 1700 references, and 924 Amazon customer reviews, Taubes demolished what the medical, scientific, and nutrition fields (since at least the 1960s) had spent countless billions of dollars building and profiting (but also dying) from: the fat food theory of the causation of "diseases of human civilization"

      Really, what all that scientists and medical studies studied? In no one study the real patient was taken into consideration. It is not study but brain washing fields. As usual, what MD said, it is right and true. But with time another grands paid for opposite studies, and the same team of researchers will demonstrate opposite result of studies.
       About calories, why they are bad? Because of MD found the way to blame patients in stead to treat them. The same about fat. It is right that too much fat is bad to consume. Is this good to consume too much veggy? Take carrot and go to clinic because of yellow color of the skin. Also take very good Veg.&F and develop allergy because of too much of it taken. Eggs are good, but not so good if taken in big amount. The only right way is all the time in everything, right balance, not too much not too little.
     With philosophy like that our Med Pro not familiar. They also present that if one is sick, it is one's fault. Diabetes type 2, what is it? It is too much sugar in blood. Sugar cannot come from nowhere. It is all come from the way we eat. So, Diabetics type 2 eat too mush sweeties. Simple and obvious. If diabetic type 2 has fat around middle area, it is because of too much fat on plate. What else it can be?

      I am not scientist. I am diabetic type 2. I do know very well what I eat, or do not eat. Also I do know very well, why I m diabetic, and what medicine I need to still alive.
       Million pages published that diabetes type 2 developed as a result wrong life style, wrong eating  and in-activity. There is nothing what can be done to prove how Med Pro wrong about there patients. But regardless of what patient do wrong or right, no one of us can be denied medical treatment. We are all denied right medicine we need. Diabetics type 2 do denied Insulin Therapy. We may have all medicine, regardless it is price. But Insulin is out of our list. Why? There are million pages how life style re-verse diabetes type 2. There is no studies how Insulin bring blood sugar level down.
        On many forums there are posted how diabetic type 2 reduces level of sugar from A1c 12.4% or 13.2% down to the 6% only with right diet and life style modifications. Just 6 month, and great job was done. Almost perfect with one exception, it is never happened. There are no one study how Insulin Therapy improved diabetic's life, and saved that life. Really why?
       Why with so wide spread public concern that there is diabetic type 2 epidemic, there still no test for blood sugar as vital? Also there is no one constant number, what level of sugar is normal and when it is elevated. In no one hospital diabetics type 2 treated with insulin when we are in ER with any other issue like wound care or Asthma attack. There are so many complications which every one diabetic does have. But still take a look at diabetic's file, what is there ? "Diabetes type 2 without complications."
       Why is this so? It is simple. If MD diagnosed some medical condition, it must be treated. If there is no medical diagnose then regardless of any reality treatment is denied. Diabetic or any other patient must cope with it by himself. No one MD responsible for diagnose which is missed. No one MD ever was sued for wrong diagnose or wrong treatment. Prove? Show me one case when MD was sued for diagnose Diabetes type 2. There are 90% of all diabetic population are diabetics type 2. How they all were diagnosed with diabetes type 2, what test was run? Yes, level of sugar was elevated. But it is elevated in many other conditions, diabetes type 1, LADA, MODY, Idiopathic Diabetes. To diagnose type of diabetes there must be test that it is Insulin Resistance, rather then Insulin Dependency. There are no any test for the level of insulin, and how much insulin our pancreas secret in normal healthy way.
      All diagnose Diabetes type 2 are wrong. There are no test no any evidence that one is resistant to Insulin.
       If diagnose is wrong, how treatment can be right? This is why treatment is "Life style modifications". Is that possible to be wrong? How treatment with 8 glasses of water a day, and work out can be wrong? But is this treatment right? Not at all.With severe edema try to drink 8 glasses of water. It can be fatal. With heart rate over 200 try to go to fitness club. I wish you luck. With severe edema try to go to ER. What is treatment? Diuretics. No Insulin. Edema already was caused by heart failure. Add diuretics, and get ready to take ride to crematorium.
      So, really what makes us unhealthy? Do we do it for ourselves, or with so high money spending America still below in health and life expectancy.
      BTW, I do remember one of the published article by this author. He mocked  is people what he has universal treatment for all of us. Do you remember it?

The most important advanced technology with which to fight obesity is the bathroom scale, used every day. Don't let that number rise. Proper use of the bathroom scale can help prevent obesity and with that, heart disease, congestive heart failure, diabetes, sleep apnea, stroke, hypertension, osteoarthritis, gastroesophageal reflux disease (GERD), various cancers, depression, and even erectile dysfunction. But way back then, maybe Chainsaw Al's Sunbeam corporation didn't sell bathroom scales.

 http://www.medscape.com/viewarticle/807574?src=wnl_edit_specol&uac=164666HZ

Medscape Internal Medicine

 I published it in March 2016. "Does Obesity is Disease? March 9, 2016" With MD who is able to treat all medical conditions with one tool, bathroom scale, there is no any hope to get healthy. Bathroom scale does not replace Insulin. Without insulin in blood human cannot live. How is that hero?

As the ultimate insider (me: organized-medicine member since 1967; JAMA journals editor for 17 years; faculty at University of Southern California, University of California, Northwestern, Harvard, Stanford) through that entire time, I am struck by how the ultimate independent outsider (Taubes) could look at the same mass of information all the rest of us had access to and come to such different conclusions.

WOW!!!!!!!!!!!!!!!!!!!!!!!
Very impressive!!!!!!!!!!!!!!!!!!!!!!!!!!

via Ravenvoron

Role of Insulin in the immune system. August 31, 2018

When I saw the title of the article I jumped to read it. In my mind it was that finally insulin got attention of Med Pro  as important for our health and well being. The reading surprised me. It is not about importance of insulin, but about studies, a new subject to study under the same clot, the way to get free money.

TGHRI scientists have identified a specific insulin signaling pathway that, when activated, revs up the response of T cells in the immune system to divide rapidly and secrete cytokines, chemical messenger proteins that activate the rest of the immune system. A fast and effective immune response protects us against disease and life-threatening infections by destroying infected cells or microbes, while a wrong or inefficient one can cause immune system disorders or diseases to develop.
https://www.sciencedaily.com/releases/2018/08/180830113035.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

What discovery of this? At first it is something specific, not old very well known insulin which on market almost 100 years already. It is type of insulin that do signaling job. Second, regardless of any reason, diabetes still metabolic disorder rather then immune system disorder.Probably studies are good and helpful in some way. Still today our Med Care has no idea how to treat diabetes type 2. They even have no one clue diabetes what is it? It is as usual metabolism of carbohydrates. There is no one study if this idea right or wrong. What if Diabetes is not metabolism of carbs but absence of insulin? If so then does not matter how effective way of signaling insulin is doing, when there is no insulin then there is no signals to boost immune system.
       So, over, over and over we come back to the same question, if there are insulin in body system?

"The link between insulin and the immune system is not obvious," says Dr. Tsai, "it is fascinating to learn that immune cells, which require energy and nutrients for proper functioning just like all other cells in the body, are also regulated by metabolic signals from insulin."

 Really I did find nothing fascinated in this. Just the idea that immune system need insulin to do the job as well as all other cells, is obvious, nothing surprising. If there is no insulin then regardless of any signals, or stimulation cells still out of nutrition and cannot function without insulin in right amount.
       In many cases we do not have answer to our questions. What we suppose to do? Usually we do our best to find solution without knowing the cause of the problem. The solution is simple, add Insulin in injections to help cells to function, and probably to buy the time when cure will found. In contrary, Med Pro looking for causes and try to find mysterious cure, but reject diabetics most important medicine to prolong their lives, Insulin. There are all very well known that with Insulin in injections people can live and even get much much better. This is not what our Med Care need. They keep live stuck, diabetics  typ2, on lush, to secure own way of lives and profit.
      Take a look at how many money spent to Med Care of diabetics type2, to hospitals, to education of those who are diabetics how to eat, and so so so on. So much drama. All would be in no need if there is no diabetes type 2, or it still diabetes type 2 but treated with Insulin it will not be in such high cost and need for specialists. 

via Ravenvoron

Understanding Insulin Resistance. August 30, 2018

 Understanding Insulin Resistance.
By Erika Gebel, PhD
 http://www.diabetesforecast.org/2011/jun/understanding-insulin-resistance.html

 The bodies of many people with diabetes are fighting a quiet war against the essential hormone insulin. This conflict is called insulin resistance, and while it's a hallmark of prediabetes and type 2 diabetes, it can also affect those with type 1. Just why a person fails to respond properly to insulin is something of a mystery. But there are ways to make the body more receptive to insulin, which can help prevent or ameliorate diabetes.

      This is author present Insulin Resistance.  As it is easy to see, type 2 diabetics do have Insulin resistance, type 1 diabetics does have Insulin resistance, and some diabetics type 1 do have Insulin resistance. So, it is important to recognize when it is resistance to insulin and what really is it? And when it is Insulin Dependency? It is unclear so far why this happened. But still, it is clear that there aare two different types of diabetes, Resistance to insulin and Insulin Dependency when insulin in  shots needed to person who effected by this condition, to survive.

In people who have neither diabetes nor insulin resistance, eating a typical meal will cause blood glucose levels to rise, triggering the pancreas to produce insulin. The hormone travels through the body and induces fat and muscle cells to absorb excess glucose from the blood for use as energy. As the cells take up glucose, blood glucose levels fall and flatten out to a normal range. Insulin also signals the liver—the body's glucose repository—to hold on to its glucose stores for later use.
However, people with insulin resistance, also known as impaired insulin sensitivity, have built up a tolerance to insulin, making the hormone less effective. As a result, more insulin is needed to persuade fat and muscle cells to take up glucose and the liver to continue to store it.

     Let us take closer look at this statement.

In people who have neither diabetes nor insulin resistance, eating a typical meal will cause blood glucose levels to rise, triggering the pancreas to produce insulin.

Are you sure, pancreas start to produce insulin in response to eating?  What if this is not really the case? What if insulin is already in blood, or in some places in cell ready to deploy in response to glucose rising in time of eating? If so then it is more obvious why level of sugaar in blood dropping fast. Also it is easy to understand why in case of diabetes type 2 level of sugar does not return back to normal level. There is no secreted insulin to be stored and ready to use. In this case insulin must be at first secreted, and only after being secreted and sent to blood stream it can be used. Time Factor. In case of diabetes type 2 the time for level of sugar in blood to drop is longer. In some cases it is more then 5 hours.

However, people with insulin resistance, also known as impaired insulin sensitivity, have built up a tolerance to insulin, making the hormone less effective. As a result, more insulin is needed to persuade fat and muscle cells to take up glucose and the liver to continue to store it.

How this claim was ever proved? How it was ever tested that insulin is not effective, and how effect of insulin was determined? Simple, with level of sugar in blood. Because of there is all the time only one test, and there are so many medical conditions then to determine which one and when it is up to MD, or Medical Care Pro. They are doctors, and we are not. we will take all for granted what they said. I am not one of them. I ask questions.

In response to the body's insulin resistance, the pancreas deploys greater amounts of the hormone to keep cells energized and blood glucose levels under control. (This is why people with type 2 diabetes tend to have elevated levels of circulating insulin.)

Really? What is the normal level of insulin that our body used during 24 hours? hen insulin use higher, at night or at day time? There are so many gustions can be asked, but the answer is only one:

 Doctors don't usually test for insulin resistance as a part of standard care. In clinical research, however, scientists may look specifically at measures of insulin resistance, often in an effort to study potential treatments for insulin resistance or type 2 diabetes.

Bingo!!!!!!!!!!!!!!!!!!!!!!
No tests for level of insulin!!!!!!!!!!!!!!!!!!!!!! In labs researchers study how diabetes type 2 developed in mice which was fed with fatty diet and deeply depressed in its cage. After study mice behavior researcher notify public that diabetes type 2 caused by fatty diet. If diabetic type 2 will starve her/him-selves for Death, they will not have diabetes type 2. No. Sugar still in bones and thiis is how many years after diabetic died the cause of death can be identified.

Insulin resistance comes in degrees, with important health implications for people with diabetes. The more insulin resistant a person with type 2 is, the harder it will be to manage the disease because more medication is needed to get enough insulin in the body to achieve target blood glucose levels.

This is also interesting point, the degrees of insulin resistance, so it is stages of diabetes. Then more insulin needed to bring level of sugar back to normal then higher stage of Insulin Resistance. Also it is very easy to see that to insulin delivered into blood stream can lead to drop blood sugar level. As we can see, there is no one medicine so far to treat any type s of diabetes in any stages of it with any degree of it. It is Insulin in injections, or insulin which was secreted by diabetic's own ill pancreas and limited beta cells.

The ability of the pancreas to increase insulin production means that insulin resistance alone won't have any symptoms at first. Over time, though, insulin resistance tends to get worse, and the pancreatic beta cells that make insulin can wear out. Eventually, the pancreas no longer produces enough insulin to overcome the cells' resistance. The result is higher blood glucose levels (prediabetes) and, ultimately, type 2 diabetes.

Now just think about it how beneficial SU, medicine to increas insulin secretion for diabetics type 2, can be for victims? Withing less then 10 years after diabetes type 2 treatment started, diabetic die.  It is not all time due to diabetes as it is stated in Death certificate. It is CVD or stroke, cancer or Asthma, and many other All Cause Death mortality causes. But diabetic type 2 die less then within 10 years after treatment with SU and Metformin started. In contrary, diabetics type 1 live longer then 60 years after being diagnosed with Diabetes type 1. Simple math. Do I really will live if I trust in MD?

via Ravenvoron

Piecemeal

We talked technology at last week's endocrinologist appointment. My daughter is using an Animas Ping pump and a Dexcom G4 CGM. The Animas can be serviced or replaced for another year before we'll have to switch to Medtronic for the last two years of its warranty. The Dexcom version we're using is almost obsolete, so we have to change something, but the question is, how much?

We could close our eyes and jump headfirst into a full switch to all things Medtronic. We would likely be transitioned to their 630G model which works with their Guardian brand CGM system and a Contour meter as a meter remote. This pump would suspend insulin delivery when low blood sugar is detected by the CGM sensor.

The low glucose suspend feature would be reassuring, especially for those few nights per year that my daughter spends away from us. On the other hand we've heard mixed reviews of the Medtronic sensors, in terms of accuracy and calibration neediness. We hear they're improving with each version, which is incentive to wait a while. There is already a more current Medtronic pump, which adjusts the basal rate every few minutes based on feedback from the CGM.. We wonder if we wait a year if we'll have the option of switching directly to their most recent version, whatever that is at the time, which would surely have more bells and whistles than the current offer.

Our other option is to keep the Animas pump for another year and upgrade to Dexcom's G6 CGM. The G6 requires no fingersticks for calibration, and can be worn for 10 days before changing the sensor. The CGM data can go straight to my daughter's phone, and be shared with us from there, or we can choose to use a receiver. The reviews of its accuracy are stellar.

My daughter is comfortable with the Animas pump, and super-excited about the Dexcom G6. So the plan is to move forward with those for the next year.

It feels like a piecemeal solution. But it's not a perfect world. Insurance and corporate deals dictate the diabetes choices we can make. We are destined to be Medtronic people.

Just not yet.





via Adventures in Diabetes Parenting

Diabetes type 2 epidemic in Guatemala. August 30, 2018

---

The diabetes epidemic in Guatemala is worse than previously thought: more than 25 percent of its indigenous people, who make up 60 percent of the population, suffer from type 2 diabetes or pre-diabetes, suggests a new study published in PLOS ONE from researchers at the Penn Center for Global Health, in collaboration with the University of San Carlos in Guatemala City and the Hospitalito Atitlán.
 https://www.sciencedaily.com/releases/2018/08/180814101416.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

There are many factors which can explain such surprising epidemic of diabetes type 2. What is not in list of explanation - obesity or BMI.

 The researchers found that age had a statistically significant association with type 2 diabetes, while BMI did not. Irrespective of BMI, an individual over 65 years old was more than 10 times more likely to have diabetes compared to individuals below the age of 40. Similarly, individuals 40 to 64 years old were more than five times more likely to have diabetes than individuals younger than 40.

It is presented that in Western world  obesity is the cause of diabetes type 2, why? Because of there were no studies when diabetes type 2 developed. We all diagnosed as adults. Diabetics type 1 diagnosed as kids. Also diabetes type 1 is fast rising level of sugar and kids diagnosed in hospital with high A1c and in stage of semi-coma. Adult with diabetes type 2 usually diagnosed with lower A1c, often in clinic. Diabetes type 2 develops slow, but steady. When it is left untreated or treated with wrong medicine, diabetic type 2 will develop many complications and die timelessly.
      When we say "Diabetes" what does it mean, how diabetes determined, and what is the problem with health it carry on? 

Around the world, being obese or overweight has long been associated with a significantly increased risk of type 2 diabetes -- a condition that causes a person's blood sugar level to become too high because of a lack of insulin or the body's inability to use it efficiently.

        Actually it is two different medical conditions which diagnosed with the same test and named the same. If there is lack of insulin then this condition must be treated with insulin added in injections, the same as diabetes type 1 treatment. But it is not. Diabetes type 2 treated with behaviour therapy and demand to change lifestyle.
       On another hand, if diabetes is result of inability body to use insulin then it is different medical condition and must be named differently. So do testing. To check up if insulin used correctly or not.  There is of cause the biggest problem. How insulin works Med Pro only speculate. It is even unknown how much insulin need adult body for daily normal function.
       Blood sugar is not the disease. It is just symptom. In no one diagnose stated that flu is elevated body temperature, and TB is when temperature of body elevated.  As it is well known there are many medical conditions when temperature of body high. They all have different names, and they are diagnosed with different testing.
        In contrary, diabetes diagnosed according to the symptom.

Pre-diabetes is when a person's blood sugar level is higher than normal, but not high enough to be considered diabetes.

 Well, what are the numbers to be diagnosed with diabetes, prediabetes, or what else?

• A fasting blood sugar level from 100 to 125 mg/dL
• If it's 126 mg/dL  or higher on two separate tests, you have diabetes.
• If random blood sugar level is 200mg/dl or higher, then it is diabetes. 
• An A1C level of 6.5 percent or higher.
• An A1C between 5.7 and 6.4 percent indicates prediabetes. 
•  Below 5.7 is considered normal.

How reliable this method to diagnose medical condition?Fasting blood sugar from 100mg/dl to 126 mg/dl is not normal level of sugar if it will be diagnosed with A1c test. Also capillary test is not accurate. It depend not only person ate or not but also when one wake up in the morning, or sick at that moment (with flu for instance) or depressed and stressed out. Many factors may effect capillary test. For that reason A1c is more reliable. If today group of researchers come to our community and will take blood sugar level in everyone, then I am sure, they will be surprised how many skinny diabetics type 2 they will find. This is why I always ask, why level of sugar in blood is not Vital? There are many conditions can be treated, but if diagnose is wrong then no one treatment will do the job.
     There are many why? Most important is, what to do about this findings?

Past studies linking diabetes to aging suggest several possible explanations, including pancreatic deterioration, epigenetic dysregulation of pancreatic islet cells, mitochondrial functional decline, increasing myosteatosis (skeletal muscle fat infiltration that occurs with aging), and reduced physical activity. Others suggested that aging is an independent factor adversely affecting insulin concentrations and insulin resistance.

          As I just said, blood sugar must be vital. We do not have tools today to test level of insulin in body. but we can control level of sugar with insulin injections. Regardless if it is diabetes or pre-diabetes, one is sick, and one needs medical help to get better. On early stages when sugar is not so highly elevated, insulin dose is small, and probably 20 units would be good for pre-diabetics. There will not low sugar, and treatment will go smooth and easy.
       When sugar on meter is over 700 mg/dl then regime of insulin therapy is complicated. It is easy to swing from high level to fatally low blood sugar level. There no types of diabetes, but stages of it, according to the level of insulin secretion sufficiency. Insulin level must be tested in every case of diabetes type 2 diagnose. And also, stop to create stigma that diabetics type 2 do need conduct correction. We are not criminals. we are ill people, and we need medicine, insulin, to survive.

via Ravenvoron

Another SGLT2 That You Can Feel Safe Prescribing. I do not see if it is safe for me to take. August 29, 2018

A new study concludes that canagliflozin (Invokana) is not associated with an increased risk for below-knee amputations. A previous large trial^[1] had raised this concern, although predominantly in patients with risk factors, including previous amputations, peripheral vascular disease, severe neuropathy, or high A1c.
 https://www.medscape.com/viewarticle/899712?nlid=124081_1521&src=WNL_mdplsfeat_180731_mscpedit_wir&uac=164666HZ&spon=17&impID=1699896&faf=1

     So, because of so negative reaction of Diabetics type on treatement and soo negative outcomes, there are another studies were conducted, and of cause they show that .... really what they show?

But this new observational study, based on data from more than 700,000 patients, found no increase in risk with use of this agent compared with other sodium-glucose co-transporter-2 (SGLT2) inhibitors or glucose-lowering medications. As expected, canagliflozin was associated with a lower rate of hospitalization due to heart failure compared with other medications for diabetes.

         As usual, if patient does not get better with medicine MD used to Rx then it is best way to change this medicine to another medicine from the same family. This will take time till patient get right understanding that newly Rx medicine has the same effect, and even worse.  When this happened, it is time to Rx another medicine from the same family of medication. The better way is to Rx two or three different medications at the same time and then manipulate naive patient. Perfect MD strategy.
      As someone mentioned in comment, Invokana or canagliflozin are the same. The difference is only time when Invokana was on market, and so complications developed so badly. New medicine is no more safe then old Invokana, but did not collect so many negative outcome.
      How Invokana work? It is great and very strong diuretic. Diuretics effect heart and kidney. It is also effect blood circulation. The result is, amputations, DVT, CVD, and high blood sugar. Really, why take Invokana, very expensive brand medicine? Take generic diuretic before and see, if your numbers will go down or up. Also pay closer attention to the heart rate.With any diuretic heart rate increased. If heart is good and patient still young then there are less obvious declines. If one is diabetic type 2 with high A1c then heart is already effected. A new medicine will add complications.
       It is easy to Rx diuretic when it is edema and it is obvious that to fight edema best way is to get rid of water. But with very close observation this way does not work, so simple, it does not work in this way.Diuretics bring additional complications, but never benefits to Diabetic type 2.
        DVT going deeper and deeper. With time at first skin goes away. Then flesh started to rib off, opening naked bones. Infection follow up. Amputation is only the option.

If one try to go to hospital then ...  there is not too much pelp. as diabetics type 2 we are very hard effected by diabetes type 2. usually MD in hospital prefer to send us home to find our way back to life. With time if right actions were not taken, amputation become not avoidable.
       Best way I found after I was sent home from hospital in the same condition I was admitted, is to wrap my legs. A little bit more then month all wounds were cleaned, and even legs still dark in color, they were dry. No wounds. Now two years later I still wear that wraps every day. It is a lot of money, because of to get Rx to supplu MD must diagnose DVT and that I need this supply. MD resist to diagnose medical condition, to Rx medical supply. I have to pay it on Amazon. Now my legs getting light and return to normal color.
    As I said before, I never take diuretics, nether types of it, Invokana including.

via Ravenvoron

Potential target for developing obesity and diabetes treatment identified. August 28, 2018

Seventeen authors were listed on the article, "HDAC11 suppresses the thermogenic program of adipose tissue via BRD2." Nine of the authors are members of the CU School of Medicine. The research was supported with funding from the National Institutes of Health, the American Heart Association, and the Canadian Institutes of Health Research.
 https://www.sciencedaily.com/releases/2018/08/180809112422.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

So, so many authors, and what they found?

Mice lacking HDAC11 were protected from obesity, insulin resistance and other effects of high-fat feeding.

        Almost perfect solution. just take off HDAC11 and the problem is solved. Which one?That's right, what is the problem 17 authors pretend to solve? Obesity? Diabetes type 2? Insulin resistance? Insulin dependency? Usually it is said by all MD that diabetics type 2 do have too much insulin in blood. No one test for insulin ever taken. Yes, it can be tested with C Peptide level, but remember, C Peptide level show only one moment of insulin secretion, the moment when blood was taken. Was it is right level of insulin in blood? What will happen when diabetic type 2 takes food? Would be level of insulin sufficient to digest this food and convert it in right way? As long as I study diabetes this studies never being run. At least they were not published  in the most popular e-journals.
        When mice taken as a subject of study, and then compared with humans, then one must remember, mice never live 76 years. Human do. So, when mice studied, what age of mice was, and to compare with humans, what age it was to take into consideration?
       Mice as I do see did not have diabetes type 2 even with so wrong fatty feed. Mice just developed obesity. It is obvious, no space to run, no food to chaise, and only food available just fat. It is cage, and in cage everyu one will develop depression, regardless it is mice of human. Did those 17 authors took this fact into consideration? Not at all. All what they need just prove, fatty food leads to develop obesity. Obesity leads to develop many medical condition. Because of people do have diabetes type 2 this mean they are fat-eaters. They done it for themselves. Cause found. Just put human on starvation and there is no diabetes type 2. Really?
       Take these studies. Study people who lived in places effected by war or Natural Disaster, and starved. How numbers on glucose meter changed after calamities passed by? How many new cases of diabetes were diagnosed in effected areas?

"Through our investigation we found that inhibiting HDAC11 increases energy expenditure, which highlights its potential as a target in obesity and metabolic disease therapeutic strategies," said McKinsey. (a postdoctoral fellow in the laboratory of Timothy A. McKinsey, PhD, associate professor of medicine in the Division of Cardiology, who is the corresponding author of the article.)

So, if I did get it right, to cure diabetes type 2 it suggested to decrease energy expenditure, right?  For me it is difficult to get. Why healthy part of my body which is working and working good, must be effected by suspicious treatment? I am already too tired because of diabetes type 2. If I will take this type of treatment, how I suppose to live? Well, probably I will not have obesity. But I will not have energy to push air or pump blood. Would I take this treatment? Not at all. Now I am able to move my 380 pounds, and it is not healthy but OK so far. If my body would be 200 pounds, and no energy to move then what is good in that?

"We now need to test the role of HDAC11 in large animal models of metabolic disease and in human cell systems as we attempt to translate these exciting findings to the clinic."

This is what I all the time use to say. Have your log book ready. Every time when MD give you any treatment, wright it in log book. Try to take a look at what medicine you take, and how this medicine effect you, or your loved one. It is important to have this log book for all family members. If it is only one log book, and all in it for every one, it is important to have, and keep it safe. Life is long. One day it can safe your life.

via Ravenvoron

Want to Save a Billion Dollars? Go to Google to lern what these drugs do for you. August 28, 2018

        I used to post many times and long time ago that to take combo medicine is not good idea. I never take it. At first it is difficult to find out which medicine works and which one does not. Second, it is difficult to find right dose of it in combo medicine. And lastly what really medicine combined for? If it is the different medicine for the same condition then why do not increase dose of medicine in stead to combine it with another medicine the same family?  If medicine is fior different medical conditions then why treat two different medical conditions with the same medicine? Really I do not trust in combo. What I did not look at is the price. I was wrong. It is better to take a look at.

The math seems fuzzy in this article...generic diovan hct is less than 50 cents a pill...generic Percocet is less than 30 cents a pill not over 14 a pill...using brand name prices instead of the prices of the generic equivalent makes no sense...so no, not using combos will not save Medicare a billion dollars if you use the actual generic prices that are being paid...why was this article even written...

       This is comment of one of the reader of this disclose.  So, if I take two different drugs, and one is generic and another is brand then what do I have to pay? Co-pay. This co-pay is the same as it is combo medicine or it is single medicine. The co-pay is the same, regardless of dose. Great discovery for me.Another reason to not take combo medicine.

If I prescribe oxycodone and acetaminophen, CMS pays 38 cents per dose. If I prescribe Percocet, CMS pays $14.23 per dose—a 37-fold increase. You may, of course, ask why Medicare agrees to such exorbitant prices for these combo pills, but that, my friends, is a topic for another time.

Acetaminophen  (Tylenol) is an analgesic used to temporarily relieve minor aches and pains.  We all take this medicine time to time in our lives.
Oxycodone, sold under brand names such as Percocet and OxyContin among many others, is an opioid medication which is used for the relief of moderate to severe pain. 
If MD Rx opioid medication for me then more likely I will say? No, I do not take this medicine. I prefer Tylenol or Excedrin. it works for me all the time. No addiction. No withdrawal effect. Did MD notified patient what medicine he Rx? Not at all. We all take what MD Rx, till we get well educated and stop to trust in MD without reason. Trust must be learned. It never happened in first visit.

 If we took all of our patients on Diovan-HCT and switched them to valsartan and hydrochlorothiazide, we could give them each $1750 a year in cash and still come out even. That might be worth a bit of inconvenience, right?

         Diovan (Valsartan) is used to treat high blood pressure, congestive heart failure, and to reduce death for people with left ventricular dysfunction after having had a heart attack. Diovan is brand name. This is why many health care plans do not pay for. Also as I said, I will pay co-pay for diovan and have diuretic I do not need, and pay for it. There are many generic diuretics, no pay for patients at all. How really I am going to safe my money?
        This medication is used to treat high blood pressure.  Hydrochlorothiazide belongs to a class of drugs known as diuretics/"water pills." It works by causing you to make more urine. This helps your body get rid of extra salt and water. 

How does this problem get fixed? Three solutions. First, Medicare can put its foot down and stop paying for combination pills. Second, the FDA can stop granting market exclusivity for combination pills when the constituents are not novel agents.

I do have a few questions to author to ask.
        First, if medicare will stop to pay for combo medicine then how you are going to convince patients to get drug addicts? Without opioids on Rx no one adult will get addicted. We take medicine to get rid of pain, not like recreational. Are you sure this will work as you suggest? Not at all. Ask your daddy.
       Second, how you are going to cheat patients when you Rx wrong medicine and this medicine does not work? Usually MD Rx one medicine. Then because of this medicine does not work, MD rx another medicine the same family, and it is also does not work. And then there is some combo medicine come to surface. There is some benefits, and patient cheated. It looks like this medicine is good. It is not, but patient takes it.
           One example of it, all combo with Metformin. try to stop to Rx Metformin. It is danger medicine, and all diabetics type 2 have to take it. Two times this medicine was taken off market. It is returned under different name. Now one time after another there is Black Box in lable. And one time after another Black Box taken Off. So, to avoid so many evidence that Metformin is danger for diabetics type 2, now it  is in combo medicine. Try to take it off. LOL  Ask your daddy before!!!!!!!!!!!!!!!!!!!!!

via Ravenvoron

Dibetes type 2, fat, mice, and natural sugar benefits. August 28, 2018

Mice fed a diet high in trans fats and cholesterol for 12 weeks show fatty deposits in the liver (red staining). A new study from Washington University School of Medicine in St. Louis shows that the natural sugar trehalose blocks glucose from getting into the liver and turns on a gene, Aloxe3, that improves insulin sensitivity and other measures of metabolic syndrome, including reducing such fatty liver deposits.

Credit: Brian DeBosch

 https://www.sciencedaily.com/releases/2018/08/180823092016.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

         So, they took healthy mice, fed it with high trans fats, and this is how fatty deposits were developed. Then they look at diabetics type 2 and see, there are fatty deposits in our bodies. The conclusion is? We eat fat trance diet. So simple. If mice developed fat then I eat fatty food. I am not. My liver does not allow me to eat any fat, oil, or batter since I was child. Fat will kill my liver. But before that there is pain, hardly bearable pain, and I do not like any pain. So, I avoid fat in any means, oil, batter, fatty food. But anyway I am 400 lbs. So, according to all medical publications I am diabetic type 2 because of I eat fatty food. Many studies prove this claim.
         Now studies show that natural sugar is very beneficial. It is actually improve health of diabetics.

While potential medicinal use of trehalose still requires considerable research, the investigators found that giving mice trehalose via drinking water resulted in beneficial effects on the animals' liver metabolism -- similar to benefits that resulted from fasting. In fasting mice, the liver also turns on the same gene that improves the body's ability to use insulin.

Great studies, I will say.  Just remember, mice were fed with wrong diet. I am not. Mice was healthy before studies were  started, and diabetics type 2 already ill people. I will add-on that if mice will jhave right food and bigger cage then mice will be healthy as it was before. So, really what studies studied? Nothing. They just studied if wrong food beneficial or not. They just need more prove that diabetics type 2 ill because of wrong food choice. And they do not see that mice have benefits from drinking water, diabetics type 2 still progress to deeper insulin limited sickness. Are you remember, one of symptom of diabetes is drinking a lot of water.
       I suggest to add to study Diuretic medicine and give it to mice. Then take a look at how mice would develop CVD and diabetes and so so on. Diuretics are in everyone diabetic medical box. Diuretics kill heart. There is no studies how danger or beneficial diuretics are. It is just must have medicine. In every hospital we do have this medicine. It helps to reduce weight. Some people take this medicine for many many years. They do have strong and healthy heart. Other who do not have such luxury die soon because of kidney failure.

"In mice, this gene is turned on as part of what seems to be the normal fasting response. Our data suggest that fasting -- or giving trehalose with a normal diet -- triggers the liver to change the way it processes nutrients, in a beneficial way. And if glucose can be blocked from the liver with a drug, it may be possible to reap the benefits of fasting without strictly limiting food."

This is why it is good to take studies on animals. It is easy to do whatever studier wish. It is not the same with humans. If we are healthy, we do not participate in medical studies. When we are ill, we do not response to wrong medicine. Say me, what Brian DeBosch, MD, PhD, an assistant professor of pediatrics is going to do if there is no insulin  in secretion? Or it is so limited that no one diabetic type 1 may have. How in this case normal diet will be processed? So, regardless of all the studies which done, they are fake. It is in no one way that healthy mice and diabetic type 2 can be compared. So, regardless of studies outcome no one diabetic type 2 can benefit from these studies. There is no way that insulin sensitivity can be improved if there is no insulin in secretion. And if there is insulin added in injection then any normal diet will be easily processed, and no weight gain will be.

The researchers found that activating Aloxe3 in the mice given trehalose improves insulin sensitivity in a way that is similar to how thiazolidinediones work. Studying healthy mice given only water over a 48-hour period, they found that fasting, likewise, activates Aloxe3 in the liver. This activation could boost insulin sensitivity in the same way.

What does it mean? In body where insulin secretion is limited with treatment like this insulin sensitivity increases, so human will be more insulin-hungry. This is how Actos and Avandia work. These med increase insulin sensitivity. These med do not add insulin. The insulin still absent and any diet cannot be processed without insulin.

via Ravenvoron

Heart Attacks and Diabetes type 2. August 28, 2018

In people with diabetes, fats accumulate within the heart muscle and stop the HIF protein from becoming active. This means that a person is more likely to suffer lasting heart muscle damage, and develop heart failure after a heart attack.
 https://www.sciencedaily.com/releases/2018/08/180827140427.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

So, diabetes type 2 is first, and  heart attack or heart failure is follow up. 

Nearly 3.7 million people in the UK have been diagnosed with diabetes, with 90% living with Type 2 diabetes. If people don't receive a swift diagnosis and the right care, it can put people at much higher risk of developing heart and circulatory disease. In the UK there are nearly 200,000 hospital visits each year due to heart attacks. It is estimated that nearly a fifth (18.6%) of people who have a heart attack in the UK, also have diabetes.

        So, to treat diabetes type 2 is most important in early stage to prevent heart failure and mortality due to CVD, number 1 cause of death in America. Diabetes type 2 progressed yo the number 6 spot in death mortality table in America. Also I can say that with diabetes type 2 treated with right medicine and in right regime Mulignant tumors would be treatable and will slow down.
      So, what is the solution? Start to treat diabetes type 2. So simple. Why for so long time diabetes type 2 still not treatable and not curable? Diabetes type 2 which is mild type of diabetes  compare with type 1 diabetes when insulin secretion absolutely absent, why diabetes type 2 not curable and diabetes type 1 treatable and curable?
       Diabetes type 1 presented that it is type of diabetes when insulin secretion is almost absent. To treat diabetes type 1 many diabetics take less then 10 units of insulin. In contrary, diabetes type 2 presented as it is resulted by wrong diet. It is treated with SU. Now say me, what is difference? SU is type of medicine which force diabetic type 2 ill pancreas to secret more insulin. With time diabetic type 2 insulin secretion stopping. Would diabetic type 2 have insulin and presented as type 1 diabetic with low or absent insulin secretion? Not at all. Regardless of any level of insulin secretion diabetic type 2 trapped in this diagnose for the rest of our short miserable lives.
       In contrary. If diabetes type 2 started to be treated with insulin as soon as it is diagnosed, pre diabetes or any level of high blood sugar, then with time insulin secretion would be re-stored. Diabetic type 2 would not die because of severity of medical condition. Diabetes type 2 complications would not be developed. Diabetics type 2 will have long normal life. Just do this study. Rx Lantus Solo Star to the newly diagnosed diabetics type 2 with moderate blood sugar elevation and see, if they will progress to the next stage of diabetes development or they would regress back to healthy normal lives.

"What we have shown with this research is that the metabolism of people with Type 2 diabetes means they have higher levels of fatty acids in the heart. This prevents signals going to the heart protective protein telling it to 'kick-in' after a heart attack.

      I can accept that fatty acids prevent signals. What I do not accept that it is well known to the medical care or researchers.  What they can see only that there are fat around heart. What signals going into heart and which do not pass through is not known. It is simple speculation. Even the fact that signals were sent is speculations.
       Why it is taken for granted that diabetes type 2 is metabolic disorder? It is not. It is insulin secretion disorder, immune system disorder. The hormone, insulin, secreted in the amount which cannot support body function. The result is, food we eat cannot be converted into energy our body system need to function. So, there are simple nothing to metabolize. Insulin is absent, and food cannot be processed without insulin. Period. End the metabolic disorder even before it started.

"But what is perhaps most exciting, is that existing drugs -- currently being trialled for people with blood disorders -- can reverse that effect and allow the protein to be activated after a heart attack.

Diabetes is already blood disorder, not metabolic disorder.  In stead to treat follow up disorder why do not start from the cause of this disorder, Diabetes type 2? And diabetes type 2 can be perfectly treated with Insulin in injections. With proper regime of Insulin Therapy there are no dangerous complications, and no low sugar will be developed. The dose of insulin in early stage of diabetes type 2 development is very small. Just less then 20 units daily Lantus Solo Star will stop diabetes development in pre- diabetics, and they would be diabetes type 2 free. even for those who dose not have diabetes right now but in risk to develop it later, 10 units of Lantus Solo Star will be beneficial to prevent diabetes type 2 development.

"For now, the best way to reduce your risk of a heart attack is to keep your blood glucose, blood pressure and blood fat at healthy levels, seek help to stop smoking, and by being active and eating a healthy, balanced diet."

Does it really best way? Well, take a look at the mortality tables. Diabetes type 2 progressed from spot number 7 up to spot number 6. No one diabetic type 2 can control blood sugar level with healthy diet, why? Simple, say me which diet is it? When I come to any hospital or any dietician, what do I have? In hospital my diet is the same as for everyone.  If it is so important part of treatment then say me why in no one hospital diabetics type 2 have different diet then anyone else? Ans Second, what dietician recommend? Do not smoke, be active, eat F&V, low fat, low carb, low sugar. If this therapy does not work it means that I do not follow doctor's recommendations. Simple. 100% work for Med Pro and public. And diabetics type 2 ding. In pain. In misery. Mocked, abused, humiliated.

via Ravenvoron

Level of sugar and weight gain in diabetes type 2. August 27, 2018

One of the side effect of Insulin is weight gain. Personally I did not gain weight when I started to take insulin. This come later when one time after another treatment regime was broken. But still, with insulin as treatment regime hunger developing. There is no reason to fight this hunger. On the other hand with time weight will increase. This happened even with very small dose of insulin. It happened with me. At one time I could not stop to eat, how hungry I was.
       Insulin presented that it is response of pancreas to food we started to eat. So, insulin started to secret in bigger quantities. Something like that.
      My theory is different. Insulin secreted in small portions all day and night long. But it does not go right to the blood stream. It kept in cell in special compartment for be ready to use when it is needed. When food started to digest insulin enter into blood stream. When there are no compartment to keep secreted insulin, or when insulin secretion is very limited so there is nothing to keep, then when we start to eat we get very very hungry. This happened not only with insulin but with SU as well, any medicine which increase level of insulin in body.
       I solved this problem with very easy solution. I took Lantus Solo Star before meal, any meal. Lantus Solo Star is long lasting type of insulin, basal. MD Rx this type of insulin one time daily at night. I take it as I need, and I do not take any other types of insulin, just Lantus Solo Star. Shortly after there is no more hunger, and not I can eat as I need.

via Ravenvoron

Attending #AADE18 As The On-Site Guest Reporter for Ascensia

Last week I attended the American Association of Diabetes Educators annual meeting in Baltimore, MD as the On-Site Guest Reporter for Ascensia.

  
There I was surrounded and inspired by thousands of passionate Diabetes Educators, (our Diabetes Mechanics,) whose jobs (and lives for that matter,) are devoted to making sure that people living with diabetes are provided with the tools/skills in the form of knowledge; support, and empathy so that we can live our best lives with diabetes.  
I was able to sit in on multiple sessions re: peer support; treating both the mental and the physical sides of diabetes, dTech, and teamwork. 

IT. WAS. AMAZING. 

I'm sharing my #AADE18 experiences and POV as a person living with diabetes in a series of 3 articles for Ascensia 's website - I did similar project with them back in June for ADA. 

Article 1 is up and running - here's the link and I'd very much appreciate you guys giving it a read!

 http://www.ascensia.com/press/aade2018/

FULL DISCLOSURE: Ascensia paid for my hotel, travel expenses, and provided me  

with an honorarium for my time and skills - all of which I appreciate.

As always, ALL THOUGHTS are mine and mine alone. 

via Diabetesaliciousness

Cardiovascular disease and type 2 diabetes. What can be done? August 24, 2018

Properly composed treatment and refraining from cigarette consumption can significantly reduce the risk of cardiovascular disease resulting from type 2 diabetes, according to a new study. In some cases, the increased risks could theoretically be eliminated.
https://www.sciencedaily.com/releases/2018/08/180816105532.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

Great to know we can eliminate heart attacks and strokes. Only one problem, how to compose this proper treatment?

The study is based on data from the Swedish National Diabetes Register of approximately 300,000 patients with type 2 diabetes in the period 1998-2014. These patients have been compared with up to five times as many gender- and age-matched control subjects from the general population.

The study found that some diabetics type 2  as high in risk as 10 fold compare with general population. Other just 15% higher in risk. So, how to get into 15% and avoid early death in 10 fold?

A crucial aspect is how well a number of risk factors are controlled with medication and by not smoking. These factors are blood pressure, long-term blood glucose, lipid status (fats and fat-like substances in the blood), renal function and smoking.

To be more precise,  stop to be diabetic type 2, and there would not be early death from CVD. So simple!!!!!!!!!!!!!! How did not we still do not know that! Really diabetics type 2 just idiots, right? In stead to take right medicine we take wrong one, and diet timelessly.
      OK, what can I do?
I can do not smoke, I never did. So, this task I accomplished.
Blood pressure?  I take many medicine to keep it as down as I can. Most valid medicine for me is Excedrin, over the counter medicine. I do know I need blood thinners such as heparin but it is only available by Rx, so I cannot have it. No one MD ever Rx this medicine for me. So, I have to relay on Excedrin last 25 years. This highly effective medicine keep me alive, and prevent strokes and heart attacks to get fatal. So happy, I do not need Rx for this medicine. On the other hand, I pay high price for this highly effective medicine, even it is just generic medicine.
Lipid status. This problem also solved. I stopped to take medicine which created that problem such as Metformin, and I do not take any generic medicine for cholesterol lowering, just brand, Lipitor. So, now my cholesterol level is in healthy ranger. No life style modification, no special diet, just stop bad medicine and take good medicine. Problem solved.
Renal function. I still not able to fix my highly damaged kidney. In spite I do have very good health plan, I have no one medicine to improve kidney health. Usually it is diuretics. They effect my poorly working heart, and I do not take it, even to reduce my high weight due to edema. There are no medicine to prevent kidney damage. No medicine to treat damaged kidney. I try to do my best. I keep my legs wrapped and pay high price for every wrap delivery. I also try to take water as much as I can. Kidney got better, but still in poor condition.
Finally, high blood sugar  level. Of cause we all try to keep our sugar level under control. Only one problem, we need right medicine to do the job. Right medicine is only by Rx. MD refuse to Rx effective medicine. Thy play safe medicine for them, and do not care how danger this medicine for their victims. What is medicine for Diabetes type 2? Metformin, to kill liver, SU to kill B-Cells and pancreas. This medicine is effective. Diabetes type 2 is number 7 cause of death in America. It is number 4 in NYC.

Smoking proved to be the most important risk factor for premature death, while elevated blood glucose level was the most dangerous factor for heart attack and stroke.

So, what study found how to lower high blood sugar level? LOL. They do not study how to avoid strokes or heart attacks or both. They simple studied what subject to take for study that without any brain work they will get proper results and get easy money.
Nice job by 

Aidin Rawshani, medical intern and doctoral student at the Institute of Medicine, Sahlgrenska Academy, Sweden, and author of the article.

What did I learned? That diabetics type 2 must keep high blood sugar under tight control. If we do not we will be in 10 folds higher risk to develop heart attack or stroke or both. But if we get proper education, stop to take Junk Medicine and switch to highly effective Insulin Therapy, we can be in 15% and even less then that in table of all cause mortality.

via Ravenvoron

GABA Starts A Phase-II? Clinical Trial in Honeymooners

This blog has two parts.  The first part describes a phase-I clinical trial in honeymooners which started recently.  The second part summarizes the rest of the GABA (Gamma-Aminobutyric Acid) research done so far in people.  GABA is well known as a neurotransmitter, but it also is generated by pancreatic beta cells and also the immune system, both of which are heavily involved in type-1 diabetes.

GABA is widely available as a "dietary supplement", and you can read a lot more about it here:
https://en.wikipedia.org/wiki/Gamma-Aminobutyric_acid
There are several mouse studies that show effectiveness against type-1 diabetes.

The Current Clinical Trial

This trial will enroll 95 people with honeymoon type-1 diabetes into three groups as described below.  It is recruiting children aged 4 to 18.  They plan to finish in June 2019.  Primary outcomes are insulin usage and C-peptide generation, while secondary outcomes are levels of diabetes autoantibodies.  All of these will be measured one year after dosing.  People will get two injections of GAD, one month apart.  They will take GABA pills twice a day.  I think the pills will be for a year, but I might be wrong about that.

The three patient groups are:
    Some people will get two different placebos, and be a control group.
    Some will get GABA and a placebo for GAD.
    Others will get both GABA and GAD.

GAD is developed by Diamyd corporation, and has been tested for at least 10 years.  I've blogged on it in the post many times:
https://cureresearch4type1diabetes.blogspot.com/search/label/Diamyd
It has a long history of safety, but also of not being effective.  So I don't hold out much hope for the GAD alone being effective.  But that doesn't really matter, because GAD alone is not being tested.  Since two different arms will get GABA, if that is effective, it will be obvious.  If the GAD + GABA arm is more successful than the GABA only arm, that would breathe new life into GAD research.  In animals, GAD is part of the biochemical mechanism which creates GABA, so the two are related.

This trial is marked in the FDA registry as still recruiting at one site, however the press release from Diamyd says it is already fully enrolled:
    Children's [Hospital] of Alabama, Birmingham, Alabama, United States, 35233
    Contact: Sharon D. May, BSN    205-638-5031    smay@peds.uab.edu 
    Contact: Heather Choat, MD    205-638-9107    hchoat@uab.edu 
    Web page: https://www.childrensal.org/endocrinology-research

The researchers considered this a phase-I trial, but because of the size and the previous GABA clinical trials, I'm treating it as a phase-II? trial, meaning a trial big enough to be phase-II, but without results from a previous phase-I trial done on people with type-1 diabetes.

Press Release: https://www.diamyd.com/docs/pressClips.aspx?ClipID=2827171
USA Clinical Trial Registry: https://clinicaltrials.gov/ct2/show/NCT02002130
WHO Clincal Trial Registry: http://apps.who.int/trialsearch/Trial3.aspx?trialid=NCT02002130

This research is funded by JDRF and the companies that manufacture GAD (Diamyd / Johnson and Johnson) and GABA (NOW foods).

Preview of Coming Attractions: Diamyd, the company that researched GAD is now also working on a GABA based drug called Remygen.  A research group in Sweden is planning to start a trial of this drug in people with established type-1 diabetes in Sept 2018. I'll blog on these trials when it starts.  Clinical Trial Record: https://clinicaltrials.gov/ct2/show/NCT03635437

A Little History

Back in 2012 Penny Jester, a researcher at the University of Alabama at Birmingham, tried to start a clinical trial in GABA.  However, the FDA did not approve her IND (Investigational New Drug) application, and so the trial was never started.  You can see the registration here:
https://www.clinicaltrials.gov/ct2/show/NCT01561508

In 2013 Zhaoyun Zhang and fellow researchers at Huashan hospital in Shanghai, China ran a small study (confirming safety) on GABA in healthy people, reported here:
https://www.ncbi.nlm.nih.gov/pubmed/26617516

and  registered here:

https://clinicaltrials.gov/ct2/show/NCT01917760

Then in 2013 the same group started a 60 person phase-II? study of GABA on people with honeymoon type-1 diabetes, but I have not been able to find published results.

You can read Dr. Zhang's rational for testing GABA in this paper:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322886/

More Reading

Because both GABA and GAD have long histories as potential cures for type-1 diabetes, there is lots of previous research to read, if you want:

    https://www.the-scientist.com/news-opinion/studies-unable-to-reproduce-results-of-two-diabetes-papers-64630

    http://diabetes.diabetesjournals.org/content/62/11/3674.full

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136292/ (mice)
    https://www.uu.se/en/news-media/news/article/?id=10440


Joshua Levy
https://ift.tt/29DuN3o
publicjoshualevy at gmail dot com
All the views expressed here are those of Joshua Levy, and nothing here is official JDRF, JDCA, or Bigfoot Biomedical news, views, policies or opinions. In my day job, I work in software for Bigfoot Biomedical. My daughter has type-1 diabetes and participates in clinical trials, which might be discussed here. My blog contains a more complete non-conflict of interest statement. Thanks to everyone who helps with the blog.

via Cure Research

About Prediabetes & Type 2 Diabetes.CDC info. August 23, 2018

More than 84 million US adults—that’s 1 in 3—have prediabetes. With prediabetes, blood sugar is higher than normal but not high enough yet to be diagnosed as diabetes. People with prediabetes are at high risk for type 2 diabetes (the most common type of diabetes), heart disease, and stroke.
https://www.cdc.gov/diabetes/prevention/prediabetes-type2/index.html

One out of three Americans has prediabetes. What out government done to prevent pre-diabetes to progress and to kill its victim?

 If you find out you have prediabetes, ask your doctor to refer you to a CDC-recognized lifestyle change program. Through the program, you’ll take small, manageable steps that add up to lasting lifestyle changes to prevent or delay type 2 diabetes.

       So, third American population are idiots who practice wrong life style?  Why our society let it happened? Probably American prisons full with other criminals, so there are no place for Diabetics type 2. If so then why do not convert some facilities into prisons for diabetics type 2 where we will practice healthy life style and be cured from diabetes type 2? For me it sounds reasonable. At leas there would not be born another potential diabetics type 2 from diabetic mother or father.

Rick to develop diabetes type 2.

• Are overweight
• Are 45 years or older
• Have a parent, brother, or sister with type 2 diabetes
• Are physically active less than 3 times a week
• Have ever had gestational diabetes (diabetes during pregnancy) or given birth to a baby who weighed more than 9 pounds
• Are African American, Hispanic/Latino American, American Indian, or Alaska Native (some Pacific Islanders and Asian Americans are also at higher risk)

There we are. Can we prevent to get over 45?
Our parents already older, so they are at rick to get diabetes type 2. Can I prevent to be born from diabetic type 2 father or mother? What if I was born to diabetic type 1 father? What if I was born to father who died, and no right cause of death in his Death Certificate? Can I prevent diabetes type 2?
Lastly, show me one who is not active and working. So, activity which taken in consideration only if it is fitness club, right? So, we can come to club, have lovely conversation, and go home. Is this activity? Sounds stupid, right? If so then why it is taken for granted that diabetics type 2 developed diabetes because of inactivity? Why this does not sound stupid?

You can prevent or delay type 2 diabetes with simple, proven lifestyle changes such as losing weight if you’re overweight, eating healthier, and getting regular physical activity.

I was almost ready to take this bite, but there is problem. My father was diabetic and he died at age of 37. No obesity. I am obese. I am 65.

Type 1 diabetes is thought to be caused by an immune reaction (the body attacks itself by mistake). Risk factors for type 1 diabetes are not as clear as for prediabetes and type 2 diabetes.

 The matter of fact, no one do know how diagnose types of diabetes. So, in stead of do it is scientific way, our Med Pro as usual skipped into speculations. In this site there are so many rick factors posted, but what is diabetes type 2 really? Is it "insulin Resistance"? Or it is "insulin - independent" type of diabetes? In some places it is named "Not sugary type of diabetes". Why type 1 is sugary diabetes and type 2 is not sugary diabetes? The diagnostic tests are the same, level of sugar in blood.

 More than 30 million Americans have diabetes (about 1 in 10), and 90% to 95% of them have type 2 diabetes. Type 2 diabetes most often develops in people over age 45, but more and more children, teens, and young adults are also developing it.

 So, diabetes type 2, what is it?

Unlike many health conditions, diabetes is managed mostly by you, with support from your health care team (including your primary care doctor, foot doctor, dentist, eye doctor, registered dietitian nutritionist, diabetes educator, and pharmacist), family, and other important people in your life. Managing diabetes can be challenging, but everything you do to improve your health is worth it!

Primary doctor Rx:
 Metformin to kill liver;
SU to kill pancreas;
Diuretics to kill kidney; and so so so on..... .
starvation diet and intensive work out. It is all the time considered to be "Healthy", so no one specialist can be bring to court for malpractice. Perfect solution. 30 million  Americans , and all must manage his health and his or her fight with potentially fatal condition by him or her self. Perfect. If diabetes progresses then it is victim to be blamed, not health care team.

 You may be able to manage your type 2 diabetes with healthy eating and being active, or your doctor may prescribe insulin, other injectable medications, or oral diabetes medicines to help control your blood sugar and avoid complications. You’ll still need to eat healthy and be active if you take insulin or other medicines. It’s also important to keep your blood pressure and cholesterol under control and get necessary screening tests.

Well, this is diabetic type 2 practitioner blog.  This is my practice and studies:
use only long acting insulin which is softer and has no pick. It stay in blood and ready to be used at any moment we need it.
do not take any injectaibles. They are not insulin.  The word, insulin, must be on pen or container with insulin. I prefer insulin in pen. It is easy to use, and very very convenient.
no one oral diabetes medication prevent from developing complications. Only insulin is valid and effective.
Blood pressure and cholesterol go down when all oral medicine for diabetes type 2 put into trash and only insulin used as valid diabetes type 2 control and prevention from progress.

Finally, there are millions of diabetics, type 2 or type 1. Why blood sugaar is still not vital? Why there are need in screening in stead to take level of sugar in blood every time when patient's blood tested? It is so easy, and not so expensive. 

Diabetes type 2 is way too profitable. All med care system stand on it. Med care system is business. This business based on life and death. Why MD will Rx insulin and ... lost patient because of with time is treatment started with pre-diabetes,  diabetic will recovery. No need in Rx for insulin. No need in clinic and visits. 

via Ravenvoron

Is One Basal Insulin Just Like Another? August 22, 2018

Long-acting insulin
Two types of this insulin currently on the market are detemir (Levemir) and glargine (Toujeo, Lantus, and Basaglar). This basal insulin begins working 90 minutes to 4 hours after injection and remains in your bloodstream for up to 24 hours. It may start weakening a few hours earlier for some people or last a few hours longer for others. There isn’t a peak time for this type of insulin. It works at a steady rate throughout the day.
https://www.healthline.com/health/type-2-diabetes/basal-insulin-types

        I used to take all types of Long-acting insulin but Basaglar. I take Lantus Solo Star right now for long many years. Highest dose I ever injected within 24 hr was 720 units of Lantus Solo Star. Very high dose I will say. Low sugar? Not at this time. But I do have low blood sugar almost every day now. Dose of insulin is dropping. I need between 300 and 400 units a day.  This is about low blood sugar. It is not type of insulin or dose of it but the right need for insulin in particular day. Easy to say, try to find this dose. I tried. I still do. 
        I started to take Levemir, 11 units. Then insurance preferred Lantus. And once I took Toujeo. All types of insulin in pan, so it is always Solo Star to be added to the name of insulin, Lantus Solo Star, Toujeo Solo Star, and so on. I took fast acting insulin too. Now I do not take it. So, there is not Med Pro blog, it is Diabetic type 2 blog.
        I do not see that Lantus Solo Start start to work 90 minutes to 4 hours after injection. If insulin injected and needed it start to do the job right away. Also when it said about 24 hr it is also not accurate info. At first what if dose of insulin too small? Would this dose stay in blood for 24 hr? Not at all. It is really low understanding in diabetes and how medicine works or not.
       BTW how author know that insulin stay in blood for 24 hr? There is no one test to check up the level of insulin in blood. If it was tested with C Peptide level then it is wrong test. C Peptide test does not show level of injected Insulin. So, it is better to ignore this wrong info.

       Another recently published study^[1] concluded that basal insulin analogs were no better than the old—and far less expensive—NPH insulin.
https://www.medscape.com/viewarticle/900600?nlid=124512_1521&src=WNL_mdplsfeat_180821_mscpedit_wir&uac=164666HZ&spon=17&impID=1718175&faf=1

With statement like that I will not trust in MD who publish this article. MPH is type of insulin where both, long acting and short acting insulin combined. I avoid to use combined medicine. How do I know if one works and another does not? If I do have side effect, then which medicine gave this effect? But it was time when I took Lantus Solo Star and Novolog, rapid acting insulin.  Side effect? Novolog "eat up" all what I ate right after meal, and soon I had to take another meal because of sugar dropping way to low, lower then 40mg/dl. On some point I lost when sugar is high and when it is low. Withing two - three  hours my sugar rised over 400 mg/dl, and then dropped down to 40 and then rised back up to 400 mg/dl. I stopped to take any short acting types of insulin, no combo insulins, and now take only Lantus Solo Star.

Bottom line: Many patients with diabetes will need insulin sooner or later. The higher cost of some newer insulins may not be matched by their clinical performance.

I like this conclusion. If so then why Insulin is not first line treatment in Diabetic type 2 therapy? When I started to take insulin back in 2011 less then 60 units was good for my day dose. Then one time after another  Insurance was terminated. Diabetes does not hold on till problem would be solver. It is blow up. This is why today I need so high dose of insulin.
      Also there is another point: Why level of sugar in blood is not vital? It is all about risk factors and prevention. But best way to prevent diabetes type 2 is diagnose it early and start treatment as soon as it was diagnosed, with most effective way to treat, Insulin?

via Ravenvoron

Evening preference, lack of sleep and Diabetes type 2. August 21, 2018

People with prediabetes who go to bed later, eat meals later and are more active and alert later in the day -- those who have an 'evening preference' -- have higher body mass indices compared with people with prediabetes who do things earlier in the day, or exhibit morning preference.
 https://www.sciencedaily.com/releases/2018/08/180815141422.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

It is so nice and easy to say: have an 'evening preference'.
Now the question is, how many nurses, doctors, any med personal work at eve shift?
How many MTA staff work at night shift?
How many ..... any professions staff must work at night shift?  Just count all those pro, and say, do they  have an 'evening preference'? Not at all. It is our life style, all those who work. Some pro does not work at night. Many have to. It is not because of those pro wish to work at night shift. They simple have no other choice.
       When it is said that pro who work at night shift will develop diabetes type 2, just remember, night shift is not healthy at all for anyone. It is not our nature to sleep at day time and be active at night time. Those shift leads to develop many medical conditions, high blood pressure and heart complications, vision decrease and Asthma attacks, and so so no, you name it, and it is true for any medical condition to be developed or to be developing.
       So, what really studies about? What it was said that no one do not know and study needed to discovery it? Really nice question, is not it?

Prediabetes is a condition where blood sugar levels are higher than normal but not yet high enough to be Type 2 diabetes. Without modifications to diet and exercise, patients with prediabetes have a very high risk of developing Type 2 diabetes.     

       Very interesting expression. Patient already does have elevated level of sugaar in blood. No, it is still not good to be treated. Diabetic must develop into deeper hole before treatment will be started. Till that treatment is only one, life style modifications. How does it work? LOL! Look at the Mortality tables which published by CDC. Diabetes is number 7 cause of death in USA. In NYC it is number 4 cause of death. Really interesting. IN NYC there are medical clinic on every corner. So, why diabetes stand so high in mortality. Well, of cause, there are  shops on every corner too, so every New Yorker stop by every shot and eatery before get to job, and after work day. Really, how people cannot develop diabetes type 2 if there is no hunger but food everywhere?
      Well, if this theory is true then ... then all people on the street will be the same size and the same wide. It is not. Someone is wider, other perfectly fit. Why so? The theory that amount of eatery and food stand lead to develop higher obesity looks like being wrong. Also, if this is true then every eatery and every food stand will have line of customers. It is not. I was in Asian Buffet last weekend. "All you can eat". What is most important, there was no food on plates left. People took one trip after another to take different food. But after they finished this food, plates were clean, no left over.  What is so important in this observation? People are intelligent being. They put on plate the amount of food they can eat, and do not put more then they needed. So, is this really true that people will stop over every eatery? Where is time for that?
       The theory that diabetics type 2 done it for themselves is very well suitable for creating public opinion that society can do nothing to safe these lives and prevent suffering. Really, how MD or nurse can stop diabetic type 2 from eating? But what if this theory is wrong? What if there is not eating problem and diabetics type 2 do not need to modify lifestyle? What if MD Rx of diet and work out is wrong? What if this treatment kill rather then heal? At least it can be done by study to support this theory or prove it is wrong.

The diabetes epidemic in Guatemala is worse than previously thought: more than 25 percent of its indigenous people, who make up 60 percent of the population, suffer from type 2 diabetes or pre-diabetes, suggests a new study.
https://www.sciencedaily.com/releases/2018/08/180814101416.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29

      When we will take into consideration that diabetes type 2 developed long before it was diagnosed and long before A1c >7.5% then the number of diabetics type 2 in  Guatemala will skyrocketing. So, why these people suffer from medical condition which considered to be priority of high developed societies with abandoned food choice?

"This alarming increase in both diabetes and pre-diabetes appears to be significantly related to aging, and not obesity or BMI (body mass index) -- a surprising finding that contradicts the traditional relationship we know between unhealthy weights and these diseases," said first author Kent D.W. Bream, MD, an assistant professor of Clinical Family Medicine and Community Health at the Perelman School of Medicine at the University of Pennsylvania and the Center for Global Health. "While it remains unclear why such a disparity exists in this population, some studies have pointed to increased physical inactivity and insulin resistance as drivers of diabetes in the elderly."

        At least it is one step up to support the idea, BMI is not the way why diabetes type 2 developed.  Now there is hope that one day someone will run studies and prove that there is no diabetes type 2 at all in first place. As soon as blood sugar started to elevate, simple start Insulin Therapy. If this diabetic will not recovery, then there is chance that next generation of these patient will not have diabetes type 2. The way to stop diabetes type 2 development. Simple, and possible to do today.
         It is all the time presented that insulin leads to low sugar. If so then say me, why there are so many studies, so many diets developed to treat diabetics type 2, and still, there is no one study how use insulin in injections? Try to find it. If you do, please, post link here. I will be grateful.

The researchers found that age had a statistically significant association with type 2 diabetes, while BMI did not. Irrespective of BMI, an individual over 65 years old was more than 10 times more likely to have diabetes compared to individuals below the age of 40. Similarly, individuals 40 to 64 years old were more than five times more likely to have diabetes than individuals younger than 40.

via Ravenvoron